{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:23:52Z","timestamp":1786983832253,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"am","delay-in-days":316,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["ZIA HL000225"],"award-info":[{"award-number":["ZIA HL000225"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.abb.2024.110268","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:21:33Z","timestamp":1734002493000},"page":"110268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Oxidation of CaMKII\u03b1 cysteines inhibits autonomous activation induced by phosphorylation"],"prefix":"10.1016","volume":"764","author":[{"given":"Nath\u00e1lia","family":"Rocco-Machado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney L.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2024.110268_bib1","first-page":"478","volume":"vol. 271","author":"Schulman","year":"1978"},{"key":"10.1016\/j.abb.2024.110268_bib2","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1742-4658.2005.05088.x","article-title":"Oligomerization states of the association domain and the holoenyzme of Ca2+\/CaM kinase II","volume":"273","author":"Rosenberg","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.abb.2024.110268_bib3","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13405","article-title":"Molecular mechanism of activation-triggered subunit exchange in Ca(2+)\/calmodulin-dependent protein kinase II","volume":"5","author":"Bhattacharyya","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.abb.2024.110268_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15742","article-title":"The CaMKII holoenzyme structure in activation-competent conformations","volume":"8","author":"Myers","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2024.110268_bib5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev.biochem.71.110601.135410","article-title":"Neuronal CA2+\/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function","volume":"71","author":"Hudmon","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.abb.2024.110268_bib6","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41583-022-00624-2","article-title":"CaMKII: a central molecular organizer of synaptic plasticity, learning and memory","volume":"23","author":"Yasuda","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.abb.2024.110268_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.ph.57.030195.002221","article-title":"The multifunctional calcium\/calmodulin-dependent protein kinase: from form to function","volume":"57","author":"Braun","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.abb.2024.110268_bib8","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1073\/pnas.80.23.7357","article-title":"Biochemical and immunochemical evidence that the \"major postsynaptic density protein\" is a subunit of a calmodulin-dependent protein kinase","volume":"80","author":"Kennedy","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.abb.2024.110268_bib9","doi-asserted-by":"crossref","first-page":"9039","DOI":"10.1016\/S0021-9258(17)39454-1","article-title":"Distinct forebrain and cerebellar isozymes of type II Ca2+\/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction","volume":"260","author":"Miller","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2024.110268_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102299","article-title":"CaMKII T286 phosphorylation has distinct essential functions in three forms of long-term plasticity","volume":"298","author":"Cook","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2024.110268_bib11","doi-asserted-by":"crossref","first-page":"8214","DOI":"10.1523\/JNEUROSCI.1469-10.2010","article-title":"CaMKII \"autonomy\" is required for initiating but not for maintaining neuronal long-term information storage","volume":"30","author":"Buard","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.abb.2024.110268_bib12","first-page":"37","volume":"vol. 94","author":"Murakoshi","year":"2017"},{"key":"10.1016\/j.abb.2024.110268_bib13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nn1431","article-title":"AlphaCaMKII autophosphorylation contributes to rapid learning but is not necessary for memory","volume":"8","author":"Irvine","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.abb.2024.110268_bib14","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.neuron.2017.04.041","article-title":"CaMKII autophosphorylation is necessary for optimal integration of Ca(2+) signals during LTP induction, but Not Maintenance","volume":"94","author":"Chang","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.abb.2024.110268_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0896-6273(02)01007-3","article-title":"Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning","volume":"36","author":"Elgersma","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.abb.2024.110268_bib16","first-page":"870","volume":"vol. 279","author":"Giese","year":"1998"},{"key":"10.1016\/j.abb.2024.110268_bib17","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ajhg.2017.10.003","article-title":"De novo mutations in protein kinase genes CAMK2A and CAMK2B cause intellectual disability","volume":"101","author":"Kury","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.abb.2024.110268_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1378648","article-title":"Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice","volume":"257","author":"Silva","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.abb.2024.110268_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315169","article-title":"Amyloid beta-peptide causes the permanent activation of CaMKIIalpha through its oxidation","volume":"23","author":"Picon-Pages","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.abb.2024.110268_bib20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","article-title":"Oxidative stress and the amyloid beta peptide in Alzheimer's disease","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.abb.2024.110268_bib21","article-title":"The role of reactive oxygen species in the pathogenesis of Alzheimer's disease, Parkinson's disease, and huntington's disease","volume":"2016","author":"Manoharan","year":"2016","journal-title":"A Mini Review Oxid Med Cell Longev"},{"key":"10.1016\/j.abb.2024.110268_bib22","first-page":"1809","volume":"vol. 16","author":"Amada","year":"2005"},{"key":"10.1016\/j.abb.2024.110268_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102579","article-title":"Oxidative stress-induced autonomous activation of the calcium\/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain","volume":"298","author":"Rocco-Machado","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2024.110268_bib24","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation","volume":"133","author":"Erickson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.abb.2024.110268_bib25","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1016\/j.ica.2007.05.020","article-title":"Bicarbonate-catalyzed hydrogen peroxide oxidation of cysteine and related thiols","volume":"360","author":"Regino","year":"2007","journal-title":"Inorg. Chim. Acta."},{"key":"10.1016\/j.abb.2024.110268_bib26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1089\/ars.2005.7.849","article-title":"Molecular determinants of S-glutathionylation of carbonic anhydrase 3","volume":"7","author":"Kim","year":"2005","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.abb.2024.110268_bib27","article-title":"Kinetics of the reaction of hydrogen peroxide with cysteine and cysteamine","author":"By John","year":"1973","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.abb.2024.110268_bib28","first-page":"732","volume":"vol. 146","author":"Chao","year":"2011"},{"key":"10.1016\/j.abb.2024.110268_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103254","article-title":"NADPH oxidase 2 activity disrupts Calmodulin\/CaMKIIalpha complex via redox modifications of CaMKIIalpha-contained Cys30 and Cys289: implications in Parkinson's disease","volume":"75","author":"Pullara","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.abb.2024.110268_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-023-06465-y","article-title":"LTP induction by structural rather than enzymatic functions of CaMKII","volume":"621","author":"Tullis","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.abb.2024.110268_bib31","article-title":"CaMKII autophosphorylation is the only enzymatic event required for synaptic memory","volume":"121","author":"Chen","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.abb.2024.110268_bib32","volume":"vol. 43","author":"Rumian","year":"2024"},{"key":"10.1016\/j.abb.2024.110268_bib33","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.drudis.2020.12.004","article-title":"Role of reactive oxygen species in the progression of Alzheimer's disease Drug","volume":"26","author":"Bhatt","year":"2021","journal-title":"Discov. Today"},{"key":"10.1016\/j.abb.2024.110268_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102604","article-title":"Chemogenetic emulation of intraneuronal oxidative stress affects synaptic plasticity","volume":"60","author":"Kalinichenko","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.abb.2024.110268_bib35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0021-9673(95)00175-M","article-title":"Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases","volume":"712","author":"Apffel","year":"1995","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.abb.2024.110268_bib36","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/rcm.2519","article-title":"Fixation of nitrogen in an electrospray mass spectrometer","volume":"20","author":"Levine","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986124003904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986124003904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T05:27:36Z","timestamp":1737264456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986124003904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":36,"alternative-id":["S0003986124003904"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2024.110268","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidation of CaMKII\u03b1 cysteines inhibits autonomous activation induced by phosphorylation","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2024.110268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110268"}}