{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:24:09Z","timestamp":1790659449347,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["EEQ\/ 2018\/000486"],"award-info":[{"award-number":["EEQ\/ 2018\/000486"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018276","name":"Indian Institute of Information Technology, Allahabad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.abb.2025.110356","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T11:54:42Z","timestamp":1740484482000},"page":"110356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Exploring the therapeutic potential of Diosgenin as a Semaphorin-4D antagonist against neurodegenerative disorders"],"prefix":"10.1016","volume":"768","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-7162","authenticated-orcid":false,"given":"Ayushi","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-0811","authenticated-orcid":false,"given":"Princy","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-1663","authenticated-orcid":false,"given":"Sangeeta","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2025.110356_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00328","article-title":"In vitro models of neurodegenerative diseases","volume":"8","author":"Slanzi","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.abb.2025.110356_bib15","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s13205-023-03789-4","article-title":"Inhibition of LINGO1 as a therapeutic target to promote axonal regeneration and repair for neurological disorders","volume":"13","author":"Atta","year":"2023","journal-title":"3 Biotech"},{"issue":"7113","key":"10.1016\/j.abb.2025.110356_bib2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.abb.2025.110356_bib3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.abb.2025.110356_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.654739","article-title":"Immunotherapies for neurodegenerative diseases","volume":"12","author":"Mortada","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.abb.2025.110356_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-022-00524-0","article-title":"Solving neurodegeneration: common mechanisms and strategies for new treatments","volume":"17","author":"Wareham","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"10.1016\/j.abb.2025.110356_bib6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12031-020-01714-5","article-title":"Therapeutic advancement in neuronal transdifferentiation of mesenchymal stromal cells for neurological disorders","volume":"71","author":"Choudhary","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.abb.2025.110356_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biochi.2023.02.012","article-title":"Therapeutical growth in oligodendroglial fate induction via transdifferentiation of stem cells for neuroregenerative therapy","volume":"211","author":"Dwivedi","year":"2023","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.abb.2025.110356_bib8","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s12035-021-02646-w","article-title":"Potential role of growth factors controlled release in achieving enhanced neuronal trans-differentiation from mesenchymal stem cells for neural tissue repair and regeneration","volume":"59","author":"Gupta","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.abb.2025.110356_bib9","first-page":"411","article-title":"Recent advances in novel therapies for neurological diseases: an overview and future scope","volume":"75","author":"Urushitani","year":"2023","journal-title":"Brain Nerve"},{"key":"10.1016\/j.abb.2025.110356_bib10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12967-022-03500-w","article-title":"SEMA4D\/PlexinB1 promotes AML progression via activation of PI3K\/Akt signaling","volume":"20","author":"Liu","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.abb.2025.110356_bib11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12974-022-02509-8","article-title":"Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity","volume":"19","author":"Evans","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.abb.2025.110356_bib12","first-page":"3","article-title":"Roles of Sema4D\u2013plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis","volume":"184","author":"Tatsusada","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.abb.2025.110356_bib13","series-title":"Semaphorins","article-title":"Semaphorins and neurodegenerative disorders","author":"Okuno","year":"2015"},{"key":"10.1016\/j.abb.2025.110356_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/cyto.b.21338","article-title":"Saturation monitoring of VX15\/2503, a novel semaphorin 4D-specific antibody in clinical trials","volume":"90B","author":"Fisher","year":"2016","journal-title":"Cytometry A B"},{"key":"10.1016\/j.abb.2025.110356_bib16","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1245\/s10434-021-10111-0","article-title":"Pepinemab (Anti-SEMA4D) in combination with ipilimumab or nivolumab for patients with resectable pancreatic and colorectal cancer","volume":"28","author":"Rossi","year":"2021","journal-title":"Ann. Surg Oncol."},{"issue":"1","key":"10.1016\/j.abb.2025.110356_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/alzrt125","article-title":"Ayurvedic medicinal plants for Alzheimer's disease: a review","volume":"4","author":"Rao","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.abb.2025.110356_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejmech.2018.11.049","article-title":"Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory","volume":"163","author":"Srivastava","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.abb.2025.110356_bib19","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1007\/s12035-020-01945-y","article-title":"Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease","volume":"57","author":"Rai","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.abb.2025.110356_bib20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3390\/diseases11030089","article-title":"WNT-\u0392 catenin signaling as a potential therapeutic target for neurodegenerative diseases: current status and future perspective","volume":"11","author":"Ramakrishna","year":"2023","journal-title":"Diseases"},{"key":"10.1016\/j.abb.2025.110356_bib21","article-title":"An in silico study on withania somnifera bioactives and curcumin analogs as potential inducers of smoothened (smo) receptor of sonic hedgehog (SHH) pathway to promote oligodendrogenesis","volume":"21","author":"Dwivedi","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.abb.2025.110356_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40816-021-00292-2","article-title":"Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review","volume":"7","author":"Ashok","year":"2021","journal-title":"Clin Phytosci"},{"key":"10.1016\/j.abb.2025.110356_bib23","first-page":"1","article-title":"Regulation of neuronal repair and regeneration through inhibition of oligodendrocyte myelin glycoprotein (OMgp)","author":"Choudhary","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.abb.2025.110356_bib24","first-page":"1","article-title":"Evaluation of phytoconstituents of Tinospora cordifolia against K417N and N501Y mutant spike glycoprotein and main protease of SARS-CoV-2- an in silico study","volume":"2022","author":"Choudhary","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.abb.2025.110356_bib25","article-title":"Two pronged approach for prevention and therapy of COVID-19 (Sars-CoV-2) by a multi-targeted herbal drug, a component of ayurvedic decoction","volume":"43","author":"Shukla","year":"2019","journal-title":"Eur. J. Integr. Med."},{"key":"10.1016\/j.abb.2025.110356_bib26","first-page":"1","article-title":"Network pharmacological evaluation of Withania somnifera bioactive phytochemicals for identifying novel potential inhibitors against neurodegenerative disorder","volume":"2021","author":"Pahal","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"10","key":"10.1016\/j.abb.2025.110356_bib27","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2174\/1570180819666211228093736","article-title":"Screening of natural compounds against SOD1 as a therapeutic target for amyotrophic lateral sclerosis","volume":"19","author":"Pahal","year":"2022","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.abb.2025.110356_bib28","first-page":"1","article-title":"Modulation of GPCR receptors common to gut infammatory diseases and neuronal disorders, Alzheimer's and Parkinson's diseases as druggable targets through Withania somnifera bioactives: an in silico study","volume":"2022","author":"Shukla","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.abb.2025.110356_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s43088-022-00196-1","article-title":"Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials","volume":"11","author":"Tripathi","year":"2022","journal-title":"Beni-Suef Univ. J. Basic Appl. Sci."},{"key":"10.1016\/j.abb.2025.110356_bib30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40495-023-00314-2","article-title":"Mechanism-based physiological effects of piperine: a review","volume":"9","author":"Siddiqui","year":"2023","journal-title":"Curr. Pharmacol. Rep."},{"key":"10.1016\/j.abb.2025.110356_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/antiox12051089","article-title":"Black pepper (piper nigrum) alleviates oxidative stress, exerts potential anti-glycation and anti-AChE activity: a multitargeting neuroprotective agent against neurodegenerative diseases","volume":"12","author":"Sharma","year":"2023","journal-title":"Antioxidants"},{"issue":"3","key":"10.1016\/j.abb.2025.110356_bib32","doi-asserted-by":"crossref","first-page":"750","DOI":"10.14336\/AD.2022.1022","article-title":"Neuroprotective effects of black pepper and its bioactive compounds in age-related neurological disorders","volume":"14","author":"Balakrishnan","year":"2023","journal-title":"Aging and disease"},{"issue":"5","key":"10.1016\/j.abb.2025.110356_bib33","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3390\/antiox12051089","article-title":"Black pepper (piper nigrum) alleviates oxidative stress, exerts potential anti-glycation and anti-AChE activity: a multitargeting neuroprotective agent against neurodegenerative diseases","volume":"12","author":"Sharma","year":"2023","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.abb.2025.110356_bib34","first-page":"1","article-title":"Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials","volume":"11","author":"Tripathi","year":"2022","journal-title":"Beni-Suef Univer. J. Basic Appli. Sci."},{"issue":"5","key":"10.1016\/j.abb.2025.110356_bib35","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3892\/ijmm.2015.2356","article-title":"Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model","volume":"36","author":"Yang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.abb.2025.110356_bib36","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bioorg.2018.12.017","article-title":"Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory","volume":"85","author":"Tripathi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.abb.2025.110356_bib37","first-page":"78","article-title":"Potential role of semaphorin 4D in neurodegeneration","volume":"105","author":"Arakelyan","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"issue":"18","key":"10.1016\/j.abb.2025.110356_bib38","first-page":"1662","article-title":"Semaphorin 4D inhibitors: a new therapeutic strategy in neurodegenerative diseases","volume":"15","author":"Kumar","year":"2020","journal-title":"ChemMedChem"},{"key":"10.1016\/j.abb.2025.110356_bib39","first-page":"494","article-title":"Investigating the neuroprotective effects of piperine on 6-OHDA induced Parkinson's disease in rat model","volume":"4","author":"Mehta","year":"2017","journal-title":"Toxicol. Rep."},{"issue":"11","key":"10.1016\/j.abb.2025.110356_bib40","first-page":"1542","article-title":"Development of piperine derivatives as bioavailability enhancers","volume":"21","author":"Tay","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.abb.2025.110356_bib41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13024-022-00525-z","article-title":"The role of inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS\/FTD","volume":"17","author":"Masrori","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.abb.2025.110356_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/10070798","article-title":"Chemical constituents of piper betle linn. (Piperaceae roots)","volume":"10","author":"Ghosh","year":"2005","journal-title":"Molecules"},{"key":"10.1016\/j.abb.2025.110356_bib43","first-page":"6","article-title":"Phytochemicals and therapeutic activities of Piper betel Linn. Leaves","volume":"10","author":"Reddy","year":"2022","journal-title":"J. Med. Plant Studies"},{"issue":"D1","key":"10.1016\/j.abb.2025.110356_bib44","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.abb.2025.110356_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.abb.2025.110356_bib46","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/pro.5560070905","article-title":"Anatomy of protein pockets and cavities: measurement of binding site geometry and implications for ligand design","volume":"7","author":"Liang","year":"1998","journal-title":"Protein Sci."},{"issue":"W1","key":"10.1016\/j.abb.2025.110356_bib47","doi-asserted-by":"crossref","first-page":"W363","DOI":"10.1093\/nar\/gky473","article-title":"CASTp 3.0: computed atlas of surface topography of proteins","volume":"46","author":"Tian","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.abb.2025.110356_bib48","series-title":"User Guide AutoDock Version 4.2 Updated for Version 4.2.5. Automated Docking of Flexible Ligands to Flexible Receptors","author":"Morris","year":"2012"},{"issue":"25","key":"10.1016\/j.abb.2025.110356_bib49","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1002\/jcc.23354","article-title":"CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data","volume":"34","author":"Huang","year":"2013","journal-title":"J. Comput. Chem."},{"issue":"12","key":"10.1016\/j.abb.2025.110356_bib50","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1063\/1.864116","article-title":"Steepest-descent moment method for three-dimensional magnetohydrodynamic equilibria","volume":"26","author":"Hirshman","year":"1983","journal-title":"Phys. Fluids"},{"key":"10.1016\/j.abb.2025.110356_bib51","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.3390\/ijms21082761","article-title":"Effect of curcumin on protein damage induced by rotenone in dopaminergic PC12 cells","volume":"21","author":"Buratta","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.abb.2025.110356_bib52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","article-title":"Cell sensitivity assays: the MTT assay","volume":"731","author":"Van Meerloo","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.abb.2025.110356_bib53","first-page":"1954","article-title":"Effects of diosgenin on PC-12 cells damaged by rotenone","volume":"12","author":"Zhang","year":"2021","journal-title":"J. Food Safety Quali."},{"issue":"1","key":"10.1016\/j.abb.2025.110356_bib54","article-title":"Diosgenin restores A\u03b2-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70)","volume":"8","author":"Yang","year":"2018","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.abb.2025.110356_bib55","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3233\/JAD-180330","article-title":"Diosgenin attenuates lipopolysaccharide-induced Parkinson's disease by inhibiting the TLR\/NF-\u03baB pathway","volume":"64","author":"Li","year":"2018","journal-title":"J. Alzheim. Dis."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125000694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125000694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:40Z","timestamp":1777377220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986125000694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":55,"alternative-id":["S0003986125000694"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2025.110356","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the therapeutic potential of Diosgenin as a Semaphorin-4D antagonist against neurodegenerative disorders","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2025.110356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110356"}}