{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:53:08Z","timestamp":1788367988526,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["232102310073"],"award-info":[{"award-number":["232102310073"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.abb.2025.110399","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T12:38:34Z","timestamp":1742733514000},"page":"110399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["UCP2 attenuates neural apoptosis and inflammation in spinal cord injury by inducing the acetylation of ANXA1 and activating the PI3K\/AKT pathway"],"prefix":"10.1016","volume":"768","author":[{"given":"Guolin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaojian","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2025.110399_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nec.2021.03.002","article-title":"Pathophysiology of spinal cord injury","volume":"32","author":"Hachem","year":"2021","journal-title":"Neurosurg. Clin."},{"key":"10.1016\/j.abb.2025.110399_bib2","first-page":"22","article-title":"Review: steroid use in patients with acute spinal cord injury and guideline update","volume":"18","author":"Lee","year":"2022","journal-title":"Korean J. Nutr."},{"key":"10.1016\/j.abb.2025.110399_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207533","article-title":"Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms","volume":"21","author":"Anjum","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.abb.2025.110399_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ncl.2021.02.004","article-title":"Acute traumatic spinal cord injury","volume":"39","author":"Eli","year":"2021","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.abb.2025.110399_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mcn.2015.04.006","article-title":"Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury","volume":"68","author":"Goldshmit","year":"2015","journal-title":"Mole Cell. Neurosci."},{"key":"10.1016\/j.abb.2025.110399_bib6","first-page":"299","article-title":"Delayed demyelination and macrophage invasion: a candidate for secondary cell damage in spinal cord injury, Central nervous system trauma","volume":"2","author":"Blight","year":"1985","journal-title":"J. Am. Paralysis Assoc."},{"key":"10.1016\/j.abb.2025.110399_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s13311-018-0631-6","article-title":"Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses","volume":"15","author":"Orr","year":"2018","journal-title":"Neurotherapeutics : J. Am. Soc. Experi. NeuroTherapeutics"},{"key":"10.1016\/j.abb.2025.110399_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neulet.2017.02.004","article-title":"Neuroprotective effects of lycopene in spinal cord injury in rats via antioxidative and anti-apoptotic pathway","volume":"642","author":"Hu","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.abb.2025.110399_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.960226","article-title":"UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling","volume":"13","author":"Sancerni","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.abb.2025.110399_bib10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41401-021-00698-1","article-title":"Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage","volume":"43","author":"Yan","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.abb.2025.110399_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112935","article-title":"UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis","volume":"141","author":"Huang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.abb.2025.110399_bib12","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/jcbfm.2008.8","article-title":"Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse","volume":"28","author":"Deierborg","year":"2008","journal-title":"J. Cerebr. Blood Flow Metabol. : Offic. J. Intern. Soc. Cerebral Blood Flow Metabo."},{"key":"10.1016\/j.abb.2025.110399_bib13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/jir.2021.0241","article-title":"Caffeine citrate protects against sepsis-associated encephalopathy and inhibits the UCP2\/NLRP3 Axis in astrocytes","volume":"42","author":"Hu","year":"2022","journal-title":"J. Interferon Cytokine Res. : Offic. J. Intern. Soc. Interferon Cytokine Rese."},{"key":"10.1016\/j.abb.2025.110399_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.kint.2021.02.025","article-title":"Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy","volume":"100","author":"Wu","year":"2021","journal-title":"Kidney Int."},{"key":"10.1016\/j.abb.2025.110399_bib15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12974-021-02174-3","article-title":"Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia\/macrophage polarization via FPR2\/ALX-dependent AMPK-mTOR pathway","volume":"18","author":"Xu","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.abb.2025.110399_bib16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s42003-024-06197-3","article-title":"Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling","volume":"7","author":"Fujita","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.abb.2025.110399_bib17","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/nen.0b013e3181567d59","article-title":"Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury","volume":"66","author":"Liu","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.abb.2025.110399_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155475","article-title":"UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia","volume":"7","author":"Rigaud","year":"2022","journal-title":"JCI insight"},{"key":"10.1016\/j.abb.2025.110399_bib19","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41467-022-28822-7","article-title":"Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43","volume":"13","author":"Garcia Morato","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2025.110399_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/sji.12148","article-title":"TREM-2 promotes macrophage-mediated eradication of Pseudomonas aeruginosa via a PI3K\/Akt pathway","volume":"79","author":"Zhu","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.abb.2025.110399_bib21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.abb.2025.110399_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153466","article-title":"Arbutin attenuates LPS-induced acute kidney injury by inhibiting inflammation and apoptosis via the PI3K\/Akt\/Nrf2 pathway","volume":"82","author":"Zhang","year":"2021","journal-title":"Phytomedicine : Intern. J. Phytothera. Phytopharmacol."},{"key":"10.1016\/j.abb.2025.110399_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110375","article-title":"Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K\/AKT signaling pathway in mice","volume":"120","author":"Yu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.abb.2025.110399_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.269","article-title":"CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K\/AKT\/Foxo1 signaling","volume":"11","author":"Xu","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.abb.2025.110399_bib25","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.4103\/1673-5374.355762","article-title":"Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K\/AKT\/mTOR pathway","volume":"18","author":"Sun","year":"2023","journal-title":"Neural Regener. Rese."},{"key":"10.1016\/j.abb.2025.110399_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100881","article-title":"RRM2 regulates sensitivity to sunitinib and PD-1 blockade in renal cancer by stabilizing ANXA1 and activating the AKT pathway","volume":"8","author":"Xiong","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.abb.2025.110399_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109546","article-title":"Tetramethylpyrazine and Astragaloside IV have synergistic effects against spinal cord injury-induced neuropathic pain via the OIP5-AS1\/miR-34a\/Sirt1\/NF-\u03baB axis","volume":"115","author":"Rao","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.abb.2025.110399_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.abb.2025.110399_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105632","article-title":"PKR inhibitor protects spinal cord injury through mitigating endoplasmic reticulum stress and pyroptosis","volume":"172","author":"Yang","year":"2024","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.abb.2025.110399_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jbiotec.2007.07.498","article-title":"A non-isotopic in vitro assay for histone acetylation","volume":"131","author":"Kuninger","year":"2007","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.abb.2025.110399_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00441-019-03039-1","article-title":"Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications","volume":"377","author":"Venkatesh","year":"2019","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.abb.2025.110399_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121190","article-title":"Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation","volume":"279","author":"Yuan","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.abb.2025.110399_bib33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13578-022-00816-4","article-title":"FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion","volume":"12","author":"Xia","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.abb.2025.110399_bib34","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.freeradbiomed.2011.06.022","article-title":"Uncoupling proteins and the control of mitochondrial reactive oxygen species production","volume":"51","author":"Mailloux","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.abb.2025.110399_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.109918","article-title":"UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury","volume":"753","author":"Geng","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.abb.2025.110399_bib36","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.intimp.2019.03.043","article-title":"UCP2 ameliorates mitochondrial dysfunction, inflammation, and oxidative stress in lipopolysaccharide-induced acute kidney injury","volume":"71","author":"Ding","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.abb.2025.110399_bib37","article-title":"UCP2 alleviates tubular epithelial cell apoptosis in lipopolysaccharide-induced acute kidney injury by decreasing ROS production","volume":"115","author":"Zhong","year":"2019","journal-title":"Biomed. pharmacothera. Biomed. Pharmacother."},{"key":"10.1016\/j.abb.2025.110399_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/7053116","article-title":"Overexpression of TRPV6 inhibits coronary atherosclerosis-related inflammatory response and cell apoptosis via the PKA\/UCP2 pathway","volume":"2024","author":"Zheng","year":"2024","journal-title":"Cardiovascular Therap."},{"key":"10.1016\/j.abb.2025.110399_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113745","article-title":"UCP2 promotes proliferation and chemoresistance through regulating the NF-\u03baB\/\u03b2-catenin axis and mitochondrial ROS in gallbladder cancer","volume":"172","author":"Yu","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.abb.2025.110399_bib40","article-title":"Downregulation of uncoupling protein 2(UCP2) mediated by MicroRNA-762 confers cardioprotection and participates in the regulation of dynamic mitochondrial homeostasis of dynamin related Protein1 (DRP1) after myocardial infarction in mice","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Cardiovascular Med."},{"key":"10.1016\/j.abb.2025.110399_bib41","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1080\/21655979.2022.2031769","volume":"13","author":"Yu","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.abb.2025.110399_bib42","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1007\/s12035-023-03357-0","article-title":"The circ_006573\/miR-376b-3p Axis advances spinal cord functional recovery after injury by modulating vascular regeneration","volume":"60","author":"Wang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.abb.2025.110399_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109616","article-title":"Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K\/Akt signaling pathway after spinal cord injury","volume":"114","author":"Hu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.abb.2025.110399_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114739","article-title":"AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K\/Akt signaling","volume":"375","author":"Miao","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.abb.2025.110399_bib45","article-title":"Knockdown of annexin-A1 inhibits growth, migration and invasion of glioma cells by suppressing the PI3K\/Akt","volume":"13","author":"Wei","year":"2021","journal-title":"Signaling Pathway"},{"key":"10.1016\/j.abb.2025.110399_bib46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jot.2023.02.001","article-title":"Cerebrospinal fluid-derived extracellular vesicles after spinal cord injury promote vascular regeneration via PI3K\/AKT signaling pathway","volume":"39","author":"Li","year":"2023","journal-title":"J. Orthopae. Transla."},{"key":"10.1016\/j.abb.2025.110399_bib47","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3892\/etm.2023.12039","article-title":"FGF23 alleviates neuronal apoptosis and inflammation, and promotes locomotion recovery via activation of PI3K\/AKT signalling in spinal cord injury","volume":"26","author":"Cui","year":"2023","journal-title":"Exp. Ther. Med."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125001122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125001122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:08:16Z","timestamp":1762088896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986125001122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":47,"alternative-id":["S0003986125001122"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2025.110399","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"UCP2 attenuates neural apoptosis and inflammation in spinal cord injury by inducing the acetylation of ANXA1 and activating the PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2025.110399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110399"}}