{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:16:29Z","timestamp":1778141789394,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["10-2314-B-038-130"],"award-info":[{"award-number":["10-2314-B-038-130"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-038 -122 -MY3"],"award-info":[{"award-number":["NSTC 112-2314-B-038 -122 -MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022600","name":"Taipei Municipal Wan-Fang Hospital","doi-asserted-by":"publisher","award":["111-wf-eva-13"],"award-info":[{"award-number":["111-wf-eva-13"]}],"id":[{"id":"10.13039\/501100022600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.abb.2025.110428","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:44:20Z","timestamp":1744890260000},"page":"110428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Modified citrus pectin protects aortic dissection development involving macrophage pyroptosis"],"prefix":"10.1016","volume":"769","author":[{"given":"Chun-Che","family":"Shih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Lun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Pin","family":"Chuu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fwu-Long","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-0923","authenticated-orcid":false,"given":"Hsin-Ying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.abb.2025.110428_bib1","first-page":"11","article-title":"Abdominal aortic aneurysm: a comprehensive review","volume":"16","author":"Aggarwal","year":"2011","journal-title":"Exp. Clin. Cardiol."},{"issue":"2","key":"10.1016\/j.abb.2025.110428_bib2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jss.2013.06.007","article-title":"Molecular mechanisms of thoracic aortic dissection","volume":"184","author":"Wu","year":"2013","journal-title":"J. Surg. Res."},{"issue":"8","key":"10.1016\/j.abb.2025.110428_bib3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3109\/07853890.2010.518156","article-title":"Inflammation and immune response in acute aortic dissection","volume":"42","author":"del Porto","year":"2010","journal-title":"Ann. Med."},{"issue":"12","key":"10.1016\/j.abb.2025.110428_bib4","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.abb.2025.110428_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9743280","article-title":"NLRP3 inflammasome activation-mediated pyroptosis aggravates myocardial ischemia\/reperfusion injury in diabetic rats","volume":"2017","author":"Qiu","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.abb.2025.110428_bib6","doi-asserted-by":"crossref","first-page":"H265","DOI":"10.1152\/ajpheart.00509.2016","article-title":"L5-LDL from ST-elevation myocardial infarction patients induces IL-1beta production via LOX-1 and NLRP3 inflammasome activation in macrophages","volume":"312","author":"Yang","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.abb.2025.110428_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cca.2017.11.005","article-title":"Pyroptosis and its relationship to atherosclerosis","volume":"476","author":"Xu","year":"2018","journal-title":"Clin. Chim. Acta"},{"issue":"26","key":"10.1016\/j.abb.2025.110428_bib8","doi-asserted-by":"crossref","first-page":"E6065","DOI":"10.1073\/pnas.1722041115","article-title":"Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis","volume":"115","author":"McKenzie","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.abb.2025.110428_bib9","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/s41374-018-0073-0","article-title":"NLRP3\/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass","volume":"98","author":"Hou","year":"2018","journal-title":"Lab. Invest."},{"key":"10.1016\/j.abb.2025.110428_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109595","article-title":"Pyroptosis: a new frontier in cancer","volume":"121","author":"Fang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.abb.2025.110428_bib11","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.3892\/mmr.2016.5077","article-title":"Resistance of mitochondrial DNA-depleted cells against oxidized low-density lipoprotein-induced macrophage pyroptosis","volume":"13","author":"Yan","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.abb.2025.110428_bib12","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1039\/C8FO00111A","article-title":"Pectin structure and particle size modify carotenoid bioaccessibility and uptake by Caco-2 cells in citrus juices vs. concentrates","volume":"9","author":"Gence","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.abb.2025.110428_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2021.100169","article-title":"Purification, chemical analysis and inhibitory effects on galectin-3 of enzymatic pH-modified citrus pectin","volume":"12","author":"Zhang","year":"2021","journal-title":"Food Chem. X"},{"key":"10.1016\/j.abb.2025.110428_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1472-6882-11-59","article-title":"Activation of human T-helper\/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin","volume":"11","author":"Ramachandran","year":"2011","journal-title":"BMC Compl. Alternative Med."},{"issue":"12","key":"10.1016\/j.abb.2025.110428_bib15","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.7314\/APJCP.2013.14.12.7561","article-title":"Synergistic effects of PectaSol-C modified citrus pectin an inhibitor of Galectin-3 and paclitaxel on apoptosis of human SKOV-3 ovarian cancer cells","volume":"14","author":"Hossein","year":"2013","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"issue":"10","key":"10.1016\/j.abb.2025.110428_bib16","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/ptr.1953","article-title":"The effect of modified citrus pectin on urinary excretion of toxic elements","volume":"20","author":"Eliaz","year":"2006","journal-title":"Phytother Res."},{"key":"10.1016\/j.abb.2025.110428_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110071","article-title":"Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4\/MyD88\/NF-kappaB signaling pathway","volume":"126","author":"Xu","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.abb.2025.110428_bib18","doi-asserted-by":"crossref","first-page":"H45","DOI":"10.1152\/ajpheart.00609.2018","article-title":"Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling","volume":"316","author":"Nguyen","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"22","key":"10.1016\/j.abb.2025.110428_bib19","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1042\/CS20171142","article-title":"Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development","volume":"131","author":"Fernandez-Garcia","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"issue":"2","key":"10.1016\/j.abb.2025.110428_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12563","article-title":"Role of pyroptosis in cardiovascular disease","volume":"52","author":"Zhaolin","year":"2019","journal-title":"Cell Prolif."},{"issue":"5","key":"10.1016\/j.abb.2025.110428_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.187","article-title":"Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma","volume":"8","author":"Li","year":"2017","journal-title":"Cell Death Dis."},{"issue":"7575","key":"10.1016\/j.abb.2025.110428_bib22","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.abb.2025.110428_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.169","article-title":"NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation","volume":"4","author":"Satoh","year":"2013","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.abb.2025.110428_bib24","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1161\/ATVBAHA.118.311727","article-title":"Vascular smooth muscle cell plasticity and autophagy in dissecting aortic aneurysms","volume":"39","author":"Clement","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.abb.2025.110428_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051171","article-title":"Gasdermin D deficiency limits the transition of atherosclerotic plaques to an inflammatory phenotype in ApoE knock-out mice","volume":"10","author":"Puylaert","year":"2022","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.abb.2025.110428_bib26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12565-016-0366-6","article-title":"Tissue- and cell-specific localization of galectins, beta-galactose-binding animal lectins, and their potential functions in health and disease","volume":"92","author":"Nio-Kobayashi","year":"2017","journal-title":"Anat. Sci. Int."},{"issue":"5","key":"10.1016\/j.abb.2025.110428_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/glycob\/12.5.329","article-title":"Shuttling of galectin-3 between the nucleus and cytoplasm","volume":"12","author":"Davidson","year":"2002","journal-title":"Glycobiology"},{"issue":"2\u20133","key":"10.1016\/j.abb.2025.110428_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0304-4165(02)00313-6","article-title":"Intracellular functions of galectins","volume":"1572","author":"Liu","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.abb.2025.110428_bib29","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1074\/jbc.M604506200","article-title":"Visualization of galectin-3 oligomerization on the surface of neutrophils and endothelial cells using fluorescence resonance energy transfer","volume":"282","author":"Nieminen","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.abb.2025.110428_bib30","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.4049\/jimmunol.180.4.2650","article-title":"Regulation of alternative macrophage activation by galectin-3","volume":"180","author":"MacKinnon","year":"2008","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.abb.2025.110428_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jacbts.2020.10.006","article-title":"Galectin-3 inhibition with modified citrus pectin in hypertension","volume":"6","author":"Lau","year":"2021","journal-title":"JACC Basic Transl Sci"},{"issue":"6","key":"10.1016\/j.abb.2025.110428_bib32","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/glycob\/cwt006","article-title":"Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice","volume":"23","author":"MacKinnon","year":"2013","journal-title":"Glycobiology"},{"issue":"2","key":"10.1016\/j.abb.2025.110428_bib33","first-page":"599","article-title":"Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)","volume":"41","author":"Dong","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.abb.2025.110428_bib34","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1186\/s12885-018-4461-z","article-title":"Galectin-3 activates TLR4\/NF-kappaB signaling to promote lung adenocarcinoma cell proliferation through activating lncRNA-NEAT1 expression","volume":"18","author":"Zhou","year":"2018","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.abb.2025.110428_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cyto.2015.01.016","article-title":"Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts","volume":"73","author":"Arad","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.abb.2025.110428_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yjmcc.2017.06.011","article-title":"Toll-like receptor-4 signaling pathway in aorta aging and diseases: \"its double nature\"","volume":"110","author":"Balistreri","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.abb.2025.110428_bib37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12872-018-0958-2","article-title":"Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: a case-control study","volume":"18","author":"Li","year":"2018","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.abb.2025.110428_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/bs.ircmb.2017.07.007","article-title":"NF-kappaB and the transcriptional control of inflammation","volume":"335","author":"Mitchell","year":"2018","journal-title":"Int Rev Cell Mol Biol"},{"issue":"3","key":"10.1016\/j.abb.2025.110428_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00003-23","article-title":"Pseudorabies virus infection activates the TLR-NF-kappaB Axis and AIM2 inflammasome to enhance inflammatory responses in mice","volume":"97","author":"Zhou","year":"2023","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.abb.2025.110428_bib40","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1038\/s41598-022-05968-4","article-title":"Galectin-3 as a potential prognostic biomarker of severe COVID-19 in SARS-CoV-2 infected patients","volume":"12","author":"Cervantes-Alvarez","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.abb.2025.110428_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1164\/rccm.202209-1758ED","article-title":"Galectin-3 inhibition in COVID-19","volume":"207","author":"Reddy","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125001419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125001419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:02:01Z","timestamp":1778140921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986125001419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":41,"alternative-id":["S0003986125001419"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2025.110428","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modified citrus pectin protects aortic dissection development involving macrophage pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2025.110428","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110428"}}