{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:09:55Z","timestamp":1778648995472,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017539","name":"Theodor Bilharz Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.abb.2025.110468","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T11:40:01Z","timestamp":1747395601000},"page":"110468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Investigating the anticancer effect of purified rCec-B peptide in a DEN murine model: Insights into tumorigenesis prevention, bioavailability, and molecular mechanisms"],"prefix":"10.1016","volume":"770","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1125-245X","authenticated-orcid":false,"given":"Hend","family":"Okasha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-3131","authenticated-orcid":false,"given":"Sami Mohamed","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-4309","authenticated-orcid":false,"given":"Ehab","family":"Hafiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-0448","authenticated-orcid":false,"given":"Safia","family":"Samir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2025.110468_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125420","article-title":"Investigation of novel HCV therapies: boscia angustifalia & Boscia senegalensis extracts loaded on galactosylated chitosan nanoparticles synthesized by eco-friendly method for HCV treatment","volume":"245","author":"Rashdan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.abb.2025.110468_bib2","first-page":"1","article-title":"Development of a novel peptide with RGD tumor homing motif: evaluation of its anticancer potential in hepatocellular carcinoma and colon cancer cells","volume":"18","author":"Mohamed","year":"2024","journal-title":"Recent Pat. Biotechnol."},{"key":"10.1016\/j.abb.2025.110468_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.pep.2021.105965","article-title":"Expression of HCV genotype-4 core antigen in prokaryotic E. coli system for diagnosis of HCV infection in Egypt","volume":"188","author":"Saleh","year":"2021","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.abb.2025.110468_bib4","doi-asserted-by":"crossref","DOI":"10.3889\/oamjms.2015.111","article-title":"Hepatocellular carcinoma: risk factors, diagnosis and treatment","volume":"3","author":"Janevska","year":"2015","journal-title":"Open Access Maced J Med Sci"},{"key":"10.1016\/j.abb.2025.110468_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111612","article-title":"Exploring the effect of Gupi Xiaoji Prescription on hepatitis B virus-related liver cancer through network pharmacology and in vitro experiments","volume":"139","author":"Yu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.abb.2025.110468_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13040377","article-title":"Association between aflatoxin M1 and liver disease in HBV\/HCV infected persons in Ghana","volume":"13","author":"Afum","year":"2016","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.abb.2025.110468_bib7","first-page":"1","article-title":"Fundamental uses of peptides as a new model in both treatment and diagnosis","volume":"7","author":"Okasha","year":"2023","journal-title":"Recent Pat. Biotechnol."},{"key":"10.1016\/j.abb.2025.110468_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1028600","article-title":"Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage","volume":"12","author":"Yin","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.abb.2025.110468_bib9","doi-asserted-by":"crossref","DOI":"10.1007\/s10534-022-00484-4","article-title":"Antitumor activity of bovine lactoferrin and its derived peptides against HepG2 liver cancer cells and Jurkat leukemia cells","volume":"36","author":"Arredondo-Beltr\u00e1n","year":"2023","journal-title":"Biometals"},{"key":"10.1016\/j.abb.2025.110468_bib10","article-title":"Antimicrobial peptides: potential application in liver cancer","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.abb.2025.110468_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-023-01719-9","article-title":"A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR","volume":"22","author":"Song","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.abb.2025.110468_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/j.1432-1033.1991.tb16252.x","article-title":"Cell\u2010free immunity in Cecropia: a model system for antibacterial proteins","volume":"201","author":"Boman","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.abb.2025.110468_bib13","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1006\/bbrc.1997.8014","article-title":"Expression of antimicrobial peptides has an antitumour effect in human cells","volume":"242","author":"Winder","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2025.110468_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2490-8-5","article-title":"Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells","volume":"8","author":"Suttmann","year":"2008","journal-title":"BMC Urol."},{"key":"10.1016\/j.abb.2025.110468_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2006.04.006","article-title":"Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action","volume":"1758","author":"Chan","year":"2006","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.abb.2025.110468_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/1872208317666230512143508","article-title":"Fundamental uses of peptides as a new model in both treatment and diagnosis","volume":"18","author":"Okasha","year":"2024","journal-title":"Recent Pat. Biotechnol."},{"key":"10.1016\/j.abb.2025.110468_bib17","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2174\/1389201022666210104121709","article-title":"Recombinant expression of Cec-B peptide in Escherichia coli with a significant anticancer effect on hepatocellular carcinoma","volume":"22","author":"Okasha","year":"2021","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.abb.2025.110468_bib18","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.3390\/cancers13225681","article-title":"Biological significance and targeting of the FGFR Axis in cancer","volume":"13","author":"Chioni","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.abb.2025.110468_bib19","article-title":"EGFR signaling in liver diseases","volume":"17","author":"Komposch","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.abb.2025.110468_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/ncb3031","article-title":"EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation","volume":"16","author":"Lanaya","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.abb.2025.110468_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106789","article-title":"Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15\/EGFR complex","volume":"192","author":"Gu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.abb.2025.110468_bib22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4314\/tjpr.v18i3.9","article-title":"Cyclopentadione-aniline conjugate suppresses proliferation and induces apoptosis in liver cancer cells via up-regulation of p38 phosphorylation","volume":"18","author":"Yu","year":"2021","journal-title":"Trop. J. Pharmaceut. Res."},{"key":"10.1016\/j.abb.2025.110468_bib23","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1913662","article-title":"Overall survival with osimertinib in untreated, EGFR -mutated advanced NSCLC","volume":"382","author":"Ramalingam","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.abb.2025.110468_bib24","doi-asserted-by":"crossref","DOI":"10.1096\/fj.05-4058com","article-title":"Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.abb.2025.110468_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cells12071078","article-title":"Development of cyclic peptides targeting the epidermal growth factor receptor in mesenchymal triple-negative breast cancer subtype","volume":"12","author":"Nistic\u00f2","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.abb.2025.110468_bib26","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s00726-023-03356-4","article-title":"A novel antibacterial approach of Cecropin-B peptide loaded on chitosan nanoparticles against MDR Klebsiella pneumoniae isolates","volume":"55","author":"Okasha","year":"2023","journal-title":"Amino Acids"},{"key":"10.1016\/j.abb.2025.110468_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv342","article-title":"I-TASSER server: new development for protein structure and function predictions","volume":"43","author":"Yang","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.abb.2025.110468_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41596-022-00728-0","article-title":"I-TASSER-MTD: a deep-learning-based platform for multi-domain protein structure and function prediction","volume":"17","author":"Zhou","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.abb.2025.110468_bib29","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2174\/1389201022666210104121709","article-title":"Recombinant expression of Cec-B peptide in Escherichia coli with a significant anticancer effect on hepatocellular carcinoma","volume":"22","author":"Okasha H","year":"2021","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.abb.2025.110468_bib30","article-title":"LD50 Estimations for diabecineTM polyherbal extracts based on in vitro diabetic models of 3T3-L1, WRL-68 and 1.1B4 cell lines","volume":"56","author":"Wong","year":"2017","journal-title":"Chem Eng Trans"},{"key":"10.1016\/j.abb.2025.110468_bib31","series-title":"Toxicology: the Basic Science of Poisons","author":"Cassarett","year":"1975"},{"key":"10.1016\/j.abb.2025.110468_bib32","series-title":"Exposure Factors Handbook","first-page":"1","year":"2011"},{"key":"10.1016\/j.abb.2025.110468_bib33","doi-asserted-by":"crossref","DOI":"10.3352\/jeehp.2021.18.17","article-title":"Sample size determination and power analysis using the G\u2217Power software","volume":"18","author":"Kang","year":"2021","journal-title":"J Educ Eval Health Prof"},{"key":"10.1016\/j.abb.2025.110468_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4103\/0976-500X.119726","article-title":"How to calculate sample size in animal studies?","volume":"4","author":"Charan","year":"2013","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.abb.2025.110468_bib35","doi-asserted-by":"crossref","first-page":"8504","DOI":"10.3390\/molecules27238504","article-title":"Metabolite profiling of Alocasia gigantea leaf extract and its potential anticancer effect through autophagy in hepatocellular carcinoma","volume":"27","author":"Okasha","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.abb.2025.110468_bib36","first-page":"83","article-title":"Anticancer activity of Cynodon dactylon L. root extract against diethyl nitrosamine induced hepatic carcinoma, South Asian","volume":"4","author":"Kowsalya","year":"2015","journal-title":"J. Cancer"},{"key":"10.1016\/j.abb.2025.110468_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183680","article-title":"CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy","volume":"12","author":"Lei","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.abb.2025.110468_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20182274","article-title":"EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis","volume":"39","author":"Xu","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.abb.2025.110468_bib39","first-page":"1037","article-title":"Evaluation of bax, bcl-2, p21 and p53 genes expression variations on cerebellum of BALB\/c mice before and after birth under mobile phone radiation exposure","volume":"20","author":"Ghatei","year":"2017","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.abb.2025.110468_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-023-01865-0","article-title":"Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation","volume":"22","author":"Chehelgerdi","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.abb.2025.110468_bib41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0140-6736(13)62224-2","article-title":"Global cancer patterns: causes and prevention","volume":"383","author":"Paolo Vineis","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.abb.2025.110468_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128637","article-title":"Interdisciplinary gene manipulation, molecular cloning, and recombinant expression of modified human growth hormone isoform-1 in E. coli system","volume":"257","author":"Nasr","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.abb.2025.110468_bib43","doi-asserted-by":"crossref","DOI":"10.34172\/jsums.2020.17","article-title":"Study of anticancer activity of cecropin B on 7, 12-dimethylbenz (a) anthracene-induced breast cancer","volume":"22","author":"Ghandehari","year":"2020","journal-title":"Journal of Shahrekord University of Medical Sciences"},{"key":"10.1016\/j.abb.2025.110468_bib44","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.7314\/APJCP.2014.15.13.5433","article-title":"Cecropin suppresses human hepatocellular carcinoma BEL-7402 cell growth and survival in vivo without side-toxicity","volume":"15","author":"Jin","year":"2014","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.abb.2025.110468_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/nrc3309","article-title":"The ERBB network: at last, cancer therapy meets systems biology","volume":"12","author":"Yarden","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.abb.2025.110468_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071590","article-title":"Drug tolerance to egfr tyrosine kinase inhibitors in lung cancers with egfr mutations","volume":"10","author":"Suda","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.abb.2025.110468_bib47","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.12.9.2629","article-title":"Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR\/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis","volume":"12","author":"Qiao","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.abb.2025.110468_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15153787","article-title":"Gender differences in a mouse model of hepatocellular carcinoma revealed using multi-modal imaging","volume":"15","author":"Engel","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.abb.2025.110468_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2023.100870","article-title":"Sex differences in chronic liver disease and benign liver lesions","volume":"5","author":"Cooper","year":"2023","journal-title":"JHEP Reports"},{"key":"10.1016\/j.abb.2025.110468_bib50","first-page":"1","article-title":"An overview of mouse models of hepatocellular carcinoma","volume":"18","author":"chuan Zheng","year":"2023","journal-title":"Infect Agent Cancer"},{"key":"10.1016\/j.abb.2025.110468_bib51","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3390\/livers2040023","article-title":"Role of oxidative stress in liver disorders","volume":"2","author":"Conde de la Rosa","year":"2022","journal-title":"Livers"},{"key":"10.1016\/j.abb.2025.110468_bib52","doi-asserted-by":"crossref","DOI":"10.4149\/neo_2023_221125N1132","article-title":"Bigelovin inhibits hepatocellular carcinoma cell growth and metastasis by regulating the MAPT-mediated Fas\/FasL pathway","volume":"70","author":"Wang","year":"2023","journal-title":"Neoplasma"},{"key":"10.1016\/j.abb.2025.110468_bib53","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20182274","article-title":"EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis","volume":"39","author":"Xu","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.abb.2025.110468_bib54","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/ijc.31374","article-title":"Caspase-3 regulates the migration, invasion, and metastasis of colon cancer cells","volume":"143","author":"Min Zhou","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.abb.2025.110468_bib55","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.abb.2025.110468_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2013.00294","article-title":"From antimicrobial to anticancer peptides. A review","volume":"4","author":"Gaspar","year":"2013","journal-title":"Front. Microbiol."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000398612500181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000398612500181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:26:17Z","timestamp":1778646377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000398612500181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":56,"alternative-id":["S000398612500181X"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2025.110468","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the anticancer effect of purified rCec-B peptide in a DEN murine model: Insights into tumorigenesis prevention, bioavailability, and molecular mechanisms","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2025.110468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110468"}}