{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:15:15Z","timestamp":1754144115898,"version":"3.41.2"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["74310325"],"award-info":[{"award-number":["74310325"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010112","name":"Nanfang Hospital","doi-asserted-by":"publisher","award":["BYYZ24007"],"award-info":[{"award-number":["BYYZ24007"]}],"id":[{"id":"10.13039\/501100010112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.abb.2025.110499","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T20:09:53Z","timestamp":1749154193000},"page":"110499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Knockdown of OPTN modulates miRNA-125b-5p expression via NF-\u03baB pathways in amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"771","author":[{"given":"Jian","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-8659","authenticated-orcid":false,"given":"Haishan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2025.110499_bib1","article-title":"Recent progress of the genetics of amyotrophic lateral sclerosis and challenges of gene therapy","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Neurosci. (Switzerland)"},{"key":"10.1016\/j.abb.2025.110499_bib2","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1038\/550S120a","article-title":"Drug therapy: on the treatment trail for ALS","volume":"550","author":"Scott","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.abb.2025.110499_bib3","article-title":"Fundamental roles of the optineurin gene in the molecular pathology of amyotrophic lateral sclerosis","volume":"17","author":"Zhao","year":"2023","journal-title":"Front. Neurosci. (Switzerland)"},{"key":"10.1016\/j.abb.2025.110499_bib4","first-page":"126","article-title":"A novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro","volume":"18","author":"Fifita","year":"2017","journal-title":"Amyotroph Lat Scl Fr"},{"key":"10.1016\/j.abb.2025.110499_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.1205405","article-title":"Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth","volume":"333","author":"Wild","year":"2011","journal-title":"SCIENCE"},{"key":"10.1016\/j.abb.2025.110499_bib6","doi-asserted-by":"crossref","first-page":"E4439","DOI":"10.1073\/pnas.1405752111","article-title":"Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation","volume":"111","author":"Wong","year":"2014","journal-title":"P. Natl. Acad. Sci USA"},{"key":"10.1016\/j.abb.2025.110499_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature08971","article-title":"Mutations of optineurin in amyotrophic lateral sclerosis","volume":"465","author":"Maruyama","year":"2010","journal-title":"NATURE"},{"key":"10.1016\/j.abb.2025.110499_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2017.04.005","article-title":"Optineurin in amyotrophic lateral sclerosis: multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms","volume":"154","author":"Markovinovic","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.abb.2025.110499_bib9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00401-013-1125-6","article-title":"Protein aggregation in amyotrophic lateral sclerosis","volume":"125","author":"Blokhuis","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.abb.2025.110499_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025545","article-title":"Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells","volume":"6","author":"Nardo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.abb.2025.110499_bib11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/1872214809666150407111420","article-title":"Is innate immunity and inflammasomes involved in pathogenesis of amyotrophic lateral sclerosis (ALS)?","volume":"9","author":"Volpe","year":"2015","journal-title":"Recent Pat. Endocr. Metab. Immune Drug Discov."},{"key":"10.1016\/j.abb.2025.110499_bib12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fnagi.2017.00242","article-title":"The dual role of microglia in ALS: mechanisms and therapeutic approaches","volume":"9","author":"Geloso","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.abb.2025.110499_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia polarization from M1 to M2 in neurodegenerative diseases","volume":"14","author":"Guo","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.abb.2025.110499_bib14","doi-asserted-by":"crossref","first-page":"24178","DOI":"10.18632\/oncotarget.4680","article-title":"Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure","volume":"6","author":"Ding","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.abb.2025.110499_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fnins.2017.00273","article-title":"Exosomes from NSC-34 cells transfected with hSOD1-g93a are enriched in miR-124 and drive alterations in microglia phenotype","volume":"11","author":"Pinto","year":"2017","journal-title":"Front. Neurosci. (Switzerland)"},{"key":"10.1016\/j.abb.2025.110499_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fncel.2019.00109","article-title":"Phenotypic effects of wild-type and mutant SOD1 expression in N9 murine microglia at steady state, inflammatory and immunomodulatory conditions","volume":"13","author":"Vaz","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.abb.2025.110499_bib17","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200116","article-title":"An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis\/motor neuron disease","volume":"10","author":"Banack","year":"2020","journal-title":"Open Biol"},{"key":"10.1016\/j.abb.2025.110499_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fnmol.2020.00053","article-title":"Circulating exosomal miRNA as diagnostic biomarkers of neurodegenerative diseases","volume":"13","author":"Wang","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.abb.2025.110499_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113414","article-title":"Elevated exosomal secretion of miR-124-3p from spinal neurons positively associates with disease severity in ALS","volume":"333","author":"Yelick","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.abb.2025.110499_bib20","first-page":"91","article-title":"MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS","volume":"61","author":"Ponomarev","year":"2013","journal-title":"GLIA (New York, N. Y.)"},{"key":"10.1016\/j.abb.2025.110499_bib21","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1084\/jem.20111313","article-title":"Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor \u03baB-mediated pathogenic pathways","volume":"208","author":"Swarup","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.abb.2025.110499_bib22","doi-asserted-by":"crossref","first-page":"418","DOI":"10.5414\/NP300493","article-title":"Nuclear factor \u03ba B expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations","volume":"31","author":"Sako","year":"2012","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.abb.2025.110499_bib23","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.neuron.2014.01.013","article-title":"Microglia induce motor neuron death via the classical NF-\u03baB pathway in amyotrophic lateral sclerosis","volume":"81","author":"Frakes","year":"2014","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.abb.2025.110499_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fncel.2014.00117","article-title":"Microglia centered pathogenesis in ALS: insights in cell interconnectivity","volume":"8","author":"Brites","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.abb.2025.110499_bib25","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798697","article-title":"NF-\u03baB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS","volume":"37","author":"Ouali Alami","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.abb.2025.110499_bib26","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.cub.2007.07.041","article-title":"Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP","volume":"17","author":"Zhu","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.abb.2025.110499_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diff.2021.11.004","article-title":"Knockdown of optineurin controls C2C12 myoblast differentiation via regulating myogenin and MyoD expressions","volume":"123","author":"Ishikawa","year":"2022","journal-title":"Differentiation"},{"key":"10.1016\/j.abb.2025.110499_bib28","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41418-022-01070-4","article-title":"Correction: global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease","volume":"30","author":"Wong","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.abb.2025.110499_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.104955","article-title":"Are extracellular vesicles new hope in clinical drug delivery for neurological disorders?","volume":"144","author":"Muhammad","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.abb.2025.110499_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3232869","article-title":"The role of exosomal microRNAs and oxidative stress in neurodegenerative diseases","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.abb.2025.110499_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.491","article-title":"Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation","volume":"4","author":"Parisi","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.abb.2025.110499_bib32","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/cdd.2015.153","article-title":"MicroRNA-125b regulates microglia activation and motor neuron death in ALS","volume":"23","author":"Parisi","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.abb.2025.110499_bib33","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.3389\/fimmu.2018.02647","article-title":"ALS-associated E478G mutation in human OPTN (optineurin) promotes inflammation and induces neuronal cell death","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.abb.2025.110499_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12547","article-title":"Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis","volume":"7","author":"Nakazawa","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2025.110499_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.neures.2025.03.005","article-title":"Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression","author":"Maetani","year":"2025","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.abb.2025.110499_bib36","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s12035-017-0543-1","article-title":"TDP-43 and cytoskeletal proteins in ALS","volume":"55","author":"Oberstadt","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.abb.2025.110499_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41420-019-0206-2","article-title":"Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells","volume":"5","author":"Ali","year":"2019","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.abb.2025.110499_bib38","article-title":"The usage and advantages of several common amyotrophic lateral sclerosis animal models","volume":"18","author":"Zhou","year":"2024","journal-title":"Front. Neurosci. (Switzerland)"},{"key":"10.1016\/j.abb.2025.110499_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12974-020-01822-4","article-title":"Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis","volume":"17","author":"Christoforidou","year":"2020","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.abb.2025.110499_bib40","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1038\/s41467-023-41603-0","article-title":"C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9","volume":"14","author":"Vahsen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2025.110499_bib41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct TAR"},{"key":"10.1016\/j.abb.2025.110499_bib42","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.abb.2025.110499_bib43","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1093\/brain\/aww237","article-title":"Exosome secretion is a key pathway for clearance of pathological TDP-43","volume":"139","author":"Iguchi","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.abb.2025.110499_bib44","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/icb.2016.89","article-title":"Impaired activation of ALS monocytes by exosomes","volume":"95","author":"Zondler","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.abb.2025.110499_bib45","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3389\/fnins.2018.00487","article-title":"Pathological proteins are transported by extracellular vesicles of sporadic amyotrophic lateral sclerosis patients","volume":"12","author":"Sproviero","year":"2018","journal-title":"Front. Neurosci. (Switzerland)"},{"key":"10.1016\/j.abb.2025.110499_bib46","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.243139","article-title":"Extracellular vesicles - propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases","volume":"133","author":"Vassileff","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.abb.2025.110499_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat0195","article-title":"Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy","volume":"10","author":"Gao","year":"2018","journal-title":"Sci. Transl. Med."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125002127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125002127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T07:55:47Z","timestamp":1752566147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986125002127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":47,"alternative-id":["S0003986125002127"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2025.110499","relation":{},"ISSN":["0003-9861"],"issn-type":[{"type":"print","value":"0003-9861"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown of OPTN modulates miRNA-125b-5p expression via NF-\u03baB pathways in amyotrophic lateral sclerosis","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2025.110499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110499"}}