{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:19:26Z","timestamp":1785302366245,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.abb.2025.110559","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T16:29:24Z","timestamp":1753201764000},"page":"110559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Prkcq in ILC2 cells-enhanced the amounts of tissue-resident macrophages promotes pancreatic fibrosis in chronic pancreatitis"],"prefix":"10.1016","volume":"772","author":[{"given":"Jianbin","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanzhuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 1","key":"10.1016\/j.abb.2025.110559_bib1","article-title":"Dachaihu decoction alleviates chronic pancreatitis by regulating MAPK signaling pathway: insights from network pharmacology and experimental validation","volume":"337","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.abb.2025.110559_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13063-022-07044-8","article-title":"Implementation of an evidence-based management algorithm for patients with chronic pancreatitis (COMBO trial): study protocol for a stepped-wedge cluster-randomized controlled trial","volume":"24","author":"de Rijk","year":"2023","journal-title":"Trials"},{"issue":"15","key":"10.1016\/j.abb.2025.110559_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12155102","article-title":"The impact of chronic pancreatitis on the occurrences of human cancers: real-world data","volume":"12","author":"Hsieh","year":"2023","journal-title":"J. Clin. Med."},{"issue":"10249","key":"10.1016\/j.abb.2025.110559_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(20)31318-0","article-title":"Chronic pancreatitis","volume":"396","author":"Beyer","year":"2020","journal-title":"Lancet (London, England)"},{"issue":"38","key":"10.1016\/j.abb.2025.110559_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202402550","article-title":"SEC16A variants predispose to chronic pancreatitis by impairing ER-to-Golgi transport and inducing ER stress","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"issue":"5","key":"10.1016\/j.abb.2025.110559_bib6","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.pan.2024.06.003","article-title":"Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases","volume":"24","author":"Stefanovics","year":"2024","journal-title":"Pancreatology: off. J. Int. Ass. Pancr. (IAP)"},{"key":"10.1016\/j.abb.2025.110559_bib7","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-024-02150-y","article-title":"Exosomes derived from bone marrow dendritic cells exhibit protective and therapeutic potential against chemically induced chronic pancreatitis in rats","author":"Bashir","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.abb.2025.110559_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106035","article-title":"Gut microbiota affects pancreatic fibrotic progression through immune modulation in chronic pancreatitis","volume":"177","author":"Liu","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.abb.2025.110559_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2016.01.018","article-title":"Regulation of group 2 innate lymphoid cells","volume":"87","author":"Duerr","year":"2016","journal-title":"Cytokine"},{"issue":"7","key":"10.1016\/j.abb.2025.110559_bib10","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.immuni.2022.06.001","article-title":"Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis","volume":"55","author":"Yang","year":"2022","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.abb.2025.110559_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41419-021-03549-3","article-title":"Neddylation pathway alleviates chronic pancreatitis by reducing HIF1\u03b1-CCL5-dependent macrophage infiltration","volume":"12","author":"Lin","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.abb.2025.110559_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115162","article-title":"Berberine attenuates severity of chronic pancreatitis and fibrosis via AMPK-mediated inhibition of TGF-\u03b21\/Smad signaling and M2 polarization","volume":"403","author":"Bansod","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.abb.2025.110559_bib13","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/s41590-023-01579-x","article-title":"Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC","volume":"24","author":"Baer","year":"2023","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.abb.2025.110559_bib14","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1042\/BST20140204","article-title":"Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration","volume":"42","author":"Long","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.abb.2025.110559_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173081","article-title":"PKC-\u03b8 is an important driver of fluoride-induced immune imbalance of regulatory T cells\/effector T cells","volume":"934","author":"Zhu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.abb.2025.110559_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13058-020-01302-w","article-title":"PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim","volume":"22","author":"Byerly","year":"2020","journal-title":"Breast Cancer Res."},{"issue":"2","key":"10.1016\/j.abb.2025.110559_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/biom11020221","article-title":"The emerging function of PKCtheta in cancer","volume":"11","author":"Nicolle","year":"2021","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.abb.2025.110559_bib18","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.jaci.2016.08.044","article-title":"Protein kinase C\u03b8 controls type 2 innate lymphoid cell and T(H)2 responses to house dust mite allergen","volume":"139","author":"Madouri","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.abb.2025.110559_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ccell.2022.01.003","article-title":"Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer","volume":"40","author":"Alam","year":"2022","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.abb.2025.110559_bib20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13578-021-00529-0","article-title":"The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis","volume":"11","author":"Oppezzo","year":"2021","journal-title":"Cell Biosci."},{"key":"10.1016\/j.abb.2025.110559_bib21","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.3389\/fimmu.2017.01808","article-title":"Positive feedback regulation between transglutaminase 2 and toll-like receptor 4 signaling in hepatic stellate cells correlates with liver fibrosis post Schistosoma japonicum infection","volume":"8","author":"Wen","year":"2017","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.abb.2025.110559_bib22","first-page":"1473","article-title":"Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer, cellular oncology","volume":"46","author":"Zhang","year":"2023"},{"issue":"5","key":"10.1016\/j.abb.2025.110559_bib23","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s12276-020-0444-7","article-title":"Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers","volume":"52","author":"Cho","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.abb.2025.110559_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.60","article-title":"Chronic pancreatitis","volume":"3","author":"Kleeff","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.abb.2025.110559_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106508","article-title":"Macrophages: a rising star in immunotherapy for chronic pancreatitis","volume":"185","author":"Xiang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.abb.2025.110559_bib26","article-title":"Macrophages in pancreatitis: mechanisms and therapeutic potential","volume":"131","author":"Hu","year":"2020","journal-title":"Biomed. & pharmacother. = Biomed. & pharmacother."},{"issue":"20","key":"10.1016\/j.abb.2025.110559_bib27","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.7150\/thno.47137","article-title":"USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated macrophages in lung cancer","volume":"10","author":"Dai","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.abb.2025.110559_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111691","article-title":"Pirfenidone alleviates chronic pancreatitis via suppressing the activation of pancreatic stellate cells and the M1 polarization of macrophages","volume":"130","author":"Guo","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"38","key":"10.1016\/j.abb.2025.110559_bib29","doi-asserted-by":"crossref","first-page":"9163","DOI":"10.1039\/D3TB01287E","article-title":"A new method for treating chronic pancreatitis and preventing fibrosis using bioactive calcium silicate ion solution","volume":"11","author":"Yin","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"40","key":"10.1016\/j.abb.2025.110559_bib30","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.3748\/wjg.v23.i40.7242","article-title":"Dachaihu decoction ameliorates pancreatic fibrosis by inhibiting macrophage infiltration in chronic pancreatitis","volume":"23","author":"Duan","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"10","key":"10.1016\/j.abb.2025.110559_bib31","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.3748\/wjg.v22.i10.2960","article-title":"Pathophysiology of chronic pancreatitis induced by dibutyltin dichloride joint ethanol in mice","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"7280","key":"10.1016\/j.abb.2025.110559_bib32","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.abb.2025.110559_bib33","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.1038\/ncomms8158","article-title":"Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis","volume":"6","author":"Xue","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.abb.2025.110559_bib34","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1038\/s41467-022-32195-2","article-title":"In mouse chronic pancreatitis CD25(+)FOXP3(+) regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response","volume":"13","author":"Glaubitz","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.abb.2025.110559_bib35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2017.03.024","article-title":"Recruited monocytes and type 2 immunity promote lung regeneration following pneumonectomy","volume":"21","author":"Lechner","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.abb.2025.110559_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107787","article-title":"Transglutaminase 2 as a novel target in chronic kidney disease - methods, mechanisms and pharmacological inhibition","volume":"222","author":"Prat-Duran","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.abb.2025.110559_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107899","article-title":"Suppressed ORAI1-STIM1-dependent Ca(2+) entry by protein kinase C isoforms regulating platelet procoagulant activity","author":"Zou","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.abb.2025.110559_bib38","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/MPA.0b013e31802f0531","article-title":"High glucose activates rat pancreatic stellate cells through protein kinase C and p38 mitogen-activated protein kinase pathway","volume":"34","author":"Nomiyama","year":"2007","journal-title":"Pancreas"},{"issue":"4","key":"10.1016\/j.abb.2025.110559_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.15430\/JCP.2019.24.4.233","article-title":"Docosahexaenoic acid inhibits expression of fibrotic mediators in mice with chronic pancreatitis","volume":"24","author":"Lee","year":"2019","journal-title":"J. cancer prev."},{"issue":"7","key":"10.1016\/j.abb.2025.110559_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/nu9070744","article-title":"Docosahexaenoic acid inhibits cerulein-induced acute pancreatitis in rats","volume":"9","author":"Jeong","year":"2017","journal-title":"Nutrients"},{"issue":"32","key":"10.1016\/j.abb.2025.110559_bib41","doi-asserted-by":"crossref","first-page":"9534","DOI":"10.3748\/wjg.v21.i32.9534","article-title":"Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis","volume":"21","author":"Chang","year":"2015","journal-title":"World J. Gastroenterol."},{"issue":"11","key":"10.1016\/j.abb.2025.110559_bib42","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1111\/bph.12621","article-title":"Inhibition of PKC-\u03b8 preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy","volume":"171","author":"Li","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.abb.2025.110559_bib43","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jid.2020.09.021","article-title":"Inverse correlation of TRIM32 and protein kinase C \u03b6 in T helper type 2-Biased inflammation","volume":"141","author":"Wang","year":"2021","journal-title":"J. Invest. Dermatol."},{"issue":"15","key":"10.1016\/j.abb.2025.110559_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241511970","article-title":"Black ginseng extract exerts potentially anti-asthmatic activity by inhibiting the protein kinase C\u03b8-Mediated IL-4\/STAT6 signaling pathway","volume":"24","author":"Song","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125002723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125002723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:25:26Z","timestamp":1755235526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986125002723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":44,"alternative-id":["S0003986125002723"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2025.110559","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prkcq in ILC2 cells-enhanced the amounts of tissue-resident macrophages promotes pancreatic fibrosis in chronic pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2025.110559","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110559"}}