{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:24:27Z","timestamp":1786983867502,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017956","name":"Health Commission of Gansu Province","doi-asserted-by":"publisher","award":["GSWSKY2024-08"],"award-info":[{"award-number":["GSWSKY2024-08"]}],"id":[{"id":"10.13039\/100017956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["20250060085"],"award-info":[{"award-number":["20250060085"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2018YFC1313900"],"award-info":[{"award-number":["2018YFC1313900"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.abb.2025.110703","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:58:14Z","timestamp":1765439894000},"page":"110703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exploring the multiple mechanisms of Hydroxytyrosol in treating obesity"],"prefix":"10.1016","volume":"776","author":[{"given":"Conghui","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbo","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5135-1415","authenticated-orcid":false,"given":"Xulei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.abb.2025.110703_bib2","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1111\/dom.15238","article-title":"Prevalence of obesity and associated complications in China: a cross-sectional, real-world study in 15.8 million adults","volume":"25","author":"Chen","year":"2023","journal-title":"Diabetes Obes. Metabol."},{"issue":"12","key":"10.1016\/j.abb.2025.110703_bib3","first-page":"1429","article-title":"Semaglutide reduces cardiomyocyte size and cardiac mass in Lean and Obese mice","volume":"9","author":"Martens","year":"2024","journal-title":"JACC (J. Am. Coll. Cardiol.): Basic Transl. Sci."},{"issue":"11","key":"10.1016\/j.abb.2025.110703_bib4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S2213-8587(24)00272-9","article-title":"Muscle matters: the effects of medically induced weight loss on skeletal muscle","volume":"12","author":"Prado","year":"2024","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.abb.2025.110703_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1632753","article-title":"Editorial: dietary and nutrigenetic contributors to metabolic syndrome","volume":"16","author":"Arunagiri","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.abb.2025.110703_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14786419.2025.2513583","article-title":"Unlocking nature's secrets: a review on the pharmacokinetics of plant-based medicines and herbal remedies","author":"Parthasarathy","year":"2025","journal-title":"Nat. Prod. Res."},{"issue":"10","key":"10.1016\/j.abb.2025.110703_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26104470","article-title":"From biosynthesis to legislation: a review of Hydroxytyrosol's biological functions and safety","volume":"26","author":"Wang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.abb.2025.110703_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/nu10101523","article-title":"Relationship between Mediterranean dietary Polyphenol intake and obesity","volume":"10","author":"Castro-Barquero","year":"2018","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.abb.2025.110703_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/nu14071525","article-title":"Effect of long-term Hydroxytyrosol administration on body weight, fat mass and urine metabolomics: a randomized double-blind prospective human Study","volume":"14","author":"Fytili","year":"2022","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.abb.2025.110703_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102326","article-title":"Modeling adipogenesis: current and future perspective","volume":"9","author":"Bahmad","year":"2020","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.abb.2025.110703_bib11","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41590-021-00922-4","article-title":"Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity","volume":"22","author":"Hildreth","year":"2021","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.abb.2025.110703_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41556-025-01609-w","article-title":"Time for lipid cell biology","volume":"27","author":"Chen","year":"2025","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.abb.2025.110703_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41580-021-00350-0","article-title":"The cellular and functional complexity of thermogenic fat","volume":"22","author":"Cohen","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.abb.2025.110703_bib14","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"12","key":"10.1016\/j.abb.2025.110703_bib15","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"9","key":"10.1016\/j.abb.2025.110703_bib16","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"8","key":"10.1016\/j.abb.2025.110703_bib17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41581-019-0158-z","article-title":"The role of inflammasomes in kidney disease","volume":"15","author":"Komada","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.abb.2025.110703_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1042\/CS20210865","article-title":"Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease","volume":"136","author":"\u00d8stergaard","year":"2022","journal-title":"Clin. Sci."},{"key":"10.1016\/j.abb.2025.110703_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.mce.2018.08.002","article-title":"NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice","volume":"478","author":"Wu","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.abb.2025.110703_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154748","article-title":"Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy","volume":"118","author":"Wu","year":"2021","journal-title":"Metab., Clin. Exp."},{"key":"10.1016\/j.abb.2025.110703_bib21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cytogfr.2022.08.006","article-title":"Alternative pathways driven by STING: from innate immunity to lipid metabolism","volume":"68","author":"Vila","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.abb.2025.110703_bib22","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.fct.2013.01.030","article-title":"Toxicological evaluation of pure hydroxytyrosol","volume":"55","author":"Au\u00f1on-Calles","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.abb.2025.110703_bib23","doi-asserted-by":"crossref","first-page":"9086","DOI":"10.1039\/D0FO01790F","article-title":"The metabolic dysfunction of white adipose tissue induced in mice by a high-fat diet is abrogated by co-administration of docosahexaenoic acid and hydroxytyrosol","volume":"11","author":"Illesca","year":"2020","journal-title":"Food Funct."},{"issue":"9","key":"10.1016\/j.abb.2025.110703_bib24","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1039\/C9FO01373C","article-title":"High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration","volume":"10","author":"Echeverr\u00eda","year":"2019","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.abb.2025.110703_bib25","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2337\/dbi18-0052","article-title":"The cGAS-cGAMP-STING pathway: a molecular link between immunity and metabolism","volume":"68","author":"Bai","year":"2019","journal-title":"Diabetes"},{"issue":"46","key":"10.1016\/j.abb.2025.110703_bib26","doi-asserted-by":"crossref","first-page":"12196","DOI":"10.1073\/pnas.1708744114","article-title":"DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway","volume":"114","author":"Bai","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.abb.2025.110703_bib27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s42003-020-0986-1","article-title":"Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice","volume":"3","author":"Bai","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.abb.2025.110703_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.151352","article-title":"STING1 targets MYH9 to drive adipogenesis through the AKT\/GSK3\u03b2\/\u03b2-catenin pathway","volume":"749","author":"Guan","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2025.110703_bib29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.phrs.2013.06.002","article-title":"Hydroxytyrosol is not genotoxic in vitro","volume":"74","author":"Au\u00f1on-Calles","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.abb.2025.110703_bib30","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.foodres.2017.11.053","article-title":"Hydroxytyrosol: bioavailability, toxicity, and clinical applications","volume":"105","author":"Robles-Almazan","year":"2018","journal-title":"Food Res. Int."},{"key":"10.1016\/j.abb.2025.110703_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156806","article-title":"Camellia Japonica Radix modulates gut microbiota and 9(S)-HpODE-mediated ferroptosis to alleviate oxidative stress against MASLD","volume":"143","author":"Gu","year":"2025","journal-title":"Phytomedicine"},{"issue":"16","key":"10.1016\/j.abb.2025.110703_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/foods14162766","article-title":"The role of olive oil polyphenols in osteosarcopenic obesity-related biological domains: a systematic review of current evidence","volume":"14","author":"Zupo","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.abb.2025.110703_bib33","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.biopha.2018.11.120","article-title":"Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-\u03b3 and NF-\u03baB","volume":"109","author":"Illesca","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"35","key":"10.1016\/j.abb.2025.110703_bib34","doi-asserted-by":"crossref","first-page":"9377","DOI":"10.1021\/acs.jafc.0c03310","article-title":"Hydroxytyrosol attenuates hepatic fat accumulation via activating mitochondrial biogenesis and autophagy through the AMPK pathway","volume":"68","author":"Dong","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.abb.2025.110703_bib35","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s00394-023-03133-9","article-title":"Positive contribution of hydroxytyrosol-enriched wheat bread to HbA(1)c levels, lipid profile, markers of inflammation and body weight in subjects with overweight\/obesity and type 2 diabetes mellitus","volume":"62","author":"Binou","year":"2023","journal-title":"Eur. J. Nutr."},{"issue":"2","key":"10.1016\/j.abb.2025.110703_bib36","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/jcp.25094","article-title":"Hydroxytyrosol inhibits cannabinoid CB1 receptor gene expression in 3T3-L1 preadipocyte cell line","volume":"231","author":"Tutino","year":"2016","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.abb.2025.110703_bib37","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.bbrc.2013.09.106","article-title":"Modulation of adipogenesis, lipolysis and glucose consumption in 3T3-L1 adipocytes and C2C12 myotubes by hydroxytyrosol acetate: a comparative study","volume":"440","author":"Drira","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.abb.2025.110703_bib38","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00394-013-0578-7","article-title":"Hydroxytyrosol stimulates lipolysis via A-kinase and extracellular signal-regulated kinase activation in 3T3-L1 adipocytes","volume":"53","author":"Drira","year":"2014","journal-title":"Eur. J. Nutr."},{"issue":"19\u201320","key":"10.1016\/j.abb.2025.110703_bib39","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.lfs.2011.08.012","article-title":"Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells","volume":"89","author":"Drira","year":"2011","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.abb.2025.110703_bib40","article-title":"Lupenone-rich fraction derived from Cissus quadrangularis L. suppresses lipid accumulation in 3T3-L1 adipocytes","volume":"13","author":"Lakthan","year":"2023","journal-title":"Life (Basel)"},{"issue":"8","key":"10.1016\/j.abb.2025.110703_bib41","article-title":"Effects of extracts of two selected strains of Haematococcus pluvialis on adipocyte function","volume":"13","author":"Pappalardo","year":"2023","journal-title":"Life (Basel)"},{"issue":"14","key":"10.1016\/j.abb.2025.110703_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411496","article-title":"Albizia julibrissin exerts anti-obesity effects by inducing the browning of 3T3L1 white adipocytes","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.abb.2025.110703_bib43","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1111\/jcmm.17255","article-title":"Olive phenols preserve lamin B1 expression reducing cGAS\/STING\/NF\u03baB-mediated SASP in ionizing radiation-induced senescence","volume":"26","author":"Frediani","year":"2022","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.abb.2025.110703_bib44","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbrc.2017.02.007","article-title":"NLRP3 inflammasome activation in mesenchymal stem cells inhibits osteogenic differentiation and enhances adipogenic differentiation","volume":"484","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2025.110703_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113520","article-title":"Perfluorodecanoic acid promotes adipogenesis via NLRP3 inflammasome-mediated pathway in HepG2 and 3T3-L1 cells","volume":"171","author":"Wang","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.abb.2025.110703_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109080","article-title":"Fructose-mediated NLRP3 activation induces inflammation and lipogenesis in adipose tissue","volume":"107","author":"Singh","year":"2022","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.abb.2025.110703_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102691","article-title":"STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome","volume":"62","author":"Xiao","year":"2023","journal-title":"Redox Biol."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125004175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986125004175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:14:35Z","timestamp":1774484075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986125004175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":46,"alternative-id":["S0003986125004175"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2025.110703","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the multiple mechanisms of Hydroxytyrosol in treating obesity","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2025.110703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110703"}}