{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:47:46Z","timestamp":1788583666465,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.abb.2026.110753","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T15:37:17Z","timestamp":1769701037000},"page":"110753","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Exosomal miR-93-5p modulates macrophage polarization to enhance prostate cancer progression"],"prefix":"10.1016","volume":"779","author":[{"given":"Yarong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2026.110753_bib1","first-page":"17","article-title":"Cancer statistics","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.abb.2026.110753_bib2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.cell.2015.10.025","article-title":"The molecular taxonomy of primary prostate cancer","volume":"163","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.abb.2026.110753_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-319-23730-5_7","article-title":"microRNAs and prostate cancer","volume":"889","author":"Josson","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.abb.2026.110753_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114168","article-title":"STAT3 signaling in prostate cancer progression and therapy resistance: an oncogenic pathway with diverse functions","volume":"158","author":"Sadrkhanloo","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.abb.2026.110753_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/cells9010217","article-title":"Role of JAK\/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial-mesenchymal transition","volume":"9","author":"Jin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.abb.2026.110753_bib6","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2147\/JIR.S353489","article-title":"Role of JAK2\/STAT3 signaling pathway in the tumorigenesis, chemotherapy resistance, and treatment of solid tumors: a systemic review","volume":"15","author":"Mengie Ayele","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.abb.2026.110753_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11427-020-1700-9","article-title":"Non-coding RNAs: the new central dogma of cancer biology","volume":"64","author":"Saw","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.abb.2026.110753_bib8","doi-asserted-by":"crossref","first-page":"10463","DOI":"10.1002\/jcb.28332","article-title":"miR-93-5p may be an important oncogene in prostate cancer by bioinformatics analysis","volume":"120","author":"Yang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.abb.2026.110753_bib9","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1038\/s41388-020-01401-0","article-title":"microRNA-93-5p promotes hepatocellular carcinoma progression via a microRNA-93-5p\/MAP3K2\/c-Jun positive feedback circuit","volume":"39","author":"Shi","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.abb.2026.110753_bib10","first-page":"310","article-title":"miRNA-93-5p promotes gemcitabine resistance in pancreatic cancer cells by targeting the PTEN-mediated PI3K\/Akt signaling pathway","volume":"51","author":"Wu","year":"2021","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.abb.2026.110753_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13046-019-1507-2","article-title":"Exosome-mediated transfer of miR-93-5p from cancer-associated fibroblasts confer radioresistance in colorectal cancer cells by downregulating FOXA1 and upregulating TGFB3","volume":"39","author":"Chen","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.abb.2026.110753_bib12","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41423-023-01061-6","article-title":"Roles of macrophages in tumor development: a spatiotemporal perspective","volume":"20","author":"Bied","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.abb.2026.110753_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1295257","article-title":"Tumor-associated macrophages: an effective player of the tumor microenvironment","volume":"14","author":"Basak","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.abb.2026.110753_bib14","doi-asserted-by":"crossref","first-page":"7117","DOI":"10.3390\/ijms21197117","article-title":"MicroRNAs: as critical regulators of tumor-associated macrophages","volume":"21","author":"Chatterjee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.abb.2026.110753_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41392-020-00261-0","article-title":"Exosomes: key players in cancer and potential therapeutic strategy","volume":"5","author":"Dai","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.abb.2026.110753_bib16","doi-asserted-by":"crossref","first-page":"9729","DOI":"10.1002\/jcp.29784","article-title":"Tumor-associated macrophages promote prostate cancer progression via exosome-mediated miR-95 transfer","volume":"235","author":"Guan","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.abb.2026.110753_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41389-022-00431-5","article-title":"Exosomes and cancer - diagnostic and prognostic biomarkers and therapeutic vehicle","volume":"11","author":"Wang","year":"2022","journal-title":"Oncogenesis"},{"key":"10.1016\/j.abb.2026.110753_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12943-021-01396-6","article-title":"Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications","volume":"20","author":"Tang","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.abb.2026.110753_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3390\/genes12010073","article-title":"The significance of exosomal RNAs in the development, diagnosis, and treatment of gastric cancer","volume":"12","author":"Zhao","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.abb.2026.110753_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/biomethods\/bpw003","article-title":"Assessment of six commercial plasma small RNA isolation kits using qRT-PCR and electrophoretic separation: higher recovery of microRNA following ultracentrifugation","volume":"1","author":"Meerson","year":"2016","journal-title":"Biol. Methods Protoc."},{"key":"10.1016\/j.abb.2026.110753_bib21","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.abb.2026.110753_bib22","article-title":"MicroRNA detection in prostate tumors by quantitative real-time PCR (qPCR)","volume":"63","author":"Gordanpour","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.abb.2026.110753_bib23","first-page":"2260","article-title":"Diagnostic and prognostic value of miR-93 in prostate cancer: a meta-analysis and bioinformatics analysis","volume":"52","author":"Gazzaz","year":"2023","journal-title":"Iran J. Public Health"},{"key":"10.1016\/j.abb.2026.110753_bib24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.omto.2018.08.001","article-title":"miR-93 promotes the growth and invasion of prostate cancer by upregulating its target genes TGFBR2, ITGB8, and LATS2","volume":"11","author":"Liu","year":"2018","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.abb.2026.110753_bib25","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1007\/s13277-015-4328-8","article-title":"miR-93 promotes TGF-\u03b2-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells","volume":"37","author":"Qu","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.abb.2026.110753_bib26","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.4161\/cc.22670","article-title":"MiR-93 enhances angiogenesis and metastasis by targeting LATS2","volume":"11","author":"Fang","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.abb.2026.110753_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.addr.2014.09.001","article-title":"Circulating miRNAs: roles in cancer diagnosis, prognosis and therapy","volume":"81","author":"Cheng","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.abb.2026.110753_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31108-y","article-title":"Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients","volume":"8","author":"Ni","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.abb.2026.110753_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41698-024-00522-z","article-title":"Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance","volume":"8","author":"Wang","year":"2024","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.abb.2026.110753_bib30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/gcc.22725","article-title":"Role of miRNAs in immune responses and immunotherapy in cancer","volume":"58","author":"Cortez","year":"2019","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.abb.2026.110753_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-3-031-08356-3_3","article-title":"Regulation of immune cells by microRNAs and microRNA-Based cancer immunotherapy","volume":"1385","author":"Veiga","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.abb.2026.110753_bib32","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.bbrc.2017.10.002","article-title":"miR-19 promotes osteosarcoma progression by targeting SOCS6","volume":"495","author":"Sun","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2026.110753_bib33","article-title":"MicroRNA-653-5p promotes gastric cancer proliferation and metastasis by targeting the SOCS6-STAT3 pathway","volume":"8","author":"Li","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.abb.2026.110753_bib34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.abb.2026.110753_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216186","article-title":"Oncogenic miR-93-5p\/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy","volume":"564","author":"Dong","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.abb.2026.110753_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1160719","article-title":"Advances in the role of STAT3 in macrophage polarization","volume":"14","author":"Xia","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000398612600024X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000398612600024X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:08:30Z","timestamp":1773277710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000398612600024X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":36,"alternative-id":["S000398612600024X"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2026.110753","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomal miR-93-5p modulates macrophage polarization to enhance prostate cancer progression","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2026.110753","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110753"}}