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A."},{"key":"10.1016\/j.abb.2026.110760_bib74","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.abb.2026.110760_bib75","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.abb.2026.110760_bib76","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1038\/s41467-022-34096-w","article-title":"A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. 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(Weinh.)"},{"key":"10.1016\/j.abb.2026.110760_bib88","article-title":"Transcriptional activation of","volume":"12","author":"Hamano","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.abb.2026.110760_bib89","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.neuropharm.2016.12.011","article-title":"The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity","volume":"116","author":"Chen","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.abb.2026.110760_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103018","article-title":"Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality","volume":"69","author":"Nishimura","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.abb.2026.110760_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166621","article-title":"Iron cycle disruption by heme oxygenase-1 activation leads to a reduced breast cancer cell survival","volume":"1869","author":"Giorgi","year":"2023","journal-title":"Biochim. 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Lipid Res."},{"key":"10.1016\/j.abb.2026.110760_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166114","article-title":"The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death","volume":"1867","author":"Kr\u00fcmmel","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.abb.2026.110760_bib118","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bbrc.2019.05.123","article-title":"Increased hepcidin in hemorrhagic plaques correlates with iron-stimulated IL-6\/STAT3 pathway activation in macrophages","volume":"515","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2026.110760_bib119","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s12603-019-1302-y","article-title":"Interleukin-1\u03b2 regulates lipid homeostasis in human glomerular mesangial cells","volume":"24","author":"Liu","year":"2020","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.abb.2026.110760_bib120","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.7150\/ijms.43981","article-title":"Interleukin-1\u03b2 promotes Ox-LDL uptake by human glomerular mesangial cells via LOX-1","volume":"17","author":"Liu","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.abb.2026.110760_bib121","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2010.08.034","article-title":"Interleukin-1\u03b2 induces ceruloplasmin and ferroportin-1 gene expression via MAP kinases and C\/EBP\u03b2, AP-1, and NF-\u03baB activation","volume":"484","author":"Persichini","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.abb.2026.110760_bib122","doi-asserted-by":"crossref","first-page":"10275","DOI":"10.1074\/jbc.M116.770974","article-title":"Interleukin-1\u03b2 (IL-1\u03b2) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein \u03b4 (C\/EBP\u03b4) expression in hepatocytes","volume":"292","author":"Kanamori","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2026.110760_bib123","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cyto.2018.09.014","article-title":"JNK facilitates IL-1\u03b2-induced hepcidin transcription via JunB activation","volume":"111","author":"Kanamori","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.abb.2026.110760_bib124","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13045-021-01223-x","article-title":"HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.abb.2026.110760_bib125","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.freeradbiomed.2021.07.019","article-title":"Glycyrrhetinic acid induces oxidative\/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells","volume":"173","author":"Wen","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.abb.2026.110760_bib126","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/hep.25746","article-title":"Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice","volume":"56","author":"Zhang","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.abb.2026.110760_bib127","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41590-017-0022-x","article-title":"Myeloid-derived suppressor cells coming of age","volume":"19","author":"Veglia","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.abb.2026.110760_bib128","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1158\/2326-6066.CIR-15-0036","article-title":"Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies","volume":"3","author":"Hossain","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.abb.2026.110760_bib129","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2021.04.004","article-title":"MDSC: markers, development, states, and unaddressed complexity","volume":"54","author":"Hegde","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.abb.2026.110760_bib130","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1158\/2159-8290.CD-21-0764","article-title":"Myeloid-derived suppressor cells: a propitious road to clinic","volume":"11","author":"Grover","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.abb.2026.110760_bib131","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3389\/fimmu.2019.01399","article-title":"Lipid metabolic pathways confer the immunosuppressive function of myeloid-derived suppressor cells in tumor","volume":"10","author":"Yan","year":"2019","journal-title":"Front. 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Res."},{"key":"10.1016\/j.abb.2026.110760_bib135","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.celrep.2016.10.086","article-title":"Tailored tumor immunogenicity reveals regulation of CD4 and CD8 T cell responses against cancer","volume":"17","author":"Knocke","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.abb.2026.110760_bib136","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nri3405","article-title":"Molecular mechanisms of T cell co-stimulation and co-inhibition","volume":"13","author":"Chen","year":"2013","journal-title":"Nat. Rev. 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