{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:24:08Z","timestamp":1786983848004,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.abb.2026.110776","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:38:31Z","timestamp":1771918711000},"page":"110776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Phosphocreatine attenuates isoproterenol-induced cardiac fibrosis via activation of the Nrf2\/ARE antioxidant pathway and preservation of endothelial integrity"],"prefix":"10.1016","volume":"779","author":[{"given":"Wu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eskandar","family":"Qaed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Aldahmash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mueataz A.","family":"Mahyoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed Ali","family":"Hailan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman Khaled","family":"Alwesabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Almoiliqy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.abb.2026.110776_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159682","article-title":"Inhibition of the unfolded protein response mechanism prevents cardiac fibrosis","volume":"11","author":"Groenendyk","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.abb.2026.110776_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1256156","article-title":"Axitinib targets cardiac fibrosis in pressure overload-induced heart failure through VEGFA-KDR pathway","volume":"10","author":"Jiao","year":"2023","journal-title":"Front. Med."},{"issue":"35","key":"10.1016\/j.abb.2026.110776_bib3","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1021\/acs.jafc.6b03001","article-title":"Protective effect of RA on myocardial infarction-induced cardiac fibrosis via AT1R\/p38 MAPK pathway signaling and modulation of the ACE2\/ACE ratio","volume":"64","author":"Liu","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.abb.2026.110776_bib4","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1582-4934.2008.00633.x","article-title":"Cellular repressor of E1A-stimulated genes attenuates cardiac hypertrophy and fibrosis","volume":"13","author":"Bian","year":"2009","journal-title":"J. Cell Mol. Med."},{"issue":"5","key":"10.1016\/j.abb.2026.110776_bib5","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s11604-021-01228-z","article-title":"Can myocardial susceptibility quantification be an imaging biomarker for cardiac amyloidosis?","volume":"40","author":"Hayashi","year":"2022","journal-title":"Jpn. J. Radiol."},{"issue":"1","key":"10.1016\/j.abb.2026.110776_bib6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3892\/etm.2021.10147","article-title":"SGLT2 promotes cardiac fibrosis following myocardial infarction and is regulated by miR-141","volume":"22","author":"Li","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.abb.2026.110776_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12872-022-02583-z","article-title":"Metabolism disorder promotes isoproterenol-induced myocardial injury in mice with high temperature and high humidity and high-fat diet","volume":"22","author":"Lan","year":"2022","journal-title":"BMC Cardiovasc. Disord."},{"issue":"1","key":"10.1016\/j.abb.2026.110776_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ame2.12496","article-title":"Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals","volume":"8","author":"Bader Eddin","year":"2025","journal-title":"Animal Model. Exp. Med."},{"issue":"10","key":"10.1016\/j.abb.2026.110776_bib9","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910865","article-title":"Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?","volume":"12","author":"Sweeney","year":"2020","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"10.1016\/j.abb.2026.110776_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/physiolgenomics.00041.2017","article-title":"Nrf2 at the heart of oxidative stress and cardiac protection","volume":"50","author":"Chen","year":"2018","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.abb.2026.110776_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.889792","article-title":"Roles of NRF2 in fibrotic diseases: from mechanisms to therapeutic approaches","volume":"13","author":"Hao","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.abb.2026.110776_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.889792","article-title":"Roles of NRF2 in fibrotic diseases: from mechanisms to therapeutic approaches","volume":"13","author":"Hao","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.abb.2026.110776_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/260429","article-title":"The role of Nrf2-mediated pathway in cardiac remodeling and heart failure","volume":"2014","author":"Zhou","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.abb.2026.110776_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: an important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.abb.2026.110776_bib15","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3389\/fimmu.2018.01383","article-title":"The role of endothelial progenitors in the repair of vascular damage in systemic sclerosis","volume":"9","author":"Del Papa","year":"2018","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.abb.2026.110776_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/MOH.0000000000000239","article-title":"Endothelial functions of platelet\/endothelial cell adhesion molecule-1 (CD31)","volume":"23","author":"Lertkiatmongkol","year":"2016","journal-title":"Curr. Opin. Hematol."},{"issue":"1","key":"10.1016\/j.abb.2026.110776_bib17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1590\/S1679-45082014RB2741","article-title":"Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles","volume":"12","author":"Guimar\u00e3es-Ferreira","year":"2014","journal-title":"Einstein (Sao Paulo)"},{"key":"10.1016\/j.abb.2026.110776_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123012","article-title":"Clinical applications of phosphocreatine and related mechanisms","volume":"355","author":"Wang","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.abb.2026.110776_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111839","article-title":"Non-energy mechanism of phosphocreatine on the protection of cell survival","volume":"141","author":"Liu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.abb.2026.110776_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113677","article-title":"Protective effects of phosphocreatine against doxorubicin-induced cardiotoxicity through mitochondrial function enhancement and apoptosis suppression via AMPK\/PGC-1\u03b1 signaling pathway","volume":"144","author":"Qaed","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.abb.2026.110776_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5408289","article-title":"Phosphocreatine attenuates isoproterenol-induced cardiac fibrosis and cardiomyocyte apoptosis","volume":"2019","author":"Dai","year":"2019","journal-title":"BioMed Res. Int."},{"issue":"12","key":"10.1016\/j.abb.2026.110776_bib22","first-page":"2726","article-title":"Phosphocreatine attenuates angiotensin II-induced cardiac fibrosis in rat cardiomyocytes through modulation of MAPK and NF-\u03baB pathway","volume":"20","author":"Fei","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.abb.2026.110776_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2023.101194","article-title":"Cardiac fibrosis in heart failure: focus on non-invasive diagnosis and emerging therapeutic strategies","volume":"93","author":"Ravassa","year":"2023","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.abb.2026.110776_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5408289","article-title":"Phosphocreatine attenuates isoproterenol-induced cardiac fibrosis and cardiomyocyte apoptosis","volume":"2019","author":"Dai","year":"2019","journal-title":"BioMed Res. Int."},{"issue":"7","key":"10.1016\/j.abb.2026.110776_bib25","article-title":"Histopathological analysis of myocardial remodeling following heart failure: a cadaveric case report","volume":"17","author":"DeSomma","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.abb.2026.110776_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.legalmed.2022.102127","article-title":"Immunohistochemical analysis of CD31 expression in myocardial tissues from autopsies of patients with ischemic heart disease","volume":"59","author":"Kondo","year":"2022","journal-title":"Leg. Med."},{"issue":"1","key":"10.1016\/j.abb.2026.110776_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1465-9921-14-56","article-title":"Endostatin, an angiogenesis inhibitor, ameliorates bleomycin-induced pulmonary fibrosis in rats","volume":"14","author":"Wan","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.abb.2026.110776_bib28","article-title":"Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction","author":"Karppinen","year":"2025","journal-title":"FEBS J."},{"key":"10.1016\/j.abb.2026.110776_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1057918","article-title":"Activation of Nrf2 signaling: a key molecular mechanism of protection against cardiovascular diseases by natural products","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.abb.2026.110776_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11091685","article-title":"The role of Nrf2 in pulmonary fibrosis: molecular mechanisms and treatment approaches","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.abb.2026.110776_bib31","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jare.2024.10.037","article-title":"Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway","volume":"75","author":"Yue","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.abb.2026.110776_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133199","article-title":"Targeting progranulin alleviated silica particles-induced pulmonary inflammation and fibrosis via decreasing Il-6 and Tgf-\u03b21\/Smad","volume":"465","author":"Zhao","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.abb.2026.110776_bib33","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1038\/s41467-020-17329-8","article-title":"Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming","volume":"11","author":"Cheung","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2026.110776_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.882027","article-title":"The roles of cardiac fibroblasts and endothelial cells in myocarditis","volume":"9","author":"Xuan","year":"2022","journal-title":"Front. Cardiovasc. Med."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986126000470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986126000470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:12:25Z","timestamp":1777439545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986126000470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":34,"alternative-id":["S0003986126000470"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2026.110776","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphocreatine attenuates isoproterenol-induced cardiac fibrosis via activation of the Nrf2\/ARE antioxidant pathway and preservation of endothelial integrity","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2026.110776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110776"}}