{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:10:10Z","timestamp":1778724610666,"version":"3.51.4"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404945"],"award-info":[{"award-number":["82404945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["H2023129"],"award-info":[{"award-number":["H2023129"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.abb.2026.110823","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:47:37Z","timestamp":1776282457000},"page":"110823","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Emerging role of protein S-nitrosylation in diabetes and diabetes-associated diseases"],"prefix":"10.1016","volume":"781","author":[{"given":"Mei","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbo","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengfan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8915-0616","authenticated-orcid":false,"given":"Penghua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10481","key":"10.1016\/j.abb.2026.110823_bib1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","article-title":"Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the global Burden of Disease Study 2021","volume":"405","author":"Collaborators","year":"2025","journal-title":"Lancet (London, England)"},{"issue":"10322","key":"10.1016\/j.abb.2026.110823_bib2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0140-6736(21)01919-X","article-title":"Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation","volume":"399","author":"Lingvay","year":"2022","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2021.12.012","article-title":"Why does obesity cause diabetes?","volume":"34","author":"Klein","year":"2022","journal-title":"Cell Metab."},{"issue":"723","key":"10.1016\/j.abb.2026.110823_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf9382","article-title":"Metaflammation in obesity and its therapeutic targeting","volume":"15","author":"Schleh","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib5","first-page":"45","article-title":"Inflammation and resolution in obesity, Nature reviews","volume":"21","author":"Sot\u00e1k","year":"2025","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41392-022-01073-0","article-title":"Trends in insulin resistance: insights into mechanisms and therapeutic strategy","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"4","key":"10.1016\/j.abb.2026.110823_bib7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.cmet.2021.03.019","article-title":"Insulin action in adipocytes, adipose remodeling, and systemic effects","volume":"33","author":"Santoro","year":"2021","journal-title":"Cell Metab."},{"issue":"22","key":"10.1016\/j.abb.2026.110823_bib8","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMra2216691","article-title":"Adipocyte regulation of insulin sensitivity and the risk of type 2 diabetes","volume":"388","author":"Santoro","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molcel.2023.12.018","article-title":"Enzymatic and non-enzymatic transnitrosylation: \"scan\"ning the SNO-proteome","volume":"84","author":"Nakamura","year":"2024","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.abb.2026.110823_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tem.2024.02.010","article-title":"'NO-how' enzymatic S-nitrosylation controls insulin pathophysiology","volume":"35","author":"Filomeni","year":"2024","journal-title":"Trends Endocrinol. Metabol.: TEM (Trends Endocrinol. Metab."},{"issue":"26","key":"10.1016\/j.abb.2026.110823_bib11","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1016\/j.cell.2023.11.009","article-title":"An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling","volume":"186","author":"Zhou","year":"2023","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib12","first-page":"111","article-title":"The manifold roles of protein S-nitrosylation in the life of insulin, Nature reviews","volume":"18","author":"Zhou","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.abb.2026.110823_bib13","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.freeradbiomed.2015.10.406","article-title":"Pro-inflammatory Macrophages suppress PPAR\u03b3 activity in Adipocytes via S-nitrosylation","volume":"89","author":"Yin","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib14","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1038\/s41598-017-07011-3","article-title":"Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1\u03b1 and mTORC1: role of protein farnesylation","volume":"7","author":"Nakazawa","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170391","article-title":"iNOS as a driver of inflammation and apoptosis in Mouse skeletal muscle after burn injury: possible involvement of Sirt1 S-Nitrosylation-Mediated acetylation of p65 NF-\u03baB and p53","volume":"12","author":"Nakazawa","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.abb.2026.110823_bib16","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1016\/j.apsb.2025.05.035","article-title":"From S-nitrosation targets to drugs: a potential new paradigm in disease treatment","volume":"15","author":"Ye","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"10","key":"10.1016\/j.abb.2026.110823_bib17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrm2764","article-title":"Protein denitrosylation: enzymatic mechanisms and cellular functions","volume":"10","author":"Benhar","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.abb.2026.110823_bib18","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1074\/jbc.RA118.004947","article-title":"Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase","volume":"294","author":"Stomberski","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.abb.2026.110823_bib19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bbagen.2011.08.012","article-title":"The role of thioredoxin in the regulation of cellular processes by S-nitrosylation","volume":"1820","author":"Sengupta","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"36","key":"10.1016\/j.abb.2026.110823_bib20","doi-asserted-by":"crossref","first-page":"30346","DOI":"10.1074\/jbc.M112.355875","article-title":"Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil \u03b2(2) integrin function","volume":"287","author":"Thom","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.abb.2026.110823_bib21","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1074\/jbc.M113.503938","article-title":"Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor \u03baB (NF-\u03baB) activation","volume":"289","author":"Kelleher","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"5879","key":"10.1016\/j.abb.2026.110823_bib22","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1126\/science.1158265","article-title":"Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins","volume":"320","author":"Benhar","year":"2008","journal-title":"Science (New York, N.Y.)"},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib23","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1038\/s41467-025-59003-x","article-title":"S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis","volume":"16","author":"Sakhuja","year":"2025","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.abb.2026.110823_bib24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nbt.1545","article-title":"Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture","volume":"27","author":"Forrester","year":"2009","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35055104","article-title":"Protein S-nitrosylation: a physiological signal for neuronal nitric oxide","volume":"3","author":"Jaffrey","year":"2001","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib26","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.013441","article-title":"Identification and quantification of S-nitrosylation by cysteine reactive tandem mass tag switch assay","volume":"11","author":"Murray","year":"2012","journal-title":"Mol. Cell. Proteomics : MCP"},{"key":"10.1016\/j.abb.2026.110823_bib27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.niox.2014.08.002","article-title":"Are nitric oxide-mediated protein modifications of functional significance in diabetic heart? ye'S, -NO', wh'Y-NO't?","volume":"43","author":"Jayakumari","year":"2014","journal-title":"Nitric Oxide : biology and chemistry"},{"issue":"6","key":"10.1016\/j.abb.2026.110823_bib28","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.molcel.2017.02.019","article-title":"PARK2 depletion connects energy and oxidative stress to PI3K\/Akt activation via PTEN S-Nitrosylation","volume":"65","author":"Gupta","year":"2017","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12933-024-02254-7","article-title":"MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1","volume":"23","author":"Chen","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"issue":"24","key":"10.1016\/j.abb.2026.110823_bib30","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1161\/CIRCULATIONAHA.123.066404","article-title":"S-Nitrosylation of Septin 2 exacerbates aortic aneurysm and dissection by coupling the TIAM1-RAC1 axis in macrophages","volume":"149","author":"Zhang","year":"2024","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.111997","article-title":"GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation","volume":"42","author":"Rizza","year":"2023","journal-title":"Cell Rep."},{"issue":"10","key":"10.1016\/j.abb.2026.110823_bib32","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.3724\/abbs.2023141","article-title":"S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis","volume":"55","author":"Zhu","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"13","key":"10.1016\/j.abb.2026.110823_bib33","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.7150\/thno.105894","article-title":"BCAA catabolism targeted therapy for heart failure with preserved ejection fraction","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2010.05.003","article-title":"Hyperglycemia induces inducible nitric oxide synthase gene expression and consequent nitrosative stress via c-Jun N-terminal kinase activation","volume":"203","author":"Yang","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.abb.2026.110823_bib35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.niox.2014.05.001","article-title":"PERK pathway are involved in NO-induced apoptosis in endothelial cells cocultured with RPE under high glucose conditions","volume":"40","author":"Zhang","year":"2014","journal-title":"Nitric Oxide : biology and chemistry"},{"key":"10.1016\/j.abb.2026.110823_bib36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.niox.2013.12.009","article-title":"Skeletal muscle nitric oxide (NO) synthases and NO-signaling in \"diabesity\"--what about the relevance of exercise training interventions?","volume":"37","author":"Eghbalzadeh","year":"2014","journal-title":"Nitric Oxide : biology and chemistry"},{"issue":"35","key":"10.1016\/j.abb.2026.110823_bib37","doi-asserted-by":"crossref","first-page":"30433","DOI":"10.1074\/jbc.M111.235945","article-title":"Increased adipocyte S-nitrosylation targets anti-lipolytic action of insulin: relevance to adipose tissue dysfunction in obesity","volume":"286","author":"Ovadia","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.abb.2026.110823_bib38","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.2337\/diabetes.53.9.2383","article-title":"Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes","volume":"53","author":"Marfella","year":"2004","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.abb.2026.110823_bib39","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/CIRCRESAHA.124.326042","article-title":"Dysregulated protein s-Nitrosylation promotes nitrosative stress and disease progression in heart failure with preserved ejection fraction","volume":"137","author":"Li","year":"2025","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib40","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1038\/s41467-021-24736-y","article-title":"S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo\/YAP-dependent diabetes-accelerated atherosclerosis","volume":"12","author":"Chao","year":"2021","journal-title":"Nat. Commun."},{"issue":"530","key":"10.1016\/j.abb.2026.110823_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao4617","article-title":"IRE1\u03b1 prevents hepatic steatosis by processing and promoting the degradation of select microRNAs","volume":"11","author":"Wang","year":"2018","journal-title":"Sci. Signal."},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib42","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2337\/db17-0223","article-title":"S-Nitrosoglutathione reductase dysfunction contributes to obesity-associated hepatic insulin resistance via regulating autophagy","volume":"67","author":"Qian","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.abb.2026.110823_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5629341","article-title":"Characterization of NO-Induced nitrosative status in human placenta from pregnant women with gestational diabetes mellitus","volume":"2017","author":"Visiedo","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.abb.2026.110823_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110003","article-title":"ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue","volume":"37","author":"Sebag","year":"2021","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/nu14010217","article-title":"IBF-R regulates IRE1\u03b1 post-translational modifications and ER stress in high-fat diet-induced Obese mice","volume":"14","author":"Lee","year":"2022","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.abb.2026.110823_bib46","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00125-009-1498-1","article-title":"Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta\/IRS-1 and Akt","volume":"52","author":"Carvalho-Filho","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.abb.2026.110823_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102153","article-title":"Endogenous S-nitrosocysteine proteomic inventories identify a core of proteins in heart metabolic pathways","volume":"47","author":"Lau","year":"2021","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.abb.2026.110823_bib48","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-016-0559-0","article-title":"Exercise does not activate the \u03b23 adrenergic receptor-eNOS pathway, but reduces inducible NOS expression to protect the heart of obese diabetic mice","volume":"111","author":"Kleindienst","year":"2016","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s44319-023-00015-3","article-title":"S-nitrosylation of AMPK\u03b3 impairs coronary collateral circulation and disrupts VSMC reprogramming","volume":"25","author":"Bai","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.abb.2026.110823_bib50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yjmcc.2019.09.008","article-title":"A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 release","volume":"136","author":"Fillmore","year":"2019","journal-title":"J. Mol. Cellular Cardiol."},{"issue":"5","key":"10.1016\/j.abb.2026.110823_bib51","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.yjmcc.2012.08.013","article-title":"Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO 1","volume":"53","author":"Puthanveetil","year":"2012","journal-title":"J. Mol. Cellular Cardiol."},{"key":"10.1016\/j.abb.2026.110823_bib52","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jare.2022.03.003","article-title":"iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation","volume":"43","author":"Guo","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.abb.2026.110823_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150589","article-title":"Exploring the role of iNOS in HFpEF-Related myocardial fibrosis: involvement of PTEN-PI3K\/AKT signaling pathway","volume":"734","author":"You","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.abb.2026.110823_bib54","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.yjmcc.2010.05.002","article-title":"Nitrative inactivation of thioredoxin-1 increases vulnerability of diabetic hearts to ischemia\/reperfusion injury","volume":"49","author":"Yin","year":"2010","journal-title":"J. Mol. Cellular Cardiol."},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib55","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/cvr\/cvp085","article-title":"High glucose sensitizes adult cardiomyocytes to ischaemia\/reperfusion injury through nitrative thioredoxin inactivation","volume":"83","author":"Luan","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.abb.2026.110823_bib56","doi-asserted-by":"crossref","first-page":"H1417","DOI":"10.1152\/ajpheart.00559.2004","article-title":"Redox regulation of Ito remodeling in diabetic rat heart","volume":"288","author":"Li","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.abb.2026.110823_bib57","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/abbs\/gmu006","article-title":"Variations of thioredoxin system contributes to increased susceptibility to apoptosis in cardiomyocytes of type 2 diabetic rats","volume":"46","author":"Zhao","year":"2014","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"9","key":"10.1016\/j.abb.2026.110823_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091958","article-title":"Thioredoxin 2 offers protection against mitochondrial oxidative stress in H9c2 cells and against myocardial hypertrophy induced by hyperglycemia","volume":"18","author":"Li","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.abb.2026.110823_bib59","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijcard.2019.12.065","article-title":"Hyperglycemia-induced endothelial dysfunction is alleviated by thioredoxin mimetic peptides through the restoration of VEGFR-2-induced responses and improved cell survival","volume":"308","author":"Hemling","year":"2020","journal-title":"Int. J. Cardiol."},{"issue":"6247","key":"10.1016\/j.abb.2026.110823_bib60","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.aaa0079","article-title":"METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction","volume":"349","author":"Yang","year":"2015","journal-title":"Science (New York, N.Y.)"},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib61","doi-asserted-by":"crossref","first-page":"C212","DOI":"10.1152\/ajpcell.00385.2024","article-title":"Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor","volume":"328","author":"Yang","year":"2025","journal-title":"Am. J. Physiol.: Cell Physiol."},{"issue":"8","key":"10.1016\/j.abb.2026.110823_bib62","doi-asserted-by":"crossref","first-page":"684","DOI":"10.21037\/atm-21-1070","article-title":"The effects of S-nitrosylation-induced PPAR\u03b3\/SFRP5 pathway inhibition on the conversion of non-alcoholic fatty liver to non-alcoholic steatohepatitis","volume":"9","author":"Wang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.abb.2026.110823_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101562","article-title":"The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand","volume":"64","author":"Kim","year":"2022","journal-title":"Mol. Metabol."},{"issue":"7","key":"10.1016\/j.abb.2026.110823_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132029","article-title":"Voluntary exercise can ameliorate insulin resistance by reducing iNOS-Mediated S-Nitrosylation of Akt in the liver in Obese rats","volume":"10","author":"Tsuzuki","year":"2015","journal-title":"PLoS One"},{"issue":"9922","key":"10.1016\/j.abb.2026.110823_bib65","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0140-6736(13)62154-6","article-title":"Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future","volume":"383","author":"Kahn","year":"2014","journal-title":"Lancet (London, England)"},{"issue":"7","key":"10.1016\/j.abb.2026.110823_bib66","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41574-025-01114-y","article-title":"Insulin resistance in type 2 diabetes mellitus","volume":"21","author":"Accili","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.abb.2026.110823_bib67","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2337\/diabetes.54.4.959","article-title":"S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B\/Akt: a novel mechanism of insulin resistance","volume":"54","author":"Carvalho-Filho","year":"2005","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.abb.2026.110823_bib68","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1074\/jbc.M411871200","article-title":"S-nitrosylation-dependent inactivation of Akt\/protein kinase B in insulin resistance","volume":"280","author":"Yasukawa","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2026.110823_bib69","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.freeradbiomed.2012.12.010","article-title":"Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry","volume":"57","author":"Su","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"351","key":"10.1016\/j.abb.2026.110823_bib70","doi-asserted-by":"crossref","first-page":"ra106","DOI":"10.1126\/scisignal.2005375","article-title":"Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65","volume":"7","author":"Shinozaki","year":"2014","journal-title":"Sci. Signal."},{"issue":"11","key":"10.1016\/j.abb.2026.110823_bib71","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ncb2114","article-title":"GAPDH mediates nitrosylation of nuclear proteins","volume":"12","author":"Kornberg","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.abb.2026.110823_bib72","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","article-title":"Obesity phenotypes, diabetes, and cardiovascular diseases","volume":"126","author":"Pich\u00e9","year":"2020","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib73","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/s12933-024-02549-9","article-title":"Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health","volume":"23","author":"Queiroz","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib74","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12933-023-01876-7","article-title":"Normal-weight visceral obesity promotes a higher 10-year atherosclerotic cardiovascular disease risk in patients with type 2 diabetes mellitus-a multicenter study in China","volume":"22","author":"Zheng","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib75","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12933-025-02748-y","article-title":"Diabetes mellitus aggravates myocardial inflammation and oxidative stress in aortic stenosis: a mechanistic link to HFpEF features","volume":"24","author":"Herwig","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib76","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12933-024-02357-1","article-title":"Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction","volume":"23","author":"Rudokas","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib77","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12933-022-01729-9","article-title":"Insulin resistance mediates obesity-related risk of cardiovascular disease: a prospective cohort study","volume":"21","author":"Tian","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"issue":"8","key":"10.1016\/j.abb.2026.110823_bib78","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4239\/wjd.v14.i8.1146","article-title":"Advanced glycation end products: key mediator and therapeutic target of cardiovascular complications in diabetes","volume":"14","author":"Bansal","year":"2023","journal-title":"World J. Diabetes"},{"issue":"4","key":"10.1016\/j.abb.2026.110823_bib79","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.cardiores.2004.05.001","article-title":"Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes","volume":"63","author":"Basta","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib80","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10741-013-9374-y","article-title":"Advanced glycation end products: role in pathology of diabetic cardiomyopathy","volume":"19","author":"Bodiga","year":"2014","journal-title":"Heart Fail. Rev."},{"issue":"4","key":"10.1016\/j.abb.2026.110823_bib81","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/CRD.0b013e318244e57c","article-title":"Advanced glycation end products and diabetic cardiovascular disease","volume":"20","author":"Prasad","year":"2012","journal-title":"Cardiol. Rev."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib82","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/jcmm.15263","article-title":"S-Nitrosylation of Akt by organic nitrate delays revascularization and the recovery of cardiac function in mice following myocardial infarction","volume":"25","author":"Li","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"7","key":"10.1016\/j.abb.2026.110823_bib83","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/ncb1268","article-title":"S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding","volume":"7","author":"Hara","year":"2005","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.abb.2026.110823_bib84","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1073\/pnas.0511321103","article-title":"Neuroprotection by pharmacologic blockade of the GAPDH death cascade","volume":"103","author":"Hara","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.abb.2026.110823_bib85","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/ncb1747","article-title":"Nitric oxide-induced nuclear GAPDH activates p300\/CBP and mediates apoptosis","volume":"10","author":"Sen","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.abb.2026.110823_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2025.107531","article-title":"Balancing act: Drp1 inhibition and mitochondrial homeostasis in cardiovascular diseases","volume":"160","author":"Dubey","year":"2025","journal-title":"Vasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib87","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12933-025-02625-8","article-title":"Piezo 1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK\/Drp1 pathway","volume":"24","author":"Niu","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"issue":"3","key":"10.1016\/j.abb.2026.110823_bib88","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/CIRCRESAHA.123.322654","article-title":"Mitochondrial GSNOR alleviates cardiac dysfunction via ANT1 denitrosylation","volume":"133","author":"Tang","year":"2023","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.abb.2026.110823_bib89","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/CIRCRESAHA.124.324872","article-title":"NEDD4-Mediated GSNOR degradation aggravates cardiac hypertrophy and dysfunction","volume":"136","author":"Tang","year":"2025","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.abb.2026.110823_bib90","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1172\/JCI73780","article-title":"S-nitrosoglutathione reductase-dependent PPAR\u03b3 denitrosylation participates in MSC-derived adipogenesis and osteogenesis","volume":"125","author":"Cao","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.abb.2026.110823_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154868","article-title":"Diabetes and metabolic dysfunction-associated fatty liver disease","volume":"123","author":"Davis","year":"2021","journal-title":"Metab. Clin. Exp."},{"issue":"5","key":"10.1016\/j.abb.2026.110823_bib92","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cmet.2024.04.006","article-title":"Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease","volume":"36","author":"Bo","year":"2024","journal-title":"Cell Metab."},{"issue":"40","key":"10.1016\/j.abb.2026.110823_bib93","doi-asserted-by":"crossref","first-page":"34959","DOI":"10.1074\/jbc.M110.187666","article-title":"Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice","volume":"286","author":"Shinozaki","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.abb.2026.110823_bib94","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.2337\/diabetes.54.5.1340","article-title":"A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice","volume":"54","author":"Fujimoto","year":"2005","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.abb.2026.110823_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100542","article-title":"Activation of hepatic acetyl-CoA carboxylase by S-nitrosylation in response to diet","volume":"65","author":"Venetos","year":"2024","journal-title":"J. Lipid Res."},{"issue":"7","key":"10.1016\/j.abb.2026.110823_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006430","article-title":"Aging-associated dysfunction of Akt\/protein kinase B: S-nitrosylation and acetaminophen intervention","volume":"4","author":"Wu","year":"2009","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.abb.2026.110823_bib97","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nm1001-1138","article-title":"Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle","volume":"7","author":"Perreault","year":"2001","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.abb.2026.110823_bib98","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00018-018-2745-8","article-title":"The role of the thioredoxin\/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?","volume":"75","author":"Tinkov","year":"2018","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"issue":"3","key":"10.1016\/j.abb.2026.110823_bib99","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-2002-23201","article-title":"Elevation of serum thioredoxin levels in patients with type 2 diabetes","volume":"34","author":"Kakisaka","year":"2002","journal-title":"Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme"},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib100","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0168-8278(02)00331-8","article-title":"Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease","volume":"38","author":"Sumida","year":"2003","journal-title":"J. Hepatol. (Amst.)"},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib101","first-page":"135","article-title":"Elevation of serum thioredoxin levels in patients with nonalcoholic steatohepatitis","volume":"33","author":"Nakashima","year":"2005","journal-title":"Hepatol. Res. : the official journal of the Japan Society of Hepatology"},{"issue":"8","key":"10.1016\/j.abb.2026.110823_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2020.129630","article-title":"New insights into serum\/extracellular thioredoxin in regulating hepatic insulin receptor activation","volume":"1864","author":"Bai","year":"2020","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"issue":"10","key":"10.1016\/j.abb.2026.110823_bib103","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.jnutbio.2013.02.012","article-title":"Antioxidant system response is modified by dietary fat in adipose tissue of metabolic syndrome patients","volume":"24","author":"Pe\u00f1a-Orihuela","year":"2013","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.abb.2026.110823_bib104","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1751-2980.2010.00422.x","article-title":"Dynamic expression of hepatic thioredoxin mRNA in rats with non-alcoholic fatty liver disease","volume":"11","author":"Duan","year":"2010","journal-title":"Journal of digestive diseases"},{"key":"10.1016\/j.abb.2026.110823_bib105","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.fob.2014.10.015","article-title":"High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance","volume":"4","author":"Qin","year":"2014","journal-title":"FEBS open bio"},{"issue":"10","key":"10.1016\/j.abb.2026.110823_bib106","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.2337\/db08-1512","article-title":"Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin","volume":"58","author":"Li","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.abb.2026.110823_bib107","series-title":"Pathobiology of Aging & Age Related Diseases 2","article-title":"Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice","author":"Salmon","year":"2012"},{"issue":"1","key":"10.1016\/j.abb.2026.110823_bib108","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1089\/ars.2007.1586","article-title":"Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus","volume":"10","author":"Yamamoto","year":"2008","journal-title":"Antioxidants Redox Signal."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986126000949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986126000949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:43:29Z","timestamp":1778723009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986126000949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":108,"alternative-id":["S0003986126000949"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2026.110823","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging role of protein S-nitrosylation in diabetes and diabetes-associated diseases","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2026.110823","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110823"}}