{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:15:53Z","timestamp":1783178153903,"version":"3.54.6"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001688","name":"International Centre for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","award":["CRP\/MYS21-04_EC"],"award-info":[{"award-number":["CRP\/MYS21-04_EC"]}],"id":[{"id":"10.13039\/501100001688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.abb.2026.110876","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:08:19Z","timestamp":1779376099000},"page":"110876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Molecular and functional consequences of the Cdc42 C81Y mutation in immune-associated malignancy"],"prefix":"10.1016","volume":"782","author":[{"given":"Chien Fung","family":"Chong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syafinaz Amin","family":"Nordin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiful Effendi","family":"Syafruddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul Izza","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-1856","authenticated-orcid":false,"given":"Ana Masara","family":"Ahmad Mokhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.111.1.131","article-title":"CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae","volume":"111","author":"Adams","year":"1990","journal-title":"JCB (J. Cell Biol.)"},{"issue":"15","key":"10.1016\/j.abb.2026.110876_bib2","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1016\/S0021-9258(19)62720-1","article-title":"Purification of the major GTP-binding proteins from human placental membranes","volume":"261","author":"Evans","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-18072-0","article-title":"AuNis modified AlGaN\/GaN HEMT biosensor for reliable detection of small rho GTPases in Jurkat T cell lysate","volume":"15","author":"Fauzi","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.abb.2026.110876_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/bies.70069","article-title":"Biosensors for detecting small rho GTPases: monitoring expression and activation","author":"Hasnizan","year":"2025","journal-title":"Bioessays"},{"key":"10.1016\/j.abb.2026.110876_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110855","article-title":"Navigating the landscape of Rho GTPase signalling system in autoimmunity : a bibliometric analysis spanning over three decades (1990 to 2023)","volume":"111","author":"Chong","year":"2023","journal-title":"Cell. Signal."},{"issue":"4","key":"10.1016\/j.abb.2026.110876_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23040787","article-title":"Regulating Cdc42 and its signaling pathways in cancer: small molecules and MicroRNA as new treatment candidates","volume":"23","author":"Xiao","year":"2018","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1586\/14737140.7.2.147","article-title":"Cdc42: an effector and regulator of ErbB1 as a strategic target in breast cancer therapy","volume":"7","author":"Hirsch","year":"2007","journal-title":"Expert Rev. Anticancer Ther."},{"issue":"4","key":"10.1016\/j.abb.2026.110876_bib8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.yexcr.2012.10.014","article-title":"Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: role of S1P3 receptor and Cdc42","volume":"319","author":"Sukocheva","year":"2013","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.abb.2026.110876_bib9","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s10875-023-01561-0","article-title":"A novel CDC42 variant with impaired thymopoiesis, IL-7R signaling, PAK1 binding, and TCR repertoire diversity","volume":"43","author":"Assing","year":"2023","journal-title":"J. Clin. Immunol."},{"issue":"5","key":"10.1016\/j.abb.2026.110876_bib10","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.4049\/jimmunol.1200156","article-title":"Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-Dependent local actin remodeling but not microtubule organizing Center polarity","volume":"189","author":"Chemin","year":"2012","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.abb.2026.110876_bib11","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.4049\/jimmunol.1401634","article-title":"The rho GTPase Cdc42 is essential for the activation and function of mature B cells","volume":"194","author":"Gerasimcik","year":"2015","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/pcmedi\/pbaa039","article-title":"RhoA and Cdc42 in T cells: are they targetable for T cell-mediated inflammatory diseases?","volume":"4","author":"Guo","year":"2021","journal-title":"Precis. Clin. Med."},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018002","article-title":"Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation","volume":"6","author":"Guo","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.abb.2026.110876_bib14","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1136\/jitc-2022-004806","article-title":"Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity","volume":"10","author":"Kalim","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3324\/haematol.2009.006890","article-title":"Rho GTPase Cdc42 is essential for human T-cell development","volume":"95","author":"Smits","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.abb.2026.110876_bib16","series-title":"Genetic Disorders and Rare Diseases","first-page":"235","article-title":"Genetic mutations and clinical diagnoses associated with increased risk of malignancy in primary immunodeficiencies","author":"Haron","year":"2023"},{"issue":"11","key":"10.1016\/j.abb.2026.110876_bib17","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1002\/ajmg.a.37275","article-title":"Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: yet another locus for thrombocytopenia and developmental delay","volume":"167","author":"Takenouchi","year":"2015","journal-title":"Am. J. Med. Genet."},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/genes12020294","article-title":"Pancytopenia, Recurrent Infection, Poor Wound Healing, Heterotopia of the Brain Probably Associated with A Candidate Novel de Novo CDC42 Gene Defect: expanding the Molecular and Phenotypic Spectrum","volume":"12","author":"Asiri","year":"2021","journal-title":"Genes"},{"issue":"5","key":"10.1016\/j.abb.2026.110876_bib19","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jaci.2020.03.020","article-title":"A toxic palmitoylation of Cdc42 enhances NF-\u03baB signaling and drives a severe autoinflammatory syndrome","volume":"146","author":"Bekhouche","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.abb.2026.110876_bib20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10875-020-00742-5","article-title":"Systemic inflammation and myelofibrosis in a patient with Takenouchi-kosaki syndrome due to CDC42 Tyr64Cys mutation","volume":"40","author":"Bucciol","year":"2020","journal-title":"J. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.abb.2026.110876_bib21","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.jaci.2019.06.017","article-title":"Severe autoinflammation in 4 patients with C-terminal variants in cell division control protein 42 homolog (CDC42) successfully treated with IL-1\u03b2 inhibition","volume":"144","author":"Gernez","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.abb.2026.110876_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109777","article-title":"C-terminal variants in CDC42 drive type I interferon-dependent autoinflammation in NOCARH syndrome reversible by ruxolitinib","volume":"256","author":"Kapp","year":"2023","journal-title":"Clin. Immunol."},{"issue":"12","key":"10.1016\/j.abb.2026.110876_bib23","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1084\/jem.20190147","article-title":"A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function","volume":"216","author":"Lam","year":"2019","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajhg.2017.12.015","article-title":"Functional dysregulation of CDC42 causes diverse developmental phenotypes","volume":"102","author":"Martinelli","year":"2018","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s10038-017-0396-5","article-title":"A hot-spot mutation in CDC42 (p.Tyr64Cys) and novel phenotypes in the third patient with Takenouchi-Kosaki syndrome","volume":"63","author":"Motokawa","year":"2018","journal-title":"J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.abb.2026.110876_bib26","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211889","article-title":"Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation","volume":"219","author":"Nishitani-Isa","year":"2022","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.abb.2026.110876_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2021.104358","article-title":"Intermittent macrothrombocytopenia in a novel patient with takenouchi-kosaki syndrome and review of literature","volume":"64","author":"Santoro","year":"2021","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.abb.2026.110876_bib28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fimmu.2020.00318","article-title":"A novel CDC42 mutation in an 11-Year old child manifesting as syndromic immunodeficiency, autoinflammation, hemophagocytic lymphohistiocytosis, and malignancy: a case report","volume":"11","author":"Szczawinska-Poplonyk","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.abb.2026.110876_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1108852","article-title":"The clinical phenotype with gastrostomy and abdominal wall infection in a pediatric patient with Takenouchi-Kosaki syndrome due to a heterozygous c.191A > G (p.Tyr64Cys) variant in CDC42: a case report","volume":"14","author":"Szczawi\u0144ska-Pop\u0142onyk","year":"2023","journal-title":"Front. Genet."},{"issue":"4","key":"10.1016\/j.abb.2026.110876_bib30","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ajmg.a.37526","article-title":"Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia","volume":"170","author":"Takenouchi","year":"2016","journal-title":"Am. J. Med. Genet."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-40988-7","article-title":"Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model","volume":"9","author":"Uehara","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10875-022-01344-z","article-title":"A CDC42 stop-loss mutation in a patient with relapsing polychondritis and autoinflammation","volume":"43","author":"van Wijck","year":"2023","journal-title":"J. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.abb.2026.110876_bib33","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s10875-020-00778-7","article-title":"Infantile myelofibrosis and myeloproliferation with CDC42 dysfunction","volume":"40","author":"Verboon","year":"2020","journal-title":"J. Clin. Immunol."},{"issue":"5","key":"10.1016\/j.abb.2026.110876_bib34","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jmb.2010.09.027","article-title":"Cysteine function governs its conservation and degeneration and restricts its utilization on protein surface","volume":"404","author":"Marino","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.abb.2026.110876_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2021.106034","article-title":"Small rho GTPases and their associated RhoGEFs mutations promote immunological defects in primary immunodeficiencies","volume":"137","author":"Hashim","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib36","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1042\/BST20200557","article-title":"Molecular subversion of Cdc42 signalling in cancer","volume":"49","author":"Murphy","year":"2021","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib37","first-page":"185","article-title":"Cdc42 highly expressed in colorectal adecarcinoma and downregulates ID4 through an epigenetic mechanism","volume":"33","author":"G\u00f3mez Del Pulgar","year":"2008","journal-title":"Int. J. Oncol."},{"issue":"9","key":"10.1016\/j.abb.2026.110876_bib38","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cellsig.2011.04.001","article-title":"Cdc42 in oncogenic transformation, invasion, and tumorigenesis","volume":"23","author":"Stengel","year":"2011","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib39","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.abb.2026.110876_bib40","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.3390\/ijms25115921","article-title":"Pathogenesis of hemophagocytic lymphohistiocytosis\/macrophage activation syndrome: a case report and review of the literature","volume":"25","author":"Gioia","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.abb.2026.110876_bib41","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1159\/000528349","article-title":"Elevated Interleukin-10 levels are associated with low platelet count and poor prognosis in 90 adult patients with hemophagocytic lymphohistiocytosis","volume":"184","author":"Hao","year":"2023","journal-title":"International Archieves of Allergy and Immunology"},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2020","journal-title":"Int. Immunol."},{"key":"10.1016\/j.abb.2026.110876_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1069499","article-title":"Cdc42 regulates cytokine expression and trafficking in bronchial epithelial cells","volume":"13","author":"Shouib","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/615630","article-title":"An overview of multiple sequence alignments and cloud computing in bioinformatics","volume":"2013","author":"Daugelaite","year":"2013","journal-title":"ISRN Biomathematics"},{"key":"10.1016\/j.abb.2026.110876_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using clustal omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib46","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/nar\/22.3.541","article-title":"Improved method for PCR-mediated site-directed mutagenesis","volume":"22","author":"Barettino","year":"1994","journal-title":"Nucleic Acids Res."},{"issue":"19","key":"10.1016\/j.abb.2026.110876_bib47","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1021\/acs.biochem.1c00120","article-title":"A Complete survey of RhoGDI targets reveals novel interactions with atypical small GTPases","volume":"60","author":"Ahmad Mokhtar","year":"2021","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib48","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.vascn.2004.08.014","article-title":"HEK293 cell line: a vehicle for the expression of recombinant proteins","volume":"51","author":"Thomas","year":"2005","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"20","key":"10.1016\/j.abb.2026.110876_bib49","doi-asserted-by":"crossref","first-page":"14153","DOI":"10.1074\/jbc.M706271200","article-title":"Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42","volume":"283","author":"Phillips","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib50","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(00)80670-4","article-title":"Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI","volume":"100","author":"Hoffman","year":"2000","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib51","doi-asserted-by":"crossref","first-page":"W338","DOI":"10.1093\/nar\/gky356","article-title":"CABS-flex 2.0: a web server for fast simulations of flexibility of protein structures","volume":"46","author":"Kuriata","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"14","key":"10.1016\/j.abb.2026.110876_bib52","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.1021\/acs.chemrev.6b00163","article-title":"Coarse-Grained protein models and their applications","volume":"116","author":"Kmiecik","year":"2016","journal-title":"Chem. Rev."},{"issue":"9","key":"10.1016\/j.abb.2026.110876_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/pro.5090","article-title":"Exploring protein functions from structural flexibility using CABS-flex modeling","volume":"33","author":"Nithin","year":"2024","journal-title":"Protein Sci."},{"key":"10.1016\/j.abb.2026.110876_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2021.105120","article-title":"Identification of immunodominant epitopes in allelic variants VK210 and VK247 of Plasmodium vivax circumsporozoite immunogen","volume":"96","author":"Naz","year":"2021","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.abb.2026.110876_bib55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.29007\/z2wx","article-title":"In silico library design, screening and MD simulation of COX-2 inhibitors for anticancer activity","volume":"70","author":"Sahu","year":"2020","journal-title":"EPiC Series in Computing"},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib56","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1080\/07391102.2023.2198016","article-title":"Carbazole derivatives as promising competitive and allosteric inhibitors of human serotonin transporter: computational pharmacology","volume":"42","author":"Ayipo","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.abb.2026.110876_bib57","doi-asserted-by":"crossref","first-page":"W338","DOI":"10.1093\/nar\/gkz383","article-title":"mCSM-PPI2: predicting the effects of mutations on protein\u2013protein interactions","volume":"47","author":"Rodrigues","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib58","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"issue":"16","key":"10.1016\/j.abb.2026.110876_bib59","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"14","key":"10.1016\/j.abb.2026.110876_bib60","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J. Comput. Chem."},{"issue":"5","key":"10.1016\/j.abb.2026.110876_bib61","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.3390\/molecules23051038","article-title":"Is it reliable to take the molecular docking top scoring position as the best solution without considering available structural data?","volume":"23","author":"Ram\u00edrez","year":"2018","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib62","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10875-022-01366-7","article-title":"Pathogenic Interleukin-10 receptor alpha variants in humans \u2014 balancing natural selection and clinical implications","volume":"43","author":"Aschenbrenner","year":"2022","journal-title":"J. Clin. Immunol."},{"issue":"18","key":"10.1016\/j.abb.2026.110876_bib63","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1074\/jbc.RA117.001163","article-title":"The balance of interleukin (IL)-6, IL-6soluble IL-6 receptor (sIL-6R), and IL-6sIL-6Rsgp130 complexes allows simultaneous classic and trans-signaling","volume":"293","author":"Baran","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.abb.2026.110876_bib64","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"issue":"6","key":"10.1016\/j.abb.2026.110876_bib65","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12032-026-03294-7","article-title":"Rho\/PAK signaling: a key driver of anthracycline and taxane resistance in breast cancer","volume":"43","author":"Fizal","year":"2026","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.70165","article-title":"Mapping three decades of rho GTPase signalling in cancer: unveiling loopholes and future directions (1990-2024)","volume":"44","author":"Hasnizan","year":"2026","journal-title":"Cell Biochem. Funct."},{"issue":"9\u201310","key":"10.1016\/j.abb.2026.110876_bib67","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.imbio.2009.06.009","article-title":"Wiskott\u2013Aldrich syndrome: immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation","volume":"214","author":"Bouma","year":"2009","journal-title":"Immunobiology"},{"issue":"JUL","key":"10.1016\/j.abb.2026.110876_bib68","article-title":"Autoimmunity in Wiskott-Aldrich syndrome: an unsolved enigma","volume":"3","author":"Catucci","year":"2012","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib69","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41591-018-0262-9","article-title":"Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma","volume":"25","author":"Menotti","year":"2019","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib70","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41388-020-01533-3","article-title":"Deficiency of Wiskott\u2013Aldrich syndrome protein has opposing effect on the pro-oncogenic pathway activation in nonmalignant versus malignant lymphocytes","volume":"40","author":"Han","year":"2020","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib71","doi-asserted-by":"crossref","DOI":"10.4161\/21541248.2014.968004","article-title":"Toward understanding RhoGTPase specificity: structure, function and local activation","volume":"5","author":"Schaefer","year":"2014","journal-title":"Small GTPases"},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib72","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1021\/bi201211v","article-title":"Structural coupling between the rho-insert domain of Cdc42 and the geranylgeranyl binding site of RhoGDI","volume":"51","author":"Abramovitz","year":"2012","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002831","article-title":"Computational analysis of rho GTPase cycling","volume":"9","author":"Falkenberg","year":"2013","journal-title":"PLoS Comput. Biol."},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib74","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bpj.2020.12.007","article-title":"Active and inactive Cdc42 differ in their insert Region conformational dynamics","volume":"120","author":"Haspel","year":"2021","journal-title":"Biophys. J."},{"key":"10.1016\/j.abb.2026.110876_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.707439","article-title":"Divergent mechanisms activating RAS and small GTPases through post-translational modification","volume":"8","author":"Osaka","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"52","key":"10.1016\/j.abb.2026.110876_bib76","doi-asserted-by":"crossref","first-page":"50893","DOI":"10.1074\/jbc.M208580200","article-title":"Functional analysis of Cdc42 residues required for guanine nucleotide exchange","volume":"277","author":"Rossman","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.abb.2026.110876_bib77","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3390\/cells10071831","article-title":"The RHO family GTPases: mechanisms of regulation and signaling","volume":"10","author":"Mosaddeghzadeh","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.abb.2026.110876_bib78","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molcel.2005.08.036","article-title":"An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich Syndrome proteins","volume":"20","author":"Hemsath","year":"2005","journal-title":"Mol. Cell"},{"issue":"6734","key":"10.1016\/j.abb.2026.110876_bib79","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/20732","article-title":"Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK","volume":"399","author":"Mott","year":"1999","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.abb.2026.110876_bib80","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.molonc.2013.04.005","article-title":"WNT-5A triggers Cdc42 activation leading to an ERK1\/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells","volume":"7","author":"Prasad","year":"2013","journal-title":"Mol. Oncol."},{"issue":"4","key":"10.1016\/j.abb.2026.110876_bib81","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/jcp.22853","article-title":"Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells","volume":"227","author":"Zuo","year":"2011","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.abb.2026.110876_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41577-023-00856-y","article-title":"Targeting IL-6 trans-signalling: past, present and future prospects","volume":"23","author":"Rose-John","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.abb.2026.110876_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1161067","article-title":"The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions","volume":"14","author":"Carlini","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.abb.2026.110876_bib84","doi-asserted-by":"crossref","DOI":"10.1177\/20503121211069012","article-title":"Tumor promoting roles of IL-10, TGF-\u03b2, IL-4, and IL-35: its implications in cancer immunotherapy","volume":"10","author":"Mirlekar","year":"2022","journal-title":"SAGE Open Med."},{"issue":"6","key":"10.1016\/j.abb.2026.110876_bib85","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.ccell.2019.05.005","article-title":"Targeting tumors with IL-10 prevents dendritic cell-mediated CD8+ T cell apoptosis","volume":"35","author":"Qiao","year":"2019","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.abb.2026.110876_bib86","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/jcp.24795","article-title":"Sphingosine-1-phosphate mediates COX-2 expression and PGE2\/IL-6 secretion via c-Src-dependent AP-1 activation","volume":"230","author":"Hsu","year":"2015","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.abb.2026.110876_bib87","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.7150\/ijms.44612","article-title":"S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK\/ERK and NF-\u03baB signaling pathways","volume":"17","author":"Hu","year":"2020","journal-title":"Int. J. Med. Sci."},{"issue":"11","key":"10.1016\/j.abb.2026.110876_bib88","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1177\/1933719119828112","article-title":"Sphingosine I phosphate (S1P) increased IL-6 expression and cell growth in endometriotic cells","volume":"26","author":"Yoshino","year":"2021","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.abb.2026.110876_bib89","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s13277-012-0568-z","article-title":"CD133 induces tumour-initiating properties in HEK293 cells","volume":"34","author":"Canis","year":"2012","journal-title":"Tumor Biol."},{"issue":"10","key":"10.1016\/j.abb.2026.110876_bib90","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.18632\/oncotarget.1324","article-title":"Upregulation of adenylate cyclase 3 ADCY3 increases the tumorigenic potential of cells by activating the CREB pathway","volume":"4","author":"Hong","year":"2013","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.abb.2026.110876_bib91","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/pathogens12060852","article-title":"TRIM16 overexpression in HEK293T cells results in cell line-specific antiviral activity","volume":"12","author":"Nigos","year":"2023","journal-title":"Pathogens"}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986126001475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986126001475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:29:00Z","timestamp":1783175340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986126001475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":91,"alternative-id":["S0003986126001475"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2026.110876","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular and functional consequences of the Cdc42 C81Y mutation in immune-associated malignancy","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2026.110876","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110876"}}