{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:13:25Z","timestamp":1788614005658,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K26858"],"award-info":[{"award-number":["23K26858"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02165"],"award-info":[{"award-number":["23H02165"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Biochemistry and Biophysics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.abb.2026.110964","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:21:20Z","timestamp":1785799280000},"page":"110964","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["GPR97\u2013G\u03b112\u2013mTORC1 signaling drives myotube hypertrophy: identification of 5-hydroxy-7-methoxyflavone as a pathway activator"],"prefix":"10.1016","volume":"785","author":[{"given":"Shuhei","family":"Fujita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Kitakaze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Goshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4729-3317","authenticated-orcid":false,"given":"Ryoichi","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abb.2026.110964_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fphys.2016.00361","article-title":"Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown, and insulin Resistance-A qualitative review","volume":"7","author":"Rudrappa","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.abb.2026.110964_bib2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1113\/JP273284","article-title":"The role of skeletal muscle contractile duration throughout the whole day: reducing sedentary time and promoting universal physical activity in all people","volume":"596","author":"Hamilton","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.abb.2026.110964_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11005\/jbm.2013.20.1.1","article-title":"Sarcopenia: definition, epidemiology, and pathophysiology","volume":"20","author":"Kim","year":"2013","journal-title":"J Bone Metab"},{"key":"10.1016\/j.abb.2026.110964_bib4","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1124\/mol.63.6.1256","article-title":"The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints","volume":"63","author":"Fredriksson","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.abb.2026.110964_bib5","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1016\/j.jmb.2016.08.002","article-title":"Regulation, signaling, and physiological functions of G-Proteins","volume":"428","author":"Syrovatkina","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.abb.2026.110964_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2174\/1875397301004010084","article-title":"Luciferase reporter assay system for deciphering GPCR pathways","volume":"4","author":"Cheng","year":"2010","journal-title":"Curr. Chem. Genom."},{"key":"10.1016\/j.abb.2026.110964_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cells13050392","article-title":"Inhibitors of Rho\/MRTF\/SRF transcription pathway regulate mitochondrial function","volume":"13","author":"Patyal","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.abb.2026.110964_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2026.153326","article-title":"Opposing effects of G\u03b112 and G\u03b113 loss on myotube size regulation via mTORC1 signaling","volume":"802","author":"Kubota","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2026.110964_bib9","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.biocel.2013.05.039","article-title":"Regulation of muscle protein synthesis and the effects of catabolic states","volume":"45","author":"Gordon","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.abb.2026.110964_bib10","doi-asserted-by":"crossref","first-page":"14065","DOI":"10.1074\/jbc.REV120.007423","article-title":"Mechanisms of adhesion G protein-coupled receptor activation","volume":"295","author":"Vizurraga","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2026.110964_bib11","first-page":"1","article-title":"Adhesion G protein-coupled receptors-structure and functions","volume":"195","author":"Thor","year":"2023","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.abb.2026.110964_bib12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1124\/pr.114.009647","article-title":"International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors","volume":"67","author":"Hamann","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.abb.2026.110964_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1182\/bloodadvances.2020003693","article-title":"Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation","volume":"5","author":"Maglitto","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.abb.2026.110964_bib14","doi-asserted-by":"crossref","first-page":"15756","DOI":"10.1073\/pnas.1417898111","article-title":"G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy","volume":"111","author":"White","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.abb.2026.110964_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118563","article-title":"Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56","volume":"1867","author":"Kitakaze","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.abb.2026.110964_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26134021","article-title":"Dietary flavonoids: cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns","volume":"26","author":"Khan","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.abb.2026.110964_bib17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/fsn3.891","article-title":"5-Hydroxy-7-methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy","volume":"7","author":"Ono","year":"2019","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.abb.2026.110964_bib18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1124\/mol.116.104828","article-title":"Dihydromunduletone is a small-molecule selective adhesion G protein-coupled receptor antagonist","volume":"90","author":"Stoveken","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.abb.2026.110964_bib19","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.cell.2019.03.036","article-title":"A forward chemical genetic screen reveals Gut Microbiota metabolites that modulate host physiology","volume":"177","author":"Chen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.abb.2026.110964_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbrc.2022.01.075","article-title":"Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid","volume":"595","author":"Harada","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.abb.2026.110964_bib21","doi-asserted-by":"crossref","first-page":"20330","DOI":"10.1074\/jbc.M800211200","article-title":"G13-dependent activation of MAPK by thyrotropin","volume":"283","author":"B\u00fcch","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.abb.2026.110964_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41538-021-00119-x","article-title":"Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin","volume":"6","author":"Harada","year":"2022","journal-title":"npj Sci. Food"},{"key":"10.1016\/j.abb.2026.110964_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0167-4889(02)00397-X","article-title":"Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+\/Ca2+ exchanger","volume":"1593","author":"Yamaji","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.abb.2026.110964_bib24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3177\/jnsv.61.481","article-title":"\u03b2-Carotene increases muscle mass and hypertrophy in the soleus muscle in mice","volume":"61","author":"Kitakaze","year":"2015","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.abb.2026.110964_bib25","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.abb.2026.110964_bib26","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41586-020-03083-w","article-title":"Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex","volume":"589","author":"Ping","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.abb.2026.110964_bib27","doi-asserted-by":"crossref","first-page":"78300","DOI":"10.18632\/oncotarget.20962","article-title":"Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7","volume":"8","author":"Jang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.abb.2026.110964_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12030639","article-title":"Rutin prevents dexamethasone-induced muscle loss in C2C12 myotube and mouse model by controlling FOXO3-Dependent signaling","volume":"12","author":"Hah","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.abb.2026.110964_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200729","article-title":"Luteolin protects against Obese Sarcopenia in mice with high-fat diet-induced obesity by ameliorating inflammation and protein degradation in muscles","volume":"67","author":"Kim","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.abb.2026.110964_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/834294","article-title":"Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy","volume":"2014","author":"Le","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.abb.2026.110964_bib31","article-title":"Nobiletin improves D-Galactose-Induced aging mice skeletal muscle atrophy by regulating protein homeostasis","volume":"15","author":"Wang","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.abb.2026.110964_bib32","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1073\/pnas.1313886111","article-title":"G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates","volume":"111","author":"Hamoud","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.abb.2026.110964_bib33","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1038\/s41467-018-06897-5","article-title":"Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion","volume":"9","author":"Hamoud","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.abb.2026.110964_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100513","article-title":"Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function","volume":"9","author":"Zyryanova","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.abb.2026.110964_bib35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/mol.117.111476","article-title":"Gedunin- and Khivorin-Derivatives are small-molecule partial agonists for adhesion G protein-coupled receptors GPR56\/ADGRG1 and GPR114\/ADGRG5","volume":"93","author":"Stoveken","year":"2018","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.abb.2026.110964_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MCB.26.1.50-62.2006","article-title":"Transactivation of platelet-derived growth factor receptor alpha by the GTPase-deficient activated mutant of Galpha12","volume":"26","author":"Kumar","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.abb.2026.110964_bib37","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.febslet.2012.03.014","article-title":"Signaling property study of adhesion G-protein-coupled receptors","volume":"586","author":"Gupte","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.abb.2026.110964_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abo5234","article-title":"Activation of GPR97\/ADGRG3 by its tethered agonist, but not by beclomethasone, induces neutrophil polarization and migration","volume":"19","author":"Bernadyn","year":"2026","journal-title":"Sci. Signal."},{"key":"10.1016\/j.abb.2026.110964_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103616","article-title":"RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth","volume":"25","author":"Noviello","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.abb.2026.110964_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cells12232673","article-title":"RhoA is a crucial regulator of myoblast fusion","volume":"12","author":"Noviello","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.abb.2026.110964_bib41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12929-022-00820-3","article-title":"SRF: a seriously responsible factor in cardiac development and disease","volume":"29","author":"Deshpande","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.abb.2026.110964_bib42","article-title":"Simultaneous determination of chrysin and tectochrysin from Alpinia oxyphylla fruits by UPLC-MS\/MS and its application to a comparative pharmacokinetic study in normal and dementia rats","volume":"23","author":"Zhao","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.abb.2026.110964_bib43","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1186\/s13018-025-06481-w","article-title":"Targeting macrophage JAK3\/STAT3 signaling with tectochrysin: a novel therapeutic strategy to ameliorate bone erosion and synovitis in rheumatoid arthritis","volume":"20","author":"Pan","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.abb.2026.110964_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300283","article-title":"A propolis-derived small molecule tectochrysin ameliorates type 2 diabetes in mice by activating insulin receptor \u03b2","volume":"68","author":"Zhang","year":"2024","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Archives of Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986126002365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003986126002365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:44:48Z","timestamp":1788612288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003986126002365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S0003986126002365"],"URL":"https:\/\/doi.org\/10.1016\/j.abb.2026.110964","relation":{},"ISSN":["0003-9861"],"issn-type":[{"value":"0003-9861","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GPR97\u2013G\u03b112\u2013mTORC1 signaling drives myotube hypertrophy: identification of 5-hydroxy-7-methoxyflavone as a pathway activator","name":"articletitle","label":"Article Title"},{"value":"Archives of Biochemistry and Biophysics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abb.2026.110964","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110964"}}