{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:47:50Z","timestamp":1792532870635,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anais Brasileiros de Dermatologia"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.abd.2019.08.023","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T06:23:35Z","timestamp":1581488615000},"page":"187-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-2810","authenticated-orcid":false,"given":"Ezgi","family":"Akta\u015f Karabay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-7486","authenticated-orcid":false,"given":"Asl\u0131","family":"Aksu \u00c7erman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abd.2019.08.023_bib0250","doi-asserted-by":"crossref","first-page":"295","DOI":"10.17219\/acem\/37081","article-title":"Demodex \u2013 an old pathogen or a new one?","volume":"23","author":"Rusiecka Zi\u00f3\u0142kowska","year":"2014","journal-title":"Adv Clin Exp Med"},{"key":"10.1016\/j.abd.2019.08.023_bib0255","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2307\/3278267","article-title":"Demodex folliculorum (Simon) and Demodex brevis akbulatova of man: redescription and reevaluation","volume":"58","author":"Desch","year":"1972","journal-title":"J Parasitol"},{"key":"10.1016\/j.abd.2019.08.023_bib0260","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1001\/archderm.1961.01580110104016","article-title":"Demodectic eruptions (demodicidosis) in the human 30 years\u2019 experience with 2 commonly unrecognized entities: pityriasis folliculorum (Demodex) and acne rosacea (Demodex type)","volume":"83","author":"Ayres","year":"1961","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0265","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0190-9622(93)70065-2","article-title":"The Demodex mites population in rosacea","volume":"28","author":"Bonnar","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0270","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1365-2133.1993.tb00261.x","article-title":"Density of Demodex folliculorum in rosacea: a case\u2013control study using standardized skin surface biopsy","volume":"128","author":"Forton","year":"1993","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0275","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1631\/jzus.B1100179","article-title":"Facial dermatosis associated with Demodex: a case\u2013control study","volume":"12","author":"Zhao","year":"2011","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.abd.2019.08.023_bib0280","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/dc.20426","article-title":"Cytologic findings in Demodex folliculitis: a case report and review of the literature","volume":"34","author":"Dong","year":"2006","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.abd.2019.08.023_bib0285","first-page":"540","article-title":"Demodex folliculorum causing solitary tuberculoid granuloma","volume":"53","author":"Seifert","year":"1978","journal-title":"Z Hautkr"},{"key":"10.1016\/j.abd.2019.08.023_bib0290","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0190-9622(86)70287-9","article-title":"Pustular folliculitis associated with Demodex folliculorum","volume":"15","author":"Purcell","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0295","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.1111\/j.1365-2230.2009.03343.x","article-title":"Is Demodex folliculorum an aetiological factor in seborrhoeic dermatitis?","volume":"34","author":"Karincaoglu","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0300","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/00015550510030069","article-title":"Density of Demodex folliculorum in Perioral Dermatitis","volume":"85","author":"Dolenc Voljc","year":"2005","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.abd.2019.08.023_bib0305","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1001\/archderm.1963.01590210056008","article-title":"Demodex folliculorum and blepharitis","volume":"88","author":"Post","year":"1963","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0310","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/09286586.2011.642052","article-title":"Association of blepharitis with Demodex: a meta-analysis","volume":"19","author":"Zhao","year":"2012","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1016\/j.abd.2019.08.023_bib0315","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1590\/abd1806-4841.20176043","article-title":"Investigation of Demodex folliculorum frequency in patients with polycystic ovary syndrome","volume":"92","author":"Eser","year":"2017","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0320","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1468-3083.2011.04310.x","article-title":"Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link","volume":"26","author":"Forton","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.abd.2019.08.023_bib0325","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.clindermatol.2016.10.014","article-title":"Demodex and rosacea revisited","volume":"35","author":"Moran","year":"2017","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0330","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/0019-5154.123498","article-title":"Human demodex mite: the versatile mite of dermatological importance","volume":"59","author":"Rather","year":"2014","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0335","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1001\/archderm.1989.01670220134028","article-title":"Demodex mites contain immunoreactive lipase","volume":"125","author":"Jimenez Acosta","year":"1989","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0340","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4103\/0378-6323.33646","article-title":"A possible role for human follicle mites in skin's defense against bacteria","volume":"73","author":"Namazi","year":"2007","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1016\/j.abd.2019.08.023_bib0345","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.ijpara.2014.08.003","article-title":"Parasitic mites of medical and veterinary importance\u2014is there a common research agenda?","volume":"44","author":"Fischer","year":"2014","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.abd.2019.08.023_bib0350","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1365-2133.2012.11114.x","article-title":"Positive correlation between serum immunoreactivity to Demodex-associated Bacillus proteins and erythematotelangiectatic rosacea","volume":"167","author":"Reilly","year":"2012","journal-title":"Br J Dermatol"},{"issue":"Suppl 1","key":"10.1016\/j.abd.2019.08.023_bib0355","first-page":"65","article-title":"TLR-2, cathelicidin-LL37 and kallikrein-5 targeting in rosacea: In tubo, ex vivo and in vivo studies","volume":"72","author":"Ionescu","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0360","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1600-0560.1997.tb00823.x","article-title":"Demodex mites of human skin express Tn but not T (Thomsen-Friedenreich) antigen immunoreactivity","volume":"24","author":"Kanitakis","year":"1997","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.abd.2019.08.023_bib0365","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/15216540601188553","article-title":"Expression of cancer-associated simple mucin-type O-glycosylated antigens in parasites","volume":"59","author":"Osinaga","year":"2007","journal-title":"IUBMB Life"},{"issue":"Suppl 1","key":"10.1016\/j.abd.2019.08.023_bib0370","first-page":"S1","article-title":"Abstracts of the 2013 International Investigative Dermatology Meeting. May 8\u201311, 2013. Edinburgh, Scotland, United Kingdom","volume":"133","author":"Lacey","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0375","first-page":"S439","article-title":"Mode of action of antibiotics in Rosacea","volume":"181","author":"Chambers","year":"2012","journal-title":"Ir J Med Sci"},{"key":"10.1016\/j.abd.2019.08.023_bib0380","doi-asserted-by":"crossref","first-page":"e16594","DOI":"10.1371\/journal.pone.0016594","article-title":"Chitin modulates innate immune responses of keratinocytes","volume":"6","author":"Koller","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.abd.2019.08.023_bib0385","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jaci.2006.02.014","article-title":"Toll-like receptor 2 ligands inhibit TH2 responses to mite allergen","volume":"117","author":"Taylor","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.abd.2019.08.023_bib0390","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s40257-014-0099-z","article-title":"Recent advances in acne pathogenesis: implications for therapy","volume":"15","author":"Das","year":"2014","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0395","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jaad.2015.12.037","article-title":"Guidelines of care for the management of acne vulgaris","volume":"74","author":"Zaenglein","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0400","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1631\/jzus.B1100285","article-title":"A meta-analysis of association between acnevulgaris A. Demodex infestation","volume":"13","author":"Zhao","year":"2012","journal-title":"J Zhejiang Univ-Sci B"},{"key":"10.1016\/j.abd.2019.08.023_bib0405","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000323009","article-title":"Demodex mites-commensals, parasites or mutualistic organisms?","volume":"222","author":"Lacey","year":"2011","journal-title":"Dermatology"},{"key":"10.1016\/j.abd.2019.08.023_bib0410","first-page":"265","article-title":"Frequency of demodicosis in various patient and age groups","volume":"21","author":"Baysal","year":"1997","journal-title":"Turkiye Parazitol Derg"},{"key":"10.1016\/j.abd.2019.08.023_bib0415","first-page":"148","article-title":"The role of Demodex folliculorum and Propionibacterium acnes in pathogenesis of acne vulgaris","volume":"27","author":"Polat","year":"2003","journal-title":"T\u00fcrkiye Parazitol Derg"},{"key":"10.1016\/j.abd.2019.08.023_bib0420","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1468-3083.2006.01470.x","article-title":"Prevalence of Demodex folliculorum in young adults: relation with sociodemographic\/hygienic factors and acne vulgaris","volume":"20","author":"Okyay","year":"2006","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.abd.2019.08.023_bib0425","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1067\/mjd.2002.120625","article-title":"Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea","volume":"46","author":"Wilkin","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0430","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/1346-8138.14281","article-title":"Epidemiological and clinical features of rosacea in Korea: a multicenter cross-sectional study","volume":"45","author":"Lee","year":"2018","journal-title":"J Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0435","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaad.2004.03.030","article-title":"Etiology, pathogenesis, and subtype classification","volume":"51","author":"Crawford","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0440","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/jid.2010.351","article-title":"TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes","volume":"131","author":"Yamasaki","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0445","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/exd.12030","article-title":"Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation","volume":"21","author":"Casas","year":"2012","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0450","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.coi.2015.03.001","article-title":"IL-17 and neutrophils: unexpected players in the type 2 immune response","volume":"34","author":"Allen","year":"2015","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.abd.2019.08.023_bib0455","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1001\/archderm.1994.01690030051008","article-title":"A comparison of the efficacy of topical tretinoin and low-dose oral isotretinoin in rosacea","volume":"130","author":"Ertl","year":"1994","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0460","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0190-9622(82)70137-9","article-title":"Demodex folliculorum and Demodex brevis in cutaneous biopsies","volume":"7","author":"Aylesworth","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000249558","article-title":"T cell subsets in acne rosacea lesions and possible role of Demodex folliculorum","volume":"169","author":"Rufli","year":"1984","journal-title":"Dermatologica"},{"key":"10.1016\/j.abd.2019.08.023_bib0470","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-4362.1998.00218.x","article-title":"The significance of Demodex folliculorum density in rosacea","volume":"37","author":"Erbagci","year":"1998","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0475","first-page":"896","article-title":"Retrospective analysis of the association between Demodex infestation and rosacea","volume":"146","author":"Zhao","year":"2010","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.abd.2019.08.023_bib0480","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4103\/0378-6323.26745","article-title":"The efficacy of 1% metronidazole gel in facial seborrheic dermatitis: a double blind study","volume":"72","author":"Siadat","year":"2006","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1016\/j.abd.2019.08.023_bib0485","first-page":"159","article-title":"Seborrheic dermatitis","volume":"52","author":"Janniger","year":"1995","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.abd.2019.08.023_bib0490","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1468-3083.2004.00693.x","article-title":"Seborrheic dermatitis","volume":"18","author":"Gupta","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059620300386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059620300386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T06:32:31Z","timestamp":1754461951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0365059620300386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0365059620300386"],"URL":"https:\/\/doi.org\/10.1016\/j.abd.2019.08.023","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Anais Brasileiros de Dermatologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abd.2019.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}