{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:47:00Z","timestamp":1768567620088,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anais Brasileiros de Dermatologia"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.abd.2020.02.005","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T08:10:52Z","timestamp":1592295052000},"page":"570-574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Decreased levels of interleukin 27 in the serum of vitiligo patients"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-6922","authenticated-orcid":false,"given":"Saeed Malek","family":"Hosseini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-3189","authenticated-orcid":false,"given":"Naser","family":"Gholijani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9836-7702","authenticated-orcid":false,"given":"Nooshafarin","family":"Chenari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9160-9449","authenticated-orcid":false,"given":"Kurosh","family":"Kalantar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.abd.2020.02.005_bib0235","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/0019-5154.80413","article-title":"Vitiligo: a review of some facts lesser known about depigmentation","volume":"56","author":"Nordlund","year":"2011","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.abd.2020.02.005_bib0240","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1477-7525-1-58","article-title":"Quality of life in patients with vitiligo","volume":"1","author":"Parsad","year":"2003","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.abd.2020.02.005_bib0245","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3349\/ymj.2015.56.3.719","article-title":"Prevalence of vitiligo and associated comorbidities in Korea","volume":"56","author":"Lee","year":"2015","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.abd.2020.02.005_bib0250","doi-asserted-by":"crossref","first-page":"e0163806","DOI":"10.1371\/journal.pone.0163806","article-title":"The prevalence of vitiligo: a meta-analysis","volume":"11","author":"Zhang","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.abd.2020.02.005_bib0255","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s12016-017-8622-7","article-title":"Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy","volume":"54","author":"Boniface","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0260","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.autrev.2011.02.004","article-title":"Immunopathogenesis of vitiligo","volume":"10","author":"Sandoval-Cruz","year":"2011","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.abd.2020.02.005_bib0265","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/exd.12103","article-title":"Vitiligo: interplay between oxidative stress and immune system","volume":"22","author":"Laddha","year":"2013","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.abd.2020.02.005_bib0270","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients","volume":"129","author":"van den Boorn","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.abd.2020.02.005_bib0275","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3892\/mmr.2012.1117","article-title":"CD8+ T cells from vitiligo perilesional margins induce autologous melanocyte apoptosis","volume":"7","author":"Wu","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.abd.2020.02.005_bib0280","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1084\/jem.188.6.1203","article-title":"High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo","volume":"188","author":"Ogg","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.abd.2020.02.005_bib0285","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/0019-5154.92668","article-title":"Serum concentration of IL-6, IL-2, TNF-\u03b1, and IFN\u03b3 in vitiligo patients","volume":"57","author":"Singh","year":"2012","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.abd.2020.02.005_bib0290","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/jocd.12517","article-title":"Cytokine profile (IL-2, IL-6, IL-17, IL-22, and TNF-alpha) in vitiligo \u2013 new insight into pathogenesis of disease","volume":"18","author":"Sushama","year":"2019","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.abd.2020.02.005_bib0295","first-page":"2","article-title":"Parasrampuria and Rasheedunnisa Begum","volume":"5","author":"Singh","year":"2016","journal-title":"Interleukin 1-\u03b1: a modulator of melanocyte homeostasis in vitiligo"},{"key":"10.1016\/j.abd.2020.02.005_bib0300","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1074-7613(02)00324-2","article-title":"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells","volume":"16","author":"Pflanz","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.abd.2020.02.005_bib0305","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.3389\/fimmu.2019.01982","article-title":"IL-17, IL-27, and IL-33: A novel axis linked to immunological dysfunction during sepsis","volume":"10","author":"Morrow","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0310","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.immunol.22.012703.104758","article-title":"Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation","volume":"25","author":"Kastelein","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0315","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.imbio.2006.05.008","article-title":"Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1","volume":"211","author":"Ruckerl","year":"2006","journal-title":"Immunobiology"},{"key":"10.1016\/j.abd.2020.02.005_bib0320","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.immuni.2012.11.003","article-title":"Interleukin-27: balancing protective and pathological immunity","volume":"37","author":"Hunter","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.abd.2020.02.005_bib0325","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.autrev.2015.08.001","article-title":"IL-27-induced modulation of autoimmunity and its therapeutic potential","volume":"14","author":"Meka","year":"2015","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.abd.2020.02.005_bib0330","doi-asserted-by":"crossref","first-page":"27350","DOI":"10.1074\/jbc.M111.221010","article-title":"Signaling events involved in interleukin 27 (IL-27)-induced proliferation of human naive CD4+ T cells and B cells","volume":"286","author":"Charlot-Rabiega","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.abd.2020.02.005_bib0335","doi-asserted-by":"crossref","first-page":"24404","DOI":"10.1074\/jbc.M110.112599","article-title":"Interleukin-27 induces a STAT1\/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes","volume":"285","author":"Guzzo","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.abd.2020.02.005_bib0340","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.imlet.2010.11.007","article-title":"IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3","volume":"136","author":"Wang","year":"2011","journal-title":"Immunol Lett"},{"key":"10.1016\/j.abd.2020.02.005_bib0345","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.4049\/jimmunol.173.9.5626","article-title":"The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity","volume":"173","author":"Artis","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0350","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.4049\/jimmunol.0801162","article-title":"IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells","volume":"182","author":"Diveu","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0355","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.4049\/jimmunol.0900735","article-title":"Differential effect of IL-27 on developing versus committed Th17 cells","volume":"183","author":"El-behi","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0360","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/eji.201040804","article-title":"IL-27 increases the proliferation and effector functions of human naive CD8+ T lymphocytes and promotes their development into Tc1 cells","volume":"41","author":"Schneider","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0365","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/eji.201444699","article-title":"IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness","volume":"45","author":"Ziblat","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0370","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4049\/jimmunol.173.2.715","article-title":"Understanding the pro-and anti-inflammatory properties of IL-27","volume":"173","author":"Villarino","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0375","doi-asserted-by":"crossref","first-page":"3958069","DOI":"10.1155\/2017\/3958069","article-title":"Dual roles of IL-27 in cancer biology and immunotherapy","volume":"2017","author":"Fabbi","year":"2017","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.abd.2020.02.005_bib0380","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.smim.2011.08.003","article-title":"Kuchroo. Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27","volume":"23","author":"Pot","year":"2011","journal-title":"Semin Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0385","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.imlet.2008.01.011","article-title":"Advances in understanding the anti-inflammatory properties of IL-27","volume":"117","author":"Stumhofer","year":"2008","journal-title":"Immunol Lett"},{"key":"10.1016\/j.abd.2020.02.005_bib0390","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/ni1541","article-title":"A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells","volume":"8","author":"Awasthi","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.abd.2020.02.005_bib0395","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/glia.22948","article-title":"Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: modulation of local immune responses","volume":"64","author":"S\u00e9n\u00e9cal","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.abd.2020.02.005_bib0400","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejr.2012.04.002","article-title":"Interleukin-27 and its relation to disease parameters in SLE patients","volume":"34","author":"Gaber","year":"2012","journal-title":"Egypt Rheumatol"},{"key":"10.1016\/j.abd.2020.02.005_bib0405","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21111565","article-title":"Circulating IL-27 is elevated in rheumatoid arthritis patients","volume":"21","author":"Lai","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.abd.2020.02.005_bib0410","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/00054725-200501000-00003","article-title":"Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis","volume":"11","author":"Schmidt","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.abd.2020.02.005_bib0415","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1034\/j.1600-0749.2003.00023.x","article-title":"Evidence for an autoimmune pathogenesis of vitiligo","volume":"16","author":"Ongenae","year":"2003","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.abd.2020.02.005_bib0420","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3349\/ymj.1996.37.6.365","article-title":"Detection of antibodies to melanocytes in vitiligo by western immunoblotting","volume":"37","author":"Hann","year":"1996","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.abd.2020.02.005_bib0425","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jaad.2010.11.061","article-title":"Vitiligo: a comprehensive overview. Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up","volume":"65","author":"Alikhan","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2020.02.005_bib0430","doi-asserted-by":"crossref","first-page":"449","DOI":"10.5114\/ada.2019.87448","article-title":"Immunophenotype of circulatory T-helper cells in patients with non-segmental vitiligo","volume":"36","author":"Kalaiselvi","year":"2019","journal-title":"Postepy Dermatol Alergol"},{"key":"10.1016\/j.abd.2020.02.005_bib0435","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00403-019-01996-9","article-title":"Predominant role of innate pro-inflammatory cytokines in vitiligo disease","volume":"312","author":"Gholijani","year":"2020","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.abd.2020.02.005_bib0440","doi-asserted-by":"crossref","first-page":"e0148919","DOI":"10.1371\/journal.pone.0148919","article-title":"Increased frequency of t follicular helper cells and elevated interleukin-27 plasma levels in patients with pemphigus","volume":"11","author":"Hennerici","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.abd.2020.02.005_bib0445","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/jid.2009.349","article-title":"Possible roles of IL-27 in the pathogenesis of psoriasis","volume":"130","author":"Shibata","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.abd.2020.02.005_bib0450","first-page":"99","volume":"34","author":"Gaber","year":"2012","journal-title":"Interleukin-27 and its relation to disease parameters in SLE patients"},{"key":"10.1016\/j.abd.2020.02.005_bib0455","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1167\/iovs.12-9863","article-title":"Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease","volume":"53","author":"Wang","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.abd.2020.02.005_bib0460","doi-asserted-by":"crossref","first-page":"R117","DOI":"10.1186\/ar4570","article-title":"Decreased interleukin 27 expression is associated with active uveitis in Beh\u00e7et's disease","volume":"16","author":"Wang","year":"2014","journal-title":"Arthritis Res Ther"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036505962030163X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036505962030163X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:37:15Z","timestamp":1759793835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036505962030163X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S036505962030163X"],"URL":"https:\/\/doi.org\/10.1016\/j.abd.2020.02.005","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased levels of interleukin 27 in the serum of vitiligo patients","name":"articletitle","label":"Article Title"},{"value":"Anais Brasileiros de Dermatologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abd.2020.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}