{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:16:09Z","timestamp":1780395369464,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anais Brasileiros de Dermatologia"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.abd.2022.01.008","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T21:06:47Z","timestamp":1667077607000},"page":"68-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Telomere length, oxidative and epigenetic changes in blood DNA of patients with exacerbated psoriasis vulgaris"],"prefix":"10.1016","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-722X","authenticated-orcid":false,"given":"Martin","family":"Beranek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5253-2808","authenticated-orcid":false,"given":"Pavel","family":"Borsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-5757","authenticated-orcid":false,"given":"Zdenek","family":"Fiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-8786","authenticated-orcid":false,"given":"Ctirad","family":"Andrys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-463X","authenticated-orcid":false,"given":"Kvetoslava","family":"Hamakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8331-3683","authenticated-orcid":false,"given":"Marcela","family":"Chmelarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-4140","authenticated-orcid":false,"given":"Helena","family":"Kovarikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-0976","authenticated-orcid":false,"given":"Adam","family":"Karas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8641-4287","authenticated-orcid":false,"given":"Jan","family":"Kremlacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7236-1647","authenticated-orcid":false,"given":"Vladimir","family":"Palicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-1485","authenticated-orcid":false,"given":"Lenka","family":"Borska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abd.2022.01.008_bib0005","doi-asserted-by":"crossref","first-page":"788","DOI":"10.2340\/00015555-2656","article-title":"Involved and uninvolved psoriatic keratinocytes display a resistance to apoptosis that may contribute to epidermal thickness","volume":"97","author":"Eding","year":"2017","journal-title":"Acta Derm Venereol."},{"key":"10.1016\/j.abd.2022.01.008_bib0010","first-page":"17","article-title":"The role of regulatory T cells and anti-inflammatory cytokines in psoriasis","volume":"27","author":"Owczarczyk-Saczonek","year":"2018","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat."},{"key":"10.1016\/j.abd.2022.01.008_bib0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12979-021-00220-5","article-title":"Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls","volume":"18","author":"Borsky","year":"2021","journal-title":"Immun Ageing."},{"key":"10.1016\/j.abd.2022.01.008_bib0020","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.arr.2012.02.001","article-title":"The role of DNA damagee and repair in aging through the prism of Koch-like criteria","volume":"12","author":"Moskalev","year":"2013","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.abd.2022.01.008_bib0025","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell."},{"key":"10.1016\/j.abd.2022.01.008_bib0030","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1468-3083.2011.04441.x","article-title":"Studies on serum 8-hydroxy guanosine (8-OHdG) as reliable biomarker for psoriasis","volume":"27","author":"Basavaraj","year":"2013","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"10.1016\/j.abd.2022.01.008_bib0035","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.3390\/ijms18112238","article-title":"Systemic inflammation, oxidative damage to nucleic acids, and metabolic syndrome in the pathogenesis of psoriasis","volume":"18","author":"Borska","year":"2017","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.abd.2022.01.008_bib0040","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jdermsci.2015.12.010","article-title":"Influence of dermal exposure to ultraviolet radiation and coal tar (polycyclic aromatic hydrocarbons) on the skin aging process","volume":"81","author":"Borska","year":"2016","journal-title":"J Dermatol Sci."},{"key":"10.1016\/j.abd.2022.01.008_bib0045","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/genes7090060","article-title":"The telomere\/telomerase system in chronic inflammatory diseases. Cause or effect?","volume":"7","author":"Kordinas","year":"2016","journal-title":"Genes (Basel)."},{"key":"10.1016\/j.abd.2022.01.008_bib0050","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1046\/j.1365-2141.2000.01970.x","article-title":"Dynamics of telomere shortening in neutrophils and T lymphocytes during ageing and the relationship to skewed X chromosome inactivation patterns","volume":"109","author":"Robertson","year":"2000","journal-title":"Br J Haematol."},{"key":"10.1016\/j.abd.2022.01.008_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021485","article-title":"Blood cell telomere length is a dynamic feature","volume":"6","author":"Svenson","year":"2011","journal-title":"PLoS One."},{"key":"10.1016\/j.abd.2022.01.008_bib0060","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mrfmmm.2009.10.010","article-title":"Differing patterns of peripheral blood leukocyte telomere length in rheumatologic diseases","volume":"683","author":"Tamayo","year":"2010","journal-title":"Mutat Res."},{"key":"10.1016\/j.abd.2022.01.008_bib0065","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.4049\/jimmunol.165.8.4742","article-title":"Telomerase activity is increased, and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis","volume":"165","author":"Wu","year":"2000","journal-title":"J Immunol."},{"key":"10.1016\/j.abd.2022.01.008_bib0070","doi-asserted-by":"crossref","first-page":"13471","DOI":"10.1073\/pnas.2233561100","article-title":"Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages","volume":"100","author":"Schonland","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.abd.2022.01.008_bib0075","doi-asserted-by":"crossref","first-page":"R380","DOI":"10.1186\/ar1499","article-title":"Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function","volume":"7","author":"Yudoh","year":"2005","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.abd.2022.01.008_bib0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0961203307077155","article-title":"Premature telomere shortening in polymorphonuclear neutrophils from patients with systemic lupus erythematosus is related to the lupus disease activity","volume":"16","author":"Wu","year":"2007","journal-title":"Lupus."},{"key":"10.1016\/j.abd.2022.01.008_bib0085","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molimm.2014.12.014","article-title":"Genetic and epigenetic basis of psoriasis pathogenesis","volume":"64","author":"Chandra","year":"2015","journal-title":"Mol Immunol."},{"key":"10.1016\/j.abd.2022.01.008_bib0090","doi-asserted-by":"crossref","first-page":"15382","DOI":"10.1038\/ncomms15382","article-title":"Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants","volume":"8","author":"Tsoi","year":"2017","journal-title":"Nat Commun."},{"key":"10.1016\/j.abd.2022.01.008_bib0095","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jdermsci.2010.07.011","article-title":"Abnormal DNA methylation in skin lesions and PBMCs of patients with psoriasis vulgaris","volume":"60","author":"Zhang","year":"2010","journal-title":"J Dermatol Sci."},{"key":"10.1016\/j.abd.2022.01.008_bib0100","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13075-019-1922-y","article-title":"Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis","volume":"21","author":"Whyte","year":"2019","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.abd.2022.01.008_bib0105","first-page":"558","article-title":"Variation of selected genotoxic and epigenetic markers due to therapeutic exposure to PAHs and ultraviolet radiation","volume":"121","author":"Borsky","year":"2020","journal-title":"Bratisl Lek Listy."},{"key":"10.1016\/j.abd.2022.01.008_bib0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5455\/medarh.2015.69.85-87","article-title":"Psoriasis and metabolic syndrome","volume":"69","author":"Salihbegovic","year":"2015","journal-title":"Med Arch."},{"key":"10.1016\/j.abd.2022.01.008_bib0115","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1590\/abd1806-4841.20175178","article-title":"Prevalence of metabolic syndrome in patients with psoriasis: A hospital-based cross-sectional study","volume":"92","author":"Milcic","year":"2017","journal-title":"An Bras Dermatol."},{"key":"10.1016\/j.abd.2022.01.008_bib0120","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jdermsci.2016.06.002","article-title":"Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients","volume":"83","author":"Barygina","year":"2016","journal-title":"J Dermatol Sci."},{"key":"10.1016\/j.abd.2022.01.008_bib0125","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7352637","article-title":"The impact of psoriasis and metabolic syndrome on the systemic inflammation and oxidative damage to nucleic acids","author":"Holmannova","year":"2020","journal-title":"J Immunol Res."},{"key":"10.1016\/j.abd.2022.01.008_bib0130","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0140-6736(03)12384-7","article-title":"Association between telomere length in blood and mortality in people aged 60 years or older","volume":"361","author":"Cawton","year":"2003","journal-title":"Lancet."},{"key":"10.1016\/j.abd.2022.01.008_bib0135","doi-asserted-by":"crossref","first-page":"12135","DOI":"10.1073\/pnas.0702703104","article-title":"Telomere length is paternally inherited and is associated with parental lifespan","volume":"104","author":"Njajou","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.abd.2022.01.008_bib0140","doi-asserted-by":"crossref","first-page":"38084","DOI":"10.1038\/srep38084","article-title":"Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial","volume":"6","author":"Tosevska","year":"2016","journal-title":"Sci Rep."},{"key":"10.1016\/j.abd.2022.01.008_bib0145","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/exd.12959","article-title":"Analysis of telomere length as predictive marker in psoriasis for comorbidities","volume":"25","author":"Coussens","year":"2016","journal-title":"Exp Dermatol."},{"key":"10.1016\/j.abd.2022.01.008_bib0150","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1365-2230.2007.02458.x","article-title":"The mRNA expression and promoter methylation status of the p16 gene in colony-forming cells with high proliferative potential in patients with psoriasis","volume":"32","author":"Zhang","year":"2007","journal-title":"Clin Exp Dermatol."},{"key":"10.1016\/j.abd.2022.01.008_bib0155","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1073\/pnas.0811332106","article-title":"Telomerase insufficiency in rheumatoid arthritis","volume":"106","author":"Fujii","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.abd.2022.01.008_bib0160","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1586\/1744666X.2013.850031","article-title":"Accelerated telomere shortening in rheumatic diseases: Cause or consequence?","volume":"9","author":"Dehbi","year":"2013","journal-title":"Expert Rev Clin Immunol."},{"key":"10.1016\/j.abd.2022.01.008_bib0165","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1365-2133.2007.08377.x","article-title":"Telomerase activity in peripheral blood mononuclear cells of psoriatic patients correlates with disease severity","volume":"158","author":"Liu","year":"2008","journal-title":"Br J Dermatol."},{"key":"10.1016\/j.abd.2022.01.008_bib0170","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/jid.2011.348","article-title":"A subset of methylated CpG sites differentiate psoriatic from normal skin","volume":"132","author":"Roberson","year":"2012","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.abd.2022.01.008_bib0175","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1365-2133.2008.08505.x","article-title":"The methylation pattern of p16INK4a gene promoter in psoriatic epidermis and its clinical significance","volume":"158","author":"Chen","year":"2008","journal-title":"Br J Dermatol."},{"key":"10.1016\/j.abd.2022.01.008_bib0180","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3109\/08820139.2014.938165","article-title":"Peripheral whole blood FOXP3 TSDR methylation: a potential marker in severity assessment of autoimmune diseases and chronic infections","volume":"44","author":"Ngalamika","year":"2015","journal-title":"Immunol Invest."},{"key":"10.1016\/j.abd.2022.01.008_bib0185","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2016.12.002","article-title":"Epigenetics of psoriatic disease: A systematic review and critical appraisal","volume":"78","author":"Pollock","year":"2017","journal-title":"J Autoimmun."},{"key":"10.1016\/j.abd.2022.01.008_bib0190","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00403-019-02005-9","article-title":"DNA methylation and inflammatory skin diseases","volume":"312","author":"Mervis","year":"2020","journal-title":"Arch Dermatol Res."},{"key":"10.1016\/j.abd.2022.01.008_bib0195","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1074\/jbc.M610529200","article-title":"A novel regulator of telomerase. S100A8 mediates differentiation-dependent and calcium-induced inhibition of telomerase activity in the human epidermal keratinocyte line HaCaT","volume":"282","author":"Rosenberger","year":"2007","journal-title":"J Biol Chem."}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059622002331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059622002331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:42:13Z","timestamp":1759794133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0365059622002331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0365059622002331"],"URL":"https:\/\/doi.org\/10.1016\/j.abd.2022.01.008","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Telomere length, oxidative and epigenetic changes in blood DNA of patients with exacerbated psoriasis vulgaris","name":"articletitle","label":"Article Title"},{"value":"Anais Brasileiros de Dermatologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abd.2022.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Sociedade Brasileira de Dermatologia. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}