{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T14:12:59Z","timestamp":1771855979744,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.132401\/2016-01"],"award-info":[{"award-number":["88881.132401\/2016-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08028-1"],"award-info":[{"award-number":["2013\/08028-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/10868-4"],"award-info":[{"award-number":["2019\/10868-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["88881.132401\/2016-01"],"award-info":[{"award-number":["88881.132401\/2016-01"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anais Brasileiros de Dermatologia"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.abd.2023.11.004","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T20:36:50Z","timestamp":1713904610000},"page":"662-669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["A dermatological assessment of pediatric patients with tuberous sclerosis complex (TSC)"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8057-0799","authenticated-orcid":false,"given":"Beatriz Azevedo","family":"Nunes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-8917","authenticated-orcid":false,"given":"Ana Karolina Ferreira Gon\u00e7alves","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-3540","authenticated-orcid":false,"given":"Mariana Aparecida","family":"Pasa Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-1197","authenticated-orcid":false,"given":"Alice Andrade","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-4152","authenticated-orcid":false,"given":"La\u00eds Faria Masulk","family":"Cardozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-0380","authenticated-orcid":false,"given":"Luiz Gustavo Dufner","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-8981","authenticated-orcid":false,"given":"Luciana Amaral","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-7312","authenticated-orcid":false,"given":"Ana Chrystina de Souza","family":"Crippa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0678-3339","authenticated-orcid":false,"given":"Sergio Antonio","family":"Antoniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-2459","authenticated-orcid":false,"given":"Kerstin Taniguchi","family":"Abagge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.abd.2023.11.004_bib0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pediatrneurol.2013.08.002","article-title":"Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference","volume":"49","author":"Krueger","year":"2013","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.abd.2023.11.004_bib0010","first-page":"82","article-title":"Esclerose Tuberosa: diagn\u00f3stico, seguimento e tratamento","volume":"44","author":"Santalha","year":"2013","journal-title":"Acta Pediatr Port"},{"key":"10.1016\/j.abd.2023.11.004_bib0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pediatrneurol.2021.07.011","article-title":"Updated international tuberous sclerosis complex diagnostic criteria and surveillance and management recommendations","volume":"123","author":"Northrup","year":"2021","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.abd.2023.11.004_bib0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2013.08.001","article-title":"Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference","volume":"49","author":"Northrup","year":"2013","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.abd.2023.11.004_bib0025","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.spen.2015.10.002","article-title":"Genotype\/phenotype correlations in tuberous sclerosis complex","volume":"22","author":"Curatolo","year":"2015","journal-title":"Semin Pediatr Neurol"},{"key":"10.1016\/j.abd.2023.11.004_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13023-018-0870-y","article-title":"Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national, prospective surveillance study","volume":"13","author":"Ebrahimi-Fakhari","year":"2018","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.abd.2023.11.004_bib0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13023-018-0764-z","article-title":"Early diagnosis of tuberous sclerosis complex: a race against time. How to make the diagnosis before seizures?","volume":"13","author":"S\u0142owi\u0144ska","year":"2018","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.abd.2023.11.004_bib0040","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1212\/WNL.0b013e3182815428","article-title":"Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma","volume":"80","author":"Krueger","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.abd.2023.11.004_bib0045","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(12)61767-X","article-title":"Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"381","author":"Bissler","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.abd.2023.11.004_bib0050","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/S0140-6736(16)31419-2","article-title":"Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study","volume":"388","author":"French","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.abd.2023.11.004_bib0055","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1056\/NEJMoa1100391","article-title":"National Institutes of Health Rare Lung Diseases Consortium; MILES Trial Group. Efficacy and safety of sirolimus in lymphangioleiomyomatosis","volume":"364","author":"McCormack","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.abd.2023.11.004_bib0060","doi-asserted-by":"crossref","first-page":"5S20","DOI":"10.1016\/S0929-693X(22)00286-X","article-title":"Use of mTOR inhibitors (rapalogs) for the treatment of skin changes in tuberous sclerosis complex","volume":"29","author":"Farges","year":"2022","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.abd.2023.11.004_bib0065","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/pde.13204","article-title":"Tuberous sclerosis complex in 29 children: clinical and genetic analysis and facial angiofibroma responses to topical sirolimus","volume":"34","author":"Wang","year":"2017","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.abd.2023.11.004_bib0070","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s13555-020-00387-7","article-title":"Safety and efficacy of the sirolimus gel for TSC patients with facial skin lesions in a long-term, open-label, extension, uncontrolled clinical trial","volume":"10","author":"Wataya-Kaneda","year":"2020","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.abd.2023.11.004_bib0075","doi-asserted-by":"crossref","first-page":"fmab012","DOI":"10.1093\/tropej\/fmab012","article-title":"Tuberous sclerosis complex: early screening and infant outcome in NICU","volume":"67","author":"Su","year":"2021","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.abd.2023.11.004_bib0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13023-016-0553-5","article-title":"TuberOus SClerosis registry to increase disease Awareness (TOSCA) \u2012 baseline data on 2093 patients","volume":"12","author":"Kingswood","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.abd.2023.11.004_bib0085","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/sj.ejhg.5201402","article-title":"Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype--phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex","volume":"13","author":"Sancak","year":"2005","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.abd.2023.11.004_bib0090","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/316951","article-title":"Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs","volume":"68","author":"Dabora","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.abd.2023.11.004_bib0095","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2350-7-72","article-title":"Molecular and clinical analyses of 84 patients with tuberous sclerosis complex","volume":"7","author":"Hung","year":"2006","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.abd.2023.11.004_bib0100","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/GIM.0b013e31803068c7","article-title":"Genotype\/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States","volume":"9","author":"Au","year":"2007","journal-title":"Genet Med"},{"key":"10.1016\/j.abd.2023.11.004_bib0105","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/cge.12920","article-title":"Phenotypic and genotypic characterization of Chinese children diagnosed with tuberous sclerosis complex","volume":"91","author":"Yang","year":"2017","journal-title":"Clin Genet"},{"key":"10.1016\/j.abd.2023.11.004_bib0110","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/s13023-022-02496-2","article-title":"Characterization and management of facial angiofibroma related to tuberous sclerosis complex in the United States: retrospective analysis of the natural history database","volume":"17","author":"Boggarapu","year":"2022","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.abd.2023.11.004_bib0115","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/s41436-020-0823-4","article-title":"TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study","volume":"22","author":"Og\u00f3rek","year":"2020","journal-title":"Genet Med"},{"key":"10.1016\/j.abd.2023.11.004_bib0120","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.annder.2022.02.007","article-title":"Dermatological and genetic data in tuberous sclerosis: a prospective single-center study of 38 patients","volume":"149","author":"Secco","year":"2022","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.abd.2023.11.004_bib0125","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1590\/abd1806-4841.20186972","article-title":"Tuberous sclerosis complex: review based on new diagnostic criteria","volume":"93","author":"Portocarrero","year":"2018","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.abd.2023.11.004_bib0130","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1542\/peds.2010-0192","article-title":"Tuberous sclerosis complex: diagnostic challenges, presenting symptoms, and commonly missed signs","volume":"127","author":"Staley","year":"2011","journal-title":"Pediatrics"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059624000588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059624000588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:51Z","timestamp":1747666851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0365059624000588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0365059624000588"],"URL":"https:\/\/doi.org\/10.1016\/j.abd.2023.11.004","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dermatological assessment of pediatric patients with tuberous sclerosis complex (TSC)","name":"articletitle","label":"Article Title"},{"value":"Anais Brasileiros de Dermatologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abd.2023.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Sociedade Brasileira de Dermatologia. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}