{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:26:31Z","timestamp":1791872791893,"version":"4.3.4"},"reference-count":114,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anais Brasileiros de Dermatologia"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.abd.2024.04.007","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T12:48:16Z","timestamp":1732884496000},"page":"87-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adverse effects of the aesthetic use of botulinum toxin and dermal fillers on the face: a narrative review"],"prefix":"10.1016","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-9205","authenticated-orcid":false,"given":"\u00c9rico Pampado","family":"Di Santis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-9664","authenticated-orcid":false,"given":"Sergio Henrique","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-5986","authenticated-orcid":false,"given":"Giulia Martins","family":"Di Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-6645","authenticated-orcid":false,"given":"Samira","family":"Yarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.abd.2024.04.007_bib0005","unstructured":"American Society of Aesthetic Plastic Surgery [Internet] [cited 2023 Jan 03] Available from: https:\/\/www.isaps.org\/discover\/about-isaps\/global-statistics\/reports-and-press-releases\/global-survey-2021-full-report-and-press-releases\/."},{"key":"10.1016\/j.abd.2024.04.007_bib0010","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.abd.2022.01.002","article-title":"Compulsory notification of injuries in aesthetic procedures. Impact on patient safety","volume":"97","author":"Di Santis","year":"2022","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.abd.2024.04.007_bib0015","unstructured":"C\u00f3digo de \u00c9tica M\u00e9dica - Cap. I- IX e X Cap. III \u2013 art. 20 Cap. VI \u2013 art. 46 Cap. VIII \u2013 art. 58, 63, 68 e 72 Cap. XIII \u2013 art. 116."},{"key":"10.1016\/j.abd.2024.04.007_bib0020","series-title":"Mortes relacionadas \u00e0 lipoaspira\u00e7\u00e3o no Brasil entre 1987 e 2015 [tese]","author":"Di Santis","year":"2018"},{"key":"10.1016\/j.abd.2024.04.007_bib0025","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1111\/jocd.14160","article-title":"Complications of botulinum toxin A: an update review","volume":"20","author":"Kroumpouzos","year":"2021","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsc.2004.04.008","article-title":"Complications of botulinum toxin A use in facial rejuvenation","volume":"13","author":"Vartanian","year":"2005","journal-title":"Facial Plast Surg Clin North Am."},{"key":"10.1016\/j.abd.2024.04.007_bib0035","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s40136-020-00308-4","article-title":"Applied anatomy for botulinum toxin injection in cosmetic interventions","volume":"8","author":"D\u2019Souza","year":"2020","journal-title":"Curr Otorhinolaryngol Rep."},{"key":"10.1016\/j.abd.2024.04.007_bib0040","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s00266-020-01983-w","article-title":"A review of complications due to the use of botulinum toxin A for cosmetic indications","volume":"45","author":"Sethi","year":"2021","journal-title":"Aesthetic Plast Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0045","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3109\/10582452.2014.883012","article-title":"Systematic review on the efficacy of topical arnica montana for the treatment of pain, swelling and bruises","volume":"22","author":"Brito","year":"2014","journal-title":"Journal of Musculoskeletal Pain."},{"key":"10.1016\/j.abd.2024.04.007_bib0050","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/14764170310023254","article-title":"How to avoid brow ptosis after forehead treatment with botulinum toxin","volume":"5","author":"Redaelli","year":"2003","journal-title":"J Cosmet Laser Ther."},{"key":"10.1016\/j.abd.2024.04.007_bib0055","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S1085-5629(96)80003-4","article-title":"Aesthetic and anatomic analysis of the aging skin","volume":"15","author":"Glogau","year":"1996","journal-title":"Semin Cutan Med Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0060","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/jocd.13266","article-title":"Complications of botulinum toxin and fillers: a narrative review","volume":"19","author":"Kassir","year":"2020","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0065","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1053\/mda.2001.25964","article-title":"Complications and adverse reactions with the use of botulinum toxin","volume":"48","author":"Klein","year":"2002","journal-title":"Dis Mon."},{"key":"10.1016\/j.abd.2024.04.007_bib0070","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/j.1524-4725.2012.02505.x","article-title":"Glabellar contraction patterns: a tool to optimize botulinum toxin treatment","volume":"38","author":"De Almeida","year":"2012","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0075","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00266-002-2047-1","article-title":"Long-term prospective follow-up of botulinum toxin treatment for facial rhytides","volume":"26","author":"Bulstrode","year":"2002","journal-title":"Aesthetic Plast Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5070\/D306G8W0MC","article-title":"The use of apraclonidine eyedrops to treat ptosis after the administration of botulinum toxin to the upper face","volume":"11","author":"Scheinfeld","year":"2005","journal-title":"Dermatol Online J."},{"key":"10.1016\/j.abd.2024.04.007_bib0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2147\/CCID.S202919","article-title":"Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect","volume":"12","author":"Satriyasa","year":"2019","journal-title":"Clin Cosmet Investig Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0090","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1524-4725.1998.tb04097.x","article-title":"Clinical indications and injection technique for the cosmetic use of botulinum A exotoxin","volume":"24","author":"Carruthers","year":"1998","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0095","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1524-4725.1992.tb03295.x","article-title":"Treatment of glabellar frown lines with C. botulinum-A exotoxin","volume":"18","author":"Carruthers","year":"1992","journal-title":"J Dermatol Surg Oncol."},{"key":"10.1016\/j.abd.2024.04.007_bib0100","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1590\/S0004-27492008000600027","article-title":"[Adverse effects associated with facial application of botulinum toxin: a systematic review with meta-analysis]","volume":"71","author":"Zagui","year":"2008","journal-title":"Arq Brasi Oftalmol."},{"key":"10.1016\/j.abd.2024.04.007_bib0105","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1524-4725.1998.tb04094.x","article-title":"Dilution and storage of botulinum toxin","volume":"24","author":"Klein","year":"1998","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3928\/0191-3913-19970701-10","article-title":"Diplopia following subcutaneous injections of botulinum A toxin for facial spasms","volume":"34","author":"Wutthiphan","year":"1997","journal-title":"J Pediatr Ophthalmol Strabismus."},{"key":"10.1016\/j.abd.2024.04.007_bib0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.coms.2019.09.004","article-title":"Aesthetic facial surgery and orthodontics: common goals","volume":"32","author":"Olivieri","year":"2020","journal-title":"Oral Maxillofac Surg Clin North Am."},{"key":"10.1016\/j.abd.2024.04.007_bib0120","unstructured":"Anonymous FDA News Release: FDA requires box warning for all botulinum toxin products. [Cited 2010 Oct 10]. Available from: http:\/\/www.fda.gov\/Newsevents\/Newsroom\/PressAnnouncements\/ucm149574.htm."},{"key":"10.1016\/j.abd.2024.04.007_bib0125","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/ced.13108","article-title":"First case of anaphylaxis after botulinum toxin type A injection","volume":"42","author":"Moon","year":"2017","journal-title":"Clin Exp Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0130","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/DSS.0000000000000291","article-title":"Effect of a second injection of botulinum toxin on lower facial contouring, as evaluated using 3-dimensional laser scanning","volume":"41","author":"Lee","year":"2015","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0135","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/14764172.2019.1690663","article-title":"Botulinum toxin type A injection-related suppurative granuloma: a case report","volume":"21","author":"Thanasarnaksorn","year":"2019","journal-title":"J Cosmet Laser Ther."},{"key":"10.1016\/j.abd.2024.04.007_bib0140","first-page":"WD01","article-title":"Mycobacterial infection after cosmetic procedure with botulinum toxin A","volume":"9","author":"Saeb-Lima","year":"2015","journal-title":"J Clin Diagn Res."},{"key":"10.1016\/j.abd.2024.04.007_bib0145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.31080\/ASDS.2023.07.1701","article-title":"Mycobacterium abscessus infection following injections of botulinum toxin: a report of two cases","volume":"7","author":"Barin","year":"2023","journal-title":"Acta Sci Dental Sci."},{"key":"10.1016\/j.abd.2024.04.007_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.idcr.2020.e00992","article-title":"Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: cases series","volume":"22","author":"Moreno-Izquierdo","year":"2020","journal-title":"IDCases"},{"key":"10.1016\/j.abd.2024.04.007_bib0155","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0733-8635(02)00097-9","article-title":"Unusual infectious complications of dermatologic procedures","volume":"21","author":"Garman","year":"2003","journal-title":"Dermatol Clin."},{"key":"10.1016\/j.abd.2024.04.007_bib0160","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/jocd.13094","article-title":"Mycobacterium abscessus infections following injection of botulinum toxin","volume":"19","author":"Rou-Yu","year":"2020","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0165","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0165-5728(93)90239-U","article-title":"Gangliosides and bacterial toxins in Guillain-Barr\u00e9 syndrome","volume":"46","author":"Willison","year":"1993","journal-title":"J Neuroimmunol."},{"key":"10.1016\/j.abd.2024.04.007_bib0170","doi-asserted-by":"crossref","first-page":"257","DOI":"10.21767\/2171-6625.1000257","article-title":"Facial nerve palsy after botulinum toxin therapy for hemifacial spasm: a case report","volume":"9","author":"Ito","year":"2018","journal-title":"J Neurol Neurosci."},{"key":"10.1016\/j.abd.2024.04.007_bib0175","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0304-4165(80)90382-7","article-title":"Interaction between Clostridium botulinum neurotoxin and gangliosides","volume":"628","author":"Kitamura","year":"1980","journal-title":"Biochim Biophys Acta."},{"key":"10.1016\/j.abd.2024.04.007_bib0180","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/00002826-200007000-00012","article-title":"Polyradiculoneuritis after botulinum toxin therapy for cervical dystonia","volume":"23","author":"Burguera","year":"2000","journal-title":"Clin Neuropharmacol."},{"key":"10.1016\/j.abd.2024.04.007_bib0185","first-page":"20","article-title":"A case report of acute polyradiculoneuritis developing after multiple injections of botulinum toxin for cervical dystonia","volume":"44","author":"Onoue","year":"2004","journal-title":"Clin Neurol Rinsho Shinkeigaku."},{"key":"10.1016\/j.abd.2024.04.007_bib0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12020-010-9410-9","article-title":"Injections of Clostridium botulinum neurotoxin A may cause thyroid complications in predisposed persons based on molecular mimicry with thyroid autoantigens","volume":"39","author":"Gregoric","year":"2011","journal-title":"Endocrine."},{"key":"10.1016\/j.abd.2024.04.007_bib0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000370245","article-title":"Serious and long-term adverse events associated with the therapeutic and cosmetic use of botulinum toxin","volume":"95","author":"Yiannakopoulou","year":"2015","journal-title":"Pharmacology."},{"key":"10.1016\/j.abd.2024.04.007_bib0200","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/DSS.0000000000001277","article-title":"Botulinum toxin in aesthetic medicine: myths and realities","volume":"44","author":"Dover","year":"2018","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0205","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jaad.2016.11.012","article-title":"Injectable and topical neurotoxins in dermatology: indications, adverse events, and controversies","volume":"76","author":"Giordano","year":"2017","journal-title":"J Am Acad Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0210","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00266-021-02483-1","article-title":"Avoiding complications on the upper face treatment with botulinum toxin: a practical guide","volume":"46","author":"Borba","year":"2022","journal-title":"Aesthetic Plast Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0215","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1055\/s-0041-1741531","article-title":"Botulinum toxin type A: adverse events and management","volume":"38","author":"Cavallini","year":"2022","journal-title":"Facial Plast Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0220","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/jab.770060209","article-title":"Educational goals for biomaterials science and engineering: prospective view","volume":"6","author":"von Recum","year":"1995","journal-title":"J Appl Biomater."},{"key":"10.1016\/j.abd.2024.04.007_bib0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2010.02.064","article-title":"Adverse reactions to injectable soft tissue fillers","volume":"64","author":"Requena","year":"2011","journal-title":"J Am Acad Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0230","unstructured":"Health C for D and R. Dermal Fillers (Soft Tissue Fillers). FDA [Internet]. 2021 Jun 25; Available from: https:\/\/www.fda.gov\/medical-devices\/aesthetic-cosmetic-devices\/dermal-fillers-soft-tissue-fillers."},{"key":"10.1016\/j.abd.2024.04.007_bib0235","unstructured":"Health C for D and R. Restylane Eyelight \u2013 P040024\/S135. FDA [Internet]. 2023 [cited 2024 May 26]; Available from: https:\/\/www.fda.gov\/medical-devices\/recently-approved-devices\/restylane-eyelight-p040024s135."},{"key":"10.1016\/j.abd.2024.04.007_bib0240","unstructured":"ISAPS International Survey on Aesthetic\/Cosmetic Procedures performed in 2020 [Internet]. Available from: https:\/\/www.isaps.org\/media\/evbbfapi\/isaps-global-survey_2020.pdf."},{"key":"10.1016\/j.abd.2024.04.007_bib0245","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1064-7406(23)00468-6","article-title":"Survey of future injectables","volume":"9","author":"Ellis","year":"2001","journal-title":"Facial Plast Surg Clin North Am."},{"key":"10.1016\/j.abd.2024.04.007_bib0250","unstructured":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria - ANVISA. [Homepage] (consultado em 28 de nov. 2023) Dispon\u00edvel em https:\/\/consultas.anvisa.gov.br\/#\/saude\/q\/?nomeTecnico=Solucao%20para%20Preenchimento%20Intradermico."},{"key":"10.1016\/j.abd.2024.04.007_bib0255","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4103\/0974-2077.172191","article-title":"Managing complications of fillers: rare and not-so-rare","volume":"8","author":"Haneke","year":"2015","journal-title":"J Cutan and Aesthetic Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0260","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/jdv.13594","article-title":"The impact of adverse reactions to injectable filler substances on quality of life: results from the Berlin Injectable Filler Safety (IFS) \u2013 study","volume":"30","author":"D\u00fcker","year":"2016","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"10.1016\/j.abd.2024.04.007_bib0265","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1524-4725.2010.01782.x","article-title":"The current state of treatment of adverse reactions to injectable fillers","volume":"36","author":"Sperling","year":"2010","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0270","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1055\/s-0034-1396905","article-title":"Diagnosis and management of filler adverse effects: an algorithm","volume":"30","author":"Feller-Heppt","year":"2014","journal-title":"Facial Plast Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0275","unstructured":"Brasil. Lei n. 12.842 de 10 de julho de 2013. Disp\u00f5e sobre o exerc\u00edcio da medicina. Di\u00e1rio Oficial da Rep\u00fablica Federativa do Brasil, Bras\u00edlia (DF); 2013 JUL 11; P 1."},{"key":"10.1016\/j.abd.2024.04.007_bib0280","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1473-2130.2004.00058.x","article-title":"Management of complications after implantation of fillers","volume":"3","author":"De Boulle","year":"2004","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0285","first-page":"295","article-title":"Dermal fillers in aesthetics: an overview of adverse events and treatment approaches","volume":"6","author":"Funt","year":"2013","journal-title":"Clin Cosmet Invest Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0290","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.anndiagpath.2014.11.004","article-title":"Dermal filler complications: a clinicopathologic study with a spectrum of histologic reaction patterns","volume":"19","author":"El-Khalawany","year":"2015","journal-title":"Ann Diagn Pathol."},{"key":"10.1016\/j.abd.2024.04.007_bib0295","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.semarthrit.2013.02.001","article-title":"Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers","volume":"43","author":"Alijotas-Reig","year":"2013","journal-title":"Semin Arthritis Rheum."},{"key":"10.1016\/j.abd.2024.04.007_bib0300","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12016-012-8348-5","article-title":"Late-onset inflammatory adverse reactions related to soft tissue filler injections","volume":"45","author":"Alijotas-Reig","year":"2013","journal-title":"Clinic Rev Allerg Immunol."},{"key":"10.1016\/j.abd.2024.04.007_bib0305","first-page":"S92","article-title":"Understanding, avoiding, and managing dermal filler complications","volume":"34","author":"Cohen","year":"2008","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0310","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2147\/CCID.S316352","article-title":"The immunogenicity of hyaluronic fillers and its consequences","volume":"14","author":"Owczarczyk-Saczonek","year":"2021","journal-title":"Clin Cosmet Investig Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0315","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1080\/14740338.2021.1962283","article-title":"Evaluating safety in hyaluronic acid lip injections","volume":"20","author":"Safran","year":"2021","journal-title":"Expert Opin Drug Saf."},{"key":"10.1016\/j.abd.2024.04.007_bib0320","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2147\/CCID.S180904","article-title":"A 10-point plan for avoiding hyaluronic acid dermal filler-related complications during facial aesthetic procedures and algorithms for management","volume":"11","author":"Heydenrych","year":"2018","journal-title":"Clin Cosmet Investig Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0325","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12663-012-0398-y","article-title":"Dental procedures: is it a risk factor for injectable dermal fillers?","volume":"14","author":"Ramzi","year":"2015","journal-title":"J Maxillofac Oral Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0330","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/jocd.12085","article-title":"A prospective, open-label, multicenter, observational, postmarket study of the use of a 15 mg\/mL hyaluronic acid dermal filler in the lips","volume":"13","author":"Philipp-Dormston","year":"2014","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0335","doi-asserted-by":"crossref","first-page":"S293","DOI":"10.1097\/DSS.0000000000000540","article-title":"Safety and effectiveness of the hyaluronic acid filler, HYC-24L, for lip and perioral augmentation","volume":"41","author":"Dayan","year":"2015","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0340","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/1090820X13478609","article-title":"Juvederm ultra for lip enhancement: an open-label, multicenter study","volume":"33","author":"Fagien","year":"2013","journal-title":"Aesthet Surg J."},{"key":"10.1016\/j.abd.2024.04.007_bib0345","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2310\/6350.2005.31246","article-title":"Randomized, double-blind comparison of the efficacy of two hyaluronic acid derivatives, restylane perlane and hylaform, in the treatment of nasolabial folds","volume":"31","author":"Carruthers","year":"2005","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0350","first-page":"145","article-title":"An open-label, pilot study to assess the effective-ness and safety of hyaluronic acid gel in the restoration of soft tissue fullness of the lips","volume":"10","author":"Solish","year":"2011","journal-title":"J Drugs Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0355","first-page":"167","article-title":"Juv\u00e9derm(\u00ae) Volbella\u2122 in the perioral area: a 12-month prospective, multicenter, open-label study","volume":"5","author":"Eccleston","year":"2012","journal-title":"Clin Cosmet Investig Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0360","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1097\/DSS.0000000000000199","article-title":"A randomized, evaluator- blinded, controlled study of effectiveness and safety of small particle hyaluronic acid plus lidocaine for lip augmentation and perioral rhytides","volume":"41","author":"Beer","year":"2015","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/DSS.0000000000000569","article-title":"Complications in the cosmetic dermatology patient: a review and our experience (part 1)","volume":"42","author":"Vanaman","year":"2016","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0370","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1586\/17434440.2013.839211","article-title":"Clinical data on injectable tissue fillers: a review","volume":"10","author":"de Vries","year":"2013","journal-title":"Expert Rev Med Devices."},{"key":"10.1016\/j.abd.2024.04.007_bib0375","series-title":"Eletrodin\u00e2mica Cl\u00e1ssica","first-page":"p199","author":"Bassalo","year":"2007"},{"issue":"8","key":"10.1016\/j.abd.2024.04.007_bib0380","article-title":"A prospective study on safety, complications and satisfaction analysis for tear trough rejuvenation using hyaluronic acid dermal fillers","volume":"29","author":"Diwan","year":"2020","journal-title":"Plast Reconstr Surg Glob Open."},{"key":"10.1016\/j.abd.2024.04.007_bib0385","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000356421","article-title":"Migrating granulomatous chronic reaction from hyaluronic acid skin filler (Restylane): review and histopathological study with histochemical stainings","volume":"228","author":"Cecchi","year":"2014","journal-title":"Dermatology."},{"key":"10.1016\/j.abd.2024.04.007_bib0390","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/DSS.0000000000000562","article-title":"Resistant and recurrent late reaction to hyaluronic acid\u2010based gel","volume":"42","author":"Artzi","year":"2016","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0395","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1001\/archdermatol.2011.3374","article-title":"Calcium hydroxylapatite nodule resolution after fractional carbon dioxide laser therapy","volume":"148","author":"Reddy","year":"2012","journal-title":"Arch Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0400","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.sder.2006.12.008","article-title":"Adverse effects when injecting facial fillers","volume":"26","author":"Gladstone","year":"2007","journal-title":"Semin Cutan Med Surg"},{"key":"10.1016\/j.abd.2024.04.007_bib0405","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000324296","article-title":"Fifty-kDa hyaluronic acid up regulates some epidermal genes without changing TNF-\u03b1 expression in reconstituted epidermis","volume":"24","author":"Farwick","year":"2011","journal-title":"Skin Pharmacol Physiol."},{"key":"10.1016\/j.abd.2024.04.007_bib0410","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jdcr.2021.02.018","article-title":"Oral angiotensin-converting enzyme inhibitors for treatment of delayed inflammatory reaction to dermal hyaluronic acid fillers following COVID-19 vaccination-a model for inhibition of angiotensin II-induced cutaneous inflammation","volume":"10","author":"Munavalli","year":"2021","journal-title":"JAAD Case Rep."},{"key":"10.1016\/j.abd.2024.04.007_bib0415","first-page":"187","article-title":"The promise of JAK inhibitors for treatment of sarcoidosis and other inflammatory disorders with macrophage activation: a review of the literature","volume":"93","author":"Wang","year":"2020","journal-title":"Yale J Biol Med."},{"key":"10.1016\/j.abd.2024.04.007_bib0420","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/IOP.0000000000000722","article-title":"Xanthelasma-like reaction to filler injection","volume":"33","author":"Or","year":"2017","journal-title":"Ophthalmic Plast Reconstr Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0425","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1111\/jocd.14166","article-title":"Lower eyelid xanthelasma following hyaluronic acid filler injections to the tear troughs","volume":"20","author":"Liu","year":"2021","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0430","first-page":"E61","article-title":"Guideline for the management of hyaluronic acid filler-induced vascular occlusion","volume":"14","author":"Murray","year":"2021","journal-title":"J Clin Aesthet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0435","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/asj\/sjz053","article-title":"Update on avoiding and treating blindness from fillers: a recent review of the world literature","volume":"39","author":"Belezney","year":"2019","journal-title":"Aesthet Surg J."},{"key":"10.1016\/j.abd.2024.04.007_bib0440","first-page":"1069","article-title":"The basic science of dermal fillers: past and present part II: adverse effects","volume":"11","author":"Gilbert","year":"2012","journal-title":"J Drugs Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0445","first-page":"587","article-title":"Arterial occlusion and necrosis following hyaluronic acid injection and a review of the literature","volume":"18","author":"Doerfler","year":"2019","journal-title":"J Drugs Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0450","doi-asserted-by":"crossref","first-page":"240e","DOI":"10.1097\/PRS.0000000000007022","article-title":"False sense of safety: blunt cannulas cause the majority of severe vascular complications in hyaluronic acid injection","volume":"146","author":"Zhou","year":"2020","journal-title":"Plast Reconstr Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0455","first-page":"E65","article-title":"Vascular complications after facial filler injection: a literature review and meta-analysis","volume":"12","author":"Sito","year":"2019","journal-title":"J Clin Aesthet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0460","unstructured":"ISAPS INTERNATIONAL SURVEY ON [Internet]. Available from: https:\/\/www.isaps.org\/media\/pubgf4jc\/global-survey-full-report-2019-english.pdf."},{"key":"10.1016\/j.abd.2024.04.007_bib0465","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/jocd.14064","article-title":"Comparison of hyaluronic acid filler ejection pressure with injection force for safe filler injection","volume":"20","author":"Lee","year":"2021","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0470","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/DSS.0000000000000395","article-title":"Blood aspiration test for cosmetic fillers to prevent accidental intravascular injection in the face","volume":"41","author":"Casabona","year":"2015","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0475","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/jocd.12437","article-title":"Sensitivity of aspiration as a safety test before injection of soft tissue fillers","volume":"17","author":"Van Loghem","year":"2018","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0480","doi-asserted-by":"crossref","first-page":"434e","DOI":"10.1097\/PRS.0000000000001579","article-title":"Clinical outcomes of impending nasal skin necrosis related to nose and nasolabial fold augmentation with hyaluronicacid fillers","volume":"136","author":"Sun","year":"2015","journal-title":"Plast Reconstr Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0485","doi-asserted-by":"crossref","first-page":"NP602","DOI":"10.1093\/asj\/sjaa381","article-title":"Asymptomatic stroke after hyaluronic acid filler injection: case report and literature review","volume":"41","author":"Moore","year":"2021","journal-title":"Aesthet Surg J."},{"key":"10.1016\/j.abd.2024.04.007_bib0490","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/ICU.0000000000000595","article-title":"Periocular hyaluronic acid fillers: applications, implications, complications","volume":"30","author":"Murthy","year":"2019","journal-title":"Curr Opin Ophthalmol."},{"key":"10.1016\/j.abd.2024.04.007_bib0495","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3109\/14764172.2016.1157260","article-title":"Nicolau syndrome due to hyaluronic acid injections","volume":"18","author":"Andre","year":"2016","journal-title":"J Cosmet Laser Ther."},{"key":"10.1016\/j.abd.2024.04.007_bib0500","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/jocd.13287","article-title":"Delayed skin necrosis following hyaluronic acid filler injection: a case report","volume":"19","author":"Cassiano","year":"2020","journal-title":"J Cosmet Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0505","first-page":"105","article-title":"Nicolau syndrome from penicillin preparations: review of the relevant literature in the search for potencial risk factors","volume":"20","author":"Saputo","year":"1998","journal-title":"Pediatr Med Chir."},{"key":"10.1016\/j.abd.2024.04.007_bib0510","first-page":"65","article-title":"Tissue necrosis following intramuscular sodium diaclofenac injection: report of 4 cases","volume":"66","author":"Golcman","year":"1991","journal-title":"An Bras Dermatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0515","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.bjps.2011.07.013","article-title":"Vascular complications of hyaluronic acid fillers and the role of hyaluronidase in management","volume":"64","author":"Kim","year":"2011","journal-title":"J Plast Reconstr Aesthet Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0520","unstructured":"Find guidance [Internet]. NICE. Available from: https:\/\/www.nice.org.uk\/Guidance\/."},{"key":"10.1016\/j.abd.2024.04.007_bib0525","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1093\/asj\/sjy032","article-title":"Differentiating nonpermanent injectable fillers: prevention and treatment of filler complications","volume":"38","author":"Graivier","year":"2018","journal-title":"Aesthet Surg J."},{"key":"10.1016\/j.abd.2024.04.007_bib0530","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/IOP.0000000000000446","article-title":"Rethinking the role of nitroglycerin ointment in ischemic vascular filler complications: an animal model with ICG imaging","volume":"32","author":"Hwang","year":"2016","journal-title":"Ophthalmic Plast Reconstr Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0535","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1038\/s41598-020-60128-w","article-title":"The effects of sildenafil and\/or nitroglycerin on random-pattern skin flaps after nicotine application in rats","volume":"10","author":"Ellabban","year":"2020","journal-title":"Sci Rep."},{"key":"10.1016\/j.abd.2024.04.007_bib0540","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1097\/DSS.0000000000002894","article-title":"Dermal filler-induced vascular occlusion successfully treated with tadalafil, hyaluronidase, and aspirin","volume":"47","author":"Chuchvara","year":"2021","journal-title":"Dermatol Surg."},{"key":"10.1016\/j.abd.2024.04.007_bib0545","article-title":"Anti-inflammatory effects of heparin and its derivatives: a systematic review","volume":"2015","author":"Mousavi","year":"2015","journal-title":"Adv Pharmacol Sci."},{"key":"10.1016\/j.abd.2024.04.007_bib0550","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaut.2010.07.003","article-title":"\u2018ASIA\u2019 - autoimmune\/inflammatory syndrome induced by adjuvants","volume":"36","author":"Shoenfeld","year":"2011","journal-title":"J Autoimmun."},{"key":"10.1016\/j.abd.2024.04.007_bib0555","doi-asserted-by":"crossref","first-page":"64","DOI":"10.31138\/mjr.28.2.64","article-title":"The ASIA syndrome: basic concepts","volume":"28","author":"Watad","year":"2017","journal-title":"Mediterr J Rheumatol."},{"key":"10.1016\/j.abd.2024.04.007_bib0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103287","article-title":"Autoimmune\/inflammatory syndrome induced by adjuvants (ASIA) in 2023","volume":"22","author":"Cohen Tervaert","year":"2023","journal-title":"Autoimmun Rev."},{"key":"10.1016\/j.abd.2024.04.007_bib0565","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3390\/biom10101436","article-title":"Classical examples of the concept of the ASIA syndrome","volume":"10","author":"Borba","year":"2020","journal-title":"Biomolecules."},{"key":"10.1016\/j.abd.2024.04.007_bib0570","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.2147\/CCID.S419716","article-title":"Hyaluronic acid fillers and ASIA syndrome: case studies","volume":"16","author":"Owczarczyk-Saczonek","year":"2023","journal-title":"Clin Cosmet Investig Dermatol."}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059624002083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059624002083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:52Z","timestamp":1747666852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0365059624002083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0365059624002083"],"URL":"https:\/\/doi.org\/10.1016\/j.abd.2024.04.007","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adverse effects of the aesthetic use of botulinum toxin and dermal fillers on the face: a narrative review","name":"articletitle","label":"Article Title"},{"value":"Anais Brasileiros de Dermatologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abd.2024.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedade Brasileira de Dermatologia.","name":"copyright","label":"Copyright"}]}}