{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:27:40Z","timestamp":1778509660767,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Clinics Hospital of Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anais Brasileiros de Dermatologia"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.abd.2025.501160","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T14:21:57Z","timestamp":1752589317000},"page":"501160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical-demographic profile, aggravating factors, comorbidities, and quality of life in patients with Rosacea: a Brazilian multicenter study (GBPER: Brazilian Research and Studies Group on Rosacea)"],"prefix":"10.1016","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-8466","authenticated-orcid":false,"given":"Renan Rangel","family":"Bonamigo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-3359","authenticated-orcid":false,"given":"Paula","family":"Barea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6963-7921","authenticated-orcid":false,"given":"Juliano","family":"Peruzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0573-1617","authenticated-orcid":false,"given":"Juliana","family":"Boza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2596-9294","authenticated-orcid":false,"given":"H\u00e9lio Amante","family":"Miot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-8241","authenticated-orcid":false,"given":"Edileia","family":"Bagatin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-021X","authenticated-orcid":false,"given":"Luiz Maur\u00edcio Costa","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-3194","authenticated-orcid":false,"given":"Giovanni Indelicato","family":"Milano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8031-4143","authenticated-orcid":false,"given":"Carla Wanderley Gayoso de","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5584-5639","authenticated-orcid":false,"given":"Lin\u00e1cia Freitas","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7375-9232","authenticated-orcid":false,"given":"Fab\u00edola Rosa","family":"Picosse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-9467","authenticated-orcid":false,"given":"Bruna Manuella de Figueiredo","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-360X","authenticated-orcid":false,"given":"Clivia Maria Moraes de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.abd.2025.501160_bib0005","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jaad.2014.08.028","article-title":"Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors","volume":"72","author":"Two","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0010","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2133.2012.11037.x","article-title":"A study on the epidemiology of rosacea in the U.K","volume":"167","author":"Spoendlin","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0015","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jaad.2013.04.043","article-title":"Rosacea: current state of epidemiology","volume":"69","author":"Tan","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0020","first-page":"282","article-title":"Incidence and prevalence of rosacea: a systematic review and meta-analysis","volume":"179","author":"Gether","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1684\/ejd.2023.4405","article-title":"Epidemiological profile of rosacea in dermatology outpatient clinics in Brazil: an observational report from the Brazilian study group on rosacea","volume":"33","author":"Suarez","year":"2023","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1468-3083.2005.01216.x","article-title":"Rosacea and its management: an overview","volume":"19","author":"Gupta","year":"2005","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.abd.2025.501160_bib0035","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2340\/00015555-2335","article-title":"Facial erythema of rosacea \u2014 aetiology, different pathophysiologies and treatment options","volume":"96","author":"Steinhoff","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.abd.2025.501160_bib0040","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.jaad.2013.04.040","article-title":"Ocular rosacea: a dermatologic perspective","volume":"69","author":"Webster","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0045","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/bjd.15122","article-title":"Updating the diagnosis, classification and assessment of rosacea: recommendations from the global ROSacea COnsensus (ROSCO) panel","volume":"176","author":"Tan","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0050","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jaad.2017.08.037","article-title":"Standard classification and pathophysiology of rosacea: the 2017 update by the National Rosacea Society Expert Committee","volume":"78","author":"Gallo","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/bjd.17590","article-title":"Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments","volume":"181","author":"van Zuuren","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0060","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.jaad.2020.01.077","article-title":"Standard management options for rosacea: the 2019 update by the National Rosacea Society Expert Committee","volume":"82","author":"Thiboutot","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0065","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2133.2010.09894.x","article-title":"The impact of rosacea on quality of life: effects of demographic and clinical characteristics and various treatment modalities","volume":"163","author":"Aksoy","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0070","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.abd.2019.03.002","article-title":"Rosacea associated with increased risk of generalized anxiety disorder: a case-control study of prevalence and risk of anxiety in patients with rosacea","volume":"94","author":"Incel Uysal","year":"2019","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0075","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s13555-021-00613-w","article-title":"Depression and anxiety in rosacea patients: a systematic review and meta-analysis","volume":"11","author":"Dai","year":"2021","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.abd.2025.501160_bib0080","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/jid.2015.53","article-title":"Assessment of the genetic basis of rosacea by genome-wide association study","volume":"135","author":"Chang","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0085","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s13555-020-00458-9","article-title":"The pathogenic role of demodex mites in rosacea: a potential therapeutic target already in erythematotelangiectatic rosacea?","volume":"10","author":"Forton","year":"2020","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.abd.2025.501160_bib0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5826\/dpc.0704a08","article-title":"Diet and rosacea: the role of dietary change in the management of rosacea","volume":"7","author":"Weiss","year":"2017","journal-title":"Dermatol Pract Concept"},{"key":"10.1016\/j.abd.2025.501160_bib0095","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/1346-8138.14771","article-title":"Relationship between rosacea and dietary factors: a multicenter retrospective case-control survey","volume":"46","author":"Yuan","year":"2019","journal-title":"J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0100","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jaad.2019.03.055","article-title":"Vascular endothelial growth factor gene polymorphisms in patients with rosacea: a case-control study","volume":"81","author":"Hayran","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0105","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2133.2000.03707.x","article-title":"Transforming growth factor-beta1 and ultraviolet A1 radiation increase production of vascular endothelial growth factor but not endothelin-1 in human dermal fibroblasts","volume":"143","author":"Trompezinski","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0110","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/jid.2010.351","article-title":"TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes","volume":"131","author":"Yamasaki","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0115","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/jid.2014.222","article-title":"Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea","volume":"134","author":"Muto","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jdermsci.2015.12.006","article-title":"The role of altered cutaneous immune responses in the induction and persistence of rosacea","volume":"82","author":"Margalit","year":"2016","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.abd.2025.501160_bib0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.det.2017.11.001","article-title":"Rosacea pathogenesis","volume":"36","author":"Ahn","year":"2018","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.abd.2025.501160_bib0130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.intimp.2018.12.031","article-title":"Tranexamic acid ameliorates rosacea symptoms through regulating immune response and angiogenesis","volume":"67","author":"Li","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.abd.2025.501160_bib0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/abd1806-4841.20163541","article-title":"Skin barrier in rosacea","volume":"91","author":"Addor","year":"2016","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0140","first-page":"SF3595563","article-title":"Supplement article: skin barrier deficiency in rosacea: an algorithm integrating OTC skincare products into treatment regimens","volume":"21","author":"Baldwin","year":"2022","journal-title":"J Drugs Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0145","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.clindermatol.2021.10.004","article-title":"Rosacea pathogenesis, common triggers, and dietary role: the cause, the trigger, and the positive effects of different foods","volume":"40","author":"Alia","year":"2022","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0150","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jaad.2017.09.016","article-title":"Comorbidities in rosacea: a systematic review and update","volume":"78","author":"Haber","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0155","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1684\/ejd.2016.2748","article-title":"The relationship between rosacea and insulin resistance and metabolic syndrome","volume":"26","author":"Akin Belli","year":"2016","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0160","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1590\/S0365-05962008000500004","article-title":"Fatores associados \u00e0 ros\u00e1cea em amostras populacionais do Sul do Brasil: an\u00e1lise de estudos casos-controles","volume":"83","author":"Bonamigo","year":"2008","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0165","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1590\/abd1806-4841.20187192","article-title":"Rosacea-specific quality of life questionnaire: translation, cultural adaptation and validation for Brazilian Portuguese","volume":"93","author":"Tannus","year":"2018","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0170","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2147\/CCID.S139352","article-title":"An empirically generated responder definition for rosacea treatment","volume":"10","author":"Staedtler","year":"2017","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0175","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jaad.2004.01.048","article-title":"Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea","volume":"50","author":"Wilkin","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0180","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.jaad.2018.08.049","article-title":"Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: review and clinical practice experience","volume":"80","author":"Alexis","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0185","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2147\/CCID.S201290","article-title":"Rhinophyma: prevalence, severity, impact and management","volume":"13","author":"Chauhan","year":"2020","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0190","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/ijd.15989","article-title":"Epidemiology of rosacea in a population-based study of 161,269 German employees","volume":"61","author":"Hilbring","year":"2022","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0195","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archderm.1988.01670060015008","article-title":"The validity and practicality of sun-reactive skin types I through VI","volume":"124","author":"Fitzpatrick","year":"1988","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0200","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/ijd.13491","article-title":"Epidemiology of rosacea in Colombia","volume":"56","author":"Rueda","year":"2017","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0205","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.abd.2020.08.001","article-title":"Consensus on the therapeutic management of rosacea \u2013 Brazilian Society of Dermatology","volume":"95","author":"Oliveira","year":"2020","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0210","series-title":"A\u00e7\u00e3o afirmativa e popula\u00e7\u00e3o negra na Educa\u00e7\u00e3o Superior: acesso e perfil discente. Texto para Discuss\u00e3o, No 2569","author":"Silva","year":"2020"},{"key":"10.1016\/j.abd.2025.501160_bib0215","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/j.1468-3083.2010.03802.x","article-title":"Prevalence analysis of smoking in rosacea","volume":"25","author":"Breton","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.abd.2025.501160_bib0220","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0738-081X(98)00044-3","article-title":"Cigarette smoking, cutaneous immunity, and inflammatory response","volume":"16","author":"Mills","year":"1998","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0225","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nri803","article-title":"Effects of cigarette smoke on the immune system","volume":"2","author":"Sopori","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.abd.2025.501160_bib0230","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.0906-6705.2004.00274.x","article-title":"Nicotine effects on skin: are they positive or negative?","volume":"13","author":"Misery","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0235","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jaad.2017.02.040","article-title":"Alcohol intake and risk of rosacea in US women","volume":"76","author":"Li","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0240","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1111\/jocd.14483","article-title":"Alcohol consumption and the risk of rosacea: a systematic review and meta-analysis","volume":"21","author":"Liu","year":"2022","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0245","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.jaad.2017.08.032","article-title":"Obesity and risk for incident rosacea in US women","volume":"77","author":"Li","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0250","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1001\/jamadermatol.2015.2230","article-title":"Genetic vs environmental factors that correlate with rosacea: a cohort-based survey of twins","volume":"151","author":"Aldrich","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0255","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/hr.2011.32","article-title":"Worsening of rosacea in patients treated with dihydropyridine calcium channel blockers: a clinical observation","volume":"34","author":"Natale","year":"2011","journal-title":"Hypertens Res"},{"key":"10.1016\/j.abd.2025.501160_bib0260","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/bjd.12838","article-title":"Antihypertensive drugs and the risk of incident rosacea","volume":"171","author":"Spoendlin","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0265","doi-asserted-by":"crossref","first-page":"676","DOI":"10.5021\/ad.2018.30.6.676","article-title":"The risk of rosacea according to chronic diseases and medications: a 5-year retrospective, multi-institutional case-control study","volume":"30","author":"Son","year":"2018","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0270","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jaad.2014.05.036","article-title":"The psychological impact of rosacea and the influence of current management options","volume":"71","author":"Moustafa","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0275","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/jocd.12903","article-title":"Global rosacea treatment guidelines and expert consensus points: the differences","volume":"18","author":"Juliandri","year":"2019","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0280","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jaad.2019.05.063","article-title":"A randomized phase 3b\/4 study to evaluate concomitant use of topical ivermectin 1% cream and doxycycline 40-mg modified-release capsules, versus topical ivermectin 1% cream and placebo in the treatment of severe rosacea","volume":"82","author":"Schaller","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0285","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/jamadermatol.2022.0526","article-title":"Assessment of frequency of rosacea subtypes in patients with rosacea: a systematic review and meta-analysis","volume":"158","author":"Barakji","year":"2022","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0290","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v101.356","article-title":"The importance of assessing burning and stinging when managing rosacea: a review","volume":"101","author":"Schaller","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.abd.2025.501160_bib0295","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jaad.2017.07.055","article-title":"Evidence-based update on rosacea comorbidities and their common physiologic pathways","volume":"78","author":"Holmes","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0300","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.clindermatol.2019.07.032","article-title":"Is rosacea a systemic disease?","volume":"37","author":"Wollina","year":"2019","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0305","article-title":"Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization","volume":"13","author":"Li","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.abd.2025.501160_bib0310","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/ajd.13401","article-title":"Rosacea and the gastrointestinal system","volume":"61","author":"Searle","year":"2020","journal-title":"Australas J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0315","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s12325-021-01624-x","article-title":"Rosacea, germs, and bowels: a review on gastrointestinal comorbidities and gut\u2013skin axis of rosacea","volume":"38","author":"Wang","year":"2021","journal-title":"Adv Ther"},{"key":"10.1016\/j.abd.2025.501160_bib0320","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/diagnostics14010023","article-title":"Evaluation of dermatological and neurological aspects of the relationship between rosacea and headaches","volume":"14","author":"Alizada","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.abd.2025.501160_bib0325","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/bjd.20578","article-title":"Male patients with rosacea have increased risk for migraine: a population-based study","volume":"185","author":"Sinikumpu","year":"2021","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0330","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.det.2017.11.006","article-title":"Rosacea comorbidities","volume":"36","author":"Vera","year":"2018","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.abd.2025.501160_bib0335","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1177\/12034754231204295","article-title":"The mind body connection in dermatologic conditions: a literature review","volume":"27","author":"Mar","year":"2023","journal-title":"J Cutan Med Surg"},{"key":"10.1016\/j.abd.2025.501160_bib0340","doi-asserted-by":"crossref","DOI":"10.2196\/47821","article-title":"Rosacea and its association with malignancy: systematic review","volume":"6","author":"Thapa","year":"2023","journal-title":"JMIR Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0345","article-title":"Association between rosacea and cardiovascular diseases and related risk factors: a systematic review and meta-analysis","volume":"2020","author":"Li","year":"2020","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.abd.2025.501160_bib0350","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3668","article-title":"Cardiovascular risk and comorbidities in patients with rosacea: a systematic review and meta-analysis","volume":"100","author":"Tsai","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.abd.2025.501160_bib0355","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1111\/jocd.13884","article-title":"Association between rosacea and cardiovascular disease: a systematic review and meta\u2010analysis","volume":"20","author":"Zhang","year":"2021","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0360","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.3390\/ijms24087053","article-title":"Lipid alterations and metabolism disturbances in selected inflammatory skin diseases","volume":"24","author":"Nowowiejska","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.abd.2025.501160_bib0365","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.jaad.2021.06.028","article-title":"Rosacea and subsequent diagnosis of venous thromboemboliS.m: a large, urban academic center case-control study","volume":"86","author":"Yi","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0370","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.det.2017.11.005","article-title":"Psychosocial burden and other impacts of rosacea on patients\u2019 quality of life","volume":"36","author":"Oussedik","year":"2018","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.abd.2025.501160_bib0375","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/jdv.18918","article-title":"Quality of life measurement in rosacea. Position statement of the European Academy of Dermatology and Venereology task forces on quality of life and patient-oriented outcomes and acne, rosacea and hidradenitis suppurativa","volume":"37","author":"Chernyshov","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.abd.2025.501160_bib0380","first-page":"180","article-title":"Aggravating factors of rosacea","volume":"65","author":"Jaworek","year":"2008","journal-title":"Przegl Lek"},{"key":"10.1016\/j.abd.2025.501160_bib0385","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1111\/jocd.14020","article-title":"Impact of ultraviolet radiation and exposome on rosacea: key role of photoprotection in optimizing treatment","volume":"20","author":"Morgado-Carrasco","year":"2021","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.abd.2025.501160_bib0390","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/15598276211026592","article-title":"Diet in dermatology: review of diet\u2019s influence on the conditions of rosacea, hidradenitis suppurativa, herpes labialis, and vitiligo","volume":"17","author":"Jamgochian","year":"2021","journal-title":"Am J Lifestyle Med"},{"key":"10.1016\/j.abd.2025.501160_bib0395","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1001\/jamadermatol.2018.3301","article-title":"Association of caffeine intake and caffeinated coffee consumption with risk of incident rosacea in women","volume":"154","author":"Li","year":"2018","journal-title":"JAMA Dermatol"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059625001023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365059625001023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:12:25Z","timestamp":1758910345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0365059625001023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":79,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0365059625001023"],"URL":"https:\/\/doi.org\/10.1016\/j.abd.2025.501160","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical-demographic profile, aggravating factors, comorbidities, and quality of life in patients with Rosacea: a Brazilian multicenter study (GBPER: Brazilian Research and Studies Group on Rosacea)","name":"articletitle","label":"Article Title"},{"value":"Anais Brasileiros de Dermatologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abd.2025.501160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Sociedade Brasileira de Dermatologia. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"501160"}}