{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:15:57Z","timestamp":1788671757233,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32430009"],"award-info":[{"award-number":["32430009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD2200601"],"award-info":[{"award-number":["2022YFD2200601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["aBIOTECH"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.abiote.2026.100085","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T23:45:21Z","timestamp":1786059921000},"page":"100085","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic engineering of Saccharomyces cerevisiae for de novo biosynthesis of isoorientin"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5006-1180","authenticated-orcid":false,"given":"Zhaoyun","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-115X","authenticated-orcid":false,"given":"Xiaoquan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/jipb.13054","article-title":"Contribution of phenylpropanoid metabolism to plant development and plant-environment interactions","volume":"63","author":"Dong","year":"2021","journal-title":"J Integr Plant Biol"},{"issue":"4","key":"10.1016\/j.abiote.2026.100085_bib2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3945\/ajcn.115.109249","article-title":"Flavonoid intake and incident hypertension in women","volume":"103","author":"Lajous","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.abiote.2026.100085_bib3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.biopha.2018.02.142","article-title":"Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair","volume":"101","author":"Huang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.abiote.2026.100085_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105753","article-title":"Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice","volume":"75","author":"Zhang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.abiote.2026.100085_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2018.10.036","article-title":"Antiviral activity of ethanol extract of Lophatherum gracile against respiratory syncytial virus infection","volume":"242","author":"Chen","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.abiote.2026.100085_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108599","article-title":"Isoorientin attenuates benzo[a]pyrene-induced colonic injury and gut microbiota disorders in mice","volume":"126","author":"He","year":"2019","journal-title":"Food Res Int"},{"issue":"37","key":"10.1016\/j.abiote.2026.100085_bib7","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.1021\/acs.jafc.8b03568","article-title":"Effects of natural flavonoid isoorientin on growth performance and gut microbiota of mice","volume":"66","author":"Yuan","year":"2018","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.abiote.2026.100085_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127807","article-title":"Structural characterization and stability study of green synthesized starch stabilized silver nanoparticles loaded with isoorientin","volume":"338","author":"Wang","year":"2021","journal-title":"Food Chem"},{"issue":"12","key":"10.1016\/j.abiote.2026.100085_bib9","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1002\/ps.5434","article-title":"Laboratory and field evaluation of the aphidicidal activity of moso bamboo (Phyllostachys pubescens) leaf extract and identification of the active components","volume":"75","author":"Gao","year":"2019","journal-title":"Pest Manag Sci"},{"issue":"6","key":"10.1016\/j.abiote.2026.100085_bib10","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1002\/fsn3.3325","article-title":"Natural extracts against agricultural pathogens: a case study of Celtis australis L","volume":"11","author":"Perovi\u0107","year":"2023","journal-title":"Food Sci Nutr"},{"key":"10.1016\/j.abiote.2026.100085_bib11","doi-asserted-by":"crossref","first-page":"skad047","DOI":"10.1093\/jas\/skad047","article-title":"Antimicrobial and antibiofilm activity of isoorientin against carbapenem non-sensitive Escherichia coli from raw milk of goats","volume":"101","author":"Zuo","year":"2023","journal-title":"J Anim Sci"},{"issue":"9","key":"10.1016\/j.abiote.2026.100085_bib12","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/jipb.12204","article-title":"Comprehensive profiling and natural variation of flavonoids in rice","volume":"56","author":"Dong","year":"2014","journal-title":"J Integr Plant Biol"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/tpj.15549","article-title":"Natural variation of ZmCGT1 is responsible for isoorientin accumulation in maize silk","volume":"109","author":"Sun","year":"2022","journal-title":"Plant J"},{"issue":"3","key":"10.1016\/j.abiote.2026.100085_bib19","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00253-017-8694-6","article-title":"Biosynthesis of flavone C-glucosides in engineered Escherichia coli","volume":"102","author":"Shrestha","year":"2018","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"10.1016\/j.abiote.2026.100085_bib13","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1104\/pp.114.239723","article-title":"Cytochrome P450 93G1 is a flavone synthase II that channels flavanones to the biosynthesis of tricin O-linked conjugates in rice","volume":"165","author":"Lam","year":"2014","journal-title":"Plant Physiol"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.febslet.2014.11.045","article-title":"Identification of the glucosyltransferase that mediates direct flavone C-glucosylation in Gentiana triflora","volume":"589","author":"Sasaki","year":"2015","journal-title":"FEBS Lett"},{"key":"10.1016\/j.abiote.2026.100085_bib15","article-title":"Flavone synthases from Lonicera japonica and L. macranthoides reveal differential flavone accumulation","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s42003-020-0834-3","article-title":"Pathway-specific enzymes from bamboo and crop leaves biosynthesize anti-nociceptive C-glycosylated flavones","volume":"3","author":"Sun","year":"2020","journal-title":"Commun Biol"},{"issue":"27","key":"10.1016\/j.abiote.2026.100085_bib18","doi-asserted-by":"crossref","first-page":"17926","DOI":"10.1074\/jbc.M109.009258","article-title":"The C-glycosylation of flavonoids in cereals","volume":"284","author":"Brazier-Hicks","year":"2009","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1021\/acs.jafc.8b05958","article-title":"Efficient biotransformation of luteolin to isoorientin through adjusting induction strategy, controlling acetic acid, and increasing UDP-Glucose supply in Escherichia coli","volume":"67","author":"Pei","year":"2019","journal-title":"J Agric Food Chem"},{"issue":"2","key":"10.1016\/j.abiote.2026.100085_bib21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12010-019-03112-z","article-title":"Production of isoorientin and isovitexin from luteolin and apigenin using coupled catalysis of glycosyltransferase and sucrose synthase","volume":"190","author":"Pei","year":"2020","journal-title":"Appl Biochem Biotechnol"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1021\/acssuschemeng.3c04761","article-title":"Synergetic engineering of multiple pathways for de novo (2S)-naringenin biosynthesis in Saccharomyces cerevisiae","volume":"12","author":"Li","year":"2024","journal-title":"ACS Sustainable Chem Eng"},{"key":"10.1016\/j.abiote.2026.100085_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.125978","article-title":"Metabolism and strategies for enhanced supply of acetyl-CoA in Saccharomyces cerevisiae","volume":"342","author":"Zhang","year":"2021","journal-title":"Bioresour Technol"},{"issue":"13","key":"10.1016\/j.abiote.2026.100085_bib24","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1039\/D4GC05241B","article-title":"Engineering budding yeast for the de novo synthesis of valuable flavanone derivatives","volume":"27","author":"Zhu","year":"2025","journal-title":"Green Chem"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12934-018-0952-5","article-title":"Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae","volume":"17","author":"Vanegas","year":"2018","journal-title":"Microb Cell Fact"},{"issue":"35","key":"10.1016\/j.abiote.2026.100085_bib26","doi-asserted-by":"crossref","first-page":"19436","DOI":"10.1021\/acs.jafc.4c05546","article-title":"De Novo biosynthesis of dihydroquercetin in Saccharomyces cerevisiae","volume":"72","author":"Li","year":"2024","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.abiote.2026.100085_bib27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ymben.2017.06.008","article-title":"Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors","volume":"42","author":"Su\u00e1stegui","year":"2017","journal-title":"Metab Eng"},{"key":"10.1016\/j.abiote.2026.100085_bib28","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ymben.2025.02.001","article-title":"Metabolic division engineering of Escherichia coli consortia for de novo biosynthesis of flavonoids and flavonoid glycosides","volume":"89","author":"Qiu","year":"2025","journal-title":"Metab Eng"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib29","doi-asserted-by":"crossref","first-page":"8759","DOI":"10.1038\/s41467-024-53045-3","article-title":"De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast","volume":"15","author":"Jiao","year":"2024","journal-title":"Nat Commun"},{"issue":"14","key":"10.1016\/j.abiote.2026.100085_bib30","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1007\/s00253-020-10643-7","article-title":"Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis","volume":"104","author":"Milke","year":"2020","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.abiote.2026.100085_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ymben.2012.11.002","article-title":"Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism","volume":"15","author":"Chen","year":"2013","journal-title":"Metab Eng"},{"key":"10.1016\/j.abiote.2026.100085_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymben.2022.05.007","article-title":"Metabolic engineering of the malonyl-CoA pathway to efficiently produce malonate in Saccharomyces cerevisiae","volume":"73","author":"Li","year":"2022","journal-title":"Metab Eng"},{"issue":"3","key":"10.1016\/j.abiote.2026.100085_bib33","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1021\/acssynbio.4c00665","article-title":"Engineering a yeast cell factory to sustainably biosynthesize parthenolide","volume":"14","author":"Wei","year":"2025","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.abiote.2026.100085_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11709","article-title":"Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories","volume":"7","author":"Zhou","year":"2016","journal-title":"Nat Commun"},{"issue":"31","key":"10.1016\/j.abiote.2026.100085_bib35","doi-asserted-by":"crossref","first-page":"19176","DOI":"10.1074\/jbc.272.31.19176","article-title":"Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5","volume":"272","author":"Urban","year":"1997","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.abiote.2026.100085_bib36","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1039\/D3NP00005B","article-title":"Engineering yeast for the production of plant terpenoids using synthetic biology approaches","volume":"40","author":"Bureau","year":"2023","journal-title":"Nat Prod Rep"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib37","doi-asserted-by":"crossref","first-page":"kiaf297","DOI":"10.1093\/plphys\/kiaf297","article-title":"Plant cytochrome P450 enzymes for bioactive metabolites biosynthesis, growth regulation, and stress adaptation","volume":"199","author":"Liu","year":"2025","journal-title":"Plant Physiol"},{"issue":"10","key":"10.1016\/j.abiote.2026.100085_bib38","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1016\/j.apsb.2024.05.019","article-title":"Engineering the microenvironment of P450s to enhance the production of diterpenoids in Saccharomyces cerevisiae","volume":"14","author":"Cheng","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.abiote.2026.100085_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.129421","article-title":"Metabolic engineering of Yarrowia lipolytica for high-level production of scutellarin","volume":"385","author":"Zhang","year":"2023","journal-title":"Bioresour Technol"},{"issue":"10","key":"10.1016\/j.abiote.2026.100085_bib40","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1021\/acs.jafc.2c09028","article-title":"Systematic engineering to enhance 8-hydroxygeraniol production in yeast","volume":"71","author":"Wang","year":"2023","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.abiote.2026.100085_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12934-015-0252-2","article-title":"Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics","volume":"14","author":"Gold","year":"2015","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.abiote.2026.100085_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.103996","article-title":"Integrative metabolic and cellular organelle engineering for improving biosynthesis of flavonoid compounds in Saccharomyces cerevisiae","volume":"60","author":"Wang","year":"2024","journal-title":"Food Biosci"},{"key":"10.1016\/j.abiote.2026.100085_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2025.132387","article-title":"Efficient synthesis of high-active multi-subunit hemoglobins through balanced expression of globins and robust heme-supply in Saccharomyces cerevisiae","volume":"426","author":"Liu","year":"2025","journal-title":"Bioresour Technol"},{"issue":"1","key":"10.1016\/j.abiote.2026.100085_bib44","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1091\/mbc.01-07-0366","article-title":"IN02, a positive regulator of lipid biosynthesis, is essential for the formation of inducible membranes in yeast","volume":"13","author":"Block-Alper","year":"2002","journal-title":"Mol Biol Cell"},{"issue":"22","key":"10.1016\/j.abiote.2026.100085_bib45","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021107958","article-title":"Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex","volume":"40","author":"Papagiannidis","year":"2021","journal-title":"EMBO J"},{"key":"10.1016\/j.abiote.2026.100085_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2025.132294","article-title":"Orchestrating multiple subcellular organelles of Saccharomyces cerevisiae for efficient production of squalene","volume":"424","author":"Tang","year":"2025","journal-title":"Bioresour Technol"},{"issue":"Pt2","key":"10.1016\/j.abiote.2026.100085_bib47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1242\/jcs.101.2.315","article-title":"Characterization of endoplasmic reticulum by co-localization of BiP and dicarbocyanine dyes","volume":"101","author":"Terasaki","year":"1992","journal-title":"J Cell Sci"},{"issue":"14","key":"10.1016\/j.abiote.2026.100085_bib48","doi-asserted-by":"crossref","first-page":"8140","DOI":"10.1021\/acs.jafc.4c01483","article-title":"Efficient conversion of stevioside to Rebaudioside M in Saccharomyces cerevisiae by a engineering hydrolase system and prolonging the growth cycle","volume":"72","author":"Li","year":"2024","journal-title":"J Agric Food Chem"},{"issue":"5","key":"10.1016\/j.abiote.2026.100085_bib49","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/bab.2256","article-title":"Biosynthesis of phenylpyruvic acid from L-phenylalanine using chromosomally engineered Escherichia coli","volume":"69","author":"Xiong","year":"2022","journal-title":"Biotechnol Appl Biochem"},{"key":"10.1016\/j.abiote.2026.100085_bib50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ymben.2023.09.004","article-title":"Combinatorial optimization and spatial remodeling of CYPs to control product profile","volume":"80","author":"Yang","year":"2023","journal-title":"Metab Eng"},{"issue":"8","key":"10.1016\/j.abiote.2026.100085_bib51","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.1021\/acscatal.5c01569","article-title":"Rational engineering of self-sufficient P450s to boost catalytic efficiency of carbene-mediated C-S bond formation","volume":"15","author":"Wang","year":"2025","journal-title":"ACS Catal"},{"issue":"12","key":"10.1016\/j.abiote.2026.100085_bib52","doi-asserted-by":"crossref","first-page":"uhad235","DOI":"10.1093\/hr\/uhad235","article-title":"Gap-free genome assembly and CYP450 gene family analysis reveal the biosynthesis of anthocyanins in Scutellaria baicalensis","volume":"10","author":"Pei","year":"2023","journal-title":"Hortic Res"},{"issue":"4","key":"10.1016\/j.abiote.2026.100085_bib53","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1021\/acscatal.4c06342","article-title":"Semirationally engineering an efficient P450 peroxygenase for regio- and enantioselective hydroxylation of steroids","volume":"15","author":"Fan","year":"2025","journal-title":"ACS Catal"},{"key":"10.1016\/j.abiote.2026.100085_bib54","article-title":"Engineering P450BM3 for highly regio- and stereoselective C15\u03b1-hydroxylation of D-ethylgonendione","volume":"587","author":"Yu","year":"2025","journal-title":"Mol Catal"},{"issue":"8","key":"10.1016\/j.abiote.2026.100085_bib55","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/biot.201600147","article-title":"EasyClone-MarkerFree: a vector toolkit for marker-less integration of genes into Saccharomyces cerevisiae via CRISPR-Cas9","volume":"11","author":"Jessop-Fabre","year":"2016","journal-title":"Biotechnol J"},{"key":"10.1016\/j.abiote.2026.100085_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2025.132294","article-title":"Orchestrating multiple subcellular organelles of Saccharomyces cerevisiae for efficient production of squalene","volume":"424","author":"Tang","year":"2025","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.abiote.2026.100085_bib57","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ymben.2024.07.007","article-title":"Multidimensional engineering of Saccharomyces cerevisiae for the efficient production of heme by exploring the cytotoxicity and tolerance of heme","volume":"85","author":"Guo","year":"2024","journal-title":"Metab Eng"}],"container-title":["aBIOTECH"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2662173826000998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2662173826000998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:46:06Z","timestamp":1788669966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2662173826000998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S2662173826000998"],"URL":"https:\/\/doi.org\/10.1016\/j.abiote.2026.100085","relation":{},"ISSN":["2662-1738"],"issn-type":[{"value":"2662-1738","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic engineering of Saccharomyces cerevisiae for de novo biosynthesis of isoorientin","name":"articletitle","label":"Article Title"},{"value":"aBIOTECH","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.abiote.2026.100085","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Agricultural Information Institute of CAAS.","name":"copyright","label":"Copyright"}],"article-number":"100085"}}