{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:06:17Z","timestamp":1791155177253,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.aca.2015.08.031","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T22:15:02Z","timestamp":1440540902000},"page":"49-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Setting local rank constraints by orthogonal projections for image resolution analysis: Application to the determination of a low dose pharmaceutical compound"],"prefix":"10.1016","volume":"892","author":[{"given":"Mathieu","family":"Boiret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"de Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Gorretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves-Michel","family":"Ginot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Roger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2015.08.031_bib1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jpba.2008.08.014","article-title":"Pharmaceutical applications of vibrational chemical imaging and chemometrics: a review","volume":"48","author":"Gendrin","year":"2008","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.aca.2015.08.031_bib2","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.trac.2008.05.010","article-title":"Study of pharmaceutical samples by NIR chemical-image and multivariate analysis","volume":"27","author":"Amigo","year":"2008","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.aca.2015.08.031_bib3","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/jrs.2943","article-title":"Comparison of chemometric methods in the analysis of pharmaceuticals with hyperspectral Raman imaging","volume":"42","author":"Vajna","year":"2011","journal-title":"J.\u00a0Raman Spectrosc."},{"key":"10.1016\/j.aca.2015.08.031_bib4","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1366\/000370206777412103","article-title":"Defining a strategy for chemical imaging of industrial pharmaceutical samples on Raman line-mapping and global illumination instruments","volume":"60","author":"\u0160a\u0161i\u0107","year":"2006","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.aca.2015.08.031_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jpba.2013.11.025","article-title":"Application of independent component analysis on Raman images of a pharmaceutical drug product: pure spectra determination and spatial distribution of constituents","volume":"90","author":"Boiret","year":"2014","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.aca.2015.08.031_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/cem.986","article-title":"Hyperspectral image regression. Part II: dataset preprocessing diagnostics","volume":"20","author":"Burger","year":"2006","journal-title":"J.\u00a0Chemom."},{"key":"10.1016\/j.aca.2015.08.031_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chemolab.2011.12.004","article-title":"Relevant aspects of quantification and sample heterogeneity in hyperspectral image resolution","volume":"117","author":"Piqueras","year":"2012","journal-title":"Chemom. Intell. Lab."},{"key":"10.1016\/j.aca.2015.08.031_bib8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0165-9936(04)00101-3","article-title":"Spectroscopic imaging and chemometrics: a powerful combination for global and local sample analysis","volume":"23","author":"de Juan","year":"2004","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.aca.2015.08.031_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.talanta.2007.04.054","article-title":"Content uniformity of pharmaceutical solid dosage forms by near infrared hyperspectral imaging: a feasibility study","volume":"73","author":"Gendrin","year":"2007","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2015.08.031_bib10","series-title":"Infrared and Raman Spectroscopic Imaging: second, Completely Revised and Updated Edition","first-page":"57","article-title":"Chemometric tools for image analysis","author":"de Juan","year":"2014"},{"key":"10.1016\/j.aca.2015.08.031_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chemolab.2004.11.006","article-title":"Local rank analysis for exploratory spectroscopic image analysis. Fixed size image-window-evolving factor analysis","volume":"77","author":"de Juan","year":"2005","journal-title":"Chemom. Intell. Lab."},{"key":"10.1016\/j.aca.2015.08.031_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jpba.2014.10.024","article-title":"Distribution of a low dose compound within pharmaceutical tablet by using multivariate curve resolution on Raman hyperspectral images","volume":"103","author":"Boiret","year":"2015","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.aca.2015.08.031_bib13","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jpba.2010.06.003","article-title":"Acetaminophen determination in low-dose pharmaceutical syrup by NIR spectroscopy","volume":"53","author":"Ziemons","year":"2010","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.aca.2015.08.031_bib14","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.talanta.2005.01.051","article-title":"Near-infrared determination of active substance content in intact low-dosage tablets","volume":"66","author":"Chalus","year":"2005","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2015.08.031_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jpba.2012.07.026","article-title":"High-throughput NIR-chemometric methods for determination of drug content and pharmaceutical properties of indapamide powder blends for tableting","volume":"70","author":"Porfire","year":"2012","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.aca.2015.08.031_bib16","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1002\/jps.21373","article-title":"Analysis of low content drug tablets by transmission near infrared spectroscopy: selection of calibration ranges according to multivariate detection and quantitation limits of PLS models","volume":"97","author":"Alcal\u00e0","year":"2008","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.aca.2015.08.031_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.aca.2008.10.006","article-title":"The use of net analyte signal (NAS) in near infrared spectroscopy pharmaceutical applications: interpretability and figures of merit","volume":"642","author":"Cruz Sarragu\u00e7a","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2015.08.031_bib18","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1021\/ac00297a042","article-title":"Error propagation and figures of merit for quantification by solving matrix equations","volume":"58","author":"Lorber","year":"1986","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2015.08.031_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0169-7439(03)00118-7","article-title":"Net analyte signal calculation for multivariate calibration","volume":"69","author":"Ferr\u00e9","year":"2003","journal-title":"Chemom. Intell. Lab."},{"key":"10.1016\/j.aca.2015.08.031_bib20","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/ac960862b","article-title":"Net analyte signal calculation in multivariate calibration","volume":"69","author":"Lorber","year":"1997","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2015.08.031_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.chemolab.2012.02.002","article-title":"Pretreatments by means of orthogonal projections","volume":"117","author":"Boulet","year":"2012","journal-title":"Chemom. Intell. Lab."},{"key":"10.1016\/j.aca.2015.08.031_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0169-7439(01)00110-1","article-title":"A\u00a0comparison of orthogonal signal correction and net analyte preprocessing methods. Theoretical and experimental study","volume":"56","author":"Goicoechea","year":"2001","journal-title":"Chemom. Intell. Lab."},{"key":"10.1016\/j.aca.2015.08.031_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.aca.2012.05.002","article-title":"Applications of direct calibration in multivariate image analysis of heterogeneous materials","volume":"734","author":"Jaillais","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2015.08.031_bib24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.aca.2006.08.018","article-title":"Determination of low analyte concentrations by near-infrared spectroscopy: effect of spectral pretreatments and estimation of multivariate detection limits","volume":"581","author":"Blanco","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2015.08.031_bib25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0003-2670(03)00724-4","article-title":"Chemometrics applied to unravel multicomponent processes and mixtures revisiting latest trends in multivariate resolution","volume":"500","author":"de Juan","year":"2003","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2015.08.031_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemolab.2014.10.003","article-title":"MCR-ALS GUI 2.0: new features and applications","volume":"140","author":"Jaumot","year":"2015","journal-title":"Chemom. Intell. Lab."},{"key":"10.1016\/j.aca.2015.08.031_bib27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/cem.1099","article-title":"Use of local rank-based spatial information for resolution of spectroscopic images","volume":"22","author":"de Juan","year":"2008","journal-title":"J.\u00a0Chemom."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267015010090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267015010090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T14:58:41Z","timestamp":1532012321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267015010090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":27,"alternative-id":["S0003267015010090"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2015.08.031","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Setting local rank constraints by orthogonal projections for image resolution analysis: Application to the determination of a low dose pharmaceutical compound","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2015.08.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}