{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:52:50Z","timestamp":1778813570481,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China","award":["LR12C20001"],"award-info":[{"award-number":["LR12C20001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21277123"],"award-info":[{"award-number":["21277123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation for the Author of a Nationally Excellent Doctoral Dissertation of China","award":["201260"],"award-info":[{"award-number":["201260"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.aca.2015.08.033","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T18:14:05Z","timestamp":1440526445000},"page":"54-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Comprehensive profiling of mercapturic acid metabolites from dietary acrylamide as short-term exposure biomarkers for evaluation of toxicokinetics in rats and daily internal exposure in humans using isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry"],"prefix":"10.1016","volume":"894","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingshun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaojiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2015.08.033_bib1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/419448a","article-title":"Acrylamide is formed in the Maillard reaction","volume":"419","author":"Mottram","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.aca.2015.08.033_bib2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/419449a","article-title":"Acrylamide from Maillard reaction products","volume":"419","author":"Stadler","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.aca.2015.08.033_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev-food-022811-101114","article-title":"Acrylamide in foods: a review of the science and future considerations","volume":"3","author":"Lineback","year":"2012","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.aca.2015.08.033_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/10937400600681430","article-title":"A\u00a0Review of the Toxicology of Acrylamide","volume":"9","author":"Exon","year":"2006","journal-title":"J.\u00a0Toxicol. Environ. Health Pt B Crit. Rev."},{"key":"10.1016\/j.aca.2015.08.033_bib5","series-title":"Summary of Data Reported and Evaluation: Acrylamide","author":"International Agency for Research on Cancer (IARC)","year":"1994"},{"key":"10.1016\/j.aca.2015.08.033_bib6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1158\/1055-9965.EPI-08-0832","article-title":"In\u00a0vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans","volume":"18","author":"Doroshyenko","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.aca.2015.08.033_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.talanta.2014.07.042","article-title":"Determination of acrylamide and glycidamide in various biological matrices by liquid chromatography\u2013tandem mass spectrometry and its application to a pharmacokinetic study","volume":"131","author":"Kim","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2015.08.033_bib8","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00204-010-0605-x","article-title":"Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide","volume":"85","author":"Hartmann","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.aca.2015.08.033_bib9","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00216-011-5692-x","article-title":"Determination of 2,3-dihydroxypropionamide, an oxidative metabolite of acrylamide, in human urine by gas chromatography coupled with mass spectrometry","volume":"402","author":"Latzin","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aca.2015.08.033_bib10","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1021\/tx034108e","article-title":"DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice","volume":"16","author":"Gamboa da Costa","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.aca.2015.08.033_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0027-5107(95)00037-J","article-title":"Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk","volume":"330","author":"Dearfield","year":"1995","journal-title":"Mutat. Res."},{"key":"10.1016\/j.aca.2015.08.033_bib12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/toxsci\/kfi069","article-title":"Metabolism and hemoglobin adduct formation of acrylamide in humans","volume":"85","author":"Fennell","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.aca.2015.08.033_bib13","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.fct.2012.04.004","article-title":"Hemoglobin adducts as a measure of variations in exposure to acrylamide in food and comparison to questionnaire data","volume":"50","author":"Vikstr\u00f6m","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.aca.2015.08.033_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00204-005-0011-y","article-title":"Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide","volume":"80","author":"Boettcher","year":"2006","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.aca.2015.08.033_bib15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mrgentox.2004.11.010","article-title":"Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population","volume":"580","author":"Boettcher","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.aca.2015.08.033_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.taap.2008.12.001","article-title":"Toxicokinetics of acrylamide in rats and humans following single oral administration of low doses","volume":"235","author":"Kopp","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aca.2015.08.033_bib17","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1158\/1055-9965.EPI-05-0647","article-title":"Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity","volume":"15","author":"Fuhr","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.aca.2015.08.033_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2014.03.037","article-title":"Risk assessment, formation, and mitigation of dietary acrylamide: current status and future prospects","volume":"69","author":"Xu","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.aca.2015.08.033_bib19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00204-008-0369-8","article-title":"J.\u00a0N-Acetyl-S-(1-carbamoyl- 2-hydroxy-ethyl)-L-cysteine (iso-GAMA) a further product of human metabolism of acrylamide: comparison with the simultaneously excreted other mercaptuic acids","volume":"83","author":"Hartmann","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.aca.2015.08.033_bib20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0378-4347(01)00242-0","article-title":"Analysis of urinary N-acetyl-S-(N-methylcarbamoyl)cysteine, the mercapturic acid derived from N,N-dimethylformamide","volume":"759","author":"Perbellini","year":"2001","journal-title":"J.\u00a0Chromatogr. B"},{"key":"10.1016\/j.aca.2015.08.033_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0378-4347(96)00250-2","article-title":"Determination of urinary mercapturic acids of styrene in man by high-performance liquid chromatography with fluorescence detection","volume":"687","author":"Maestri","year":"1996","journal-title":"J.\u00a0Chromatogr. B"},{"key":"10.1016\/j.aca.2015.08.033_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0021-9673(99)00022-9","article-title":"Gas chromatography-negative ion chemical ionization mass spectrometry as a powerful tool for the detection of mercapturic acids and DNA and protein adducts as biomarkers of exposure to halogenated olefins","volume":"847","author":"V\u00f6lkel","year":"1999","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2015.08.033_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4155\/bio.09.185","article-title":"Stable isotope-dilution LC-MS for quantitative biomarker analysis","volume":"2","author":"Ciccimaro","year":"2010","journal-title":"Bioanalysis"},{"key":"10.1016\/j.aca.2015.08.033_bib24","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1021\/tx800468w","article-title":"Simultaneous determination of six mercapturic acid metabolites of volatile organic compounds in human urine","volume":"22","author":"Ding","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.aca.2015.08.033_bib25","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1002\/rcm.3659","article-title":"Simultaneous determination of mercapturic acids derived from ethylene oxide (HEMA), propylene oxide (2-HPMA), acrolein (3-HPMA), acrylamide (AAMA) and N,N-dimethylformamide (AMCC) in human urine using liquid chromatography\/tandem mass spectrometry","volume":"22","author":"Schettgen","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.aca.2015.08.033_bib26","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.taap.2004.07.001","article-title":"Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice","volume":"202","author":"Doerge","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aca.2015.08.033_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.taap.2005.03.003","article-title":"Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats","volume":"208","author":"Doerge","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aca.2015.08.033_bib28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chroma.2006.07.026","article-title":"Quantitation of mercapturic acids from acrylamide and glycidamide in human urine using a column switching tool with two trap columns and electrospray tandem mass spectrometry","volume":"1131","author":"Kellert","year":"2006","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2015.08.033_bib29","doi-asserted-by":"crossref","first-page":"9828","DOI":"10.1021\/jf801715f","article-title":"Rapid and sensitive HILIC-ESI-MS\/MS quantitation of polar metabolites of acrylamide in human urine using column switching with an online trap column","volume":"56","author":"Kopp","year":"2008","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.aca.2015.08.033_bib30","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1021\/ac1029538","article-title":"Ultra high-performance liquid chromatographytandem mass spectrometry for the simultaneous analysis of asparagine, sugars, and acrylamide in Maillard reactions","volume":"83","author":"Zhang","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2015.08.033_bib31","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.1021\/ac4019928","article-title":"Simultaneous analysis of acrylamide and its key precursors, intermediates, and products in model systems by liquid chromatography triple quadrupole mass spectrometry","volume":"85","author":"Liu","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2015.08.033_bib32","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/toxsci\/kfl069","article-title":"Kinetics of elimination of urinary metabolites of acrylamide in humans","volume":"93","author":"Fennell","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.aca.2015.08.033_bib33","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1016\/j.chroma.2009.06.084","article-title":"Theoretical and experimental comparison of mobile phase consumption between ultra-high-performance liquid chromatography and high performance liquid chromatography","volume":"1216","author":"Chen","year":"2009","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2015.08.033_bib34","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/jssc.200600451","article-title":"Selectivity in reversed-phase separations: general influence of solvent type and mobile phase pH","volume":"30","author":"Neue","year":"2007","journal-title":"J.\u00a0Sep. Sci."},{"key":"10.1016\/j.aca.2015.08.033_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9673(99)00331-3","article-title":"Simultaneous optimisation of gradient time, gradient shape and initial composition of the mobile phase in the high-performance liquid chromatography of homologous and oligomeric series","volume":"845","author":"Jandera","year":"1999","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2015.08.033_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.trac.2004.04.001","article-title":"Trends in quality in the analytical laboratory. II. Analytical method validation and quality assurance","volume":"23","author":"Taverniers","year":"2004","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.aca.2015.08.033_bib37","series-title":"Accuracy (Trueness and Precision) of Measurement Methods and Results","author":"International Standard Organization (ISO) Guide 5725","year":"1994"},{"key":"10.1016\/j.aca.2015.08.033_bib38","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1080\/08958370600748430","article-title":"Urinary mercapturic acids and a hemoglobin adduct for the dosimetry of acrylamide exposure in smokers and nonsmokers","volume":"18","author":"Urban","year":"2006","journal-title":"Inhal. Toxicol."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267015010119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267015010119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T21:20:21Z","timestamp":1537392021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267015010119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":38,"alternative-id":["S0003267015010119"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2015.08.033","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive profiling of mercapturic acid metabolites from dietary acrylamide as short-term exposure biomarkers for evaluation of toxicokinetics in rats and daily internal exposure in humans using isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2015.08.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}