{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:08:24Z","timestamp":1776402504095,"version":"3.51.2"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008257","name":"Tarbiat Modares University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.aca.2016.07.048","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T19:48:49Z","timestamp":1470253729000},"page":"61-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Simultaneous extraction of acidic and basic drugs via on-chip electromembrane extraction"],"prefix":"10.1016","volume":"937","author":[{"given":"Yousef Abdossalami","family":"Asl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadollah","family":"Yamini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Seidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Rezazadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2016.07.048_bib1","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1021\/ac301421k","article-title":"Automated liquid\u2013liquid extraction by pneumatic recirculation on a centrifugal microfluidic platform","volume":"84","author":"Kazarine","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib2","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1021\/ac800088s","article-title":"Microfluidic droplet-based Liquid\u2212Liquid extraction","volume":"80","author":"Mary","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib3","series-title":"1-Materials and Methods for the Microfabrication of Microfluidic Biomedical Devices, Microfluidic Devices for Biomedical Applications","first-page":"3","author":"Wu","year":"2013"},{"key":"10.1016\/j.aca.2016.07.048_bib4","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1021\/ac401606p","article-title":"Microfluidic droplet-based liquid\u2013liquid extraction and on-chip IR spectroscopy detection of cocaine in human saliva","volume":"85","author":"W\u00e4gli","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.aca.2005.04.033","article-title":"Microfluidic supported liquid membrane extraction","volume":"543","author":"Wang","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2016.07.048_bib6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.talanta.2006.02.069","article-title":"Microfluidic liquid\u2013liquid extraction system based on stopped-flow technique and liquid core waveguide capillary","volume":"70","author":"Sun","year":"2006","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2016.07.048_bib7","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1039\/C4LC01460J","article-title":"Microfluidic droplet-based liquid-liquid extraction: online model validation","volume":"15","author":"Lubej","year":"2015","journal-title":"Lab a Chip"},{"key":"10.1016\/j.aca.2016.07.048_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1021\/ac049068d","article-title":"Microfluidic chip for peptide analysis with an integrated HPLC column, sample enrichment column, and nanoelectrospray tip","volume":"77","author":"Yin","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib9","series-title":"7-Microfluidic Devices for Drug Discovery and Analysis, Microfluidic Devices for Biomedical Applications","first-page":"231","author":"Kochhar","year":"2013"},{"key":"10.1016\/j.aca.2016.07.048_bib10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.talanta.2015.02.046","article-title":"Liquid\u2013liquid extraction of uranium(VI) with Aliquat\u00ae 336 from HCl media in microfluidic devices: combination of micro-unit operations and online ICP-MS determination","volume":"139","author":"Hell\u00e9","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2016.07.048_bib11","series-title":"Liquid\u2013Liquid Extraction in Environmental Analysis","first-page":"39","author":"Hii","year":"2010"},{"key":"10.1016\/j.aca.2016.07.048_bib12","series-title":"Treatise on Geochemistry","first-page":"147","article-title":"15.8-Separation methods based on liquid\u2013liquid extraction, extraction chromatography, and other miscellaneous solid phase extraction processes","author":"Pin","year":"2014"},{"key":"10.1016\/j.aca.2016.07.048_bib13","series-title":"Comprehensive Sampling and Sample Preparation","first-page":"51","article-title":"2.03-Liquid\u2013Liquid extraction: basic principles and automation","author":"Clement","year":"2012"},{"key":"10.1016\/j.aca.2016.07.048_bib14","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1021\/ac503384e","article-title":"Mass spectrometric detection of short-lived drug metabolites generated in an electrochemical microfluidic chip","volume":"87","author":"van den Brink","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib15","doi-asserted-by":"crossref","DOI":"10.1021\/ac404081j","article-title":"Correction to microfluidic droplet-based liquid\u2013liquid extraction and on-chip IR-spectroscopy detection of cocaine in human saliva","volume":"86","author":"W\u00e4gli","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/ac403417z","article-title":"Isolation and amplification of mRNA within a simple microfluidic lab on a chip","volume":"86","author":"Reinholt","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chroma.2015.09.077","article-title":"Dynamic electromembrane extraction: automated movement of donor and acceptor phases to improve extraction efficiency","volume":"1419","author":"Asl","year":"2015","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib18","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.1039\/C4AY01055H","article-title":"Comprehensive two-dimensional chromatography for analyzing complex samples: recent new advances","volume":"6","author":"Shi","year":"2014","journal-title":"Anal. Methods"},{"key":"10.1016\/j.aca.2016.07.048_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chroma.2011.08.001","article-title":"Advancing liquid\/liquid extraction through a novel microfluidic device: theory, instrumentation and applications in gas chromatography","volume":"1226","author":"Peroni","year":"2012","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib20","series-title":"Solvent Extraction","first-page":"451","article-title":"Chapter 13-Advances in development of solvents for liquid\u2013liquid extraction","author":"Kislik","year":"2012"},{"key":"10.1016\/j.aca.2016.07.048_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.chroma.2006.01.025","article-title":"Electrokinetic migration across artificial liquid membranes: new concept for rapid sample preparation of biological fluids","volume":"1109","author":"Pedersen-Bjergaard","year":"2006","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1021\/ac1027148","article-title":"On-chip electro membrane extraction with online ultraviolet and mass spectrometric detection","volume":"83","author":"Petersen","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib23","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.chroma.2008.12.079","article-title":"Drop-to-drop microextraction across a supported liquid membrane by an electrical field under stagnant conditions","volume":"1216","author":"Petersen","year":"2009","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib24","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s10404-010-0603-6","article-title":"On-chip electro membrane extraction","volume":"9","author":"Petersen","year":"2010","journal-title":"Microfluid Nanofluid"},{"key":"10.1016\/j.aca.2016.07.048_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.aca.2009.11.002","article-title":"Implementation of droplet-membrane-droplet liquid-phase microextraction under stagnant conditions for lab-on-a-chip applications","volume":"658","author":"Sikanen","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2016.07.048_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jpba.2011.08.026","article-title":"Exhaustive electromembrane extraction of some basic drugs from human plasma followed by liquid chromatography\u2013mass spectrometry","volume":"57","author":"Eibak","year":"2012","journal-title":"J.\u00a0Pharm. Biomed. Analysis"},{"key":"10.1016\/j.aca.2016.07.048_bib27","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1039\/c2an35264h","article-title":"On-chip electromembrane extraction for monitoring drug metabolism in real time by electrospray ionization mass spectrometry","volume":"137","author":"Petersen","year":"2012","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2016.07.048_bib28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aca.2012.05.023","article-title":"Liquid-phase microextraction in a microfluidic-chip \u2013 high enrichment and sample clean-up from small sample volumes based on three-phase extraction","volume":"735","author":"Ramos Pay\u00e1n","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2016.07.048_bib29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.aca.2015.09.052","article-title":"A\u00a0new effective on chip electromembrane extraction coupled with high performance liquid chromatography for enhancement of extraction efficiency","volume":"898","author":"Abdossalami Asl","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2016.07.048_bib30","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1021\/ac0708801","article-title":"Simultaneous ultrasound-assisted Emulsification\u2212Extraction of polar and nonpolar compounds from solid plant samples","volume":"79","author":"P\u00e9rez-Serradilla","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.chroma.2003.10.036","article-title":"Simultaneous solid-phase extraction of acidic, neutral and basic pharmaceuticals from aqueous samples at ambient (neutral) pH and their determination by gas chromatography\u2013mass spectrometry","volume":"1023","author":"Weigel","year":"2004","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib32","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1021\/ac030071r","article-title":"Simultaneous extraction and concentration by on-line hollow fiber membrane extraction","volume":"75","author":"Kou","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0021-9673(01)85256-0","article-title":"Simultaneous determination of atropine and its acidic and basic degradation products by mixed-column high-performance liquid chromatography","volume":"161","author":"Lund","year":"1978","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/elps.201200330","article-title":"Simultaneous determination of acidic and basic drugs using dual hollow fibre electromembrane extraction combined with CE","volume":"34","author":"Tabani","year":"2013","journal-title":"Electrophoresis"},{"key":"10.1016\/j.aca.2016.07.048_bib35","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1016\/j.chroma.2011.04.060","article-title":"A\u00a0new strategy to simultaneous microextraction of acidic and basic compounds","volume":"1218","author":"Moradi","year":"2011","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib36","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.chroma.2009.11.046","article-title":"Dispersive liquid\u2013liquid microextraction based on the solidification of floating organic drop followed by inductively coupled plasma-optical emission spectrometry as a fast technique for the simultaneous determination of heavy metals","volume":"1217","author":"Yamini","year":"2010","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib37","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1021\/acs.analchem.5b01610","article-title":"Combination of electromembrane extraction and liquid-phase microextraction in a single step: simultaneous group separation of acidic and basic drugs","volume":"87","author":"Huang","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2016.07.048_bib38","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1016\/j.chroma.2010.04.066","article-title":"Simultaneous extraction of acidic and basic drugs at neutral sample pH: a novel electro-mediated microextraction approach","volume":"1217","author":"Basheer","year":"2010","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib39","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.chroma.2012.04.050","article-title":"Low-voltage electrically-enhanced microextraction as a novel technique for simultaneous extraction of acidic and basic drugs from biological fluids","volume":"1243","author":"Seidi","year":"2012","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2013.12.019","article-title":"Electrical field-induced extraction and separation techniques: promising trends in analytical chemistry \u2013 a review","volume":"814","author":"Yamini","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2016.07.048_bib41","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ab.2013.03.027","article-title":"Pulsed electromembrane method for simultaneous extraction of drugs with different properties","volume":"438","author":"Arjomandi-Behzad","year":"2013","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.aca.2016.07.048_bib42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.chroma.2013.11.034","article-title":"Voltage-step pulsed electromembrane as a novel view of electrical field-induced liquid-phase microextraction","volume":"1324","author":"Rezazadeh","year":"2014","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2016.07.048_bib43","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1039\/C4AY02327G","article-title":"Electromembrane extraction using a cylindrical electrode: a new view for the augmentation of extraction efficiency","volume":"7","author":"Asl","year":"2015","journal-title":"Anal. Methods"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267016308844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267016308844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:03:03Z","timestamp":1757703783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267016308844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":43,"alternative-id":["S0003267016308844"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2016.07.048","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous extraction of acidic and basic drugs via on-chip electromembrane extraction","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2016.07.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}