{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:19:42Z","timestamp":1771064382361,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Instituto Carlos III","award":["FISPI14\/0433"],"award-info":[{"award-number":["FISPI14\/0433"]}]},{"name":"Spanish Ministry of Health, Social Services and Equality","award":["EC11-246"],"award-info":[{"award-number":["EC11-246"]}]},{"DOI":"10.13039\/100007929","name":"Institute of Translational Medicine & Therapeutics (ITMAT)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), Imperial College London","doi-asserted-by":"publisher","award":["P60743"],"award-info":[{"award-number":["P60743"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Network on Maternal and Child Health and Development Retic Red SAMID","award":["RD12\/0026\/11"],"award-info":[{"award-number":["RD12\/0026\/11"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselleria de Educaci\u00f3n, Investigaci\u00f3n, Cultura y Deporte of the Generalitat Valenciana","award":["GV 2016\/062"],"award-info":[{"award-number":["GV 2016\/062"]}]},{"name":"Instituto Carlos III (Ministry of Economy and Competitiveness, Spain)","award":["CP16\/00034"],"award-info":[{"award-number":["CP16\/00034"]}]},{"name":"Instituto Carlos III (Ministry of Economy and Competitiveness, Spain)","award":["FI16\/00380"],"award-info":[{"award-number":["FI16\/00380"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.aca.2017.09.026","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T03:04:22Z","timestamp":1506567862000},"page":"88-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma"],"prefix":"10.1016","volume":"996","author":[{"given":"\u00c1ngel","family":"S\u00e1nchez-Illana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhin","family":"Thayyil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Montaldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Quint\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Oger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marie","family":"Galano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-0425","authenticated-orcid":false,"given":"Claire","family":"Vigor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ximo","family":"Vento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kuligowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2017.09.026_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2016.00029","article-title":"Oxygen supplementation to stabilize preterm infants in the fetal to neonatal transition: No satisfactory answer","volume":"4","author":"Torres-Cuevas","year":"2016","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.aca.2017.09.026_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.freeradbiomed.2009.10.043","article-title":"Isoprostanes in fetal and neonatal health and disease","volume":"48","author":"Belik","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"Suppl 3","key":"10.1016\/j.aca.2017.09.026_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/dmcn.12726","article-title":"Early predictors of outcome in infants treated with hypothermia for hypoxic-ischaemic encephalopathy","volume":"57","author":"Merchant","year":"2015","journal-title":"Dev. Med. Child. Neurol."},{"key":"10.1016\/j.aca.2017.09.026_bib4","series-title":"Perinat. Prenat. Disord","first-page":"213","article-title":"Use of oxygen in the resuscitation of neonates","author":"Vento","year":"2014"},{"key":"10.1016\/j.aca.2017.09.026_bib5","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.freeradbiomed.2012.07.022","article-title":"Resuscitation with supplementary oxygen induces oxidative injury in the cerebral cortex","volume":"53","author":"Solberg","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.aca.2017.09.026_bib6","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1073\/pnas.87.23.9383","article-title":"A\u00a0series of prostaglandin F2-like compounds are produced in\u00a0vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism","volume":"87","author":"Morrow","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.aca.2017.09.026_bib7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bbalip.2014.10.007","article-title":"The isoprostanes\u201325 years later","volume":"1851","author":"Milne","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.aca.2017.09.026_bib8","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1021\/cr200160h","article-title":"Isoprostane generation and function","volume":"111","author":"Milne","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aca.2017.09.026_bib9","doi-asserted-by":"crossref","first-page":"5894","DOI":"10.1002\/anie.200705122","article-title":"Beyond prostaglandins\u2013chemistry and biology of cyclic oxygenated metabolites formed by free-radical pathways from polyunsaturated fatty acids","volume":"47","author":"Jahn","year":"2008","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.aca.2017.09.026_bib10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1074\/jbc.M706124200","article-title":"Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid","volume":"283","author":"Song","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.aca.2017.09.026_bib11","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3109\/10715762.2015.1014812","article-title":"Unresolved issues in the analysis of F2-isoprostanes, F4-neuroprostanes, isofurans, neurofurans, and F2-dihomo-isoprostanes in body fluids and tissue using gas chromatography\/negative-ion chemical-ionization mass spectrometry","volume":"49","author":"Yen","year":"2015","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.aca.2017.09.026_bib12","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.3109\/14767058.2012.718004","article-title":"Biomarkers of oxidative stress in fetal and neonatal diseases","volume":"25","author":"Perrone","year":"2012","journal-title":"J.\u00a0Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.aca.2017.09.026_bib13","first-page":"13","article-title":"Pathology of perinatal brain damage: background and oxidative stress markers","volume":"290","author":"Tonni","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.aca.2017.09.026_bib14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1089\/ars.2015.6262","article-title":"Urinary lipid peroxidation byproducts: are they relevant for predicting neonatal morbidity in preterm infants?","volume":"23","author":"Kuligowski","year":"2015","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.aca.2017.09.026_bib15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.freeradbiomed.2016.06.006","article-title":"Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy","volume":"97","author":"Chafer-Pericas","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.aca.2017.09.026_bib16","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s11745-016-4198-x","article-title":"Assessment of isoprostanes in human plasma: technical considerations and the use of mass spectrometry","volume":"51","author":"Lee","year":"2016","journal-title":"Lipids"},{"key":"10.1016\/j.aca.2017.09.026_bib17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2012.09.030","article-title":"Measurement of F2- isoprostanes and isofurans using gas chromatography-mass spectrometry","volume":"59","author":"Milne","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.aca.2017.09.026_bib18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.aca.2015.06.028","article-title":"Ultra high performance liquid chromatography coupled to tandem mass spectrometry determination of lipid peroxidation biomarkers in newborn serum samples","volume":"886","author":"Ch\u00e1fer-Peric\u00e1s","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2017.09.026_bib19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.talanta.2016.03.010","article-title":"Development of a reliable analytical method to determine lipid peroxidation biomarkers in newborn plasma samples","volume":"153","author":"Ch\u00e1fer-Peric\u00e1s","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2017.09.026_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aca.2016.03.024","article-title":"Simultaneous quantitative profiling of 20 isoprostanoids from omega-3 and omega-6 polyunsaturated fatty acids by LC-MS\/MS in various biological samples","volume":"921","author":"Dupuy","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2017.09.026_bib21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.freeradbiomed.2017.01.019","article-title":"\u00c1. Gil-Izquierdo, Potential applications of lipid peroxidation products - F4-neuroprostanes, F3-neuroprostanesn-6 DPA, F2-dihomo-isoprostanes and F2-isoprostanes - in the evaluation of the allograft function in renal transplantation","volume":"104","author":"De Las Heras-G\u00f3mez","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.aca.2017.09.026_bib22","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/1099-0690(200102)2001:4<809::AID-EJOC809>3.0.CO;2-6","article-title":"Total syntheses of four metabolites of 15-F2t-isoprostane","volume":"2001","author":"Durand","year":"2001","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.aca.2017.09.026_bib23","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/S0960-894X(01)00473-5","article-title":"Syntheses and preliminary pharmacological evaluation of the two epimers of the 5-F2t-isoprostane","volume":"11","author":"T","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.aca.2017.09.026_bib24","unstructured":"Total synthesis of 4(RS)-F4t-isoprostane methyl ester | Thierry Durand - Academia.edu, (n.d.). http:\/\/www.academia.edu\/13386671\/Total_synthesis_of_4_RS_-F4t-isoprostane_methyl_ester (accessed May 26, 2017)."},{"key":"10.1016\/j.aca.2017.09.026_bib25","first-page":"13976","article-title":"The handy use of Brown's P2-Ni catalyst for a skipped diyne deuteration: application to the synthesis of a [D4]-labeled F4t-neuroprostane","volume":"16","author":"Oger","year":"2010","journal-title":"Chem. Weinh. Bergstr. Ger."},{"key":"10.1016\/j.aca.2017.09.026_bib26","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1002\/ejoc.201200070","article-title":"Total synthesis of isoprostanes derived from adrenic acid and EPA","volume":"2012","author":"Oger","year":"2012","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.aca.2017.09.026_bib27","first-page":"6374","article-title":"Oxygenated metabolites of n-3 polyunsaturated fatty acids as potential oxidative stress biomarkers: total synthesis of 8-F3t-IsoP, 10-F4t-NeuroP and [D4]-10-F4t-NeuroP","volume":"20","author":"Guy","year":"2014","journal-title":"Chem. Weinh. Bergstr. Ger."},{"key":"10.1016\/j.aca.2017.09.026_bib28","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1002\/anie.201402440","article-title":"Synthesis, Discovery, and quantitation of dihomo-isofurans: biomarkers for in\u00a0vivo adrenic acid peroxidation","volume":"53","author":"de La Torre","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2017.09.026_bib29","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/chem.201405497","article-title":"Total syntheses and in\u00a0vivo quantitation of novel neurofuran and dihomo-isofuran derived from docosahexaenoic acid and adrenic acid","volume":"21","author":"de la Torre","year":"2015","journal-title":"Chem. \u2013 Eur. J."},{"key":"10.1016\/j.aca.2017.09.026_bib30","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1007\/s00216-014-7824-6","article-title":"Analysis of lipid peroxidation biomarkers in extremely low gestational age neonate urines by UPLC-MS\/MS","volume":"406","author":"Kuligowski","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aca.2017.09.026_bib31","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1002\/rcm.4197","article-title":"Determination of 8-epi PGF2\u03b1 concentrations as a biomarker of oxidative stress using triple-stage liquid chromatography\/tandem mass spectrometry","volume":"23","author":"Bastani","year":"2009","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.aca.2017.09.026_bib32","series-title":"Guidance for Industry: Bioanalytical Method Validation","author":"Food and Drug Administration (FDA)","year":"2001"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267017310759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267017310759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T03:31:56Z","timestamp":1535340716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267017310759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":32,"alternative-id":["S0003267017310759"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2017.09.026","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2017.09.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}