{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T01:54:22Z","timestamp":1787709262280,"version":"build-2784847793"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21365006"],"award-info":[{"award-number":["21365006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21765004"],"award-info":[{"award-number":["21765004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Science Foundation of China","doi-asserted-by":"publisher","award":["2014GXNSFDA118004"],"award-info":[{"award-number":["2014GXNSFDA118004"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Science Foundation of China","doi-asserted-by":"publisher","award":["1598025-4"],"award-info":[{"award-number":["1598025-4"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Project of Guangxi Graduate Education","award":["YCSZ2013039"],"award-info":[{"award-number":["YCSZ2013039"]}]},{"DOI":"10.13039\/501100009007","name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)","doi-asserted-by":"publisher","award":["CMEMR2017-A5"],"award-info":[{"award-number":["CMEMR2017-A5"]}],"id":[{"id":"10.13039\/501100009007","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.aca.2018.04.039","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T12:29:45Z","timestamp":1524054585000},"page":"22-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Based on ZnSe quantum dots labeling and single particle mode ICP-MS coupled with sandwich magnetic immunoassay for the detection of carcinoembryonic antigen in human serum"],"prefix":"10.1016","volume":"1028","author":[{"given":"Yupin","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guichun","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhe","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2018.04.039_bib1","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.1021\/acs.analchem.5b01038","article-title":"Surface-enhanced electrochemiluminescence of Ru@SiO2 for ultrasensitive detection of carcinoembryonic antigen","volume":"87","author":"Wang","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib2","first-page":"1","article-title":"Single-step cycle pulse operation of the label-free electrochemiluminescence immunosensor based on branched polypyrrole for carcinoembryonic antigen detection","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aca.2018.04.039_bib3","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/ac902162e","article-title":"Amperometric immunosensor for carcinoembryonic antigen in colon cancer samples based on monolayers of dendritic bipodal scaffolds","volume":"82","author":"Laboria","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib4","doi-asserted-by":"crossref","first-page":"18786","DOI":"10.1021\/acsami.5b05443","article-title":"Corallite-like magnetic Fe3O4@MnO2@Pt nanocomposites as multiple signal amplifiers for the detection of carcinoembryonic antigen","volume":"7","author":"Wu","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2018.04.039_bib5","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1039\/c1an15387k","article-title":"Nanoparticle labelling-based magnetic immunoassay on chip combined with electrothermal vaporization-inductively coupled plasma mass spectrometry for the determination of carcinoembryonic antigen in human serum","volume":"136","author":"Chen","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2018.04.039_bib6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bios.2012.03.025","article-title":"Carbon nanospheres-promoted electrochemical immunoassay coupled with hollow platinum nanolabels for sensitivity enhancement","volume":"35","author":"Zhou","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2018.04.039_bib7","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1021\/ac101339q","article-title":"Development of a high sensitivity rapid sandwich ELISA procedure and its comparison with the conventional approach","volume":"82","author":"Dixit","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cccn.2004.05.010","article-title":"Rapid and simple quantitative measurement of \u03b1\u2013fetoprotein by combining immunochromatographic strip test and artificial neural network image analysis system","volume":"384","author":"Chuang","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.aca.2018.04.039_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.trac.2016.11.003","article-title":"Nanomaterials for use in immunosensing of carcinoembryonic antigen (CEA): recent advances","volume":"86","author":"Hasanzadeh","year":"2017","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.snb.2011.01.007","article-title":"An ultra-sensitive chemiluminescence immunosensor of CEA using HRP-functionalized mesoporous silica nanoparticles as labels","volume":"155","author":"Chen","year":"2011","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bios.2017.08.034","article-title":"Label-free photoelectrochemical immunoassay for CEA detection based on CdS sensitized WO3@BiOI heterostructure nanocomposite","volume":"99","author":"Han","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2018.04.039_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bios.2013.11.032","article-title":"Layer-by-layer multienzyme assembly for highly sensitive electrochemical immunoassay based on tyramine signal amplification strategy","volume":"54","author":"Zhou","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2018.04.039_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/mas.21391","article-title":"Inductively coupled plasma mass spectrometry-based immunoassay: a review","volume":"33","author":"Liu","year":"2014","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.aca.2018.04.039_bib14","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/anie.201206903","article-title":"Absolute and relative quantification of multiplex DNA assays based on an elemental labeling strategy","volume":"52","author":"Han","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2018.04.039_bib15","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1021\/ac4036668","article-title":"Multicore magnetic nanoparticles (MMNPs) doped with Cs and FITC for the determination of biomarker in serum using ICP-MS","volume":"86","author":"Ko","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2016.07.035","article-title":"Metal-doped inorganic nanoparticles for multiplex detection of biomarkers by a sandwich-type ICP-MS immunoassay","volume":"938","author":"Ko","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2018.04.039_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.trac.2017.05.008","article-title":"Application of inductively coupled plasma mass spectrometry in the quantitative analysis of biomolecules with exogenous tags: a review","volume":"93","author":"Liu","year":"2017","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib18","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1021\/ac103265z","article-title":"Highly sensitive immunoassay based on immunogold-silver amplification and inductively coupled plasma mass spectrometric detection","volume":"83","author":"Liu","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib19","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.1021\/ac500964s","article-title":"Immunomagnetic separation combined with inductively coupled plasma mass spectrometry for the detection of tumor cells using gold nanoparticle labeling","volume":"86","author":"Zhang","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.sab.2015.01.011","article-title":"Magnetic immunoassay coupled with inductively coupled plasma mass spectrometry for simultaneous quantification of alpha-fetoprotein and carcinoembryonic antigen in human serum","volume":"106","author":"Zhang","year":"2015","journal-title":"Spectrochim. Acta, Part B"},{"key":"10.1016\/j.aca.2018.04.039_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bios.2011.12.046","article-title":"Elemental and molecular detection for quantum dots-based immunoassays: a critical appraisal","volume":"33","author":"Montoro Bustos","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2018.04.039_bib22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.aca.2015.03.015","article-title":"Sensitive targeted multiple protein quantification based on elemental detection of quantum dots","volume":"879","author":"Montoro Bustos","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2018.04.039_bib23","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1039\/c003029e","article-title":"Immunoaffinity monolithic capillary microextraction coupled with ICP-MS for immunoassay with quantum dot labels","volume":"25","author":"Chen","year":"2010","journal-title":"J.\u00a0Anal. At. Spectrom"},{"key":"10.1016\/j.aca.2018.04.039_bib24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bios.2016.04.090","article-title":"Highly sensitive nanoparticle-based immunoassays with elemental detection: application to prostate-specific antigen quantification","volume":"85","author":"Garcia-Cortes","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2018.04.039_bib25","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1039\/c1ja10213c","article-title":"Inductively coupled plasma mass spectrometry for determination of total urinary protein with CdTe quantum dots label","volume":"26","author":"Tang","year":"2011","journal-title":"J.\u00a0Anal. At. Spectrom"},{"key":"10.1016\/j.aca.2018.04.039_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aca.2014.08.041","article-title":"Cerium oxide-deposited mesoporous silica nanoparticles for the determination of carcinoembryonic antigen in serum using inductively coupled plasma-mass spectrometry","volume":"847","author":"Choi","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2018.04.039_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bios.2017.04.041","article-title":"A\u00a0multifunctional probe for ICP-MS determination and multimodal imaging of cancer cells","volume":"96","author":"Yang","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2018.04.039_bib28","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1021\/acs.analchem.6b04314","article-title":"Quantum dots labeling strategy for \u201ccounting and visualization\u201d of HepG2 cells","volume":"89","author":"Yang","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bios.2016.11.030","article-title":"Simultaneous detection of MCF-7 and HepG2 cells in blood by ICP-MS with gold nanoparticles and quantum dots as elemental tags","volume":"90","author":"Li","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2018.04.039_bib30","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.biotechadv.2013.05.009","article-title":"Magnetic separations in biotechnology","volume":"31","author":"Borlido","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.aca.2018.04.039_bib31","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1021\/la060093j","article-title":"Long-term exposure to CdTe quantum dots causes functional impairments in live cell","volume":"23","author":"Cho","year":"2007","journal-title":"Langmuir"},{"key":"10.1016\/j.aca.2018.04.039_bib32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1021\/nl0347334","article-title":"Probing the cytotoxicity of semiconductor quantum dots","volume":"4","author":"Derfus","year":"2004","journal-title":"Nano Lett"},{"key":"10.1016\/j.aca.2018.04.039_bib33","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1021\/ac201952t","article-title":"Determining transport efficiency for the purpose of counting and sizing nanoparticles via single particle inductively coupled plasma mass spectrometry","volume":"83","author":"Pace","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.talanta.2017.02.057","article-title":"An environmentally-friendly, highly efficient, gas pressure-assisted sample introduction system for ICP-MS and its application to detection of cadmium and lead in human plasma","volume":"167","author":"Cao","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2018.04.039_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.chroma.2015.03.061","article-title":"Selenium speciation using capillary electrophoresis coupled with modified electrothermal atomic absorption spectrometry after selective extraction with 5-sulfosalicylic acid functionalized magnetic nanoparticles","volume":"1395","author":"Yan","year":"2015","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2018.04.039_bib36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jelechem.2015.12.014","article-title":"Electrochemical immunosensor for carcinoembryonic antigen based on signal amplification strategy of graphene and Fe3O4\/Au NPs","volume":"761","author":"Peng","year":"2016","journal-title":"J.\u00a0Electroanal. Chem."},{"key":"10.1016\/j.aca.2018.04.039_bib37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.elecom.2015.03.011","article-title":"Tunable electrochemiluminescence of CdSe@ZnSe quantum dots by adjusting ZnSe shell thickness","volume":"55","author":"Ding","year":"2015","journal-title":"Electrochem. Commun."},{"key":"10.1016\/j.aca.2018.04.039_bib38","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1039\/C5JA00501A","article-title":"On the applicability and performance of the single particle ICP-MS nano-dispersion characterization method in cases complicated by spectral interferences","volume":"31","author":"Kalomista","year":"2016","journal-title":"J.\u00a0Anal. At. Spectrom"},{"key":"10.1016\/j.aca.2018.04.039_bib39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0003-2670(02)00768-7","article-title":"Determination of calcium, iron and zinc in milk powder by reaction cell inductively coupled plasma mass spectrometry","volume":"470","author":"Chen","year":"2002","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2018.04.039_bib40","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.talanta.2013.07.075","article-title":"Determination of quantum dots in single cells by inductively coupled plasma mass spectrometry","volume":"116","author":"Zheng","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2018.04.039_bib41","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1039\/c1ja00007a","article-title":"Magnetic quantitative immunoanalysis of carcinoembryonic antigen by ICP-MS with mercury labels","volume":"26","author":"Peng","year":"2011","journal-title":"J.\u00a0Anal. At. Spectrom"},{"key":"10.1016\/j.aca.2018.04.039_bib42","doi-asserted-by":"crossref","first-page":"9421","DOI":"10.1039\/c2cc34115h","article-title":"Multilayered shell SERS nanotags with a highly uniform single-particle Raman readout for ultrasensitive immunoassays","volume":"48","author":"Liu","year":"2012","journal-title":"Chem. Commun. (J. Chem. Soc. Sect. D)"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267018305245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267018305245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T10:44:45Z","timestamp":1568976285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267018305245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":42,"alternative-id":["S0003267018305245"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2018.04.039","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Based on ZnSe quantum dots labeling and single particle mode ICP-MS coupled with sandwich magnetic immunoassay for the detection of carcinoembryonic antigen in human serum","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2018.04.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}