{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:36:34Z","timestamp":1790948194258,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21974068"],"award-info":[{"award-number":["21974068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21890740"],"award-info":[{"award-number":["21890740"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.aca.2020.08.035","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:33:13Z","timestamp":1598603593000},"page":"19-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Nitronyl nitroxide monoradical TEMPO as new electrochemical label for ultrasensitive detection of nucleic acids"],"prefix":"10.1016","volume":"1136","author":[{"given":"Chen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5721-6513","authenticated-orcid":false,"given":"Jinming","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2020.08.035_bib1","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1021\/acs.analchem.7b02039","article-title":"Electrochemically mediated surface-initiated de novo growth of polymers for amplified electrochemical detection of DNA","volume":"89","author":"Hu","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2020.08.035_bib2","doi-asserted-by":"crossref","first-page":"9198","DOI":"10.1021\/acs.analchem.9b01961","article-title":"Ultrasensitive detection of DNA via SI-eRAFT and in situ metalization dual-signal amplification","volume":"91","author":"Sun","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2020.08.035_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-anchem-061417-125811","article-title":"DNA electrochemistry and electrochemical sensors for nucleic acids","volume":"11","author":"Ferapontova","year":"2018","journal-title":"Annu. Rev. Anal. Chem."},{"key":"10.1016\/j.aca.2020.08.035_bib4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bios.2014.11.024","article-title":"RNA aptamer based electrochemical biosensor for sensitive and selective detection of cAMP","volume":"66","author":"Zhao","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2020.08.035_bib5","first-page":"2045","article-title":"Electrochemistry of nonconjugated proteins and glycoproteins","volume":"115","author":"Pale\u010dek","year":"2015","journal-title":"Toward sensors for biomedicine and glycomics, Chem. Rev."},{"key":"10.1016\/j.aca.2020.08.035_bib6","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1021\/ja060005h","article-title":"Quantum-dot\/aptamer-based ultrasensitive multi-analyte electrochemical biosensor","volume":"128","author":"Hansen","year":"2006","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.aca.2020.08.035_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioelechem.2017.02.003","article-title":"Electrochemical DNA biosensor for detection of DNA damage induced by hydroxyl radicals","volume":"116","author":"H\u00e1jkov\u00e1","year":"2017","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.aca.2020.08.035_bib8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.trac.2015.11.018","article-title":"Recent progress in electrochemical sensors and assays for DNA damage and repair","volume":"79","author":"Fojta","year":"2016","journal-title":"TrAC Trends Anal. Chem. (Reference Ed.)"},{"key":"10.1016\/j.aca.2020.08.035_bib9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1021\/ac0493469","article-title":"Direct detection of DNA with an electrocatalytic threading intercalator","volume":"77","author":"Tansil","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2020.08.035_bib10","doi-asserted-by":"crossref","first-page":"6466","DOI":"10.1073\/pnas.0601184103","article-title":"Direct electrical detection of DNA synthesis","volume":"103","author":"Pourmand","year":"2006","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.aca.2020.08.035_bib11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1039\/b701816a","article-title":"An introduction to electrochemical DNA biosensors","volume":"132","author":"Odenthal","year":"2007","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2020.08.035_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bios.2018.11.029","article-title":"Ultrasensitive DNA biosensor based on electrochemical atom transfer radical polymerization","volume":"131","author":"Sun","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2020.08.035_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/B:TOCA.0000013540.69309.46","article-title":"TEMPO-mediated oxidation of polysaccharides: survey of methods and applications","volume":"27","author":"Bragd","year":"2004","journal-title":"Top. Catal."},{"key":"10.1016\/j.aca.2020.08.035_bib14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/196472a0","article-title":"Free radical reactions involving no unpaired electrons","volume":"196","author":"Neiman","year":"1962","journal-title":"Nature"},{"key":"10.1016\/j.aca.2020.08.035_bib15","article-title":"Nitroxide spin probes for studies of molecular dynamics and microstructure","author":"Likhtenshtein","year":"2008","journal-title":"in: Nitroxides: applications in chemistry, biomedicine, and materials science, John Wiley & Sons., New Jersey,"},{"key":"10.1016\/j.aca.2020.08.035_bib16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cis.2017.08.008","article-title":"Surface modification using TEMPO and its derivatives","volume":"250","author":"Megiel","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.aca.2020.08.035_bib17","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1021\/acs.joc.5b02333","article-title":"Aerobic oxidative conversion of aromatic aldehydes to nitriles using a nitroxyl\/NO x catalyst system","volume":"80","author":"Noh","year":"2015","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.aca.2020.08.035_bib18","first-page":"1157","article-title":"A\u00a0mild TEMPO-catalyzed aerobic oxidative conversion of aldehydes into nitriles, Adv. Synth","volume":"358","author":"Fang","year":"2016","journal-title":"Catalyst"},{"key":"10.1016\/j.aca.2020.08.035_bib19","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1039\/c3cs60464k","article-title":"Redox catalysis in organic electrosynthesis: basic principles and recent developments","volume":"43","author":"Francke","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2020.08.035_bib20","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1039\/c0gc00382d","article-title":"Organic electrosynthesis: a promising green methodology in organic chemistry","volume":"12","author":"Frontana-Uribe","year":"2010","journal-title":"Green Chem."},{"key":"10.1016\/j.aca.2020.08.035_bib21","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1016\/j.bmcl.2004.04.076","article-title":"Nitroxide-labeled guanine as an ESR spin probe for structural study of DNA","volume":"14","author":"Okamoto","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.aca.2020.08.035_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/ar50013a003","article-title":"Nitroxide free radicals: spin labels for probing biomolecular structure","volume":"2","author":"Griffith","year":"1969","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.aca.2020.08.035_bib23","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/adsc.201100067","article-title":"Activation of dioxygen by cobaloxime and nitric oxide for efficient TEMPO-catalyzed oxidation of alcohols","volume":"353","author":"Jing","year":"2011","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.aca.2020.08.035_bib24","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1021\/jo00388a038","article-title":"Fast and selective oxidation of primary alcohols to aldehydes or to carboxylic acids and of secondary alcohols to ketones mediated by oxoammonium salts under two-phase conditions","volume":"52","author":"Lucio Anelli","year":"1987","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.aca.2020.08.035_bib25","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1021\/cr000019k","article-title":"Synthetic applications of nonmetal catalysts for homogeneous oxidations","volume":"101","author":"Adam","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aca.2020.08.035_bib26","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.3987\/COM-10-12053","article-title":"Voltammetric behavior of mediator-modified electrode by electrochemical polymerization of nitroxyl radical precursor containing pyrrole side chain","volume":"81","author":"Ono","year":"2010","journal-title":"Heterocycles"},{"key":"10.1016\/j.aca.2020.08.035_bib27","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1021\/jacs.8b13192","article-title":"Aminoxyl-catalyzed electrochemical diazidation of alkenes mediated by a metastable charge-transfer complex","volume":"141","author":"Siu","year":"2019","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.aca.2020.08.035_bib28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.electacta.2014.03.028","article-title":"Electrochemical polymerization of pyrrole containing TEMPO side chain on Pt electrode and its electrochemical activity","volume":"130","author":"Lu","year":"2014","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.aca.2020.08.035_bib29","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.snb.2017.12.043","article-title":"TEMPO-based immuno-lateral flow quantitative detection of dengue NS1 protein","volume":"259","author":"Sinawang","year":"2018","journal-title":"Sens. Actuators B."},{"key":"10.1016\/j.aca.2020.08.035_bib30","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/j.bios.2010.03.017","article-title":"Electrochemical detection of oligonucleotide by attaching redox probes onto its backbone","volume":"26","author":"Fang","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2020.08.035_bib31","doi-asserted-by":"crossref","first-page":"27568","DOI":"10.1021\/acsami.9b08037","article-title":"Dual signal amplification by eATRP and DNA-templated silver nanoparticles for ultrasensitive electrochemical detection of nucleic acids","volume":"11","author":"Sun","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2020.08.035_bib32","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.snb.2011.10.013","article-title":"Electrochemical DNA biosensor based on aldehyde-agarose hydrogel modified glassy carbon electrode for detection of PML\/RARa fusion gene","volume":"160","author":"Liu","year":"2011","journal-title":"Sens. Actuators, B"},{"key":"10.1016\/j.aca.2020.08.035_bib33","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1021\/bm3018802","article-title":"Electrochemiluminescence biosensor based on conducting poly (5-formylindole) for sensitive detection of ramos cells","volume":"14","author":"Nie","year":"2013","journal-title":"Biomacromolecules"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267020308680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267020308680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:23:45Z","timestamp":1757705025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267020308680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":33,"alternative-id":["S0003267020308680"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2020.08.035","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitronyl nitroxide monoradical TEMPO as new electrochemical label for ultrasensitive detection of nucleic acids","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2020.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}