{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:24:49Z","timestamp":1792729489436,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.aca.2021.338893","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:23:12Z","timestamp":1627579392000},"page":"338893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Sulphur-doped graphene quantum dot based fluorescent turn-on aptasensor for selective and ultrasensitive detection of omethoate"],"prefix":"10.1016","volume":"1181","author":[{"given":"Raji V.","family":"Nair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvathy R.","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Peer","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saju","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 3","key":"10.1016\/j.aca.2021.338893_bib1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1289\/ehp.99107s3409","article-title":"Exposures of children to organophosphate pesticides and their potential adverse health effects","volume":"107","author":"Eskenazi","year":"1999","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.aca.2021.338893_bib2","first-page":"315","article-title":"Adverse effects of pesticides and related chemicals on enzyme and hormone systems of fish, amphibians and reptiles: a review","volume":"42","author":"Khan","year":"2005","journal-title":"Proc. Pakistan Acad. Sci."},{"issue":"1\u20132","key":"10.1016\/j.aca.2021.338893_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0021-9673(93)80546-K","article-title":"Environmental Protection Agency and other methods for the determination of priority pesticides and their transformation products in water","volume":"643","author":"Barcel\u00f3","year":"1993","journal-title":"J.\u00a0Chromatogr. A"},{"issue":"1","key":"10.1016\/j.aca.2021.338893_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aca.2004.06.056","article-title":"Nanoparticle-based optical biosensors for the direct detection of organophosphate chemical warfare agents and pesticides","volume":"534","author":"Simonian","year":"2005","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.aca.2021.338893_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/ac302781r","article-title":"Fe3O4 magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent","volume":"85","author":"Liang","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.338893_bib6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.snb.2013.08.102","article-title":"Label-free immunosensor based on micromachined bulk acoustic resonator for the detection of trace pesticide residues","volume":"190","author":"Wang","year":"2014","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2021.338893_bib7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bios.2018.10.014","article-title":"Origami multiple paper-based electrochemical biosensors for pesticide detection","volume":"126","author":"Arduini","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2021.338893_bib8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.snb.2019.02.057","article-title":"Electrochemical aptasensor based on one step co-electrodeposition of aptamer and GO-CuNPs nanocomposite for organophosphorus pesticide detection","volume":"287","author":"Fu","year":"2019","journal-title":"Sensor. Actuator. B Chem."},{"issue":"5","key":"10.1016\/j.aca.2021.338893_bib9","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0039-9140(01)00533-1","article-title":"Antibody-based immobilization of bioluminescent bacterial sensor cells","volume":"55","author":"Premkumar","year":"2001","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2021.338893_bib10","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.snb.2018.03.023","article-title":"Multicolor sensor for organophosphorus pesticides determination based on the bi-enzyme catalytic etching of gold nanorods","volume":"265","author":"Liu","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"issue":"2","key":"10.1016\/j.aca.2021.338893_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.trac.2007.12.004","article-title":"Aptamer-based biosensors","volume":"27","author":"Song","year":"2008","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.aca.2021.338893_bib12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bios.2016.04.011","article-title":"Aptasensors for quantitative detection of kanamycin","volume":"82","author":"Robati","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"10.1016\/j.aca.2021.338893_bib13","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3390\/ph4081137","article-title":"Aptamer-gated nanoparticles for smart drug delivery","volume":"4","author":"Ozalp","year":"2011","journal-title":"Pharmaceuticals"},{"issue":"9","key":"10.1016\/j.aca.2021.338893_bib14","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/clinchem\/45.9.1628","article-title":"Aptamers: an emerging class of molecules that rival antibodies in diagnostics","volume":"45","author":"Jayasena","year":"1999","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.aca.2021.338893_bib15","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1021\/acsnano.7b00373","article-title":"Aptasensor with expanded nucleotide using DNA nanotetrahedra for electrochemical detection of cancerous exosomes","volume":"11","author":"Wang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.aca.2021.338893_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bios.2018.04.024","article-title":"Multiplexed aptasensor based on metal ions labels for simultaneous detection of multiple antibiotic residues in milk","volume":"115","author":"Li","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2021.338893_bib17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.snb.2018.03.042","article-title":"Multiplex electrochemical aptasensor for detecting multiple antibiotics residues based on carbon fiber and mesoporous carbon-gold nanoparticles","volume":"265","author":"Li","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"issue":"22","key":"10.1016\/j.aca.2021.338893_bib18","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1002\/anie.200700269","article-title":"Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles","volume":"46","author":"Lee","year":"2007","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2021.338893_bib19","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.snb.2017.08.167","article-title":"A\u00a0\u201cturn-on\u201d fluorescence sensor for Pb2+ detection based on graphene quantum dots and gold nanoparticles","volume":"255","author":"Niu","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2021.338893_bib20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bios.2012.10.038","article-title":"Hydrogel based QCM aptasensor for detection of avian influenzavirus","volume":"42","author":"Wang","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2021.338893_bib21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bios.2014.07.022","article-title":"A\u00a0label-free aptasensor for highly sensitive detection of ATP and thrombin based on metal-enhanced PicoGreen fluorescence","volume":"63","author":"Wang","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"17","key":"10.1016\/j.aca.2021.338893_bib22","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1021\/ac101456x","article-title":"CdSe\/ZnS quantum dots-G-quadruplex\/hemin hybrids as optical DNA sensors and aptasensors","volume":"82","author":"Sharon","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.338893_bib23","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.bios.2015.07.067","article-title":"A\u00a0label-free photoelectrochemical aptasensor based on nitrogen-doped graphene quantum dots for chloramphenicol determination","volume":"74","author":"Liu","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"11","key":"10.1016\/j.aca.2021.338893_bib24","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1021\/acsomega.7b01262","article-title":"Rapid, acid-free synthesis of high-quality graphene quantum dots for aggregation induced sensing of metal ions and bioimaging","volume":"2","author":"Nair","year":"2017","journal-title":"ACS Omega"},{"issue":"52","key":"10.1016\/j.aca.2021.338893_bib25","doi-asserted-by":"crossref","first-page":"27228","DOI":"10.1039\/C4RA01572J","article-title":"Highly sensitive turn-on fluorescent detection of cartap via a nonconjugated gold nanoparticle\u2013quantum dot pair mediated by inner filter effect","volume":"4","author":"Guo","year":"2014","journal-title":"RSC Adv."},{"issue":"3","key":"10.1016\/j.aca.2021.338893_bib26","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1021\/acs.analchem.6b03913","article-title":"Tuning the aggregation\/disaggregation behavior of graphene quantum dots by structure-switching aptamer for high-sensitivity fluorescent ochratoxin A sensor","volume":"89","author":"Wang","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.338893_bib27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.snb.2015.08.130","article-title":"Aptamer-based fluorescent detection of bisphenol A using nonconjugated gold nanoparticles and CdTe quantum dots","volume":"222","author":"Li","year":"2016","journal-title":"Sensor. Actuator. B Chem."},{"issue":"21","key":"10.1016\/j.aca.2021.338893_bib28","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1039\/C8AN01166D","article-title":"A\u00a0novel fluorescent aptasensor for ultrasensitive and selective detection of acetamiprid pesticide based on the inner filter effect between gold nanoparticles and carbon dots","volume":"143","author":"Wang","year":"2018","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2021.338893_bib29","doi-asserted-by":"crossref","first-page":"104971","DOI":"10.1016\/j.microc.2020.104971","article-title":"Fluorescent turn-off sensor based on sulphur-doped graphene quantum dots in colloidal and film forms for the ultrasensitive detection of carbamate pesticides","author":"Nair","year":"2020","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2021.338893_bib30","doi-asserted-by":"crossref","first-page":"49386","DOI":"10.1039\/C7RA10479K","article-title":"How to make nanobiosensors: surface modification and characterisation of nanomaterials for biosensing applications","volume":"7","author":"Y\u00fcce","year":"2017","journal-title":"RSC Adv."},{"issue":"14","key":"10.1016\/j.aca.2021.338893_bib31","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1021\/acs.jafc.7b00166","article-title":"Fluorescence determination of omethoate based on a dual strategy for improving sensitivity","volume":"65","author":"Zhang","year":"2017","journal-title":"J.\u00a0Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.aca.2021.338893_bib32","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1039\/C7RA11927E","article-title":"Detection of pesticide residue distribution on fruit surfaces using surface-enhanced Raman spectroscopy imaging","volume":"8","author":"Chen","year":"2018","journal-title":"RSC Adv."},{"issue":"5","key":"10.1016\/j.aca.2021.338893_bib33","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/jrs.2823","article-title":"Surface-enhanced Raman spectra of dimethoate and omethoate","volume":"42","author":"Guerrini","year":"2011","journal-title":"J.\u00a0Raman Spectrosc."},{"issue":"45","key":"10.1016\/j.aca.2021.338893_bib34","doi-asserted-by":"crossref","first-page":"39056","DOI":"10.1021\/acsami.8b14472","article-title":"Novel fluorescence sensor based on all-inorganic perovskite quantum dots coated with molecularly imprinted polymers for highly selective and sensitive detection of omethoate","volume":"10","author":"Huang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"9","key":"10.1016\/j.aca.2021.338893_bib35","doi-asserted-by":"crossref","DOI":"10.1007\/s12161-018-1233-y","article-title":"Detection of omethoate residues in peach with surface-enhanced Raman spectroscopy","volume":"11","author":"Yaseen","year":"2018","journal-title":"Food Analytical Methods"},{"key":"10.1016\/j.aca.2021.338893_bib36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.aca.2015.08.012","article-title":"A\u00a0gold-based nanobeacon probe for fluorescence sensing of organophosphorus pesticides","volume":"891","author":"Dou","year":"2015","journal-title":"Anal. Chim. Acta"},{"issue":"6","key":"10.1016\/j.aca.2021.338893_bib37","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1021\/acsanm.0c00641","article-title":"Multicolor colorimetric sensor for detection of omethoate based on the inhibition of the enzyme-induced metallization of gold nanorods","volume":"3","author":"Zhang","year":"2020","journal-title":"ACS Applied Nano Mater."},{"issue":"4","key":"10.1016\/j.aca.2021.338893_bib38","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1166\/jnn.2020.17358","article-title":"Colorimetric detection of organophosphorus pesticides based on the broad-spectrum aptamer","volume":"20","author":"Liu","year":"2020","journal-title":"J.\u00a0Nanosci. Nanotechnol."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267021007194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267021007194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:32:24Z","timestamp":1762083144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267021007194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":38,"alternative-id":["S0003267021007194"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2021.338893","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulphur-doped graphene quantum dot based fluorescent turn-on aptasensor for selective and ultrasensitive detection of omethoate","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2021.338893","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"338893"}}