{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:18:00Z","timestamp":1777432680786,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21775113"],"award-info":[{"award-number":["21775113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21974100"],"award-info":[{"award-number":["21974100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.aca.2021.339134","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T02:47:17Z","timestamp":1633142837000},"page":"339134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["A homogeneous nucleic acid assay for simultaneous detection of SARS-CoV-2 and influenza A (H3N2) by single-particle inductively coupled plasma mass spectrometry"],"prefix":"10.1016","volume":"1186","author":[{"given":"Yan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-5171","authenticated-orcid":false,"given":"Beibei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-8098","authenticated-orcid":false,"given":"Man","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-2202","authenticated-orcid":false,"given":"Bin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2021.339134_bib1","unstructured":"World Health Organization. Coronavirus disease (COVID-19) Situation Report. https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/situation-reports (Accessed 9 August 2021)."},{"key":"10.1016\/j.aca.2021.339134_bib2","doi-asserted-by":"crossref","first-page":"2000045","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","article-title":"Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR","volume":"25","author":"Corman","year":"2020","journal-title":"Euro Surveill."},{"key":"10.1016\/j.aca.2021.339134_bib3","doi-asserted-by":"crossref","DOI":"10.1099\/jmm.0.001295","article-title":"Clinical evaluation of a fully automated, laboratory-developed multiplex RT-PCR assay integrating dual-target SARS-CoV-2 and influenza A\/B detection on a high-throughput platform","volume":"70","author":"N\u00f6rz","year":"2021","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.aca.2021.339134_bib4","doi-asserted-by":"crossref","first-page":"34088","DOI":"10.1039\/D0RA04507A","article-title":"Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform","volume":"10","author":"Ji","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.aca.2021.339134_bib5","doi-asserted-by":"crossref","first-page":"16204","DOI":"10.1021\/acs.analchem.0c04047","article-title":"Isothermal amplification and ambient visualization in a single tube for the detection of SARS-CoV-2 using loop-mediated amplification and CRISPR technology","volume":"92","author":"Pang","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib6","doi-asserted-by":"crossref","first-page":"680728","DOI":"10.3389\/fcimb.2021.680728","article-title":"A\u00a0ligation\/recombinase polymerase amplification assay for rapid detection of SARS-CoV-2","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.aca.2021.339134_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00604-019-3540-4","article-title":"Simultaneous determination of two phosphorylated p53 proteins in SCC-7 cells by an ICP-MS immunoassay using apoferritin-templated europium(III) and lutetium(III) phosphate nanoparticles as labels","volume":"186","author":"Yin","year":"2019","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.aca.2021.339134_bib8","doi-asserted-by":"crossref","first-page":"13075","DOI":"10.1039\/C7CC08052B","article-title":"A\u00a0combinatorial immunoassay for multiple biomarkers via a stable isotope tagging strategy","volume":"53","author":"Sun","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.aca.2021.339134_bib9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1039\/c0ja00232a","article-title":"Ultrasensitive, selective and simultaneous detection of cytochrome c and insulin based on immunoassay and aptamer-based bioassay in combination with Au\/Ag nanoparticle tagging and ICP-MS detection","volume":"26","author":"Liu","year":"2011","journal-title":"J.\u00a0Anal. Atom. Spectrom."},{"key":"10.1016\/j.aca.2021.339134_bib10","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/anie.201206903","article-title":"Absolute and relative quantification of multiplex DNA assays based on an elemental labeling strategy","volume":"52","author":"Han","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2021.339134_bib11","doi-asserted-by":"crossref","first-page":"11111","DOI":"10.1021\/acs.analchem.0c01074","article-title":"Three-dimensional DNA nanomachine biosensor by integrating DNA walker and rolling machine cascade amplification for ultrasensitive detection of cancer-related gene","volume":"92","author":"Wu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.sab.2017.10.015","article-title":"Determination of avian influenza A (H9N2) virions by inductively coupled plasma mass spectrometry based magnetic immunoassay with gold nanoparticles labeling","volume":"138","author":"Xiao","year":"2017","journal-title":"Spectrochim. Acta B"},{"key":"10.1016\/j.aca.2021.339134_bib13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/acs.analchem.8b05085","article-title":"Combination of magnetic-beads-based multiple metal nanoparticles labeling with hybridization chain reaction amplification for simultaneous detection of multiple cancer cells with inductively coupled plasma mass spectrometry","volume":"91","author":"He","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bios.2016.11.030","article-title":"Simultaneous detection of MCF-7 and HepG2 cells in blood by ICP-MS with gold nanoparticles and quantum dots as elemental tags","volume":"90","author":"Li","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2021.339134_bib15","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1039\/b202306g","article-title":"Simultaneous determination of proteins using an element-tagged immunoassay coupled with ICP-MS detection","volume":"17","author":"Quinn","year":"2002","journal-title":"J.\u00a0Anal. Atom. Spectrom."},{"key":"10.1016\/j.aca.2021.339134_bib16","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1039\/c4ja00003j","article-title":"Magnetic quantitative analysis for multiplex glycoprotein with polymer-based elemental tags","volume":"29","author":"Peng","year":"2014","journal-title":"J.\u00a0Anal. Atom. Spectrom."},{"key":"10.1016\/j.aca.2021.339134_bib17","doi-asserted-by":"crossref","first-page":"9428","DOI":"10.1021\/ac402446a","article-title":"ICP-MS-based multiplex and ultrasensitive assay of viruses with lanthanide-coded biospecific tagging and amplification strategies","volume":"85","author":"Luo","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib18","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1021\/acs.analchem.0c02455","article-title":"MNAzyme-catalyzed amplification assay with lanthanide tags for the simultaneous detection of multiple microRNAs by inductively coupled plasma-mass spectrometry","volume":"93","author":"Kang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib19","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1021\/ac402980q","article-title":"Single particle inductively coupled plasma mass spectrometry: a powerful tool for nanoanalysis","volume":"86","author":"Laborda","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib20","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1021\/ac404245z","article-title":"Multiplex DNA assay based on nanoparticle probes by single particle inductively coupled plasma mass spectrometry","volume":"86","author":"Zhang","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib21","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1021\/cr300340p","article-title":"DNA-mediated homogeneous binding assays for nucleic acids and proteins","volume":"113","author":"Zhang","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aca.2021.339134_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1039\/C0AN00281J","article-title":"Homogeneous assays using aptamers","volume":"136","author":"Sassolas","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2021.339134_bib23","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1002\/anie.201006838","article-title":"One-step homogeneous DNA assay with single-nanoparticle detection","volume":"50","author":"Han","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2021.339134_bib24","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1021\/acs.analchem.9b05596","article-title":"Self-validated homogeneous immunoassay by single nanoparticle in-depth scrutinization","volume":"92","author":"Huang","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib25","doi-asserted-by":"crossref","first-page":"16105","DOI":"10.1021\/acs.analchem.0c03780","article-title":"Homogeneous multiplex immunoassay for one-step pancreatic cancer biomarker evaluation","volume":"92","author":"Huang","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib26","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1021\/acs.analchem.0c05444","article-title":"A\u00a0homogeneous multicomponent nucleic acid enzyme assay for universal nucleic acid detection by single-particle inductively coupled plasma mass spectrometry","volume":"93","author":"Yin","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib27","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1021\/acs.analchem.9b05741","article-title":"Single-nanoparticle ICPMS DNA assay based on hybridization-chain-reaction-mediated spherical nucleic acid assembly","volume":"92","author":"Li","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib28","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1021\/ac500590d","article-title":"A\u00a0general strategy for label-free sensitive DNA detection based on quantum dot doping","volume":"86","author":"He","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib29","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1016\/j.bios.2010.12.037","article-title":"A\u00a0versatile graphene-based fluorescence \u201con\/off\u201d switch for multiplex detection of various targets","volume":"26","author":"Zhang","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2021.339134_bib30","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.talanta.2017.01.020","article-title":"A\u00a0novel CdTe quantum dots probe amplified resonance light scattering signals to detect microRNA-122","volume":"165","author":"Lv","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2021.339134_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jelechem.2016.11.027","article-title":"A\u00a0recyclable electrochemical sensing platform for breast cancer diagnosis based on homogeneous DNA hybridization and host-guest interaction between cucurbit [7]uril and ferrocene-nanosphere with signal amplification","volume":"783","author":"Yang","year":"2016","journal-title":"J.\u00a0Electroanal. Chem."},{"key":"10.1016\/j.aca.2021.339134_bib32","doi-asserted-by":"crossref","first-page":"112707","DOI":"10.1016\/j.bios.2020.112707","article-title":"Label-free homogeneous electrochemical detection of MicroRNA based on target-induced anti-shielding against the catalytic activity of two-dimension nanozyme","volume":"171","author":"Wu","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2021.339134_bib33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bios.2018.04.035","article-title":"Enzyme-free homogeneous electrochemical biosensor for DNA assay using toehold-triggered strand displacement reaction coupled with host-guest recognition of Fe3O4@SiO2@\u03b2-CD nanocomposites","volume":"114","author":"Jiang","year":"2018","journal-title":"Biosens. Bioelectron."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267021009600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267021009600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:48:44Z","timestamp":1777376924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267021009600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":33,"alternative-id":["S0003267021009600"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2021.339134","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A homogeneous nucleic acid assay for simultaneous detection of SARS-CoV-2 and influenza A (H3N2) by single-particle inductively coupled plasma mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2021.339134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"339134"}}