{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:48:54Z","timestamp":1792633734676,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010882","name":"Tianjin Municipal Education Commission","doi-asserted-by":"publisher","award":["2017ZD07"],"award-info":[{"award-number":["2017ZD07"]}],"id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872996"],"award-info":[{"award-number":["81872996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["20JCYBJC00060"],"award-info":[{"award-number":["20JCYBJC00060"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.aca.2021.339320","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T17:27:43Z","timestamp":1637774863000},"page":"339320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["A novel hybrid scan approach enabling the ion-mobility separation and the alternate data-dependent and data-independent acquisitions (HDDIDDA): Its combination with off-line two-dimensional liquid chromatography for comprehensively characterizing the multicomponents from Compound Danshen Dripping Pill"],"prefix":"10.1016","volume":"1193","author":[{"given":"Hong-da","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-jian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-miao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-xin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-mei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-an","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2021.339320_bib1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.apsb.2018.01.005","article-title":"Authentic compound-free strategy for simultaneous determination of primary coumarins in Peucedani Radix using offline high performance liquid chromatography\u2013nuclear magnetic resonance spectroscopy\u2013tandem mass spectrometry","volume":"8","author":"Liu","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.aca.2021.339320_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.aca.2019.04.013","article-title":"Advanced liquid chromatography-mass spectrometry enables merging widely targeted metabolomics and proteomics","volume":"1069","author":"Liu","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2021.339320_bib3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1021\/acs.analchem.5b02729","article-title":"Global profiling and novel structure discovery using multiple neutral loss\/precursor ion scanning combined with Substructure recognition and statistical analysis (MNPSS): characterization of terpene-conjugated curcuminoids in curcuma longa as a case study","volume":"88","author":"Qiao","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.aca.2019.06.040","volume":"1079","author":"Cao","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2021.339320_bib5","doi-asserted-by":"crossref","first-page":"11569","DOI":"10.1021\/acs.analchem.9b01615","article-title":"Three-dimensional high-performance liquid chromatographic determination of asn, ser, ala, and pro enantiomers in the plasma of patients with chronic kidney disease","volume":"91","author":"Furusho","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib6","doi-asserted-by":"crossref","first-page":"462237","DOI":"10.1016\/j.chroma.2021.462237","volume":"1649","author":"Feng","year":"2021","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2021.339320_bib7","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1021\/acs.analchem.6b04401","article-title":"Online three dimensional liquid chromatography\/mass spectrometry method for the separation of complex samples","volume":"89","author":"Wang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib8","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1021\/acs.analchem.0c05022","article-title":"DADIA: hybridizing data-dependent and data-independent acquisition modes for generating high-quality metabolomic data","volume":"93","author":"Guo","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib9","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1007\/s00216-019-02180-8","article-title":"In-depth profiling, characterization, and comparison of the ginsenosides among three different parts (the root, stem leaf, and flower bud) of Panax quinquefolius L. by ultra-high performance liquid chromatography\/quadrupole-Orbitrap mass spectrometry","volume":"411","author":"Wang","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chroma.2018.05.066","article-title":"An enhanced strategy integrating offline two-dimensional separation and step-wise precursor ion list-based raster-mass defect filter: characterization of indole alkaloids in five botanical origins of Uncariae Ramulus Cum Unicis as an exemplary application","volume":"1563","author":"Pan","year":"2018","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2021.339320_bib11","doi-asserted-by":"crossref","first-page":"460674","DOI":"10.1016\/j.chroma.2019.460674","article-title":"An integrated approach for global profiling of multi-type constituents: comprehensive chemical characterization of Lonicerae Japonicae Flos as a case study","volume":"1613","author":"Pan","year":"2020","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.aca.2021.339320_bib12","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1007\/s00216-019-01709-1","article-title":"Advancing untargeted metabolomics using data-independent acquisition mass spectrometry technology","volume":"411","author":"Wang","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.aca.2020.10.058","article-title":"Multi-dimensional characterization and identification of sterols in untargeted LC-MS analysis using all ion fragmentation technology","volume":"142","author":"Qiu","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2021.339320_bib14","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1021\/acs.analchem.0c04602","article-title":"Integrated strategy drives direct infusion-tandem mass spectrometry as an eligible tool for shotgun pseudo-targeted metabolomics of medicinal plants","volume":"93","author":"Zhang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib15","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.apsb.2021.02.017","article-title":"Insight into chemical basis of traditional Chinese medicine based on the state-of-the-art techniques of liquid chromatography-mass spectrometry","volume":"11","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.aca.2021.339320_bib16","doi-asserted-by":"crossref","first-page":"8072","DOI":"10.1021\/acs.analchem.9b05135","article-title":"Comparison of full-scan, data-dependent, and data-independent acquisition modes in liquid chromatography-mass spectrometry based untargeted metabolomics","volume":"92","author":"Guo","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib17","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1021\/acs.jproteome.0c00186","article-title":"Data dependent-independent acquisition (DDIA) proteomics","volume":"19","author":"Guan","year":"2020","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.aca.2021.339320_bib18","doi-asserted-by":"crossref","first-page":"12326","DOI":"10.1016\/j.jhazmat.2020.123266","article-title":"An integrated data-dependent and data-independent acquisition method for hazardous compounds screening in foods using a single UHPLC-Q-Orbitrap run","volume":"401","author":"Sun","year":"2021","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.aca.2021.339320_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cbpa.2017.10.022","article-title":"Fundamentals of ion mobility spectrometry","volume":"42","author":"Gabelica","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.aca.2021.339320_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jpha.2019.11.001","article-title":"Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling four-dimensional separation and characterization of the multicomponents from white ginseng and red ginseng","volume":"10","author":"Zuo","year":"2020","journal-title":"J.\u00a0Pharm. Anal."},{"key":"10.1016\/j.aca.2021.339320_bib21","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.trac.2019.03.017","article-title":"The emerging role of ion mobility-mass spectrometry in lipidomics to facilitate lipid separation and identification","volume":"116","author":"Tu","year":"2019","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib22","first-page":"3","article-title":"Major achievements of evidence-based traditional Chinese medicine in treating major diseases","volume":"1439","author":"Chao","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.aca.2021.339320_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11306-019-1577-3","article-title":"Compound danshen dripping pills normalize a reprogrammed metabolism of myocardial ischemia rats to interpret its time-dependent efficacy in clinic trails: a metabolomic study","volume":"15","author":"Aa","year":"2017","journal-title":"Metabolomics"},{"key":"10.1016\/j.aca.2021.339320_bib24","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3389\/fphar.2017.00826","article-title":"The clinical pharmacokinetics and of warfarin when combined with compound danshen: a case study for combined treatment of coronary heart diseases with atrial fibrillation","volume":"8","author":"Lv","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.aca.2021.339320_bib25","first-page":"728020","article-title":"Inhibition of NADPH oxidase mediates protective effect of cardiotonic pills against rat heart ischemia\/reperfusion injury, Evid.-based Complement Altern","author":"Yang","year":"2013","journal-title":"An. Med. Med."},{"key":"10.1016\/j.aca.2021.339320_bib26","first-page":"1144","article-title":"Long-term compound danshen dripping pills therapy reduces the no-reflow phenomenon in nondiabetes mellitus patients after primary percutaneous coronary intervention for acute myocardial infarction","volume":"93","author":"Xiangren","year":"2020","journal-title":"Ann. Pallliat. Med."},{"key":"10.1016\/j.aca.2021.339320_bib27","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1039\/C7AY00938K","article-title":"Quantitative analysis of salvianolic acids, ginsenosides and borneols using 1H qNMR for quality control of compound Danshen dripping pills","volume":"9","author":"Chen","year":"2017","journal-title":"Anal. Methods"},{"key":"10.1016\/j.aca.2021.339320_bib28","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/jssc.200600287","article-title":"Determination of the main bioactive metabolites of Radix Salvia miltiorrhizae in compound danshen dripping pills and the tissue distribution of danshensu in rabbit by SPE-HPLC-MSn","volume":"30","author":"Zheng","year":"2007","journal-title":"J.\u00a0Separ. Sci."},{"key":"10.1016\/j.aca.2021.339320_bib29","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/ac503715v","article-title":"Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification","volume":"87","author":"Paglia","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.aca.2014.05.048","article-title":"A\u00a0new measure of orthogonality for multi-dimensional chromatography","volume":"838","author":"Camenzuli","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2021.339320_bib31","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1021\/ac801772u","article-title":"Equation for peak capacity estimation in two-dimensional liquid chromatography","volume":"81","author":"Li","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aca.2015.08.048","article-title":"A\u00a0green protocol for efficient discovery of novel natural compounds: characterization of new ginsenosides from the stems and leaves of Panax ginseng as a case study","volume":"893","author":"Qiu","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2021.339320_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jpba.2012.06.025","article-title":"Trace analysis in complex mixtures using a high-component filtering strategy with liquid chromatography-mass spectrometry","volume":"70","author":"Zhang","year":"2012","journal-title":"J.\u00a0Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.aca.2021.339320_bib34","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.2174\/0929867327666200521124850","article-title":"Tanshinones: an update in the medicinal chemistry in recent 5 years","volume":"28","author":"Lai","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.aca.2021.339320_bib35","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.apsb.2015.07.008","article-title":"The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF\/VEGFR 2 expression on the human non-small cell lung cancer A 549 cell line","volume":"5","author":"Xie","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.aca.2021.339320_bib36","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1248\/bpb.28.1795","article-title":"PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza","volume":"28","author":"Han","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.aca.2021.339320_bib37","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/aps.2017.193","article-title":"Salvia miltiorrhiza Burge (danshen): a golden herbal medicine in cardiovascular therapeutics","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.aca.2021.339320_bib38","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.apsb.2020.12.017","article-title":"Ginsenosides in Panax genus and their biosynthesis","volume":"11","author":"Hou","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.aca.2021.339320_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.phytochem.2014.07.012","article-title":"Saponins in the genus Panax L. (Araliaceae): a systematic review of their chemical diversity","volume":"106","author":"Yang","year":"2014","journal-title":"Phytochemistry"},{"key":"10.1016\/j.aca.2021.339320_bib40","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1021\/acs.jnatprod.6b00789","article-title":"Malonylginsenosides with potential antidiabetic activities from the flower buds of Panax ginseng","volume":"80","author":"Qiu","year":"2017","journal-title":"J.\u00a0Nat. Prod."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267021011466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267021011466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:41:31Z","timestamp":1757706091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267021011466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":40,"alternative-id":["S0003267021011466"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2021.339320","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel hybrid scan approach enabling the ion-mobility separation and the alternate data-dependent and data-independent acquisitions (HDDIDDA): Its combination with off-line two-dimensional liquid chromatography for comprehensively characterizing the multicomponents from Compound Danshen Dripping Pill","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2021.339320","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"339320"}}