{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:25:22Z","timestamp":1781684722604,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P32326"],"award-info":[{"award-number":["P32326"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P33188"],"award-info":[{"award-number":["P33188"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003065","name":"Universit\u00e4t Wien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.aca.2022.339977","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T16:15:28Z","timestamp":1653322528000},"page":"339977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Quantifying up to 90 polyphenols simultaneously in human bio-fluids by LC-MS\/MS"],"prefix":"10.1016","volume":"1216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-5452","authenticated-orcid":false,"given":"Ian","family":"Oesterle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-0553","authenticated-orcid":false,"given":"Annette","family":"Rompel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Warth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.aca.2022.339977_bib1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3390\/ijms19061573","article-title":"Bioactivities of phenolics by focusing on suppression of chronic diseases: a review","volume":"19","author":"Shahidi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.aca.2022.339977_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cofs.2021.06.003","article-title":"Berry polyphenols and human health: evidence of antioxidant, anti-inflammatory, microbiota modulation, and cell-protecting effects","volume":"42","author":"Pap","year":"2021","journal-title":"Curr. Opin. Food Sci."},{"key":"10.1016\/j.aca.2022.339977_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fnut.2018.00087","article-title":"The role of polyphenols in human health and food systems: a mini-review","volume":"5","author":"Cory","year":"2018","journal-title":"Front. Nutr."},{"key":"10.1016\/j.aca.2022.339977_bib4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ccr.2018.05.023","article-title":"Recent progress in synthesis and characterization of metal chalcone complexes and their potential as bioactive agents","volume":"374","author":"Sulpizio","year":"2018","journal-title":"Coord. Chem. Rev."},{"issue":"5","key":"10.1016\/j.aca.2022.339977_bib5","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/1541-4337.12351","article-title":"The bioavailability, transport, and bioactivity of dietary flavonoids: a review from a historical perspective","volume":"17","author":"Williamson","year":"2018","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"40","key":"10.1016\/j.aca.2022.339977_bib6","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1021\/jf402506c","article-title":"Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition","volume":"61","author":"Etxeberria","year":"2013","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.aca.2022.339977_bib7","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1038\/s41598-019-39687-0","article-title":"Biochemical and structural characterization of tomato polyphenol oxidases provide novel insights into their substrate specificity","volume":"9","author":"Kampatsikas","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aca.2022.339977_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2019.100053","article-title":"Inhibition of apricot polyphenol oxidase by combinations of plant proteases and ascorbic acid","volume":"4","author":"Derardja","year":"2019","journal-title":"Food Chem. X"},{"issue":"bap024","key":"10.1016\/j.aca.2022.339977_bib9","article-title":"Phenol-explorer: an online comprehensive database on polyphenol contents in foods","volume":"2010","author":"Neveu","year":"2010","journal-title":"Database"},{"issue":"5","key":"10.1016\/j.aca.2022.339977_bib10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant polyphenols as dietary antioxidants in human health and disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"14","key":"10.1016\/j.aca.2022.339977_bib11","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (Poly)Phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases","volume":"18","author":"del Rio","year":"2012","journal-title":"Antioxidants Redox Signal."},{"issue":"3","key":"10.1016\/j.aca.2022.339977_bib12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/anie.201000044","article-title":"Plant polyphenols: chemical properties, biological activities, and synthesis","volume":"50","author":"Quideau","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"issue":"4","key":"10.1016\/j.aca.2022.339977_bib13","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/ajcn\/nqaa204","article-title":"Recommendations for standardizing nomenclature for dietary (Poly)Phenol catabolites","volume":"112","author":"Kay","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"issue":"8","key":"10.1016\/j.aca.2022.339977_bib14","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/87559129.2020.1717523","article-title":"Immunomodulatory; anti-inflammatory\/antioxidant effects of polyphenols: a comparative review on the parental compounds and their metabolites","volume":"37","author":"Sobhani","year":"2021","journal-title":"Food Rev. Int."},{"issue":"2","key":"10.1016\/j.aca.2022.339977_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/jn\/133.2.399","article-title":"Glucuronides are the main isoflavone metabolites in women","volume":"133","author":"Zhang","year":"2003","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.aca.2022.339977_bib16","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.3945\/ajcn.113.076133","article-title":"The food metabolome: a window over dietary exposure","volume":"99","author":"Scalbert","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.aca.2022.339977_bib17","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1039\/C8NP00062J","article-title":"Phenyl-\u03b3-Valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity","volume":"36","author":"Mena","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.aca.2022.339977_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tifs.2020.01.010","article-title":"Is a higher ingestion of phenolic compounds the best dietary strategy? A scientific opinion on the deleterious effects of polyphenols in vivo","volume":"98","author":"Granato","year":"2020","journal-title":"Trends Food Sci. Technol."},{"issue":"1","key":"10.1016\/j.aca.2022.339977_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s13318-012-0112-y","article-title":"Isoflavones: estrogenic activity, biological effect and bioavailability","volume":"38","author":"Vitale","year":"2013","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"issue":"4","key":"10.1016\/j.aca.2022.339977_bib20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jand.2016.09.036","article-title":"Association between dietary isoflavones in soy and legumes and endometrial cancer: a systematic review and meta-analysis","volume":"118","author":"Zhong","year":"2018","journal-title":"J. Acad. Nutr. Diet."},{"key":"10.1016\/j.aca.2022.339977_bib21","series-title":"Metabonomics: Methods and Protocols","first-page":"161","article-title":"The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research","author":"Emwas","year":"2015"},{"issue":"1","key":"10.1016\/j.aca.2022.339977_bib22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-food-032818-121233","article-title":"Nontargeted detection methods for food safety and integrity","volume":"10","author":"Shao","year":"2019","journal-title":"Annu. Rev. Food Sci. Technol."},{"issue":"1","key":"10.1016\/j.aca.2022.339977_bib23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev-food-062220-090807","article-title":"Polyphenol exposure, metabolism, and analysis: a global exposomics perspective","volume":"12","author":"Oesterle","year":"2021","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.aca.2022.339977_bib24","doi-asserted-by":"crossref","first-page":"16289","DOI":"10.1021\/acs.analchem.1c02660","article-title":"An introduction to the benchmarking and publications for non-targeted analysis working group","volume":"93","author":"Place","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2022.339977_bib25","first-page":"8","article-title":"Commission decision of 12 august 2002 implementing council directive 96\/23\/EC concerning the performance of analytical methods and the interpretation of results","volume":"221","year":"2002","journal-title":"Off. J. Eur. Commun."},{"key":"10.1016\/j.aca.2022.339977_bib26","series-title":"In Eurachem Guide: the Fitness for Purpose of Analytical Methods \u2013 A Laboratory Guide to Method Validation and Related Topics","isbn-type":"print","author":"Magnusson","year":"2014","ISBN":"https:\/\/id.crossref.org\/isbn\/9789187461590"},{"issue":"5","key":"10.1016\/j.aca.2022.339977_bib27","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1021\/acs.analchem.5b03609","article-title":"Differential isotope labeling of 38 dietary polyphenols and their quantification in urine by liquid chromatography electrospray ionization tandem mass spectrometry","volume":"88","author":"Achaintre","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2022.339977_bib28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chroma.2018.09.016","article-title":"A critical evaluation of the use of gas chromatography- and high performance liquid chromatography-mass spectrometry techniques for the analysis of microbial metabolites in human urine after consumption of orange juice","volume":"1575","author":"Ord\u00f3\u00f1ez","year":"2018","journal-title":"J. Chromatogr. A"},{"issue":"20","key":"10.1016\/j.aca.2022.339977_bib29","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.1021\/ac500565a","article-title":"Methods for isolating, identifying, and quantifying anthocyanin metabolites in clinical samples","volume":"86","author":"de Ferrars","year":"2014","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.aca.2022.339977_bib30","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/acs.jafc.0c07055","article-title":"Quantitative assessment of dietary (Poly)Phenol intake: a high-throughput targeted metabolomics method for blood and urine samples","volume":"69","author":"Dom\u00ednguez-Fern\u00e1ndez","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.aca.2022.339977_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.chroma.2018.05.017","article-title":"Quantification of 38 dietary polyphenols in plasma by differential isotope labelling and liquid chromatography electrospray ionization tandem mass spectrometry","volume":"1558","author":"Achaintre","year":"2018","journal-title":"J. Chromatogr. A"},{"issue":"4","key":"10.1016\/j.aca.2022.339977_bib32","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3945\/ajcn.2009.28854","article-title":"Disposition of soy isoflavones in normal human breast tissue","volume":"91","author":"Bolca","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"issue":"9","key":"10.1016\/j.aca.2022.339977_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201801239","article-title":"Metabolic profiling of dietary polyphenols and methylxanthines in normal and malignant mammary tissues from breast cancer patients","volume":"63","author":"\u00c1vila\u2010G\u00e1lvez","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.aca.2022.339977_bib34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/jn\/136.1.52","article-title":"Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity","volume":"136","author":"Gao","year":"2006","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.aca.2022.339977_bib35","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0891-5849(02)00877-8","article-title":"The metabolic fate of dietary polyphenols in humans","volume":"33","author":"Rechner","year":"2002","journal-title":"Free Radical Biol. Med."},{"issue":"11","key":"10.1016\/j.aca.2022.339977_bib36","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/jn\/130.11.2733","article-title":"Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids","volume":"130","author":"D\u00e9prez","year":"2000","journal-title":"J. Nutr."},{"issue":"12","key":"10.1016\/j.aca.2022.339977_bib37","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.tips.2020.09.012","article-title":"Drug\u2013exposome interactions: the next frontier in precision medicine","volume":"41","author":"Pristner","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.aca.2022.339977_bib38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fnut.2021.691872","article-title":"Systemically achievable doses of beer flavonoids induce estrogenicity in human endometrial cells and cause synergistic effects with selected pesticides","volume":"8","author":"Aichinger","year":"2021","journal-title":"Front. Nutr."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267022005487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267022005487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:37:01Z","timestamp":1762083421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267022005487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":38,"alternative-id":["S0003267022005487"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2022.339977","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantifying up to 90 polyphenols simultaneously in human bio-fluids by LC-MS\/MS","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2022.339977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"339977"}}