{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T16:10:23Z","timestamp":1780762223081,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62071413"],"award-info":[{"award-number":["62071413"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003482","name":"Hebei Province Department of Education","doi-asserted-by":"publisher","award":["ZD2020147"],"award-info":[{"award-number":["ZD2020147"]}],"id":[{"id":"10.13039\/501100003482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["C2019203556"],"award-info":[{"award-number":["C2019203556"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["F2020203056"],"award-info":[{"award-number":["F2020203056"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.aca.2022.340299","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T08:27:01Z","timestamp":1661588821000},"page":"340299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["An entropy-driven three-dimensional multipedal-DNA walker for ultrasensitive detection of cancer cells"],"prefix":"10.1016","volume":"1228","author":[{"given":"Hong","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2022.340299_bib1","first-page":"394","article-title":"Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.aca.2022.340299_bib2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","author":"Vos","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.aca.2022.340299_bib3","doi-asserted-by":"crossref","first-page":"11889","DOI":"10.1039\/C7CC06218D","article-title":"Temperature-responsive split aptamers coupled with polymerase chain reaction for label-free and sensitive detection of cancer cells","volume":"53","author":"Tang","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.aca.2022.340299_bib4","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1039\/c2cc32085a","article-title":"Aptamer-based polymerase chain reaction for ultrasensitive cell detection","volume":"48","author":"Song","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.aca.2022.340299_bib5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s12274-009-9041-8","article-title":"Highly fluorescent dye-doped silica nanoparticles increase flow cytometry sensitivity for cancer cell monitoring","volume":"2","author":"Est\u00e9vez","year":"2009","journal-title":"Nano Res."},{"key":"10.1016\/j.aca.2022.340299_bib6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1039\/c3lc41310a","article-title":"Time-of-flight magnetic flow cytometry in whole blood with integrated sample preparation","volume":"13","author":"Helou","year":"2013","journal-title":"Lab Chip"},{"key":"10.1016\/j.aca.2022.340299_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/cac2.12023","article-title":"Overview of multiplex immunohistochemistry\/immunofluorescence techniques in the era of cancer immunotherapy","volume":"40","author":"Tan","year":"2020","journal-title":"Cancer Commun."},{"key":"10.1016\/j.aca.2022.340299_bib8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","article-title":"Identification of human brain tumor initiating cells","volume":"432","author":"Singh","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.aca.2022.340299_bib9","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/acs.analchem.8b05085","article-title":"Combination of magnetic-beads-based multiple metal nanoparticles labeling with hybridization chain reaction amplification for simultaneous detection of multiple cancer cells with inductively coupled plasma mass spectrometry","volume":"91","author":"He","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2022.340299_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113455","article-title":"Versatile photoelectrochemical and electrochemiluminescence biosensor based on 3D CdSe QDs-DNA nanonetwork-SnO2 nanoflower coupled with DNA walker amplification for HIV detection","volume":"191","author":"Cai","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2022.340299_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.338781","article-title":"Novel preparation method of bipedal DNA walker based on hybridization chain reaction for ultrasensitive DNA biosensing","volume":"1176","author":"Feng","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2022.340299_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202004518","article-title":"DNA walking and rolling nanomachine for electrochemical detection of miRNA","volume":"16","author":"Miao","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.aca.2022.340299_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.aca.2020.11.043","article-title":"An integrated fluorescence biosensor for microRNA detection based on exponential amplification reaction-triggered three-dimensional bipedal DNA walkers","volume":"1143","author":"Yang","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2022.340299_bib14","doi-asserted-by":"crossref","first-page":"14253","DOI":"10.1021\/acsnano.1c02229","article-title":"Near-infrared light controllable DNA walker driven by endogenous adenosine triphosphate for in situ spatiotemporal imaging of intracellular microRNA","volume":"15","author":"Ye","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.aca.2022.340299_bib15","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1039\/C5SC00891C","article-title":"Simple electrochemical sensing of attomolar proteins using fabricated complexes with enhanced surface binding avidity","volume":"6","author":"Li","year":"2015","journal-title":"Chem. Sci."},{"key":"10.1016\/j.aca.2022.340299_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bios.2017.10.009","article-title":"Ultrasensitive electrochemiluminescence biosensor for detection of laminin based on DNA dendrimer-carried luminophore and DNA nanomachine-mediated target recycling amplification","volume":"101","author":"Li","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2022.340299_bib17","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1021\/acssensors.8b00304","article-title":"Portable aptasensor of aflatoxin B1 in bread based on a personal glucose meter and DNA walking machine","volume":"3","author":"Yang","year":"2018","journal-title":"ACS Sens."},{"key":"10.1016\/j.aca.2022.340299_bib18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1126\/science.1148532","article-title":"Engineering entropy-driven reactions and networks catalyzed by DNA","volume":"318","author":"Zhang","year":"2007","journal-title":"Science"},{"issue":"2015","key":"10.1016\/j.aca.2022.340299_bib19","doi-asserted-by":"crossref","first-page":"11714","DOI":"10.1021\/acs.analchem.5b02654","article-title":"Entropy beacon: a hairpin-free DNA amplification strategy for efficient detection of nucleic acids","volume":"87","author":"Lv","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2022.340299_bib20","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/anie.201307418","article-title":"Mismatches improve the performance of strand-displacement nucleic acid circuits","volume":"53","author":"Jiang","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2022.340299_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.116142","article-title":"Entropy driven circuit as an emerging molecular tool for biological sensing: a review","volume":"134","author":"Li","year":"2021","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.aca.2022.340299_bib22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nnano.2015.246","article-title":"A stochastic DNA walker that traverses a microparticle surface","volume":"11","author":"Jung","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.aca.2022.340299_bib23","doi-asserted-by":"crossref","first-page":"9593","DOI":"10.1021\/acs.analchem.1c01765","article-title":"Flap endonuclease 1-assisted DNA walkers for sensitively and specifically sensing ctDNAs","volume":"93","author":"Cheng","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2022.340299_bib24","doi-asserted-by":"crossref","first-page":"10361","DOI":"10.1039\/D0SC03698F","article-title":"A bipedal DNA nanowalker fueled by catalytic assembly for imaging of base-excision repairing in living cells","volume":"11","author":"Lv","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.aca.2022.340299_bib25","doi-asserted-by":"crossref","first-page":"15317","DOI":"10.1021\/acs.analchem.9b04987","article-title":"Binding-induced 3D-bipedal DNA walker for cascade signal amplification detection of thrombin combined with catalytic hairpin assembly strategy","volume":"91","author":"Xiong","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2022.340299_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202000647","article-title":"Bioinspired DNA nanointerface with anisotropic aptamers for accurate capture of circulating tumor cells","volume":"7","author":"Qin","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.aca.2022.340299_bib27","doi-asserted-by":"crossref","first-page":"14171","DOI":"10.1039\/D0CC06347A","article-title":"Fluorescent imaging of cytoplasmic nucleolin in live cells by a functionalized-engineered aptamer","volume":"56","author":"Yin","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.aca.2022.340299_bib28","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1158\/0008-5472.CAN-07-5723","article-title":"The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells","volume":"68","author":"Soundararajan","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.aca.2022.340299_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bios.2018.09.076","article-title":"Aptamer-DNA concatamer-quantum dots based electrochemical biosensing strategy for green and ultrasensitive detection of tumor cells via mercury-free anodic stripping voltammetry","volume":"126","author":"Zheng","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2022.340299_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.snb.2018.05.162","article-title":"A ratiometric magnesium sensor using DNAzyme-templated CdTe quantum dots and Cy5","volume":"272","author":"Wang","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2022.340299_bib31","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/s41596-020-0355-z","article-title":"Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment","volume":"15","author":"Zhang","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.aca.2022.340299_bib32","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1021\/ac3003402","article-title":"One-pot synthesis of aptamer-functionalized silver nanoclusters for cell-type-specific imaging","volume":"84","author":"Li","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2022.340299_bib33","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1021\/acs.nanolett.8b02004","article-title":"Photoactivated specific mRNA detection in single living cells by coupling \u201csignal-on\u201d fluorescence and \u201csignal-off\u201d electrochemical signals","volume":"18","author":"Huang","year":"2018","journal-title":"Nano Lett."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267022008704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267022008704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:38:25Z","timestamp":1762083505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267022008704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":33,"alternative-id":["S0003267022008704"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2022.340299","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An entropy-driven three-dimensional multipedal-DNA walker for ultrasensitive detection of cancer cells","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2022.340299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"340299"}}