{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:58:22Z","timestamp":1785427102756,"version":"3.56.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21874087"],"award-info":[{"award-number":["21874087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274090"],"award-info":[{"award-number":["22274090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015301","name":"Shanxi Province Hundred Talents Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.aca.2023.341786","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T08:59:05Z","timestamp":1693990745000},"page":"341786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["A novel multi-functional fluorescent probe for dual-channel detection of SO2 and Hg2+ and dynamic visualization of SO2 fluctuations in vivo upon mercury exposure"],"prefix":"10.1016","volume":"1279","author":[{"given":"Jianhua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuobin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaomin","family":"Shuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2023.341786_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.aca.2023.341786_bib2","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1089\/ars.2008.2331","article-title":"Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function","volume":"11","author":"Stowe","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.aca.2023.341786_bib3","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1021\/acs.accounts.9b00302","article-title":"Reaction-based fluorescent probes for the detection and imaging of reactive oxygen, nitrogen, and sulfur species","volume":"52","author":"Wu","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.aca.2023.341786_bib4","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1021\/cr300163e","article-title":"Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery","volume":"113","author":"Paulsen","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aca.2023.341786_bib5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nrd.2018.174","article-title":"Mitochondria as a therapeutic target for common pathologies","volume":"17","author":"Murphy","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.aca.2023.341786_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bcp.2017.12.010","article-title":"H2S and polysulfide metabolism: conventional and unconventional pathways","volume":"149","author":"Olson","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.aca.2023.341786_bib7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ccr.2019.03.001","article-title":"Reaction-based fluorescent probes for SO2 derivatives and their biological applications","volume":"388","author":"Li","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2023.341786_bib8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.snb.2019.01.170","article-title":"A near-infrared and two-photon ratiometric fluorescent probe with a large Stokes shift for sulfur dioxide derivatives detection and its applications in vitro and in vivo","volume":"288","author":"Zhao","year":"2019","journal-title":"Sensor Actuat B Chem."},{"key":"10.1016\/j.aca.2023.341786_bib9","doi-asserted-by":"crossref","first-page":"11935","DOI":"10.1021\/jf2032928","article-title":"A boron-dipyrromethene-based fluorescent probe for colorimetric and ratiometric detection of sulfite","volume":"59","author":"Gu","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.aca.2023.341786_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.dyepig.2015.04.016","article-title":"\u201cQuinone-phenol\u201d transduction activated excited-state intramolecular proton transfer: a new strategy toward ratiometric fluorescent probe for sulfite in living cells","volume":"120","author":"Geng","year":"2015","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.aca.2023.341786_bib11","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1126\/science.1085941","article-title":"The chemical form of mercury in fish","volume":"301","author":"Harris","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.aca.2023.341786_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2018.11.007","article-title":"The thioredoxin system as a target for mercury compounds","volume":"1863","author":"Branco","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.aca.2023.341786_bib13","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1039\/C4CS00292J","article-title":"Fluorescence imaging of metal ions implicated in diseases","volume":"44","author":"Qian","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2023.341786_bib14","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1021\/acs.analchem.9b04381","article-title":"Glutathione peroxidase-activatable two-photon ratiometric fluorescent probe for redox mechanism research in aging and mercury exposure mice models","volume":"92","author":"Wang","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2023.341786_bib15","doi-asserted-by":"crossref","first-page":"127038","DOI":"10.1016\/j.snb.2019.127038","article-title":"A sulfydryl-based near-infrared ratiometic fluorescent probe for assessment of acute\/chronic mercury exposure via associated determination of superoxide anion and mercury ion in cells and in vivo","volume":"301","author":"Wang","year":"2019","journal-title":"Sensor Actuat B Chem."},{"key":"10.1016\/j.aca.2023.341786_bib16","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1021\/acs.analchem.8b01442","article-title":"Associated detection of superoxide anion and mercury (II) under chronic mercury exposure in cells and mice models via a three-channel fluorescent probe","volume":"90","author":"Wang","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2023.341786_bib17","doi-asserted-by":"crossref","first-page":"213691","DOI":"10.1016\/j.ccr.2020.213691","article-title":"Small molecular fluorescent probes for the detection of lead, cadmium and mercury ions","volume":"429","author":"Chen","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2023.341786_bib18","doi-asserted-by":"crossref","first-page":"127166","DOI":"10.1016\/j.cej.2020.127166","article-title":"Fluorescent probe for mercury ion imaging analysis: strategies and applications","volume":"406","author":"Wang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.aca.2023.341786_bib19","first-page":"28527","article-title":"Fluorescent probes for biomolecule detection under environmental stress","volume":"431","author":"Han","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.aca.2023.341786_bib20","doi-asserted-by":"crossref","first-page":"130244","DOI":"10.1016\/j.snb.2021.130244","article-title":"Dual-emission NIR fluorescent probe sensitive response biological microenvironment and sulfur dioxide","volume":"344","author":"Zhang","year":"2021","journal-title":"Sensor Actuat B Chem."},{"key":"10.1016\/j.aca.2023.341786_bib21","doi-asserted-by":"crossref","first-page":"339723","DOI":"10.1016\/j.aca.2022.339723","article-title":"A novel isophorone-derived fluorescent probe for detecting sulfite and the application in monitoring the state of hybridoma cells","volume":"1205","author":"Rui","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2023.341786_bib22","doi-asserted-by":"crossref","first-page":"110111","DOI":"10.1016\/j.dyepig.2022.110111","article-title":"Engineering an ESIPT-based fluorescent probe for dual-channel (Vis\/NIR) ratiometric monitoring of intracellular sulfur dioxide by single wavelength excitation","volume":"199","author":"Ren","year":"2022","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.aca.2023.341786_bib23","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1021\/acs.jafc.2c00820","article-title":"Mitochondria-Targeted fluorescent turn-on probe for rapid detection of bisulfite\/sulfite in water and food samples","volume":"70","author":"Zhong","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.aca.2023.341786_bib24","doi-asserted-by":"crossref","first-page":"127179","DOI":"10.1016\/j.jhazmat.2021.127179","article-title":"Insight into sulfur dioxide and its derivatives metabolism in living system with visualized evidences via ultra-sensitive fluorescent probe","volume":"423","author":"Zhang","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.aca.2023.341786_bib25","doi-asserted-by":"crossref","first-page":"127229","DOI":"10.1016\/j.jhazmat.2021.127229","article-title":"All-in-one: accurate quantification, on-site detection, and bioimaging of sulfite using a colorimetric and ratiometric fluorescent probe in vitro and in vivo","volume":"424","author":"Lan","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.aca.2023.341786_bib26","doi-asserted-by":"crossref","first-page":"139023","DOI":"10.1016\/j.cej.2022.139023","article-title":"A multifunctional fluorescent probe for dual-color visualization of intracellular mitochondria and lipid droplets and monitoring of SO2 in vivo","volume":"451","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.aca.2023.341786_bib27","doi-asserted-by":"crossref","first-page":"126242","DOI":"10.1016\/j.jhazmat.2021.126242","article-title":"Detection of hazardous mercury ion using [5] helicene-based fluorescence probe with \u201cTurn-ON\u201d sensing response for practical applications","volume":"418","author":"Kaewnok","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.aca.2023.341786_bib28","doi-asserted-by":"crossref","first-page":"340337","DOI":"10.1016\/j.aca.2022.340337","article-title":"Rational design of a water-soluble TICT-AIEE-active fluorescent probe for mercury ion detection","volume":"1230","author":"Su","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2023.341786_bib29","doi-asserted-by":"crossref","first-page":"107481","DOI":"10.1016\/j.microc.2022.107481","article-title":"Ultrasensitive detection and high-contrast bioimaging of Hg2+ using monothiosquaraine-based fluorescent probe via hydrogen bond promoted desulfurization","volume":"179","author":"Wang","year":"2022","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2023.341786_bib30","doi-asserted-by":"crossref","first-page":"12165","DOI":"10.1016\/j.saa.2022.121651","article-title":"A quinoline-rhodamine hybrid probe for ratiometricly sensing of Hg2+ in water and cell imaging application","volume":"281","author":"Huang","year":"2022","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.aca.2023.341786_bib31","doi-asserted-by":"crossref","first-page":"127701","DOI":"10.1016\/j.jhazmat.2021.127701","article-title":"A small molecule fluorescent probe for mercury ion analysis in broad low pH range: spectral, optical mechanism and application studies","volume":"424","author":"Liu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.aca.2023.341786_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2021.109928","article-title":"A dual-site and dual-turn-on fluorescence probe for imaging mitochondrial HClO and SO2","volume":"197","author":"Bao","year":"2022","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.aca.2023.341786_bib33","doi-asserted-by":"crossref","first-page":"122606","DOI":"10.1016\/j.talanta.2021.122606","article-title":"Mitochondria-targeted NIR fluorescent probe for sensing Hg2+\/HSO3- and its intracellular applications","volume":"234","author":"Liu","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2023.341786_bib34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.dyepig.2019.02.018","article-title":"Silica nanoparticles doped with a benzo[e]indolium-tethered iridium (III) complex for reversible detection of HSO3- and Hg2+\/Cu2+ in water","volume":"165","author":"Li","year":"2019","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.aca.2023.341786_bib35","doi-asserted-by":"crossref","first-page":"27968","DOI":"10.1021\/acsami.5b10607","article-title":"Mitochondria-Targeted near-infrared fluorescent off-on probe for selective detection of cysteine in living cells and in vivo","volume":"7","author":"Han","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2023.341786_bib36","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1021\/jacs.0c00992","article-title":"Employing an ICT-FRET integration platform for the real-time tracking of SO2 metabolism in cancer cells and tumor models","volume":"142","author":"Zhang","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2023.341786_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.131982","article-title":"Fluorescence imaging to probe mercury induced oxidative stress in living systems","volume":"366","author":"Zhang","year":"2022","journal-title":"Sensor Actuat B Chem."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267023010073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267023010073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T20:06:09Z","timestamp":1757707569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267023010073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":37,"alternative-id":["S0003267023010073"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2023.341786","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel multi-functional fluorescent probe for dual-channel detection of SO2 and Hg2+ and dynamic visualization of SO2 fluctuations in vivo upon mercury exposure","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2023.341786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"341786"}}