{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:50:48Z","timestamp":1790088648332,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.aca.2023.341877","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:28:46Z","timestamp":1696494526000},"page":"341877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Hybrid chain reaction and selective recognition-based homogeneous dual-fluorescence analysis of circulating tumor cells in clinical ovarian cancer samples"],"prefix":"10.1016","volume":"1281","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-5903","authenticated-orcid":false,"given":"Qian","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2023.341877_bib1","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1126\/science.1235226","article-title":"Cancer. Circulating tumor cells","volume":"341","author":"Plaks","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.aca.2023.341877_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112893","article-title":"A dual recognition strategy for accurate detection of CTCs based on novel branched PtAuRh trimetallic nanospheres","volume":"176","author":"Cai","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2023.341877_bib3","doi-asserted-by":"crossref","first-page":"16078","DOI":"10.1021\/jacs.1c06436","article-title":"In situ programmable DNA circuit-promoted electrochemical characterization of stemlike phenotype in breast cancer","volume":"143","author":"Cao","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2023.341877_bib4","doi-asserted-by":"crossref","first-page":"16747","DOI":"10.1002\/anie.202007451","article-title":"Facile preparation of WO(3-x) dots with remarkably low toxicity and uncompromised activity as Co-reactants for clinical diagnosis by electrochemiluminescence","volume":"59","author":"Pan","year":"2020","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.aca.2023.341877_bib5","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1021\/acs.nanolett.9b05066","article-title":"Dendrimer-Au nanoparticle network covered alumina membrane for ion rectification and enhanced bioanalysis","volume":"20","author":"Wang","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.aca.2023.341877_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112780","article-title":"Colorimetric detection of immunomagnetically captured rare number CTCs using mDNA-wrapped single-walled carbon nanotubes","volume":"172","author":"Zhu","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2023.341877_bib7","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nnano.2012.211","article-title":"A mechanical metamaterial made from a DNA hydrogel","volume":"7","author":"Lee","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.aca.2023.341877_bib8","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/anie.201611777","article-title":"An exonuclease III-powered, on-particle stochastic DNA walker","volume":"56","author":"Qu","year":"2017","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.aca.2023.341877_bib9","doi-asserted-by":"crossref","first-page":"14038","DOI":"10.1021\/jacs.8b08121","article-title":"Visual detection of amplified DNA by polymerase chain reaction using a genetic alphabet expansion system","volume":"140","author":"Yamashige","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2023.341877_bib10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nnano.2015.259","article-title":"High-speed DNA-based rolling motors powered by RNase H","volume":"11","author":"Yehl","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.aca.2023.341877_bib11","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1021\/jacs.0c11245","article-title":"DNA-based dynamic mimicry of membrane proteins for programming adaptive cellular interactions","volume":"143","author":"Li","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2023.341877_bib12","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1039\/C8SC01981A","article-title":"Construction of an enzyme-free concatenated DNA circuit for signal amplification and intracellular imaging","volume":"9","author":"Wang","year":"2018","journal-title":"Chem. Sci."},{"key":"10.1016\/j.aca.2023.341877_bib13","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.1021\/jacs.1c00570","article-title":"Orthogonal demethylase-activated deoxyribozyme for intracellular imaging and gene regulation","volume":"143","author":"Wang","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2023.341877_bib14","doi-asserted-by":"crossref","first-page":"36476","DOI":"10.1021\/acsami.9b15594","article-title":"Multimode MicroRNA sensing via multiple enzyme-free signal amplification and cation-exchange reaction","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2023.341877_bib15","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1021\/acs.analchem.2c01530","article-title":"Fluorescence aptasensor of tuberculosis interferon-\u03b3 in clinical samples regulated by steric hindrance and selective identification","volume":"94","author":"Chen","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2023.341877_bib16","doi-asserted-by":"crossref","first-page":"21030","DOI":"10.1021\/acsami.1c03538","article-title":"Ultrasensitive nanopore sensing of mucin 1 and circulating tumor cells in whole blood of breast cancer patients by analyte-triggered triplex-DNA release","volume":"13","author":"Sun","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2023.341877_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10432","article-title":"In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics","volume":"7","author":"Ai","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.aca.2023.341877_bib18","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1002\/anie.201712803","article-title":"An intracellular H(2) O(2) -responsive AIEgen for the peroxidase-mediated selective imaging and inhibition of inflammatory cells","volume":"57","author":"Cheng","year":"2018","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.aca.2023.341877_bib19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1021\/acs.nanolett.0c03930","article-title":"Engineering fluorescent gold nanoclusters using xanthate-functionalized hydrophilic polymers: toward enhanced monodispersity and stability","volume":"21","author":"Deepagan","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.aca.2023.341877_bib20","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1021\/acs.chemmater.6b00208","article-title":"Highly fluorescent ribonuclease-A-encapsulated lead sulfide quantum dots for ultrasensitive fluorescence in vivo imaging in the second near-infrared window","volume":"28","author":"Kong","year":"2016","journal-title":"Chem. Mater."},{"key":"10.1016\/j.aca.2023.341877_bib21","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1039\/C9SC06408G","article-title":"Quantification of cyclic DNA polymerization with lanthanide coordination nanomaterials for liquid biopsy","volume":"11","author":"Zhou","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.aca.2023.341877_bib22","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1021\/acs.nanolett.1c04818","article-title":"Homogeneous binary visual and fluorescence detection of tetanus toxoid in clinical samples based on enzyme-free parallel hybrid chain reaction","volume":"22","author":"Chen","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.aca.2023.341877_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114009","article-title":"Homogeneous two-dimensional visual and fluorescence analysis of circulating tumor cells in clinical samples via steric hindrance regulated enzymes recognition cleavage and elongation","volume":"202","author":"Chen","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2023.341877_bib24","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1021\/acs.analchem.0c04562","article-title":"Filter-assisted separation of multiple nanomaterials: mechanism and application in atomic\/mass spectrometry\/fluorescence label-free multimode bioassays","volume":"93","author":"Wang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2023.341877_bib25","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.1021\/ja9038054","article-title":"Terminal protection of small-molecule-linked DNA for sensitive electrochemical detection of protein binding via selective carbon nanotube assembly","volume":"131","author":"Wu","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2023.341877_bib26","doi-asserted-by":"crossref","first-page":"11836","DOI":"10.1002\/anie.202003905","article-title":"DNA nanoribbon-templated self-assembly of ultrasmall fluorescent copper nanoclusters with enhanced luminescence","volume":"59","author":"Ouyang","year":"2020","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.aca.2023.341877_bib27","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.1039\/D0TB01108H","article-title":"Rapid and highly sensitive visual detection of oxalate for metabolic assessment of urolithiasis via selective recognition reaction of CdTe quantum dots","volume":"8","author":"Chen","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.aca.2023.341877_bib28","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/smll.201202739","article-title":"Graphene oxide-based fluorescent biosensor for protein detection via terminal protection of small-molecule-linked DNA","volume":"9","author":"He","year":"2013","journal-title":"Small"},{"key":"10.1016\/j.aca.2023.341877_bib29","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1039\/C8CC01186A","article-title":"Selective reduction-based, highly sensitive and homogeneous detection of iodide and melamine using chemical vapour generation-atomic fluorescence spectrometry","volume":"54","author":"Chen","year":"2018","journal-title":"Chem Commun (Camb)."},{"key":"10.1016\/j.aca.2023.341877_bib30","doi-asserted-by":"crossref","first-page":"9737","DOI":"10.1039\/C4CC03734K","article-title":"Ultrasensitive aptamer-based SERS detection of PSAs by heterogeneous satellite nanoassemblies","volume":"50","author":"Ma","year":"2014","journal-title":"Chem Commun (Camb)."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702301098X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702301098X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:45:11Z","timestamp":1762083911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000326702301098X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":30,"alternative-id":["S000326702301098X"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2023.341877","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hybrid chain reaction and selective recognition-based homogeneous dual-fluorescence analysis of circulating tumor cells in clinical ovarian cancer samples","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2023.341877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"341877"}}