{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:06:39Z","timestamp":1790201199410,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274005"],"award-info":[{"award-number":["22274005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2167222"],"award-info":[{"award-number":["U2167222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2067214"],"award-info":[{"award-number":["U2067214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22334001"],"award-info":[{"award-number":["22334001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1201000"],"award-info":[{"award-number":["2021YFA1201000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1207300"],"award-info":[{"award-number":["2022YFA1207300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.aca.2024.343372","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T16:21:34Z","timestamp":1729786894000},"page":"343372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["A mitochondria-targeted nitric oxide probe with large Stokes shift for real-time imaging and evaluation of inflammatory bowel disease in situ"],"prefix":"10.1016","volume":"1332","author":[{"given":"Jiatian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-4466","authenticated-orcid":false,"given":"Dongdong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2024.343372_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0002-9343(00)00480-0","article-title":"Nitric oxide and intestinal inflammation","volume":"109","author":"Kubes","year":"2000","journal-title":"Am. J. Med."},{"key":"10.1016\/j.aca.2024.343372_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202301391","article-title":"Recent advances in cell-based in vitro models to recreate human intestinal inflammation","volume":"10","author":"Macedo","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.aca.2024.343372_bib3","first-page":"1","article-title":"Functions and signaling pathways of amino acids in intestinal inflammation","volume":"2018","author":"He","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.aca.2024.343372_bib4","first-page":"33","article-title":"Inflammatory bowel disease: an expanding global health problem","volume":"6","author":"M'Koma","year":"2013","journal-title":"Clin. Med. Insights Geriatr."},{"key":"10.1016\/j.aca.2024.343372_bib5","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.aca.2024.343372_bib6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/acs.analchem.9b02264","article-title":"Microenvironment-responsive small-molecule probe for pulmonary fibrosis detection","volume":"92","author":"Dong","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib7","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1021\/acs.jmedchem.3c02344","article-title":"Mitochondrial-targeted ratiometric near-infrared fluorescence probe for monitoring nitric oxide in rheumatoid arthritis","volume":"67","author":"Han","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib8","doi-asserted-by":"crossref","first-page":"12663","DOI":"10.1021\/acs.analchem.8b02891","article-title":"Ultra-rapid detection of endogenous nitric oxide based on fluorescent conjugated polymers probe","volume":"90","author":"Zhao","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib9","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1021\/jacs.7b10783","article-title":"A ratiometric acoustogenic probe for in vivo imaging of endogenous nitric oxide","volume":"140","author":"Reinhardt","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2024.343372_bib10","doi-asserted-by":"crossref","first-page":"12186","DOI":"10.1021\/ja901016a","article-title":"Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase","volume":"131","author":"Sabat","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2024.343372_bib11","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1021\/acs.analchem.1c00281","article-title":"Highly sensitive D\u2013a\u2013D-type near-infrared fluorescent probe for nitric oxide real-time imaging in inflammatory bowel disease","volume":"93","author":"Liu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib12","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/sj.bjp.0706227","article-title":"The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice","volume":"145","author":"Pol","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.aca.2024.343372_bib13","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1021\/acs.analchem.9b05435","article-title":"A smart fluorescent probe for NO detection and application in myocardial fibrosis imaging","volume":"92","author":"Zhou","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib14","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1021\/acs.analchem.2c04896","article-title":"Development of a facile lysosome-targeting nitric oxide fluorescent probe based on a novel reaction mechanism","volume":"95","author":"Wang","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib15","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.talanta.2017.08.044","article-title":"Dihydropyridine-derived BODIPY probe for detecting exogenous and endogenous nitric oxide in mitochondria","volume":"176","author":"Gao","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2024.343372_bib16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.aca.2019.03.048","article-title":"Visualizing Nitric oxide in mitochondria and lysosomes of living cells with N-Nitrosation of BODIPY-based fluorescent probes","volume":"1067","author":"Yu","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2024.343372_bib17","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1021\/ac401916z","article-title":"Targetable fluorescent probe for monitoring exogenous and endogenous NO in mitochondria of living cells","volume":"85","author":"Yu","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib18","doi-asserted-by":"crossref","first-page":"10511","DOI":"10.1021\/acs.analchem.7b02680","article-title":"Selective and real-time detection of nitric oxide by a two-photon fluorescent probe in live cells and tissue slices","volume":"89","author":"Dai","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib19","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1021\/jacs.8b04404","article-title":"A general method to increase Stokes shift by introducing alternating vibronic structures","volume":"140","author":"Ren","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2024.343372_bib20","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.1021\/ja500962u","article-title":"Tunable heptamethine\u2013azo dye conjugate as an NIR fluorescent probe for the selective detection of mitochondrial glutathione over cysteine and homocysteine","volume":"136","author":"Lim","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2024.343372_bib21","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1021\/acs.analchem.2c00041","article-title":"Mitochondria-targeted fluorescence\/photoacoustic dual-modality imaging probe tailored for visual precise diagnosis of drug-induced liver injury","volume":"94","author":"Zhang","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib22","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1021\/ja511014w","article-title":"New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT","volume":"137","author":"Takakura","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2024.343372_bib23","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1007\/s12274-022-4166-0","article-title":"Specific generation of nitric oxide in mitochondria of cancer cell for selective oncotherapy","volume":"15","author":"Sun","year":"2022","journal-title":"Nano Res."},{"key":"10.1016\/j.aca.2024.343372_bib24","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1021\/ac303787p","article-title":"Inaccuracies of nitric oxide measurement methods in biological media","volume":"85","author":"Hunter","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib25","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1021\/acs.analchem.9b00169","article-title":"BODIPY-based fluorescent probe for dual-channel detection of nitric oxide and glutathione: visualization of cross-talk in living cells","volume":"91","author":"Chen","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343372_bib26","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.3748\/wjg.v26.i24.3365","article-title":"Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways","volume":"26","author":"Kamalian","year":"2020","journal-title":"World J. Gastroenterol."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267024011735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267024011735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T21:30:20Z","timestamp":1732224620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267024011735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":26,"alternative-id":["S0003267024011735"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2024.343372","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A mitochondria-targeted nitric oxide probe with large Stokes shift for real-time imaging and evaluation of inflammatory bowel disease in situ","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2024.343372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"343372"}}