{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:16:46Z","timestamp":1780514206507,"version":"3.54.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20OC0065428"],"award-info":[{"award-number":["NNF20OC0065428"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF135"],"award-info":[{"award-number":["DNRF135"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.aca.2024.343472","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T15:10:03Z","timestamp":1732288203000},"page":"343472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Nanobodies\u2019 duo facilitates ultrasensitive serum HER-2\/neu immunoassays via enhanced avidity interactions"],"prefix":"10.1016","volume":"1335","author":[{"given":"Suchanat","family":"Boonkaew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Teodori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0431-2522","authenticated-orcid":false,"given":"Mikkel H.","family":"Vendelbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Kjems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-3204","authenticated-orcid":false,"given":"Elena E.","family":"Ferapontova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2024.343472_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jid.2013.287","article-title":"Enzyme immunoassay and enzyme-linked immunosorbent assay","volume":"133","author":"Gan","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.aca.2024.343472_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/prca.201400130","article-title":"ELISA in the multiplex era: potentials and pitfalls","volume":"9","author":"Tighe","year":"2015","journal-title":"Proteonomics Clin. Appl."},{"key":"10.1016\/j.aca.2024.343472_bib3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri1837","article-title":"Potent antibody therapeutics by design","volume":"6","author":"Carter","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.aca.2024.343472_bib4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40164-021-00250-1","article-title":"Recent advances and challenges of bispecific antibodies in solid tumors","volume":"10","author":"Wu","year":"2021","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.aca.2024.343472_bib5","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s40291-021-00560-4","article-title":"Economic evaluation of monoclonal antibodies in metastatic colorectal cancer: a systematic review","volume":"25","author":"Koilakou","year":"2021","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.aca.2024.343472_bib6","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1200\/JCO.2014.59.7245","article-title":"Economic evaluation of bevacizumab for the first-line treatment of newly diagnosed glioblastoma multiforme","volume":"33","author":"Kovic","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.aca.2024.343472_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta11120","article-title":"Systematic review and economic evaluation of bevacizumab and cetuximab for the treatment of metastatic colorectal cancer","volume":"11","author":"Tappenden","year":"2007","journal-title":"Health Technol. Assess."},{"key":"10.1016\/j.aca.2024.343472_bib8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3390\/s21030736","article-title":"Design strategies for electrochemical aptasensors for cancer diagnostic devices","volume":"21","author":"Malecka","year":"2021","journal-title":"Sensors"},{"key":"10.1016\/j.aca.2024.343472_bib9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12935-024-03295-4","article-title":"Aptamers as an approach to targeted cancer therapy","volume":"24","author":"Mahmoudian","year":"2024","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.aca.2024.343472_bib10","doi-asserted-by":"crossref","first-page":"32231","DOI":"10.1021\/acsomega.3c04345","article-title":"Recent advancements of aptamers in cancer therapy","volume":"8","author":"Venkatesan","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.aca.2024.343472_bib11","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2217\/fon.10.67","article-title":"Aptamer applications for targeted cancer therapy","volume":"6","author":"Barbas","year":"2010","journal-title":"Future Oncol."},{"key":"10.1016\/j.aca.2024.343472_bib12","first-page":"3","article-title":"Oligonucleotide aptamers: new tools for targeted cancer therapy","author":"Sun","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.aca.2024.343472_bib13","doi-asserted-by":"crossref","first-page":"9500","DOI":"10.1021\/acsami.0c05750","article-title":"Recent progress in aptamer discoveries and modifications for therapeutic applications","volume":"13","author":"Ni","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2024.343472_bib14","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3389\/fimmu.2017.01589","article-title":"Camelid single-domain antibodies: historical perspective and future outlook","volume":"8","author":"Arbabi-Ghahroudi","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.aca.2024.343472_bib15","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1016\/j.ddtec.2010.03.002","article-title":"Nanobodies \u2013 from llamas to therapeutic proteins","volume":"7","author":"Kolkman","year":"2010","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.aca.2024.343472_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11349","article-title":"Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation","volume":"4","author":"Pleiner","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.aca.2024.343472_bib17","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.14440\/jbm.2022.381","article-title":"Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging","volume":"9","author":"Teodori","year":"2022","journal-title":"J. Biol. Meth."},{"key":"10.1016\/j.aca.2024.343472_bib18","article-title":"Engineered multivalent nanobodies potently and broadly neutralize SARS-CoV-2 variants","volume":"4","author":"Zupancic","year":"2021","journal-title":"Adv. Ther."},{"key":"10.1016\/j.aca.2024.343472_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2024.102305","article-title":"Plug-and-play nucleic acid-mediated multimerization of biparatopic nanobodies for molecular imaging","author":"Teodori","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.aca.2024.343472_bib20","doi-asserted-by":"crossref","first-page":"6616","DOI":"10.1158\/1078-0432.CCR-17-0310","article-title":"131I-labeled anti-HER2 camelid sdAb as a theranostic tool in cancer treatment","volume":"23","author":"D'Huyvetter","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.aca.2024.343472_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/protein\/gzab030","article-title":"Generation of a nanobody against HER2 tyrosine kinase using phage display library screening for HER2-positive breast cancer therapy development","volume":"34","author":"Lamtha","year":"2021","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.aca.2024.343472_bib22","article-title":"A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.aca.2024.343472_bib23","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1096\/fj.10-180331","article-title":"Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer","volume":"25","author":"Vaneycken","year":"2011","journal-title":"Faseb. J."},{"key":"10.1016\/j.aca.2024.343472_bib24","article-title":"A novel small molecular antibody, HER2-nanobody, inhibits tumor proliferation in HER2-positive breast cancer cells in vitro and in vivo","volume":"11","author":"Yan","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.aca.2024.343472_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.aca.2024.343472_bib26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrm1962","article-title":"EGF\u2013ERBB signalling: towards the systems level","volume":"7","author":"Citri","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.aca.2024.343472_bib27","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/s41416-023-02426-4","article-title":"Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level, Brit","volume":"129","author":"Atallah","year":"2023","journal-title":"J. Cancer"},{"key":"10.1016\/j.aca.2024.343472_bib28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10549-016-4080-9","article-title":"Survival with metastatic breast cancer based on initial presentation, de novo versus relapsed","volume":"161","author":"den Brok","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.aca.2024.343472_bib29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41572-019-0111-2","article-title":"Breast cancer","volume":"5","author":"Harbeck","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.aca.2024.343472_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ygyno.2022.12.018","article-title":"Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody\u2013drug conjugate with topoisomerase I inhibitor payload, shows antitumor activity in uterine and ovarian carcinosarcoma with HER2\/neu expression","volume":"170","author":"Mauricio","year":"2023","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.aca.2024.343472_bib31","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1634\/theoncologist.2008-0230","article-title":"The HER-2 receptor and breast cancer: ten years of targeted anti\u2013HER-2 therapy and personalized medicine","volume":"14","author":"Ross","year":"2009","journal-title":"Oncol."},{"key":"10.1016\/j.aca.2024.343472_bib32","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1039\/C3RA45401K","article-title":"Detection of ErbB2: nanotechnological solutions for clinical diagnostics","volume":"4","author":"Mahfoud","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.aca.2024.343472_bib33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ctrv.2013.09.001","article-title":"HER2 testing: current status and future directions","volume":"40","author":"Perez","year":"2014","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.aca.2024.343472_bib34","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1021\/acsmeasuresciau.2c00067","article-title":"Electrochemical cellulase-linked ELASA for rapid liquid biopsy testing of serum HER-2\/neu","volume":"3","author":"D\u00edaz-Fern\u00e1ndez","year":"2023","journal-title":"ACS Meas. Sci. Au"},{"key":"10.1016\/j.aca.2024.343472_bib35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.aca.2019.05.052","article-title":"Femtomolar electroanalysis of a breast cancer biomarker HER-2\/neu protein in human serum by the cellulase-linked sandwich assay on magnetic beads","volume":"1077","author":"Malecka","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2024.343472_bib36","series-title":"Method and Electronic Device for Determining the Concentration of an Analyte. US 2019\/0002948; US Patent Number 11807893, Granted 2023","author":"Ferapontova","year":"2019"},{"key":"10.1016\/j.aca.2024.343472_bib37","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1073\/pnas.1302594110","article-title":"Aptamer to ErbB-2\/HER2 enhances degradation of the target and inhibits tumorigenic growth","volume":"110","author":"Mahlknecht","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.aca.2024.343472_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340049","article-title":"Covalent Hemin\/G4 complex-linked sandwich bioassay on magnetic beads for femtomolar HER-2\/neu detection in human serum via direct electrocatalytic reduction of oxygen","volume":"1219","author":"D\u00edaz-Fern\u00e1ndez","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2024.343472_bib39","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1021\/acs.analchem.6b04391","article-title":"Electrochemical assay for a total cellulase activity with improved sensitivity","volume":"89","author":"Fapyane","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343472_bib40","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1021\/acssensors.8b00662","article-title":"Electrochemical enzyme-linked sandwich assay with a cellulase label for ultrasensitive analysis of synthetic DNA and cell-isolated RNA","volume":"3","author":"Fapyane","year":"2018","journal-title":"ACS Sens."},{"key":"10.1016\/j.aca.2024.343472_bib41","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature01392","article-title":"Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab","volume":"421","author":"Cho","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.aca.2024.343472_bib42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1535-6108(04)00083-2","article-title":"Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex","volume":"5","author":"Franklin","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.aca.2024.343472_bib44","doi-asserted-by":"crossref","first-page":"37979","DOI":"10.1021\/acsami.1c03784","article-title":"Femtomolar detection of thrombin in serum and cerebrospinal fluid via direct electrocatalysis of oxygen reduction by the covalent G4-hemin-aptamer complex","volume":"13","author":"Malecka","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2024.343472_bib45","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/celc.201700025","article-title":"Specific picomolar detection of a breast cancer biomarker HER-2\/neu protein in serum: electrocatalytically amplified electroanalysis by the aptamer\/PEG-modified electrode","volume":"4","author":"Salimian","year":"2017","journal-title":"Chemelectrochem"},{"key":"10.1016\/j.aca.2024.343472_bib46","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1039\/C4AN02354D","article-title":"Electroanalysis of pM-levels of urokinase plasminogen activator in serum by phosphorothioated RNA aptamer","volume":"140","author":"Jarczewska","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2024.343472_bib47","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1096\/fj.10-180331","article-title":"Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer","volume":"25","author":"Vaneycken","year":"2011","journal-title":"Faseb. J."},{"key":"10.1016\/j.aca.2024.343472_bib48","article-title":"Cryo-EM structure of HER2-trastuzumab-pertuzumab complex","volume":"14","author":"Hao","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.aca.2024.343472_bib49","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijbiomac.2021.07.080","article-title":"The development of human serum albumin-based drugs and relevant fusion proteins for cancer therapy","volume":"187","author":"Tao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.aca.2024.343472_bib50","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1213\/ANE.0000000000002864","article-title":"Correlation coefficients: appropriate use and interpretation","volume":"126","author":"Schober","year":"2018","journal-title":"Anesth. Analges."},{"key":"10.1016\/j.aca.2024.343472_bib51","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/elan.201100501","article-title":"An electrochemical immunoassay for HER2 detection","volume":"24","author":"Al-Khafaji","year":"2012","journal-title":"Electroanalysis"},{"key":"10.1016\/j.aca.2024.343472_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jelechem.2020.114722","article-title":"Label-free electrochemical immunosensor for sensitive HER2 biomarker detection using the core-shell magnetic metal-organic frameworks","volume":"877","author":"Ehzari","year":"2020","journal-title":"J. Electroanal. Chem."},{"key":"10.1016\/j.aca.2024.343472_bib53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bios.2015.03.017","article-title":"Amperometric magnetoimmunosensor for ErbB2 breast cancer biomarker determination in human serum, cell lysates and intact breast cancer cells","volume":"70","author":"Eletxigerra","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2024.343472_bib55","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.talanta.2014.06.035","article-title":"Electrochemical immunosensor for the analysis of the breast cancer biomarker HER2 ECD","volume":"129","author":"Marques","year":"2014","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2024.343472_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.109963","article-title":"Label-free and early detection of HER2 breast cancer biomarker based on UiO-66-NH2 modified gold chip (Au\/UiO-66-NH2) using surface plasmon resonance technique","volume":"199","author":"Rahmidar","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2024.343472_bib57","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/bios13030355","article-title":"Development of electrochemical immunosensors for HER-1 and HER-2 analysis in serum for breast cancer patients","volume":"13","author":"Wignarajah","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.aca.2024.343472_bib58","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1146\/annurev-biochem-063011-092449","article-title":"Nanobodies: natural single-domain antibodies","volume":"82","author":"Muyldermans","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.aca.2024.343472_bib59","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ymben.2024.07.012","article-title":"Scalable, robust, high-throughput expression & purification of nanobodies enabled by 2-stage dynamic control","volume":"85","author":"Hennigan","year":"2024","journal-title":"Metab. Eng."},{"key":"10.1016\/j.aca.2024.343472_bib60","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1007\/s00253-016-7388-9","article-title":"Advances in recombinant antibody manufacturing","volume":"100","author":"Kunert","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.aca.2024.343472_bib61","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.clinbiochem.2010.05.008","article-title":"Pediatric reference intervals for 28 chemistries and immunoassays on the Roche cobas\u00ae 6000 analyzer\u2014a CALIPER pilot study","volume":"43","author":"Kulasingam","year":"2010","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.aca.2024.343472_bib62","unstructured":"https:\/\/www.pointofcare.abbott\/int\/en\/offerings\/istat (last access 28 October 2024)."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702401273X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702401273X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T01:04:52Z","timestamp":1733360692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000326702401273X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":60,"alternative-id":["S000326702401273X"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2024.343472","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanobodies\u2019 duo facilitates ultrasensitive serum HER-2\/neu immunoassays via enhanced avidity interactions","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2024.343472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"343472"}}