{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:54:22Z","timestamp":1792468462462,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.aca.2024.343558","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T19:06:11Z","timestamp":1734462371000},"page":"343558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Lysosome-targeted dual-locked NIR fluorescent probe for visualization of H2S and viscosity in drug-induced liver injury and tumor models"],"prefix":"10.1016","volume":"1337","author":[{"given":"Jingcan","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2024.343558_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41580-019-0185-4","article-title":"Lysosomes as dynamic regulators of cell and organismal homeostasis","volume":"21","author":"Ballabio","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.aca.2024.343558_bib2","article-title":"Multi-organelle-targeting pH-dependent NIR fluorescent probe for lysosomal viscosity","volume":"34","author":"Wang","year":"2023","journal-title":"Chinese Chem Lett"},{"key":"10.1016\/j.aca.2024.343558_bib3","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1158\/2159-8290.CD-17-0741","article-title":"A Unified approach to targeting the lysosomes degradative and growth signaling roles","volume":"7","author":"Rebecca","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.aca.2024.343558_bib4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.tcb.2021.12.009","article-title":"Built to last: lysosome remodeling and repair in health and disease","volume":"32","author":"Zoncu","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.aca.2024.343558_bib5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.nbd.2018.05.015","article-title":"Lysosome trafficking and signaling in health and neurodegenerative diseases","volume":"122","author":"Lie","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.aca.2024.343558_bib6","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.bbadis.2019.03.009","article-title":"Lysosome motility and distribution: relevance in health and disease","volume":"1865","author":"Oyarz\u00fan","year":"2019","journal-title":"Biochim.Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.aca.2024.343558_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.340867","article-title":"A dual-emission fluorescence probe for the detection of viscosity and hydrazine in environmental and biological samples","volume":"1245","author":"Liu","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2024.343558_bib8","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/j.bpj.2019.03.038","article-title":"Measuring intracellular viscosity in conditions of hypergravity","volume":"116","author":"Woodcock","year":"2019","journal-title":"Biophys. J."},{"key":"10.1016\/j.aca.2024.343558_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214336","article-title":"Recent advances in multifunctional fluorescent probes for viscosity and analytes","volume":"453","author":"Yang","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2024.343558_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202316487","article-title":"An ER-targeted, viscosity-sensitive hemicyanine dye for the diagnosis of nonalcoholic fatty liver and photodynamic cancer therapy by activating pyroptosis pathway","volume":"63","author":"Zeng","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2024.343558_bib11","first-page":"770","article-title":"Enzymology of H2S biogenesis, decay and signaling, Antioxid","volume":"20","author":"Kabil","year":"2014","journal-title":"Redox Sign."},{"key":"10.1016\/j.aca.2024.343558_bib12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H2S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.aca.2024.343558_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135496","article-title":"A mitochondria-targeting fluorescent probe for the dual-emission fluorescence-enhanced detection of hydrogen sulfide and turn-on detection of hydrazine","volume":"409","author":"Tian","year":"2024","journal-title":"Sensor Actuat B-chem."},{"key":"10.1016\/j.aca.2024.343558_bib14","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical biology of H2S signaling through persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aca.2024.343558_bib15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3390\/antiox10050671","article-title":"Current perspective of hydrogen sulfide as a novel gaseous modulator of oxidative stress in glaucoma","volume":"10","author":"Feng","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.aca.2024.343558_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143611","article-title":"A novel fluorescent probe for imaging endogenous hydrogen sulfide in living cells and mice models of acute liver injury","volume":"468","author":"Wang","year":"2023","journal-title":"Chem Eng J"},{"key":"10.1016\/j.aca.2024.343558_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bcp.2017.11.019","article-title":"Gasotransmitter hydrogen sulfide signaling in neuronal health and disease","volume":"149","author":"Paul","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.aca.2024.343558_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.aca.2024.343558_bib19","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1021\/acs.chemrev.3c00683","article-title":"Activity-based fluorescent probes for hydrogen sulfide and related reactive sulfur species","volume":"124","author":"Fosnacht","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aca.2024.343558_bib20","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1021\/acs.chemrev.3c00683","article-title":"Activity-based fluorescent probes for hydrogen sulfide and related reactive sulfur species","volume":"124","author":"Fosnacht","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aca.2024.343558_bib21","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.1039\/D1CS00083G","article-title":"Fluorescence imaging of pathophysiological microenvironments","volume":"50","author":"Wang","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2024.343558_bib22","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1021\/acssensors.0c02005","article-title":"Sensing and bioimaging of the gaseous signaling molecule hydrogen sulfide by near-infrared fluorescent probes","volume":"5","author":"Jose","year":"2020","journal-title":"ACS Sens."},{"key":"10.1016\/j.aca.2024.343558_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132297","article-title":"A novel fluorescent probe for imagining hydrogen sulfide upregulation in acute lung injury","volume":"369","author":"Su","year":"2022","journal-title":"Sensor Actuat B-chem."},{"key":"10.1016\/j.aca.2024.343558_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.talanta.2017.02.012","article-title":"A ratiometric two-photon fluorescent probe for imaging hydrogen sulfide in lysosomes","volume":"167","author":"Feng","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2024.343558_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134594","article-title":"A novel activatable fluorescent probe for revealing the dynamic of esterase and viscosity during ferroptosis and DILI","volume":"396","author":"Liu","year":"2023","journal-title":"Sensor Actuat B-chem."},{"key":"10.1016\/j.aca.2024.343558_bib26","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1021\/jacs.2c03832","article-title":"Ect, precision navigation of hepatic ischemia-reperfusion injury guided by lysosomal viscosity-activatable NIR-II fluorescence","volume":"144","author":"Liu","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2024.343558_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214336","article-title":"Recent advances in multifunctional fluorescent probes for viscosity and analytes","volume":"453","author":"Yang","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2024.343558_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.135236","article-title":"TICT improved NIR emission and lysosome-specific functional dye visualizing viscosity in disease model","volume":"404","author":"Zhang","year":"2024","journal-title":"Sensor Actuat B-chem."},{"key":"10.1016\/j.aca.2024.343558_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2022.107941","article-title":"A \u201cturn-on\u201d chalcone-based probe for hydrogen sulfide and imaging applications in lysosomes of living cells and zebrafish","volume":"183","author":"Zhang","year":"2022","journal-title":"Microchemical J"},{"key":"10.1016\/j.aca.2024.343558_bib30","doi-asserted-by":"crossref","first-page":"12139","DOI":"10.1021\/acs.analchem.3c02381","article-title":"Rational design of orange-red emissive carbon dots for tracing lysosomal viscosity dynamics in living cells and zebrafish","volume":"95","author":"Guo","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343558_bib31","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1021\/acs.analchem.0c04644","article-title":"One stone, three birds: pH triggered transformation of aminopyronine and iminopyronine based lysosome targeting viscosity probe for cancer visualization","volume":"93","author":"Song","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343558_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.142553","article-title":"Multifunctional 1,3-benzoxazole-merocyanine-based probe for the ratiometric fluorescence detection of pH\/HSO3-\/viscosity in mitochondria","volume":"464","author":"Wu","year":"2023","journal-title":"Chem Eng J"},{"key":"10.1016\/j.aca.2024.343558_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132883","article-title":"A novel probe for identifying breast cancer cells based on fluorescence response of the cascade process of biothiol and viscosity","volume":"375","author":"Zhao","year":"2023","journal-title":"Sensor Actuat B-chem."},{"key":"10.1016\/j.aca.2024.343558_bib34","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1039\/C7CS00491E","article-title":"Molecular logic gates: the past, present and future","volume":"47","author":"Erbas-Cakmak","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2024.343558_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.144341","article-title":"A dual lock-and-key probe for high-fidelity visualizing abdominal aortic aneurysm-related inflammation via a PET-TICT integrated near-infrared platform","volume":"471","author":"Yuan","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.aca.2024.343558_bib36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.biomaterials.2017.06.032","article-title":"Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues","volume":"140","author":"Zhang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.aca.2024.343558_bib37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.polymer.2015.12.008","article-title":"Ultrahigh performance bio-based polyimides from 4,4\u2032-diaminostilbene","volume":"83","author":"Kumar","year":"2016","journal-title":"Polymer"},{"key":"10.1016\/j.aca.2024.343558_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301230","article-title":"Dual key-activated nir-I\/II fluorescence probe for monitoring photodynamic and photothermal synergistic therapy efficacy","volume":"12","author":"Wang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.aca.2024.343558_bib39","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1039\/D3SC06459J","article-title":"Near-infrared imaging for visualizing the synergistic relationship between autophagy and NFS1 protein during multidrug resistance using an ICT-TICT integrated platform","volume":"15","author":"Hu","year":"2024","journal-title":"Chem. Sci."},{"key":"10.1016\/j.aca.2024.343558_bib40","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1039\/D1CC01819A","article-title":"Bo Tang, A\u201cdouble-locked\u201dprobe for the detection of hydrogen sulfide in a viscous system","volume":"57","author":"Kong","year":"2021","journal-title":"Chem. Commun."},{"key":"10.1016\/j.aca.2024.343558_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117868","article-title":"Study on synthesis and fluorescence property of rhodamine-naphthalene conjugate","volume":"229","author":"Qin","year":"2020","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.aca.2024.343558_bib42","article-title":"Dual-locked NIR fluorescent probe for detection of GSH and lipid droplets and its bioimaging application in cancer model","volume":"327","author":"Qin","year":"2024","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.aca.2024.343558_bib43","article-title":"A dual-response fluorescent hemicyanine probe for the detection of mitochondrial hypochlorite and viscosity based on ESIPT\/AIE and TICT","volume":"423","author":"Wu","year":"2024","journal-title":"Sensor Actuat B-chem."},{"key":"10.1016\/j.aca.2024.343558_bib44","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1021\/acs.analchem.2c05713","article-title":"Dihydroxanthene-based near-infrared fluorescent probes for monitoring mitochondrial viscosity in living cells and mice","volume":"95","author":"Wu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343558_bib45","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1039\/C6SC05646F","article-title":"A new H2S-specific near-infrared fluorescence-enhanced probe that can visualize the H2S level in colorectal cancer cells in mice","volume":"8","author":"Zhang","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.aca.2024.343558_bib46","doi-asserted-by":"crossref","first-page":"9356","DOI":"10.1021\/acs.analchem.1c00427","article-title":"In situ activatable ratiometric NIR-II fluorescence nanoprobe for quantitative detection of H2S in colon cancer","volume":"93","author":"Wang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343558_bib47","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.1039\/D3CC01101A","article-title":"A novel near-infrared fluorescent probe for the imaging of viscosity in cells and tumor-bearing mice","volume":"59","author":"Liao","year":"2023","journal-title":"Chem. Commun."},{"key":"10.1016\/j.aca.2024.343558_bib48","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1039\/D3AN01631E","article-title":"Activatable fluorescent probes for early diagnosis and evaluation of liver injury","volume":"149","author":"Lin","year":"2024","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2024.343558_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122190","article-title":"Viscosity-responsive NIR-II fluorescent probe with aggregation-induced emission features for early diagnosis of liver injury","volume":"300","author":"Ge","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.aca.2024.343558_bib50","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1021\/acs.accounts.0c00646","article-title":"Design strategy of fluorescent probes for live drug-induced acute liver injury imaging","volume":"54","author":"Cheng","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.aca.2024.343558_bib51","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1007\/s00259-022-05854-1","article-title":"In vivo detection of hydrogen sulfide in the brain of live mouse: application in neuroinflammation models","volume":"49","author":"Nam","year":"2022","journal-title":"Eur J Nucl Med Mol I"},{"key":"10.1016\/j.aca.2024.343558_bib52","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1021\/acs.analchem.0c05081","article-title":"An activatable near-infrared fluorescence hydrogen sulfide (H2S) donor for imaging H2S release and inhibiting inflammation in cells","volume":"93","author":"Zhao","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2024.343558_bib53","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1039\/D2AN00623E","article-title":"A nitrobenzoxadiazole-based near-infrared fluorescent probe for the specific imaging of H2S in inflammatory and tumor mice","volume":"147","author":"Wang","year":"2022","journal-title":"Analyst"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702401359X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702401359X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T01:04:04Z","timestamp":1736557444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000326702401359X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":53,"alternative-id":["S000326702401359X"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2024.343558","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosome-targeted dual-locked NIR fluorescent probe for visualization of H2S and viscosity in drug-induced liver injury and tumor models","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2024.343558","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"343558"}}