{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:27:23Z","timestamp":1787563643442,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.aca.2025.343704","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T04:31:36Z","timestamp":1738038696000},"page":"343704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A critical analysis of Adaptive Box-Cox transformation for skewed distributed data management: Metabolomics of Spanish and Argentinian truffles as a case study"],"prefix":"10.1016","volume":"1345","author":[{"given":"Leonardo","family":"Sibono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-3920","authenticated-orcid":false,"given":"Massimiliano","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5635-413X","authenticated-orcid":false,"given":"Eva","family":"Tejedor-Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Casula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Marco-Montori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-234X","authenticated-orcid":false,"given":"Sergi","family":"Garcia-Barreda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-7908","authenticated-orcid":false,"given":"Cristina","family":"Manis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Caboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2025.343704_bib1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.aca.2012.05.049","article-title":"NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review","volume":"750","author":"Smolinska","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2025.343704_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341848","article-title":"Exploratory optimisation of a LC-HRMS based analytical method for untargeted metabolomic screening of Cannabis Sativa L. through Data Mining","volume":"1279","author":"San Nicolas","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2025.343704_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-394598-3.00001-0","article-title":"Metabolomics in food science","volume":"67","author":"Cevallos-Cevallos","year":"2012","journal-title":"Adv. Food Nutr. Res."},{"key":"10.1016\/j.aca.2025.343704_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126573","article-title":"Multi-platform metabolomic approach to discriminate ripening markers of black truffles (Tuber melanosporum)","volume":"319","author":"Caboni","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.aca.2025.343704_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2144\/000113133","article-title":"What is metabolomics all about?","volume":"46","author":"Roessner","year":"2009","journal-title":"Biotechniques"},{"key":"10.1016\/j.aca.2025.343704_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/metabo10060243","article-title":"Machine learning applications for mass spectrometry-based metabolomics","volume":"10","author":"Liebal","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.aca.2025.343704_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.729512","article-title":"Untargeted GC-MS-based metabolomics for early detection of colorectal cancer","volume":"11","author":"Zhu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.aca.2025.343704_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2021.106350","article-title":"GC\u2013MS urinary metabolomics analysis of inherited metabolic diseases and stable metabolic biomarker screening by a comprehensive chemometric method","volume":"168","author":"Yang","year":"2021","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2025.343704_bib9","article-title":"Pretreating and normalizing metabolomics data for statistical analysis","author":"Sun","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.aca.2025.343704_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-3-319-47656-8_6","article-title":"Preprocessing and pretreatment of metabolomics data for statistical analysis","volume":"965","author":"Karaman","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.aca.2025.343704_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fams.2015.00012","article-title":"A new approach to the Box\u2013Cox transformation","volume":"1","author":"V\u00e9lez","year":"2015","journal-title":"Front. Appl. Math. Stat."},{"key":"10.1016\/j.aca.2025.343704_bib12","doi-asserted-by":"crossref","first-page":"8267","DOI":"10.1021\/acs.analchem.2c00503","article-title":"Adaptive box-cox transformation: a highly flexible feature-specific data transformation to improve metabolomic data normality for better statistical analysis","volume":"94","author":"Yu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.343704_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jprot.2015.01.019","article-title":"Enhancing metabolomics research through data mining","volume":"127","author":"Mart\u00ednez-Arranz","year":"2015","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.aca.2025.343704_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmr.2020.106750","article-title":"Stable isotope resolved metabolomics classification of prostate cancer cells using hyperpolarized NMR data","volume":"316","author":"Frahm","year":"2020","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.aca.2025.343704_bib15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.microc.2018.08.062","article-title":"Fully optimized new sensitive electrochemical sensing platform for the selective determination of antiepileptic drug ezogabine","volume":"144","author":"Mohamed","year":"2019","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2025.343704_bib16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.aca.2018.02.032","article-title":"Mass spectrometry profiling reveals altered plasma levels of monohydroxy fatty acids and related lipids in healthy humans after controlled exposure to biodiesel exhaust","volume":"1018","author":"Gouveia-Figueira","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2025.343704_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00294-002-0343-6","article-title":"Identification of putative genes involved in the development of Tuber borchii fruit body by mRNA differential display in agarose gel","volume":"42","author":"Zeppa","year":"2002","journal-title":"Curr. Genet."},{"key":"10.1016\/j.aca.2025.343704_bib18","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.foodcont.2010.10.015","article-title":"Selection of a decontamination treatment for fresh Tuber aestivum and Tuber melanosporum truffles packaged in modified atmospheres","volume":"22","author":"Susana Rivera","year":"2011","journal-title":"Food Control"},{"key":"10.1016\/j.aca.2025.343704_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.aca.2025.343704_bib20","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1039\/c3ay40582f","article-title":"Classification tools in chemistry. Part 1: linear models. PLS-DA","volume":"5","author":"Ballabio","year":"2013","journal-title":"Anal. Methods"},{"key":"10.1016\/j.aca.2025.343704_bib21","first-page":"32","article-title":"Missing values, outliers, robust statistics & non-parametric methods","volume":"1","author":"Shaun","year":"1998","journal-title":"Sci. Data Manag."},{"key":"10.1016\/j.aca.2025.343704_bib22","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.2307\/1939920","article-title":"Distribution-free and robust statistical methods: viable alternatives to parametric statistics?","volume":"74","author":"Potvin","year":"1993","journal-title":"Ecology"},{"key":"10.1016\/j.aca.2025.343704_bib23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/wics.177","article-title":"Permutation methods","volume":"3","author":"Berry","year":"2011","journal-title":"Wiley Interdiscip. Rev. Comput. Stat."},{"key":"10.1016\/j.aca.2025.343704_bib24","first-page":"169","article-title":"The box-cox transformation technique: a review","volume":"41","author":"Sakia","year":"1992","journal-title":"Stat"},{"key":"10.1016\/j.aca.2025.343704_bib25","first-page":"21","article-title":"Power comparisons of shapiro-wilk, Kolmogorov-smirnov, Lilliefors and anderson-darling tests","volume":"2","author":"Bee Wah","year":"2011","journal-title":"J. Stat. Model. Anal."},{"key":"10.1016\/j.aca.2025.343704_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.eja.2022.126666","article-title":"Sample size and Shapiro-Wilk test: an analysis for soybean grain yield","volume":"142","author":"de Souza","year":"2023","journal-title":"Eur. J. Agron."},{"key":"10.1016\/j.aca.2025.343704_bib27","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Stat."},{"key":"10.1016\/j.aca.2025.343704_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-7439(00)00122-2","article-title":"Monte Carlo cross validation","volume":"56","author":"Xu","year":"2001","journal-title":"Chemometr. Intell. Lab. Syst."},{"key":"10.1016\/j.aca.2025.343704_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113300","article-title":"Aromatic profile of black truffle grown in Argentina: characterization of commercial categories and alterations associated to maturation, harvesting date and orchard management practices","volume":"173","author":"Tejedor-Calvo","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.aca.2025.343704_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2020.107698","article-title":"Differentiation between species and regional origin of fresh and freeze-dried truffles according to their volatile profiles","volume":"123","author":"\u0160i\u0161kovi\u010d","year":"2021","journal-title":"Food Control"},{"key":"10.1016\/j.aca.2025.343704_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodcont.2017.11.045","article-title":"Composition and authentication of commercial and home-made white truffle-flavored oils","volume":"87","author":"Wernig","year":"2018","journal-title":"Food Control"},{"key":"10.1016\/j.aca.2025.343704_bib32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.aca.2009.05.027","article-title":"Fermentation condition outweighed truffle species in affecting volatile organic compounds analyzed by chromatographic fingerprint system","volume":"647","author":"Tang","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2025.343704_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2016.00030","article-title":"Feature selection methods for early predictive biomarker discovery using untargeted metabolomic data","volume":"3","author":"Grissa","year":"2016","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.aca.2025.343704_bib34","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1021\/pr1011069","article-title":"Applying random forests to identify biomarker panels in serum 2D-DIGE data for the detection and staging of prostate cancer","volume":"10","author":"Fan","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.aca.2025.343704_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27103304","article-title":"Comparison of multivariate ANOVA-based approaches for the determination of relevant variables in experimentally designed metabolomic studies","volume":"27","author":"P\u00e9rez-Cova","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.aca.2025.343704_bib36","author":"Brereton"},{"key":"10.1016\/j.aca.2025.343704_bib37","doi-asserted-by":"crossref","first-page":"154975","DOI":"10.1109\/ACCESS.2020.3018874","article-title":"On box-cox transformation for image normality and pattern classification","volume":"8","author":"Cheddad","year":"2020","journal-title":"IEEE Access"},{"key":"10.1016\/j.aca.2025.343704_bib38","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.neucom.2016.08.081","article-title":"Properties of the Box\u2013Cox transformation for pattern classification","volume":"218","author":"Bicego","year":"2016","journal-title":"Neurocomputing"},{"key":"10.1016\/j.aca.2025.343704_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11306-006-0022-6","article-title":"Assessing the performance of statistical validation tools for megavariate metabolomics data","volume":"2","author":"Rubingh","year":"2006","journal-title":"Metabolomics"},{"key":"10.1016\/j.aca.2025.343704_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13070877","article-title":"Investigation of seasonal variation in fatty acid and mineral concentrations of pecorino romano PDO cheese: imputation of missing values for enhanced classification and metabolic profile reconstruction","volume":"13","author":"Sibono","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.aca.2025.343704_bib41","first-page":"371","article-title":"Increasing the performance and consistency of classification trees by using the accuracy criterion at the leaves","volume":"vol. 1995","author":"Lubinsky","year":"1995"},{"key":"10.1016\/j.aca.2025.343704_bib42","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-3-030-03146-6_44","article-title":"Improvement in software defect prediction outcome using principal component analysis and ensemble machine learning algorithms","volume":"26","author":"Dhamayanthi","year":"2019","journal-title":"Lect. Notes Data Eng. Commun. Technol."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025000984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025000984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T04:49:07Z","timestamp":1744951747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267025000984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":42,"alternative-id":["S0003267025000984"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2025.343704","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A critical analysis of Adaptive Box-Cox transformation for skewed distributed data management: Metabolomics of Spanish and Argentinian truffles as a case study","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2025.343704","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"343704"}}