{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:46:32Z","timestamp":1782431192009,"version":"3.54.5"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006928","name":"The Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM133510"],"award-info":[{"award-number":["R35GM133510"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.aca.2025.343826","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:20:03Z","timestamp":1739992803000},"page":"343826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Online monitoring and stable isotope tracing of cancer associated volatiles in murine model captures tumor associated markers in vivo"],"prefix":"10.1016","volume":"1349","author":[{"given":"Fouad","family":"Choueiry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0571-2482","authenticated-orcid":false,"given":"Hyein","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-8949","authenticated-orcid":false,"given":"Jiangjiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2025.343826_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.aca.2025.343826_bib2","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1097\/JTO.0b013e3182637d5f","article-title":"Non-invasive breath analysis of pulmonary nodules","volume":"7","author":"Peled","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.aca.2025.343826_bib3","article-title":"A study of diagnostic accuracy using a chemical sensor array and a machine learning technique to detect lung cancer","volume":"18","author":"Huang","year":"2018","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.aca.2025.343826_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1001\/jamainternmed.2013.12738","article-title":"Overdiagnosis in low-dose computed tomography screening for lung cancer","volume":"174","author":"Patz","year":"2014","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.aca.2025.343826_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-028448","article-title":"VOC biomarkers identification and predictive model construction for lung cancer based on exhaled breath analysis: research protocol for an exploratory study","volume":"9","author":"Li","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.aca.2025.343826_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-17795-8","article-title":"Breast cancer detection by analyzing the volatile organic compound (VOC) signature in human urine","volume":"12","author":"Gir\u00f3 Benet","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aca.2025.343826_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/biom13060989","article-title":"Volatile phases derived from serum, DC, or MLC culture supernatants to deduce a VOC-based diagnostic profiling strategy for leukemic diseases","volume":"13","author":"Baudrexler","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.aca.2025.343826_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-4347(99)00127-9","article-title":"Variation in volatile organic compounds in the breath of normal humans","volume":"729","author":"Phillips","year":"1999","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.aca.2025.343826_bib9","doi-asserted-by":"crossref","DOI":"10.1088\/1752-7155\/8\/3\/034001","article-title":"The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva","volume":"8","author":"Amann","year":"2014","journal-title":"J. Breath Res."},{"key":"10.1016\/j.aca.2025.343826_bib10","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.2174\/1871520617666170327110712","article-title":"Post-transcriptional and post-translational regulation of central carbon metabolic enzymes in cancer","volume":"17","author":"Wang","year":"2017","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.aca.2025.343826_bib11","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1021\/cr300174a","article-title":"Volatile organic compounds of lung cancer and possible biochemical pathways","volume":"112","author":"Hakim","year":"2012","journal-title":"Chem Rev"},{"key":"10.1016\/j.aca.2025.343826_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9030052","article-title":"Critical review of volatile organic compound analysis in breath and in vitro cell culture for detection of lung cancer","volume":"9","author":"Jia","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.aca.2025.343826_bib13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jtho.2016.02.017","article-title":"Exhaled breath analysis for monitoring response to treatment in advanced lung cancer","volume":"11","author":"Nardi-Agmon","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.aca.2025.343826_bib14","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1177\/15353702221082634","article-title":"Analyses of lung cancer-derived volatiles in exhaled breath and in vitro models","volume":"247","author":"Choueiry","year":"2022","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.aca.2025.343826_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15082308","article-title":"A systematic review and meta-analysis: volatile organic compound analysis in the detection of hepatobiliary and pancreatic cancers","volume":"15","author":"Pelling","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.aca.2025.343826_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cca.2016.05.013","article-title":"VOC breath biomarkers in lung cancer","volume":"459","author":"Saalberg","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.aca.2025.343826_bib17","doi-asserted-by":"crossref","first-page":"38643","DOI":"10.18632\/oncotarget.5938","article-title":"Detection of cancer through exhaled breath: a systematic review","volume":"6","author":"Krilaviciute","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.aca.2025.343826_bib18","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1039\/C8CS00317C","article-title":"Synergy between nanomaterials and volatile organic compounds for non-invasive medical evaluation","volume":"47","author":"Broza","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2025.343826_bib19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/thx.2006.072892","article-title":"Diagnosis of lung cancer by the analysis of exhaled breath with a colorimetric sensor array","volume":"62","author":"Mazzone","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.aca.2025.343826_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/rcm.6457","article-title":"A simple criterion for gas chromatography\/mass spectrometric analysis of thermally unstable compounds, and reassessment of the by-products of alkyl diazoacetate synthesis","volume":"27","author":"Kornilova","year":"2013","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.aca.2025.343826_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.339230","article-title":"Secondary electrospray ionization-high resolution mass spectrometry (SESI-HRMS) fingerprinting enabled treatment monitoring of pulmonary carcinoma cells in real time","volume":"1189","author":"Choueiry","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2025.343826_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092146","article-title":"Integration of metabolomics and gene expression profiling elucidates IL4I1 as modulator of ibrutinib resistance in ABC-diffuse large B cell lymphoma","volume":"13","author":"Choueiry","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.aca.2025.343826_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40170-022-00287-8","article-title":"(13)C tracer analysis suggests extensive recycling of endogenous CO(2) in vivo","volume":"10","author":"Duan","year":"2022","journal-title":"Cancer Metabol."},{"key":"10.1016\/j.aca.2025.343826_bib24","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2337\/db07-1615","article-title":"Glucose metabolism in vivo in four commonly used inbred mouse strains","volume":"57","author":"Berglund","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.aca.2025.343826_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10090351","article-title":"Optimizing secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) for the analysis of volatile fatty acids from gut microbiome","volume":"10","author":"Lee","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.aca.2025.343826_bib26","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1039\/D3AN01487H","article-title":"Database-assisted, globally optimized targeted secondary electrospray ionization high resolution mass spectrometry (dGOT-SESI-HRMS) and spectral stitching enhanced volatilomics analysis of bacterial metabolites","volume":"148","author":"Choueiry","year":"2023","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2025.343826_bib27","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1021\/jasms.3c00304","article-title":"Secondary-electrospray ionization mass spectrometry-based online analyses of mouse volatilome uncover gut microbiome-dictated metabolic changes in the host","volume":"34","author":"Choueiry","year":"2023","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.aca.2025.343826_bib28","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.aca.2025.343826_bib29","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.aca.2025.343826_bib30","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"Hmdb 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.aca.2025.343826_bib31","first-page":"2020","article-title":"Human breathomics database","author":"Kuo","year":"2020","journal-title":"Database"},{"key":"10.1016\/j.aca.2025.343826_bib32","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"Hmdb 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.aca.2025.343826_bib33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.aca.2025.343826_bib34","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s41592-020-0933-6","article-title":"Feature-based molecular networking in the GNPS analysis environment","volume":"17","author":"Nothias","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.aca.2025.343826_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9060119","article-title":"Mass spectrometry data repository enhances novel metabolite discoveries with advances in computational metabolomics","volume":"9","author":"Tsugawa","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.aca.2025.343826_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2018.08.060","article-title":"Comprehensive MS\/MS profiling by UHPLC-ESI-QTOF-MS\/MS using SWATH data-independent acquisition for the study of platelet lipidomes in coronary artery disease","volume":"1046","author":"Schlotterbeck","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2025.343826_bib37","doi-asserted-by":"crossref","DOI":"10.1177\/11772719221100709","article-title":"Volatile organic compounds analysis as a potential novel screening tool for breast cancer: a systematic review","volume":"17","author":"Leemans","year":"2022","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.aca.2025.343826_bib38","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/S0140-6736(98)07552-7","article-title":"Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study","volume":"353","author":"Phillips","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.aca.2025.343826_bib39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1465-9921-6-71","article-title":"Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study","volume":"6","author":"Poli","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.aca.2025.343826_bib40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cccn.2004.04.023","article-title":"Diagnostic potential of breath analysis--focus on volatile organic compounds","volume":"347","author":"Miekisch","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.aca.2025.343826_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The emerging hallmarks of cancer metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.aca.2025.343826_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10080317","article-title":"Target analysis of volatile organic compounds in exhaled breath for lung cancer discrimination from other pulmonary diseases and healthy persons","volume":"10","author":"Koureas","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.aca.2025.343826_bib43","article-title":"Identification of urinary volatile organic compounds as a potential non-invasive biomarker for esophageal cancer","volume":"13","author":"Liu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aca.2025.343826_bib44","first-page":"1","article-title":"Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies","volume":"11","author":"Phan","year":"2014","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.aca.2025.343826_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168661","article-title":"Current and future development in lung cancer diagnosis","volume":"22","author":"Nooreldeen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.aca.2025.343826_bib46","first-page":"409","article-title":"Cancer treatment and survivorship statistics, 2022","volume":"72","author":"Miller","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.aca.2025.343826_bib47","first-page":"41","article-title":"Cancer, comorbidities, and health-related quality of life of older adults","volume":"29","author":"Smith","year":"2008","journal-title":"Health Care Financ. Rev."},{"key":"10.1016\/j.aca.2025.343826_bib48","doi-asserted-by":"crossref","DOI":"10.1088\/1752-7155\/3\/2\/027002","article-title":"Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS","volume":"3","author":"Schwarz","year":"2009","journal-title":"J. Breath Res."},{"key":"10.1016\/j.aca.2025.343826_bib49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ymben.2017.02.002","article-title":"Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis","volume":"43","author":"Dong","year":"2017","journal-title":"Metab. Eng."},{"key":"10.1016\/j.aca.2025.343826_bib50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ymben.2017.11.013","article-title":"Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease","volume":"45","author":"Badur","year":"2018","journal-title":"Metab. Eng."},{"key":"10.1016\/j.aca.2025.343826_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12010129","article-title":"Potential role of oxidative stress in the production of volatile organic compounds in obesity","volume":"12","author":"Oyerinde","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.aca.2025.343826_bib52","doi-asserted-by":"crossref","DOI":"10.1088\/1752-7163\/ab14a5","article-title":"Effect of H(2)O(2) induced oxidative stress (OS) on volatile organic compounds (VOCs) and intracellular metabolism in MCF-7 breast cancer cells","volume":"13","author":"Liu","year":"2019","journal-title":"J. Breath Res."},{"key":"10.1016\/j.aca.2025.343826_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/biomethods\/bpz014","article-title":"Digging deeper into volatile organic compounds associated with cancer","volume":"4","author":"Janfaza","year":"2019","journal-title":"Biol. Methods Protoc."},{"key":"10.1016\/j.aca.2025.343826_bib54","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.copbio.2013.04.016","article-title":"Metabolic flux rewiring in mammalian cell cultures","volume":"24","author":"Young","year":"2013","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.aca.2025.343826_bib55","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1038\/s41467-019-13419-4","article-title":"Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer","volume":"10","author":"Luengo","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.aca.2025.343826_bib56","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3389\/fonc.2019.01215","article-title":"The metabolic landscape of lung cancer: new insights in a disturbed glucose metabolism","volume":"9","author":"Vanhove","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.aca.2025.343826_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1037341","article-title":"Targeting glycolysis in non-small cell lung cancer: promises and challenges","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.aca.2025.343826_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.925816","article-title":"Cancer therapy's impact on lipid metabolism: mechanisms and future avenues","volume":"9","author":"Bhatnagar","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.aca.2025.343826_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1046630","article-title":"Effects of metabolic cancer therapy on tumor microenvironment","volume":"12","author":"Hyro\u0161\u0161ov\u00e1","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.aca.2025.343826_bib60","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/annonc\/mdz279","article-title":"Prediction of response to anti-PD-1 therapy in patients with non-small-cell lung cancer by electronic nose analysis of exhaled breath","volume":"30","author":"de Vries","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.aca.2025.343826_bib61","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41467-020-20223-y","article-title":"Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy","volume":"12","author":"Tajan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.aca.2025.343826_bib62","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1021\/acscentsci.8b00296","article-title":"In vitro tracking of intracellular metabolism-derived cancer volatiles via isotope labeling","volume":"4","author":"Lee","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.aca.2025.343826_bib63","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1021\/acs.analchem.3c00516","article-title":"Real-time volatile metabolomics analysis of dendritic cells","volume":"95","author":"Arnold","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.343826_bib64","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jpba.2016.07.028","article-title":"Determination of low-molecular-weight organic acids in non-small cell lung cancer with a new liquid chromatography-tandem mass spectrometry method","volume":"129","author":"Klupczynska","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.aca.2025.343826_bib65","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00432-017-2347-0","article-title":"Study of early stage non-small-cell lung cancer using Orbitrap-based global serum metabolomics","volume":"143","author":"Klupczynska","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.aca.2025.343826_bib66","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/resp.13465","article-title":"Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis","volume":"24","author":"Gaugg","year":"2019","journal-title":"Respirology"},{"key":"10.1016\/j.aca.2025.343826_bib67","doi-asserted-by":"crossref","DOI":"10.1183\/20734735.0147-2022","article-title":"Idiopathic pulmonary fibrosis and lung cancer: future directions and challenges","volume":"18","author":"Abu Qubo","year":"2022","journal-title":"Breathe"},{"key":"10.1016\/j.aca.2025.343826_bib68","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/JEP.S267383","article-title":"Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy","volume":"13","author":"Tchounwou","year":"2021","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.aca.2025.343826_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00280-016-3003-0","article-title":"Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective","volume":"78","author":"Ciccolini","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.aca.2025.343826_bib70","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2174\/138945012802009017","article-title":"Vinorelbine in cancer therapy","volume":"13","author":"Capasso","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.aca.2025.343826_bib71","first-page":"299","article-title":"Distribution of gemcitabine is nearly homogenous in two orthotopic murine models of pancreatic cancer","volume":"30","author":"Kramer","year":"2015","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.aca.2025.343826_bib72","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6404853","article-title":"Research status of mouse models for non-small-cell lung cancer (NSCLC) and antitumor therapy of traditional Chinese medicine (TCM) in mouse models","volume":"2022","author":"Chen","year":"2022","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.aca.2025.343826_bib73","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200247","article-title":"Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories","volume":"11","author":"Hynds","year":"2021","journal-title":"Open Biol."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702500220X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702500220X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:41:16Z","timestamp":1777552876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000326702500220X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":73,"alternative-id":["S000326702500220X"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2025.343826","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Online monitoring and stable isotope tracing of cancer associated volatiles in murine model captures tumor associated markers in vivo","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2025.343826","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"343826"}}