{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:37:41Z","timestamp":1792647461966,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP \/R031118\/1"],"award-info":[{"award-number":["EP \/R031118\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP \/X034933\/1"],"award-info":[{"award-number":["EP \/X034933\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP \/X015491\/1"],"award-info":[{"award-number":["EP \/X015491\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/W019116\/1"],"award-info":[{"award-number":["BB\/W019116\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003513","name":"University of Surrey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003513","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.aca.2025.344272","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T20:09:48Z","timestamp":1749154188000},"page":"344272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Correlative multimodal imaging of tissue structure, metabolome and elemental distribution using stimulated Raman scattering, desorption electrospray ionisation and MeV ion beam analysis"],"prefix":"10.1016","volume":"1367","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-5296","authenticated-orcid":false,"given":"Johanna","family":"von Gerichten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Belsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasundhara","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Newstead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Couture","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Palitsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Dexter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse E.","family":"Mallaupoma Camarena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Giannella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvya Stuchi","family":"Maria-Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9050-7910","authenticated-orcid":false,"given":"Melanie J.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.aca.2025.344272_bib1","first-page":"1","article-title":"Review of stimulated raman scattering microscopy techniques and applications in the biosciences","volume":"5","author":"Li","year":"2021","journal-title":"Adv. Bio Tech"},{"issue":"5","key":"10.1016\/j.aca.2025.344272_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.gde.2011.09.003","article-title":"Label-free imaging of lipid dynamics using coherent anti-stokes raman scattering (CARS) and stimulated raman scattering (SRS) microscopy","volume":"21","author":"Folick","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"7","key":"10.1016\/j.aca.2025.344272_bib3","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1021\/acs.chemrev.6b00545","article-title":"Stimulated raman scattering: from bulk to nano","volume":"117","author":"Prince","year":"2017","journal-title":"Chem. Rev."},{"issue":"5695","key":"10.1016\/j.aca.2025.344272_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.1104404","article-title":"Mass spectrometry sampling under ambient conditions with desorption electrospray ionization","volume":"306","author":"Takats","year":"2004","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s13361-015-1278-8","article-title":"Comparison of DESI-MS and LC-MS for the lipidomic profiling of human cancer tissue","volume":"27","author":"Abbassi-Ghadi","year":"2016","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"1","key":"10.1016\/j.aca.2025.344272_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1021\/ac2021322","article-title":"Tissue imaging using nanospray desorption electrospray ionization mass spectrometry","volume":"84","author":"Laskin","year":"2012","journal-title":"Anal. Chem."},{"issue":"22","key":"10.1016\/j.aca.2025.344272_bib7","first-page":"2639","article-title":"Improved imaging resolution in desorption electrospray ionization mass spectrometryy","volume":"22","author":"Berkel","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.aca.2025.344272_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.339085","article-title":"High-resolution imaging and identification of biomolecules using Nano-DESI coupled to ion mobility spectrometry","volume":"1186","author":"Unsihuay","year":"2021","journal-title":"Anal. Chim. Acta"},{"issue":"03n04","key":"10.1016\/j.aca.2025.344272_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1142\/S0129083514400142","article-title":"Micro-PIXE elemental mapping for ionome studies of crop plants","volume":"24","author":"Vogel-Miku\u0161","year":"2014","journal-title":"Int. J. PIXE"},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/qubs3020012","article-title":"Pixe and its applications to elemental analysis","volume":"3","author":"Ishii","year":"2019","journal-title":"Quantum Beam Sci."},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/jnc.16040","article-title":"Metal dyshomeostasis in the substantia nigra of patients with parkinson's disease or multiple sclerosis","volume":"168","author":"Carmona","year":"2024","journal-title":"J. Neurochem."},{"key":"10.1016\/j.aca.2025.344272_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/192026","article-title":"Comparative trace elemental analysis in cancerous and noncancerous human tissues using PIXE","volume":"2013","author":"Mulware","year":"2013","journal-title":"J. Biophys."},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13020262","article-title":"A multimodal desorption electrospray ionisation workflow enabling visualisation of lipids and biologically relevant elements in a single tissue section","volume":"13","author":"Costa","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.aca.2025.344272_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101494","article-title":"Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine\/glutamate antiporter in alzheimer's disease: evidence of ferroptosis","volume":"32","author":"Ashraf","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.aca.2025.344272_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2022.102152","article-title":"Quantitative imaging approaches to understanding biological processing of metal ions","volume":"69","author":"Zee","year":"2022","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.aca.2025.344272_bib16","author":"Towers"},{"issue":"14","key":"10.1016\/j.aca.2025.344272_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/advs.202302962","article-title":"Opto-lipidomics of tissues","volume":"11","author":"Jensen","year":"2024","journal-title":"Adv. Sci."},{"issue":"40","key":"10.1016\/j.aca.2025.344272_bib18","doi-asserted-by":"crossref","first-page":"13450","DOI":"10.1021\/acs.analchem.1c01927","article-title":"Correlative imaging of trace elements and intact molecular species in a single-tissue sample at the 50 \u039cm scale","volume":"93","author":"de Jesus","year":"2021","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.aca.2025.344272_bib19","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1684\/ejd.2013.2060","article-title":"Comparative histology and immunohistochemistry of porcine versus human skin","volume":"23","author":"Debeer","year":"2013","journal-title":"Eur. J. Dermatol."},{"issue":"10","key":"10.1016\/j.aca.2025.344272_bib20","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1039\/d0mt00121j","article-title":"Elemental and molecular imaging of human full thickness skin after exposure to heavy metals","volume":"12","author":"Chavatte","year":"2020","journal-title":"Metallomics"},{"key":"10.1016\/j.aca.2025.344272_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119316","article-title":"Human skin responses to environmental pollutants: a review of current scientific models","volume":"306","author":"Fitoussi","year":"2022","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14840","article-title":"The impact of air pollution on skin and related disorders: a comprehensive review","volume":"34","author":"Abolhasani","year":"2021","journal-title":"Dermatol. Ther."},{"issue":"1","key":"10.1016\/j.aca.2025.344272_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/life13010069","article-title":"Beneficial effect of wound dressings containing silver and silver nanoparticles in wound healing\u2014from experimental studies to clinical practice","volume":"13","author":"Rybka","year":"2023","journal-title":"Life"},{"issue":"7","key":"10.1016\/j.aca.2025.344272_bib24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1021\/jasms.3c00332","article-title":"Evaluation of inlet temperature with three sprayer designs for desorption electrospray ionization mass spectrometry tissue analysis","volume":"35","author":"Steven","year":"2024","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"10","key":"10.1016\/j.aca.2025.344272_bib26","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"issue":"19","key":"10.1016\/j.aca.2025.344272_bib27","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1021\/acs.analchem.6b01643","article-title":"SpectralAnalysis: software for the masses","volume":"88","author":"Race","year":"2016","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.aca.2025.344272_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.4072","article-title":"FDR-controlled metabolite annotation for high-resolution imaging mass spectrometry","volume":"14","author":"Palmer","year":"2017","journal-title":"Nat. Methods"},{"issue":"D1","key":"10.1016\/j.aca.2025.344272_bib29","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"Hmdb 5.0: the human metabolome database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.aca.2025.344272_bib30","doi-asserted-by":"crossref","first-page":"D1677","DOI":"10.1093\/nar\/gkad896","article-title":"Lipid maps: update to databases and tools for the lipidomics community","volume":"52","author":"Conroy","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.aca.2025.344272_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/jacs.9b09186","article-title":"High-throughput PIXE as an essential quantitative assay for accurate metalloprotein structural analysis: development and application","volume":"142","author":"Grime","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"21","key":"10.1016\/j.aca.2025.344272_bib32","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1039\/D2AN00817C","article-title":"Practical considerations for quantitative and reproducible measurements with stimulated raman scattering microscopy","volume":"147","author":"Tsikritsis","year":"2022","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.aca.2025.344272_bib33","article-title":"Background signals in stimulated raman scattering microscopy and current solutions to avoid them","volume":"8","author":"Genchi","year":"2023","journal-title":"Adv. Phys. X"},{"issue":"July","key":"10.1016\/j.aca.2025.344272_bib34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jconrel.2023.10.026","article-title":"Visualisation of drug distribution in skin using correlative optical spectroscopy and mass spectrometry imaging","volume":"364","author":"Belsey","year":"2023","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.aca.2025.344272_bib35","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1039\/D0AN02039G","article-title":"Raman microscopy for skin evaluation","volume":"146","author":"Egawa","year":"2021","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.aca.2025.344272_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-34286-x","article-title":"Imaging the distribution of skin lipids and topically applied compounds in human skin using mass spectrometry","volume":"8","author":"Sj\u00f6vall","year":"2018","journal-title":"Sci. Rep."},{"issue":"34","key":"10.1016\/j.aca.2025.344272_bib37","doi-asserted-by":"crossref","first-page":"11798","DOI":"10.1021\/acs.analchem.2c01940","article-title":"Colocation of lipids, drugs, and metal biomarkers using spatially resolved lipidomics with elemental mapping","volume":"94","author":"Lewis","year":"2022","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jdermsci.2009.12.005","article-title":"Targeting to the hair follicles: current status and potential","volume":"57","author":"Wosicka","year":"2010","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.aca.2025.344272_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-4165(02)00441-5","article-title":"Evidence for various calcium sites in human hair shaft revealed by sub-micrometer X-Ray fluorescence","volume":"1619","author":"M\u00e9rigoux","year":"2003","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/bj3390419","article-title":"Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes","volume":"339","author":"Hagens","year":"1999","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.aca.2025.344272_bib41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/1523-1747.ep12466230","article-title":"Expression of calcyclin, a calcium-binding protein, in the keratogenous region of growing hair follicles","volume":"96","author":"Wood","year":"1991","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/0010-406X(65)90345-2","article-title":"A comparative study of high-sulphur proteins from \u03b1-Keratins","volume":"15","author":"Gillespie","year":"1965","journal-title":"Comp. Biochem. Physiol."},{"issue":"2","key":"10.1016\/j.aca.2025.344272_bib43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12565-016-0330-5","article-title":"Ultrastructural localization of hair keratins, high sulfur keratin-associated proteins and sulfhydryl oxidase in the human hair","volume":"92","author":"Alibardi","year":"2017","journal-title":"Anat. Sci. Int."},{"issue":"3","key":"10.1016\/j.aca.2025.344272_bib44","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00216-011-5562-6","article-title":"Improved sample preparation for MALDI\u2013MSI of endogenous compounds in skin tissue sections and mapping of exogenous active compounds subsequent to Ex-Vivo skin penetration","volume":"402","author":"Enthaler","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"issue":"12","key":"10.1016\/j.aca.2025.344272_bib45","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1021\/jasms.2c00226","article-title":"Exploring new methods to study and moderate proton beam damage for multimodal imaging on a single tissue section","volume":"33","author":"Costa","year":"2022","journal-title":"J. Am. Soc. Mass Spectrom."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702500666X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702500666X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:41:37Z","timestamp":1777394497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000326702500666X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":45,"alternative-id":["S000326702500666X"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2025.344272","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlative multimodal imaging of tissue structure, metabolome and elemental distribution using stimulated Raman scattering, desorption electrospray ionisation and MeV ion beam analysis","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2025.344272","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"344272"}}