{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:13:45Z","timestamp":1782890025173,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SWU-XDJH202321"],"award-info":[{"award-number":["SWU-XDJH202321"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.aca.2025.344510","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T23:28:43Z","timestamp":1754436523000},"page":"344510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Manganese oxide assisted atomic nanocomposite with multienzyme-like antioxidant activities for chemiluminescent immunoassay of fentanyl"],"prefix":"10.1016","volume":"1374","author":[{"given":"Jin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8522-0608","authenticated-orcid":false,"given":"Shuai","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3976-1468","authenticated-orcid":false,"given":"Xinyue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8238-7987","authenticated-orcid":false,"given":"Zhifeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2025.344510_bib1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.cell.2017.10.035","article-title":"Bias factor and therapeutic window correlate to predict safer opioid analgesics","volume":"171","author":"Schmid","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.aca.2025.344510_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.drugalcdep.2016.11.033","article-title":"A review: fentanyl and non-pharmaceutical fentanyl","volume":"171","author":"Suzuki","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.aca.2025.344510_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1021\/acs.chemrestox.1c00225","article-title":"In vitro and in vivo analysis of fentanyl and fentalog metabolites using hyphenated chromatographic techniques: a review","volume":"35","author":"Patel","year":"2022","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.aca.2025.344510_bib4","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1080\/10408347.2021.1927668","article-title":"Gas chromatography-mass spectrometry analysis of synthetic opioids belonging to the fentanyl class: a review","volume":"52","author":"Valdez","year":"2022","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.aca.2025.344510_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuropharm.2017.10.016","article-title":"Fentanyl, fentanyl analogs and novel synthetic opioids: a comprehensive review","volume":"134","author":"Armenian","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.aca.2025.344510_bib6","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1039\/D0NR08008J","article-title":"Ultrasensitive chemiluminescence immunoassay with enhanced precision for the detection of cTnI amplified by acridinium ester-loaded microspheres and internally calibrated by magnetic fluorescent nanoparticles","volume":"13","author":"Zhao","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.aca.2025.344510_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124870","article-title":"Ultra-sensitive detection of 5-fluorouracil by flow injection chemiluminescence immunoassay based on Fenton-like effect of single atom Co nanozyme","volume":"265","author":"Li","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2025.344510_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2019.115780","article-title":"Research progress on chemiluminescence immunoassay combined with novel technologies","volume":"124","author":"Xiao","year":"2020","journal-title":"Trac-Trend. Anal. Chem."},{"key":"10.1016\/j.aca.2025.344510_bib9","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1021\/acs.analchem.2c01690","article-title":"Dithiothreitol\u2212lucigenin chemiluminescent system for ultrasensitive dithiothreitol and superoxide dismutase detection","volume":"94","author":"Abdussalam","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344510_bib10","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1039\/D1QM00947H","article-title":"Recent trends in nanozymes design: from materials and structures to environmental applications","volume":"5","author":"Ballesteros","year":"2021","journal-title":"Mater. Chem. Front."},{"key":"10.1016\/j.aca.2025.344510_bib11","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1021\/jacs.5b12070","article-title":"Prussian blue nanoparticles as multienzyme mimetics and reactive oxygen species scavengers","volume":"138","author":"Zhang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2025.344510_bib12","article-title":"2D cobalt oxyhydroxide nanozymes inhibit inflammation by targeting the NLRP3 inflammasome","volume":"33","author":"Chen","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.aca.2025.344510_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101317","article-title":"Unveiling the active sites on ferrihydrite with apparent catalase-like activity for potentiating radiotherapy","volume":"41","author":"Zhang","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.aca.2025.344510_bib14","first-page":"12482","article-title":"Hybrid Mn atomic clusters\/single-dispersed atoms with dual antioxidant activities for a chemiluminescent immunoassay","volume":"96","author":"Luo","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344510_bib15","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1021\/acsmaterialslett.2c00075","article-title":"Bimetal biomimetic engineering utilizing metal-organic frameworks for superoxide dismutase mimic","volume":"4","author":"Wu","year":"2022","journal-title":"ACS Mater. Lett."},{"key":"10.1016\/j.aca.2025.344510_bib16","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41929-022-00839-7","article-title":"Ensemble effect for single-atom, small cluster and nanoparticle catalysts","volume":"5","author":"Guo","year":"2022","journal-title":"Nat. Catal."},{"key":"10.1016\/j.aca.2025.344510_bib17","article-title":"Synthesis strategies, catalytic applications, and performance regulation of single-atom catalysts","volume":"31","author":"Li","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.aca.2025.344510_bib18","doi-asserted-by":"crossref","first-page":"6971","DOI":"10.1039\/C8NR00325D","article-title":"The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce3+ surface area concentration","volume":"10","author":"Baldim","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.aca.2025.344510_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112342","article-title":"Facile synthesis of magnetic hierarchical flower-like Co3O4 spheres: mechanism, excellent tetra-enzyme mimics and their colorimetric biosensing applications","volume":"165","author":"Liu","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2025.344510_bib20","doi-asserted-by":"crossref","first-page":"18155","DOI":"10.1021\/jacs.1c12642","article-title":"The progress and outlook of metal single-atom-site catalysis","volume":"144","author":"Liang","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2025.344510_bib21","doi-asserted-by":"crossref","first-page":"13533","DOI":"10.1021\/acs.analchem.2c02825","article-title":"Defective site modulation strategy for preparing single atom-dispersed catalysts as superior chemiluminescent signal probes","volume":"94","author":"Luo","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344510_bib22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.6023\/A24100321","article-title":"Advances in paper-based colorimetric sensors based on nanozymes for point-of-care testing","volume":"83","author":"Zhou","year":"2025","journal-title":"Acta Chim. Sin."},{"key":"10.1016\/j.aca.2025.344510_bib23","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1021\/jacs.3c04612","article-title":"Adjacent copper single atoms promote C\u2212C coupling in electrochemical CO2 reduction for the efficient conversion of ethanol","volume":"145","author":"Xia","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2025.344510_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s41664-024-00319-w","article-title":"Rapid and selective detection of foodborne pathogens using a disposable bio-sensing system designed by stepwise antibody immobilization on AuNPs@Cu-MOF nanocomposite","volume":"8","author":"Magar","year":"2024","journal-title":"J. Anal. Test."},{"key":"10.1016\/j.aca.2025.344510_bib25","first-page":"13941","article-title":"Vanadium oxide nanozymes with multiple enzyme-mimic activities for tumor catalytic therapy","volume":"15","author":"Zeng","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2025.344510_bib26","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.foodchem.2017.10.062","article-title":"Interaction of chromium(III) or chromium(VI) with catalase and its effect on the structure and function of catalase: an in vitro study","volume":"244","author":"Chen","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.aca.2025.344510_bib27","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1021\/am405009f","article-title":"Co3O4 nanoparticles with multi-enzyme activities and their application in immunohistochemical assay","volume":"6","author":"Dong","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2025.344510_bib28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1021\/acsmaterialslett.3c01459","article-title":"Multivalence manganese mediated dual ROS generator for augmented chemodynamic therapy and activated antitumor immunogenic responses","volume":"6","author":"Huo","year":"2024","journal-title":"ACS Mater. Lett."},{"key":"10.1016\/j.aca.2025.344510_bib29","doi-asserted-by":"crossref","first-page":"11382","DOI":"10.1021\/acs.inorgchem.9b00661","article-title":"Mixed-valence Ce-BPyDC metal-organic framework with dual enzyme-like activities for colorimetric biosensing","volume":"58","author":"Luo","year":"2019","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.aca.2025.344510_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.125929","article-title":"Nitrogenase-inspired mixed-valence MIL-53(FeII\/FeIII) for photocatalytic nitrogen fixation","volume":"400","author":"Zhao","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.aca.2025.344510_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/anie.201308589","article-title":"Well-defined metal\u2013organic framework hollow nanocages","volume":"53","author":"Zhang","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2025.344510_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113189","article-title":"Lateral flow assay of methicillin-resistant Staphylococcus aureus using bacteriophage cellular wall-binding domain as recognition agent","volume":"182","author":"Yang","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2025.344510_bib33","doi-asserted-by":"crossref","first-page":"49386","DOI":"10.1039\/C7RA10479K","article-title":"How to make nanobiosensors: surface modification and characterisation of nanomaterials for biosensing applications","volume":"7","author":"Yuce","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.aca.2025.344510_bib34","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1002\/anie.201004745","article-title":"Hollow ferrocenyl coordination polymer microspheres with micropores in shells prepared by ostwald ripening","volume":"49","author":"Huo","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.aca.2025.344510_bib35","doi-asserted-by":"crossref","first-page":"16574","DOI":"10.1039\/c1jm12609a","article-title":"Terbium-based infinite coordination polymer hollow microspheres: preparation and white-light emission","volume":"21","author":"Zhong","year":"2011","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.aca.2025.344510_bib36","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1039\/b807085g","article-title":"Infinite coordination polymer nano- and microparticle structures","volume":"38","author":"Spokoyny","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2025.344510_bib37","doi-asserted-by":"crossref","first-page":"9480","DOI":"10.1002\/anie.202017152","article-title":"Stimuli-responsive manganese single-atom nanozyme for tumor therapy via integrated Cascade reactions","volume":"60","author":"Zhu","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2025.344510_bib38","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1038\/s41467-019-12510-0","article-title":"A universal ligand mediated method for large scale synthesis of transition metal single atom catalysts","volume":"10","author":"Yang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.aca.2025.344510_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341909","article-title":"Preparation of Co dual atomic site catalysts loaded on defect-engineered MOFs material with superb chemiluminescent enhancement effect for sensitive detection of bacteria","volume":"1282","author":"Gao","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2025.344510_bib40","article-title":"Single-atom Mn catalysts via integration with Mn sub nano-clusters synergistically enhance oxygen reduction reaction","volume":"20","author":"Li","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.aca.2025.344510_bib41","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cpc.2008.12.020","article-title":"Wavelet data analysis of EXAFS spectra","volume":"180","author":"Timoshenko","year":"2009","journal-title":"Comput. Phys. Commun."},{"key":"10.1016\/j.aca.2025.344510_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.apcatb.2019.118188","article-title":"Co single-atom anchored on Co3O4 and nitrogen-doped active carbon toward bifunctional catalyst for zinc-air batteries","volume":"260","author":"Zhong","year":"2020","journal-title":"Appl. Catal., B"},{"key":"10.1016\/j.aca.2025.344510_bib43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s40820-024-01463-9","article-title":"Advances of synergistic electrocatalysis between single atoms and nanoparticles\/clusters","volume":"16","author":"Luo","year":"2024","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.aca.2025.344510_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.electacta.2023.142747","article-title":"Synthesis of nanoflower-like NiMnO3 combined with MWCNTs for the electrochemical determination of fentanyl","volume":"462","author":"Zhao","year":"2023","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.aca.2025.344510_bib45","doi-asserted-by":"crossref","first-page":"9373","DOI":"10.1021\/acs.analchem.1c00792","article-title":"Rapid SERS quantification of trace fentanyl laced in recreational drugs with a portable raman module","volume":"93","author":"Wang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344510_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.131215","article-title":"Surfactants directly participate in the molecular recognition for visual and sensitive detection of fentanyl","volume":"354","author":"Lin","year":"2022","journal-title":"Sens. Actuators, B"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025009043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025009043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:03:25Z","timestamp":1772795005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267025009043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":46,"alternative-id":["S0003267025009043"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2025.344510","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Manganese oxide assisted atomic nanocomposite with multienzyme-like antioxidant activities for chemiluminescent immunoassay of fentanyl","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2025.344510","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"344510"}}