{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:55:01Z","timestamp":1792702501243,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.aca.2025.344552","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T05:07:57Z","timestamp":1755493677000},"page":"344552","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Constructing promising amino acid hydrogel functionalized silica for mixed-mode chromatographic separation through crosslinking agent modification"],"prefix":"10.1016","volume":"1374","author":[{"given":"Hanlin","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-4679","authenticated-orcid":false,"given":"Jingdong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.aca.2025.344552_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0021-9673(94)01298-9","article-title":"Recent progress in reversed-phase and hydrophobic interaction chromatography of carbohydrate species","volume":"720","author":"ElRassi","year":"1996","journal-title":"J. Chromatogr. A"},{"issue":"10","key":"10.1016\/j.aca.2025.344552_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0165-9936(01)00098-X","article-title":"Trends and progress in the characterization of stationary phases for reversed-phase liquid chromatography","volume":"20","author":"Claessens","year":"2001","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.aca.2025.344552_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0021-9673(00)96972-3","article-title":"HYDROPHILIC-INTERACTION chromatography for the separation of peptides, nucleic-acids and other polar compounds","volume":"499","author":"Alpert","year":"1990","journal-title":"J. Chromatogr."},{"issue":"1\u20132","key":"10.1016\/j.aca.2025.344552_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2011.02.047","article-title":"Stationary and mobile phases in hydrophilic interaction chromatography: a review","volume":"692","author":"Jandera","year":"2011","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.aca.2025.344552_bib5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00216-011-5308-5","article-title":"Hydrophilic interaction liquid chromatography (HILIC)-a powerful separation technique","volume":"402","author":"Buszewski","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aca.2025.344552_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.aca.2017.01.060","article-title":"Recent advances in stationary phases and understanding of retention in hydrophilic interaction chromatography. A review","volume":"967","author":"Jandera","year":"2017","journal-title":"Anal. Chim. Acta"},{"issue":"11","key":"10.1016\/j.aca.2025.344552_bib7","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1021\/ac60361a017","article-title":"Novel ION-exchange chromatographic method using conductimetric detectION","volume":"47","author":"Small","year":"1975","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344552_bib8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.trac.2016.04.001","article-title":"Recent advances in materials for stationary phases of mixed-mode high-performance liquid chromatography","volume":"80","author":"Wang","year":"2016","journal-title":"Trac. Trends Anal. Chem."},{"issue":"48","key":"10.1016\/j.aca.2025.344552_bib9","doi-asserted-by":"crossref","first-page":"16017","DOI":"10.1021\/acs.analchem.1c03514","article-title":"Hydrogel coating with temperature response retention behavior and its application in selective separation of liquid chromatography","volume":"93","author":"Fan","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344552_bib10","first-page":"349","article-title":"Synergistic expression of ZIF-67 and amphiphilic polymer hydrogel in multi-mode liquid chromatographic separation","author":"Liu","year":"2024","journal-title":"Separ. Purif. Technol."},{"key":"10.1016\/j.aca.2025.344552_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.chroma.2016.02.039","article-title":"Crosslinked structurally-tuned polymeric ionic liquids as stationary phases for the analysis of hydrocarbons in kerosene and diesel fuels by comprehensive two-dimensional gas chromatography","volume":"1440","author":"Zhang","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.aca.2025.344552_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.aca.2019.12.016","article-title":"Fabrication and application of zwitterionic phosphorylcholine functionalized monoliths with different hydrophilic crosslinkers in hydrophilic interaction chromatography","volume":"1101","author":"Wang","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2025.344552_bib13","doi-asserted-by":"crossref","unstructured":"Ren, Y., J. Guo, Z. Liu, Z. Sun, Y. Wu, L. Liu and F. Yan,Ionic liquid\u2013based click-ionogels,Sci. Adv.. (5(8): eaax0648.https:\/\/doi.org\/10.1126\/sciadv.aax0648.","DOI":"10.1126\/sciadv.aax0648"},{"key":"10.1016\/j.aca.2025.344552_bib14","first-page":"139","article-title":"Application of microporous organic networks in separation science","author":"Cui","year":"2021","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"3","key":"10.1016\/j.aca.2025.344552_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41563-022-01195-4","article-title":"Tough and stretchable ionogels by in situ phase separation","volume":"21","author":"Wang","year":"2022","journal-title":"Nat. Mater."},{"issue":"9","key":"10.1016\/j.aca.2025.344552_bib16","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1039\/D1TA08915C","article-title":"Spontaneous self-healing ionogels for efficient and reliable carbon dioxide separation","volume":"10","author":"Fu","year":"2022","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.aca.2025.344552_bib17","first-page":"87","article-title":"Stable hierarchical ionic liquid nanochannels for highly efficient CO2 adsorption, separation and conversion","author":"Li","year":"2024","journal-title":"J. CO2 Util."},{"key":"10.1016\/j.aca.2025.344552_bib18","first-page":"709","article-title":"Ionic liquid fluoropolymer membranes for the separation of R-410A: understanding the effect of ionic liquid on membrane characteristics and separation performance","author":"Harders","year":"2024","journal-title":"J. Membr. Sci."},{"key":"10.1016\/j.aca.2025.344552_bib19","first-page":"330","article-title":"Multifunctional amphibious superhydrophilic-oleophobic cellulose nanofiber aerogels for oil and water purification","author":"Xu","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.aca.2025.344552_bib20","first-page":"1739","article-title":"Synthesis and applications of ionic liquids for chromatographic analysis","author":"Waheed","year":"2025","journal-title":"J. Chromatogr. A"},{"issue":"6","key":"10.1016\/j.aca.2025.344552_bib21","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.3390\/ijms10062591","article-title":"Application of ionic liquids in high performance reversed-phase chromatography","volume":"10","author":"Wang","year":"2009","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.aca.2025.344552_bib22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/01496395.2011.608402","article-title":"Preparation and application of ionic liquid-modified stationary phases in high performance liquid chromatography","volume":"47","author":"Bi","year":"2012","journal-title":"Separ. Sci. Technol."},{"key":"10.1016\/j.aca.2025.344552_bib23","first-page":"266","article-title":"Graft copolymerization of anion and cation onto silica and application in mixed-mode of reversed phase\/hydrophilic interaction\/ion exchange chromatography","author":"Wang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2025.344552_bib24","first-page":"1303","article-title":"Dicationic imidazole ionic liquid stationary phase for preservative detection and its application under mixed mode of HILIC\/RPLC\/IEC","author":"Yang","year":"2024","journal-title":"Anal. Chim. Acta"},{"issue":"18","key":"10.1016\/j.aca.2025.344552_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/macp.201700078","article-title":"Phosgene-free synthesis of Poly(L-cysteine) containing styrene moiety as a reactive function","volume":"218","author":"Akbulut","year":"2017","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.aca.2025.344552_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125547","article-title":"Fabrication of ionic liquid functionalized silica with different anions and the application in mixed-mode and chiral chromatography","volume":"270","author":"Wang","year":"2024","journal-title":"Talanta"},{"issue":"4","key":"10.1016\/j.aca.2025.344552_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5332","article-title":"A survey of polar stationary phases for hydrophilic interaction chromatography and recent progress in understanding retention and selectivity","volume":"36","author":"Guo","year":"2022","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.aca.2025.344552_bib28","first-page":"202","article-title":"Preparation and post-modified of dicationic ionic liquid stationary phase and their application in mixed-mode liquid chromatography","author":"Zeng","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2025.344552_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462543","article-title":"Volume and composition of semi-adsorbed stationary phases in hydrophilic interaction liquid chromatography. Comparison of water adsorption in common stationary phases and eluents","volume":"1656","author":"Red\u00f3n","year":"2021","journal-title":"J. Chromatogr. A"},{"issue":"2","key":"10.1016\/j.aca.2025.344552_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chroma.2008.03.049","article-title":"Estimation of the extent of the water-rich layer associated with the silica surface in hydrophilic interaction chromatography","volume":"1192","author":"McCalley","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.aca.2025.344552_bib31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.chroma.2015.03.082","article-title":"Retention prediction of highly polar ionizable solutes under gradient conditions on a mixed-mode reversed-phase and weak anion-exchange stationary phase","volume":"1396","author":"Balkatzopoulou","year":"2015","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.aca.2025.344552_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chroma.2005.03.058","article-title":"Retention behavior of small polar compounds on polar stationary phases in hydrophilic interaction chromatography","volume":"1074","author":"Guo","year":"2005","journal-title":"J. Chromatogr. A"},{"issue":"7","key":"10.1016\/j.aca.2025.344552_bib33","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1021\/acs.analchem.4c05880","article-title":"Quantitative assessment of retention mechanisms for ionized compounds in hydrophilic interaction chromatography (HILIC)","volume":"97","author":"Guo","year":"2025","journal-title":"Anal. Chem."},{"issue":"1\u20132","key":"10.1016\/j.aca.2025.344552_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.chroma.2003.12.004","article-title":"Determination of sets of solute descriptors from chromatographic measurements","volume":"1037","author":"Abraham","year":"2004","journal-title":"J. Chromatogr. A"},{"issue":"35","key":"10.1016\/j.aca.2025.344552_bib35","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1016\/j.chroma.2011.04.002","article-title":"Investigations on the chromatographic behaviour of zwitterionic stationary phases used in hydrophilic interaction chromatography","volume":"1218","author":"Chirita","year":"2011","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"10.1016\/j.aca.2025.344552_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/separations9030072","article-title":"The crosslinker matters: vinylimidazole-based anion exchange polymer for dispersive solid-phase extraction of phenolic acids","volume":"9","author":"Harder","year":"2022","journal-title":"Separations"},{"key":"10.1016\/j.aca.2025.344552_bib37","first-page":"123","article-title":"Pure water as a mobile phase in liquid chromatography techniques","author":"Dembek","year":"2020","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"1","key":"10.1016\/j.aca.2025.344552_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/17518253.2019.1576775","article-title":"The separations using pure water as a mobile phase in liquid chromatography using polar-embedded stationary phases","volume":"12","author":"Bocian","year":"2019","journal-title":"Green Chem. Lett. Rev."},{"issue":"2","key":"10.1016\/j.aca.2025.344552_bib39","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.electacta.2005.04.031","article-title":"Investigation of antioxidant activity and lipophilicity parameters of some preservatives","volume":"51","author":"Korotkova","year":"2005","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.aca.2025.344552_bib40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.foodchem.2017.05.059","article-title":"Inhibition effect of food preservatives on endoproteinases","volume":"235","author":"Esimbekova","year":"2017","journal-title":"Food Chem."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025009468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025009468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:17:09Z","timestamp":1758356229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267025009468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":40,"alternative-id":["S0003267025009468"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2025.344552","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Constructing promising amino acid hydrogel functionalized silica for mixed-mode chromatographic separation through crosslinking agent modification","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2025.344552","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"344552"}}