{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:12:31Z","timestamp":1792156351534,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000008","name":"Health Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021155","name":"Janeway Children's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.aca.2025.344606","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:06:37Z","timestamp":1757030797000},"page":"344606","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Identification of micro-\/nanoplastics in human placental blood using comprehensive multidimensional pyrolysis - gas chromatography x ion mobility mass spectrometry"],"prefix":"10.1016","volume":"1376","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1593-5602","authenticated-orcid":false,"given":"Justine R.","family":"Bissonnette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita E.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3486-5210","authenticated-orcid":false,"given":"Mikela L.","family":"Rowsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9510-1609","authenticated-orcid":false,"given":"Sophie","family":"Kiefte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-2896","authenticated-orcid":false,"given":"Kas J.","family":"Houthuijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic M.","family":"B\u00e9en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja H.","family":"Lamoree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay S.","family":"Cahill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7687-6629","authenticated-orcid":false,"given":"Karl J.","family":"Jobst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.aca.2025.344606_bib1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/acs.est.8b05297","article-title":"Are we speaking the same language? Recommendations for a definition and categorization framework for plastic Debris","volume":"53","author":"Hartmann","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.aca.2025.344606_bib2","article-title":"Presence of microplastics and nanoplastics in food, with particular focus on seafood","volume":"14","year":"2016","journal-title":"EFSA J."},{"issue":"5","key":"10.1016\/j.aca.2025.344606_bib3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3349\/ymj.2023.0048","article-title":"Health effects of microplastic exposures: current issues and perspectives in South Korea","volume":"64","author":"Lee","year":"2023","journal-title":"Yonsei Med. J."},{"issue":"5672","key":"10.1016\/j.aca.2025.344606_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.1094559","article-title":"Lost at sea: where is all the plastic?","volume":"304","author":"Thompson","year":"2004","journal-title":"Science"},{"issue":"27","key":"10.1016\/j.aca.2025.344606_bib5","doi-asserted-by":"crossref","first-page":"21530","DOI":"10.1007\/s11356-017-9910-8","article-title":"Microplastic pollution, a threat to marine ecosystem and human health: a short review","volume":"24","author":"Sharma","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"3","key":"10.1016\/j.aca.2025.344606_bib6","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3390\/nu15030617","article-title":"Microplastics: a real global threat for environment and food safety: a state of the art review","volume":"15","author":"Ziani","year":"2023","journal-title":"Nutrients"},{"issue":"6407","key":"10.1016\/j.aca.2025.344606_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/361023a0","article-title":"Marine litter keeps increasing","volume":"361","author":"Ryan","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.aca.2025.344606_bib8","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1098\/rstb.2008.0207","article-title":"Monitoring the abundance of plastic Debris in the marine environment","volume":"364","author":"Ryan","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.aca.2025.344606_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146569","article-title":"The rise of artificial soil carbon inputs: reviewing microplastic pollution effects in the soil environment","volume":"780","author":"Mbachu","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.aca.2025.344606_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1021\/jasms.3c00362","article-title":"Size-resolved identification and quantification of micro\/nanoplastics in indoor air using pyrolysis gas chromatography\u2013ion mobility mass spectrometry","volume":"35","author":"Hashemihedeshi","year":"2024","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"7","key":"10.1016\/j.aca.2025.344606_bib11","doi-asserted-by":"crossref","DOI":"10.1289\/EHP13540","article-title":"Microplastics and anthropogenic particles in recreationally caught freshwater fish from an urbanized region of the north American great lakes","volume":"132","author":"Milne","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aca.2025.344606_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104147","article-title":"Microplastics detected in cirrhotic liver tissue","volume":"82","author":"Horvatits","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.aca.2025.344606_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154907","article-title":"Detection of microplastics in human lung tissue using \u03bcFTIR spectroscopy","volume":"831","author":"Jenner","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aca.2025.344606_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.aca.2025.344606_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s43591-024-00090-w","article-title":"Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography\u2013mass spectrometry","volume":"4","author":"Brits","year":"2024","journal-title":"Microplastics Nanoplastics"},{"issue":"13","key":"10.1016\/j.aca.2025.344606_bib16","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.3390\/polym14132700","article-title":"Raman microspectroscopy detection and characterisation of microplastics in human breastmilk","volume":"14","author":"Ragusa","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.aca.2025.344606_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108444","article-title":"MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue","volume":"184","author":"Massardo","year":"2024","journal-title":"Environ. Int."},{"issue":"18","key":"10.1016\/j.aca.2025.344606_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph191811593","article-title":"Deeply in plasticenta: presence of microplastics in the intracellular compartment of human placentas","volume":"19","author":"Ragusa","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"7","key":"10.1016\/j.aca.2025.344606_bib19","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/pharmaceutics13070921","article-title":"Detection of microplastic in human placenta and meconium in a clinical setting","volume":"13","author":"Braun","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.aca.2025.344606_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: first evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.aca.2025.344606_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158699","article-title":"Detection of various microplastics in placentas, Meconium, infant Feces, breastmilk and infant formula: a pilot prospective study","volume":"854","author":"Liu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aca.2025.344606_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159060","article-title":"Identification of microplastics in human placenta using laser direct infrared spectroscopy","volume":"856","author":"Zhu","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"46","key":"10.1016\/j.aca.2025.344606_bib23","doi-asserted-by":"crossref","first-page":"17774","DOI":"10.1021\/acs.est.2c04706","article-title":"The association between microplastics and microbiota in placentas and Meconium: the first evidence in humans","volume":"57","author":"Liu","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aca.2025.344606_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120174","article-title":"Placental plastics in young women from general population correlate with reduced foetal growth in IUGR pregnancies","volume":"314","author":"Amereh","year":"2022","journal-title":"Environ. Pollut."},{"issue":"22","key":"10.1016\/j.aca.2025.344606_bib25","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1080\/10643389.2020.1807450","article-title":"Contributions of fourier transform infrared spectroscopy in microplastic pollution research: a review","volume":"51","author":"Veerasingam","year":"2021","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.aca.2025.344606_bib26","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/jrs.5367","article-title":"Fast microplastics identification with stimulated Raman scattering microscopy","volume":"49","author":"Zada","year":"2018","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.aca.2025.344606_bib27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.trac.2018.10.010","article-title":"Raman microspectroscopy as a tool for microplastic particle analysis","volume":"109","author":"Anger","year":"2018","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.aca.2025.344606_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108751","article-title":"Microplastics in human blood: polymer types, concentrations and characterisation using \u03bcFTIR","volume":"188","author":"V L Leonard","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.aca.2025.344606_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164157","article-title":"Standardization of micro-FTIR methods and applicability for the detection and identification of microplastics in environmental matrices","volume":"888","author":"Rathore","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aca.2025.344606_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105118","article-title":"Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites","volume":"103","author":"Wang","year":"2024","journal-title":"eBioMedicine"},{"key":"10.1016\/j.aca.2025.344606_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133855","article-title":"Microplastics in three types of human arteries detected by pyrolysis-gas chromatography\/mass spectrometry (Py-GC\/MS)","volume":"469","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.aca.2025.344606_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/toxsci\/kfae021","article-title":"Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry","volume":"199","author":"Garcia","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.aca.2025.344606_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.115979","article-title":"Emerging use thermo-analytical method coupled with mass spectrometry for the quantification of micro(Nano)Plastics in environmental samples","volume":"131","author":"Yakovenko","year":"2020","journal-title":"TrAC Trends Anal. Chem."},{"issue":"9","key":"10.1016\/j.aca.2025.344606_bib34","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1021\/acs.est.6b06362","article-title":"Simultaneous trace identification and quantification of common types of microplastics in environmental samples by pyrolysis-gas chromatography\u2013mass spectrometry","volume":"51","author":"Fischer","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aca.2025.344606_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133013","article-title":"Quantitative analysis of nanoplastics in environmental and potable waters by pyrolysis-gas chromatography\u2013mass spectrometry","volume":"464","author":"Okoffo","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"26","key":"10.1016\/j.aca.2025.344606_bib36","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1007\/s00216-019-02066-9","article-title":"Quantification of microplastics in environmental samples via pressurized liquid extraction and pyrolysis-gas chromatography","volume":"411","author":"Dierkes","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"issue":"19","key":"10.1016\/j.aca.2025.344606_bib37","doi-asserted-by":"crossref","first-page":"12164","DOI":"10.1021\/acs.est.0c03742","article-title":"When good intentions go bad\u2014false positive microplastic detection caused by disposable gloves","volume":"54","author":"Witzig","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.aca.2025.344606_bib38","doi-asserted-by":"crossref","DOI":"10.20517\/jeea.2022.04","article-title":"Extraction and pyrolysis-GC-MS analysis of polyethylene in samples with medium to high lipid content","volume":"1","author":"Rauert","year":"2022","journal-title":"J. Environ. Expo. Assess."},{"key":"10.1016\/j.aca.2025.344606_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169709","article-title":"Depth distribution of nano- and microplastics and their contribution to carbon storage in Chinese agricultural soils","volume":"913","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.aca.2025.344606_bib40","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1021\/acs.est.4c12599","article-title":"Assessing the efficacy of pyrolysis\u2013gas chromatography\u2013mass spectrometry for nanoplastic and microplastic analysis in human blood","volume":"59","author":"Rauert","year":"2025","journal-title":"Environ. Sci. Technol."},{"issue":"32","key":"10.1016\/j.aca.2025.344606_bib41","doi-asserted-by":"crossref","first-page":"11113","DOI":"10.1021\/acs.analchem.2c02351","article-title":"Unwrapping wrap-around in gas (or liquid) chromatographic cyclic ion mobility\u2013mass spectrometry","volume":"94","author":"Breen","year":"2022","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.aca.2025.344606_bib42","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/ac503715v","article-title":"Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification","volume":"87","author":"Paglia","year":"2015","journal-title":"Anal. Chem."},{"issue":"13","key":"10.1016\/j.aca.2025.344606_bib43","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1021\/acs.analchem.9b01838","article-title":"A cyclic ion mobility-mass spectrometry system","volume":"91","author":"Giles","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344606_bib44","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.chemosphere.2017.02.010","article-title":"Fast identification of microplastics in complex environmental samples by a thermal degradation method","volume":"174","author":"D\u00fcmichen","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.aca.2025.344606_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117566","article-title":"Microplastic aging processes: environmental relevance and analytical implications","volume":"172","author":"Binda","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.aca.2025.344606_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137584","article-title":"Improved multivariate quantification of plastic particles in human blood using non-targeted pyrolysis GC-MS","volume":"489","author":"Nijenhuis","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.aca.2025.344606_bib47","article-title":"Determination of polystyrene microplastic in soil by pyrolysis \u2013 gas chromatography \u2013 mass spectrometry (Pyr-GC-MS)","author":"Carvalho","year":"2024","journal-title":"Anal. Lett."},{"issue":"2","key":"10.1016\/j.aca.2025.344606_bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/10408347.2014.980775","article-title":"Biological matrix effects in quantitative tandem mass spectrometry-based analytical methods: advancing biomonitoring","volume":"46","author":"Panuwet","year":"2016","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"8","key":"10.1016\/j.aca.2025.344606_bib49","article-title":"Study of matrix-induced effects in multi-residue determination of pesticides by online gel permeation chromatography-gas chromatography\/mass spectrometry","volume":"26","author":"S","year":"2012","journal-title":"Rapid Commun. Mass Spectrom. RCM"},{"issue":"23","key":"10.1016\/j.aca.2025.344606_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300571","article-title":"Matrix effects demystified: strategies for resolving challenges in analytical separations of complex samples","volume":"46","author":"Williams","year":"2023","journal-title":"J. Sep. Sci."},{"issue":"30","key":"10.1016\/j.aca.2025.344606_bib51","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1021\/acs.est.2c07179","article-title":"Detection of various microplastics in patients undergoing cardiac surgery","volume":"57","author":"Yang","year":"2023","journal-title":"Environ. Sci. Technol."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025010001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025010001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:12:40Z","timestamp":1772831560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267025010001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":51,"alternative-id":["S0003267025010001"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2025.344606","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of micro-\/nanoplastics in human placental blood using comprehensive multidimensional pyrolysis - gas chromatography x ion mobility mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2025.344606","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"344606"}}