{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:49:15Z","timestamp":1791395355078,"version":"4.3.3"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632024TD05"],"award-info":[{"award-number":["2632024TD05"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632024PY05"],"award-info":[{"award-number":["2632024PY05"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX23_1167"],"award-info":[{"award-number":["KYCX23_1167"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008048","name":"Nanjing University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.aca.2025.344782","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T07:08:57Z","timestamp":1760512137000},"page":"344782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Synthesis and characterization of coumarin-quinoline based NIR probes for viscosity: Mitochondria-Targeted probe with superior performance in autophagy and liver injury imaging"],"prefix":"10.1016","volume":"1380","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6852-9491","authenticated-orcid":false,"given":"Lei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0999-8300","authenticated-orcid":false,"given":"Wenze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-4694","authenticated-orcid":false,"given":"Jiangwei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8721-3310","authenticated-orcid":false,"given":"Haijun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2025.344782_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/tcr.202200035","article-title":"Intracellular physical properties with small organic fluorescent probes: recent advances and future perspectives","volume":"22","author":"Dutta","year":"2022","journal-title":"Chem. Rec."},{"key":"10.1016\/j.aca.2025.344782_bib2","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1039\/C4CS00051J","article-title":"Macro-\/micro-environment-sensitive chemosensing and biological imaging","volume":"43","author":"Yang","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2025.344782_bib3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1251\/bpo52","article-title":"Measuring solution viscosity and its effect on enzyme activity","volume":"5","author":"Uribe","year":"2003","journal-title":"Biol. Proced. Online"},{"key":"10.1016\/j.aca.2025.344782_bib4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.actbio.2007.04.002","article-title":"Biomechanics and biophysics of cancer cells","volume":"3","author":"Suresh","year":"2007","journal-title":"Acta Biomater."},{"key":"10.1016\/j.aca.2025.344782_bib5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/BF00969020","article-title":"Membrane fluidity of platelets and erythrocytes in patients with alzheimer's disease and the effect of small amounts of aluminium on platelet and erythrocyte membranes","volume":"17","author":"van Rensburg","year":"1992","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.aca.2025.344782_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2017.10.003","article-title":"17\u03b2-Estradiol directly lowers mitochondrial membrane microviscosity and improves bioenergetic function in skeletal muscle","volume":"27","author":"Torres","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.aca.2025.344782_bib7","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nrm3877","article-title":"Mitochondrial dynamics and inheritance during cell division, development and disease","volume":"15","author":"Mishra","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.aca.2025.344782_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","article-title":"The role of mitochondria in metabolism and cell death","volume":"482","author":"Vakifahmetoglu-Norberg","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.aca.2025.344782_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis","volume":"43","author":"Wang","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.aca.2025.344782_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1114231","article-title":"Mitochondria: it is all about energy","volume":"14","author":"Casanova","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.aca.2025.344782_bib11","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stem.2021.02.011","article-title":"Mitochondria as signaling organelles control mammalian stem cell fate","volume":"28","author":"Chakrabarty","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.aca.2025.344782_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1595","article-title":"Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells","volume":"15","author":"Begum","year":"2023","journal-title":"WIREs Mech. Disease"},{"key":"10.1016\/j.aca.2025.344782_bib13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fcell.2020.00467","article-title":"Mitophagy, mitochondrial homeostasis, and cell fate","volume":"8","author":"Ma","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.aca.2025.344782_bib14","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1111\/febs.16115","article-title":"Mitochondria and oxygen homeostasis","volume":"289","author":"Mori","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.aca.2025.344782_bib15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/jcm7020016","article-title":"Biomarkers for detecting mitochondrial disorders","author":"Finsterer","year":"2018","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.aca.2025.344782_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/biology9060137","article-title":"The role of mitochondria in cardiovascular diseases","author":"Poznyak","year":"2020","journal-title":"Biology"},{"key":"10.1016\/j.aca.2025.344782_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.671908","article-title":"The role of mitochondrial dysfunction in vascular disease, tumorigenesis, and diabetes","volume":"8","author":"Zhunina","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.aca.2025.344782_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2024.112524","article-title":"A review of the application of small organic molecule fluorescent probes in ischemia-reperfusion injury","volume":"233","author":"Zhang","year":"2025","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.aca.2025.344782_bib19","article-title":"Small-molecule fluorescent probe for bioimaging of organ fibrosis: progress, challenges and prospects","author":"Li","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2025.344782_bib20","article-title":"A NIR and ratiometric fluorescent probe for quantitative detection of SO2 derivatives in Chinese medicinal materials and bioimaging in vivo","author":"Wu","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.aca.2025.344782_bib21","article-title":"Evaluating the global thiols redox state in living cells using a reducing sulfur species responsive fluorescence switching platform","volume":"36","author":"Zhang","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.aca.2025.344782_bib22","article-title":"Small-molecule fluorescent probes for imaging and diagnosing ischemia-reperfusion injury","author":"Guo","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.aca.2025.344782_bib23","doi-asserted-by":"crossref","first-page":"15244","DOI":"10.1021\/acs.analchem.5c01887","article-title":"Viscosity-tuned mitochondrial probe for precision tumor theranostics and apoptosis imaging","volume":"97","author":"Tian","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344782_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.125884","article-title":"A wash-free fluorescent probe with red-emission for monitoring mitochondrial viscosity changes during cellular metabolism and different death processes","volume":"333","author":"Wang","year":"2025","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.aca.2025.344782_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136911","article-title":"ROS-Tolerant and mitochondria-targeted fluorescent probe for accurate decipherment of viscosity change in mitochondria","volume":"424","author":"Chen","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2025.344782_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137580","article-title":"Dual-responsive near-infrared fluorescent probe for monitoring viscosity and mitochondria-generated peroxynitrite-induced lipid droplet migration in live cells and non-alcoholic fatty liver","volume":"433","author":"Xu","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2025.344782_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.127694","article-title":"Advances in fluorescent probes of non-alcoholic fatty liver disease","volume":"287","author":"Han","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2025.344782_bib28","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1021\/acs.jafc.5c00114","article-title":"Applications and challenges of fluorescent probes for the detection of pesticide residues in food","volume":"73","author":"Li","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.aca.2025.344782_bib29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1021\/acs.accounts.4c00671","article-title":"Near-Infrared-II fluorescent probes for analytical applications: from in vitro detection to in vivo imaging monitoring","volume":"58","author":"Liu","year":"2025","journal-title":"Accounts Chem. Res."},{"key":"10.1016\/j.aca.2025.344782_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.actbio.2025.07.024","article-title":"Advancements and future perspectives of triphenylamine-based fluorescent probes in biomedical applications","volume":"202","author":"Ding","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.aca.2025.344782_bib31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41551-016-0010","article-title":"Near-infrared fluorophores for biomedical imaging","volume":"1","author":"Hong","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.aca.2025.344782_bib32","article-title":"Mechanism study of the molluscicide candidate PBQ on Pomacea canaliculata using a viscosity-sensitive fluorescent probe","volume":"36","author":"Zhang","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.aca.2025.344782_bib33","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cclet.2021.11.082","article-title":"Forthrightly monitoring ferroptosis induced by endoplasmic reticulum stresses through fluorescence lifetime imaging of microviscosity increases with a specific rotor","volume":"33","author":"Liu","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.aca.2025.344782_bib34","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1021\/acs.analchem.3c00436","article-title":"Rational design of MMP-independent near-infrared fluorescent probes for accurately monitoring mitochondrial viscosity","volume":"95","author":"Wu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344782_bib35","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1021\/acs.analchem.2c05713","article-title":"Dihydroxanthene-based near-infrared fluorescent probes for monitoring mitochondrial viscosity in living cells and mice","volume":"95","author":"Wu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2025.344782_bib36","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1002\/anie.201303690","article-title":"The ferroquine antimalarial conundrum: Redox activation and reinvasion inhibition","volume":"52","author":"Dubar","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2025.344782_bib37","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1016\/j.cclet.2020.03.020","article-title":"A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation","volume":"31","author":"Zhang","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.aca.2025.344782_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.135163","article-title":"Dual-response near-infrared fluorescent probe for detecting cyanide and mitochondrial viscosity and its application in bioimaging","volume":"407","author":"Pan","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.aca.2025.344782_bib39","doi-asserted-by":"crossref","first-page":"9575","DOI":"10.1021\/acs.langmuir.6b02118","article-title":"Effect of molecular structure on stability of organic nanoparticles formed by bodipy dimers","volume":"32","author":"Lin","year":"2016","journal-title":"Langmuir"},{"key":"10.1016\/j.aca.2025.344782_bib40","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1039\/D4AY02192D","article-title":"A quinoline-malononitrile-based fluorescent probe with aggregation-induced emission effect for the in vivo monitoring of viscosity","volume":"17","author":"Zhang","year":"2025","journal-title":"Anal. Methods"},{"key":"10.1016\/j.aca.2025.344782_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132003","article-title":"Quinolinium-based viscosity probes for lysosome imaging and tracing lysosomal viscosity changes in living cells","volume":"367","author":"Tantipanjaporn","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2025.344782_bib42","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jhep.2014.05.033","article-title":"Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice","volume":"61","author":"Lin","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.aca.2025.344782_bib43","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1007\/s00204-020-02780-9","article-title":"Autophagy: a promising process for the treatment of acetaminophen-induced liver injury","volume":"94","author":"Tan","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.aca.2025.344782_bib44","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/liv.13866","article-title":"Role and mechanisms of autophagy in acetaminophen-induced liver injury","volume":"38","author":"Chao","year":"2018","journal-title":"Liver Int."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025011766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267025011766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:21:19Z","timestamp":1773181279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267025011766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"alternative-id":["S0003267025011766"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2025.344782","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and characterization of coumarin-quinoline based NIR probes for viscosity: Mitochondria-Targeted probe with superior performance in autophagy and liver injury imaging","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2025.344782","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"344782"}}