{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:24:42Z","timestamp":1786983882142,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 TR004926"],"award-info":[{"award-number":["UM1 TR004926"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 MH075673"],"award-info":[{"award-number":["P30 MH075673"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R 01 CA264901"],"award-info":[{"award-number":["R 01 CA264901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P 30 CA006973"],"award-info":[{"award-number":["P 30 CA006973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007114","name":"African Institute for Mathematical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012304","name":"School of Medicine, Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH22C0047"],"award-info":[{"award-number":["W81XWH22C0047"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.aca.2026.345110","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:56:30Z","timestamp":1769100990000},"page":"345110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Histology-guided spatial lipidomics and proteomics of the trisynaptic circuit in the human hippocampus"],"prefix":"10.1016","volume":"1392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9152-8123","authenticated-orcid":false,"given":"Caitlin M.","family":"Tressler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"DeVine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1834-3056","authenticated-orcid":false,"given":"Dalton R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Glunde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5790","key":"10.1016\/j.aca.2026.345110_bib1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1128134","article-title":"Learning induces long-term potentiation in the hippocampus","volume":"313","author":"Whitlock","year":"2006","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.aca.2026.345110_bib2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrn2614","article-title":"The anatomy of memory: an interactive overview of the parahippocampal\u2013hippocampal network","volume":"10","author":"van Strien","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.aca.2026.345110_bib3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0306-4522(89)90424-7","article-title":"The three-dimensional organization of the hippocampal formation: a review of anatomical data","volume":"31","author":"Amaral","year":"1989","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.aca.2026.345110_bib4","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41593-020-0604-z","article-title":"Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk","volume":"23","author":"Jaffe","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.aca.2026.345110_bib5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-2275(20)39619-X","article-title":"Lipid composition of the normal human brain: gray matter, white matter, and myelin","volume":"6","author":"O'Brien","year":"1965","journal-title":"J. Lipid Res."},{"issue":"6","key":"10.1016\/j.aca.2026.345110_bib6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1039\/c0ib00157k","article-title":"From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy","volume":"3","author":"Zhong","year":"2011","journal-title":"Integr. Biol."},{"issue":"1","key":"10.1016\/j.aca.2026.345110_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1385\/MN:32:1:089","article-title":"Lipid signaling in neural plasticity, brain repair, and neuroprotection","volume":"32","author":"Bazan","year":"2005","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.aca.2026.345110_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnmol.2018.00010","article-title":"Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease","volume":"11","author":"Tracey","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.aca.2026.345110_bib9","series-title":"Advances in Understanding of the Role of Lipid Metabolism in Aging Cells","author":"Chung","year":"2021"},{"key":"10.1016\/j.aca.2026.345110_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105143","article-title":"Fatty acids and beyond: age and Alzheimer's disease related changes in lipids reveal the neuro-nutraceutical potential of lipids in cognition","volume":"149","author":"Ooi","year":"2021","journal-title":"Neurochem. Int."},{"issue":"18","key":"10.1016\/j.aca.2026.345110_bib11","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1039\/D1AN01109J","article-title":"Chemical analysis of the human brain by imaging mass spectrometry","volume":"146","author":"Ajith","year":"2021","journal-title":"Analyst"},{"issue":"10","key":"10.1016\/j.aca.2026.345110_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.517","article-title":"Hippocampal lipid differences in Alzheimer's disease: a human brain study using matrix-assisted laser desorption\/ionization-imaging mass spectrometry","volume":"6","author":"Mendis","year":"2016","journal-title":"Brain and Behavior"},{"issue":"3","key":"10.1016\/j.aca.2026.345110_bib13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1158\/0008-5472.CAN-11-2465","article-title":"Classifying human brain tumors by lipid imaging with mass spectrometry","volume":"72","author":"Eberlin","year":"2012","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.aca.2026.345110_bib14","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/hipo.22246","article-title":"Human temporal lobe epilepsy analyses by tissue proteomics","volume":"24","author":"M\u00e9riaux","year":"2014","journal-title":"Hippocampus"},{"issue":"4","key":"10.1016\/j.aca.2026.345110_bib15","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1021\/acs.analchem.0c04572","article-title":"Mass spectrometry spatial-omics on a single conductive slide","volume":"93","author":"Mezger","year":"2021","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.aca.2026.345110_bib16","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00216-024-05178-z","article-title":"Spatial MS multiomics on clinical prostate cancer tissues","volume":"416","author":"Truong","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"issue":"10","key":"10.1016\/j.aca.2026.345110_bib17","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/s41592-023-02007-6","article-title":"Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome","volume":"20","author":"Rosenberger","year":"2023","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.aca.2026.345110_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4770","article-title":"A multimodal pipeline using NMR spectroscopy and MALDI-TOF mass spectrometry imaging from the same tissue sample","volume":"36","author":"Tressler","year":"2023","journal-title":"NMR Biomed."},{"issue":"4","key":"10.1016\/j.aca.2026.345110_bib19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00401-019-01966-5","article-title":"Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease","volume":"137","author":"Semick","year":"2019","journal-title":"Acta Neuropathol."},{"issue":"16","key":"10.1016\/j.aca.2026.345110_bib20","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1002\/cne.24080","article-title":"Comprehensive cellular-resolution atlas of the adult human brain","volume":"524","author":"Ding","year":"2016","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.aca.2026.345110_bib21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41596-018-0082-x","article-title":"Single-pot, solid-phase-enhanced sample preparation for proteomics experiments","volume":"14","author":"Hughes","year":"2019","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.aca.2026.345110_bib22","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/pr300624g","article-title":"Statistical inference from multiple iTRAQ experiments without using common reference standards","volume":"12","author":"Herbrich","year":"2013","journal-title":"J. Proteome Res."},{"issue":"41","key":"10.1016\/j.aca.2026.345110_bib24","doi-asserted-by":"crossref","first-page":"29172","DOI":"10.1074\/jbc.274.41.29172","article-title":"Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis","volume":"274","author":"Hiroyama","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"27","key":"10.1016\/j.aca.2026.345110_bib25","doi-asserted-by":"crossref","first-page":"19049","DOI":"10.1074\/jbc.M800364200","article-title":"Molecular identification of a novel Mammalian brain isoform of Acyl-CoA:Lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2","volume":"283","author":"Cao","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.aca.2026.345110_bib26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/labinvest.2014.156","article-title":"MALDI imaging mass spectrometry: current frontiers and perspectives in pathology research and practice","volume":"95","author":"Aichler","year":"2015","journal-title":"Lab. Invest."},{"issue":"22","key":"10.1016\/j.aca.2026.345110_bib27","doi-asserted-by":"crossref","first-page":"9012","DOI":"10.1158\/0008-5472.CAN-10-0360","article-title":"Multimodal mass spectrometric imaging of small molecules reveals distinct spatio-molecular signatures in differentially metastatic breast tumor models","volume":"70","author":"Amstalden van Hove","year":"2010","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.aca.2026.345110_bib28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12974-022-02493-z","article-title":"CEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE mice","volume":"19","author":"Thomas","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.aca.2026.345110_bib29","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1021\/jasms.0c00156","article-title":"Pneumatically sprayed gold nanoparticles for mass spectrometry imaging of neurotransmitters","volume":"31","author":"McLaughlin","year":"2020","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"11","key":"10.1016\/j.aca.2026.345110_bib30","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.3390\/ijms25115624","article-title":"Characterization of humanized mouse model of organophosphate poisoning and detection of countermeasures via MALDI-MSI","volume":"25","author":"Tressler","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.aca.2026.345110_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/7651_2017_81","article-title":"MALDI imaging mass spectrometry of N-glycans and tryptic peptides from the same formalin-fixed, paraffin-embedded tissue section","volume":"1788","author":"Angel","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.aca.2026.345110_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/cpps.68","article-title":"In situ imaging of N-Glycans by MALDI imaging mass spectrometry of fresh or formalin-fixed paraffin-embedded tissue","volume":"94","author":"Drake","year":"2018","journal-title":"Curr Protoc Protein Sci"},{"issue":"24","key":"10.1016\/j.aca.2026.345110_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.146945","article-title":"Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis","volume":"6","author":"\u0160\u010dup\u00e1kov\u00e1","year":"2021","journal-title":"JCI Insight."},{"issue":"4","key":"10.1016\/j.aca.2026.345110_bib34","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1021\/jasms.0c00473","article-title":"Highly multiplexed immunohistochemical MALDI-MS imaging of biomarkers in tissues","volume":"32","author":"Yagnik","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"7","key":"10.1016\/j.aca.2026.345110_bib35","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.bbapap.2016.10.014","article-title":"MALDI imaging mass spectrometry - from bench to bedside","volume":"1865","author":"Schwamborn","year":"2017","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"10.1016\/j.aca.2026.345110_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106491","article-title":"Spatial omics reveals molecular changes in focal cortical dysplasia type II","volume":"195","author":"Vermeulen","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.aca.2026.345110_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101346","article-title":"Omics sciences for systems biology in alzheimer's disease: state-of-the-art of the evidence","volume":"69","author":"Hampel","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"6","key":"10.1016\/j.aca.2026.345110_bib38","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1074\/mcp.RA120.001986","article-title":"Investigation of Inter- and intratumoral heterogeneity of glioblastoma using TOF-SIMS","volume":"19","author":"Gularyan","year":"2020","journal-title":"Mol. Cell. Proteomics"},{"issue":"1","key":"10.1016\/j.aca.2026.345110_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/mas.21719","article-title":"Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: target identification and clinical applications","volume":"42","author":"Mallah","year":"2023","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.aca.2026.345110_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154712","article-title":"Brain regional pharmacokinetics of hydroxytyrosol and its molecular mechanism against depression assessed by multi-omics approaches","volume":"112","author":"Fan","year":"2023","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.aca.2026.345110_bib41","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1021\/acs.analchem.3c05850","article-title":"MALDI-MSI-LC-MS\/MS workflow for single-section single step combined proteomics and quantitative lipidomics","volume":"96","author":"Hendriks","year":"2024","journal-title":"Anal. Chem."},{"issue":"11","key":"10.1016\/j.aca.2026.345110_bib42","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.neuron.2023.03.010","article-title":"Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: reconciling controversy or fueling the debate?","volume":"111","author":"Tosoni","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.aca.2026.345110_bib43","article-title":"An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus","volume":"2024","author":"Nelson","year":"2024","journal-title":"bioRxiv"},{"issue":"4308","key":"10.1016\/j.aca.2026.345110_bib44","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.887941","article-title":"Neurogenesis in the adult rat: Electron microscopic analysis of light radioautographs","volume":"197","author":"Kaplan","year":"1977","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.aca.2026.345110_bib45","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.aca.2026.345110_bib46","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0306-4522(84)90166-0","article-title":"Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey","volume":"12","author":"Goldman-Rakic","year":"1984","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.aca.2026.345110_bib47","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/hipo.450050604","article-title":"Topographically specific hippocampal projections target functionally distinct prefrontal areas in the rhesus monkey","volume":"5","author":"Barbas","year":"1995","journal-title":"Hippocampus"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026000607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026000607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:19:52Z","timestamp":1781857192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026000607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":46,"alternative-id":["S0003267026000607"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.345110","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histology-guided spatial lipidomics and proteomics of the trisynaptic circuit in the human hippocampus","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.345110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"345110"}}