{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:45:03Z","timestamp":1789872303690,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.aca.2026.345120","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:40:53Z","timestamp":1769240453000},"page":"345120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A peptide-functionalized quantum Dots\/MOF nanosheets fluorescence biosensor for glutathione sensing and cellular imaging"],"prefix":"10.1016","volume":"1391","author":[{"given":"Tongfang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanci","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2490-1930","authenticated-orcid":false,"given":"Xie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.345120_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121110","article-title":"Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy","volume":"277","author":"Niu","year":"2021","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.aca.2026.345120_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13195-022-00961-5","article-title":"Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: a meta-analysis","volume":"14","author":"Chen","year":"2022","journal-title":"Alzheimers Res. Ther."},{"issue":"5","key":"10.1016\/j.aca.2026.345120_bib3","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.scib.2020.10.021","article-title":"Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis","volume":"66","author":"Yang","year":"2021","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.aca.2026.345120_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102349","article-title":"Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation","volume":"53","author":"Xu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.aca.2026.345120_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/972913","article-title":"Role of glutathione in cancer progression and chemoresistance","volume":"2013","author":"Traverso","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.aca.2026.345120_bib6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrc3278","article-title":"NRF2 and cancer: the good, the bad and the importance of context","volume":"12","author":"Sporn","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.aca.2026.345120_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccell.2014.11.019","article-title":"Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression","volume":"27","author":"Harris","year":"2015","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.aca.2026.345120_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ccr.2014.05.004","article-title":"Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis","volume":"26","author":"Valencia","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.aca.2026.345120_bib9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.colsurfa.2019.06.002","article-title":"pH\/redox dual response nanoparticles with poly-\u03b3-glutamic acid for enhanced intracellular drug delivery","volume":"577","author":"Ren","year":"2019","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.aca.2026.345120_bib10","article-title":"Glutathione-activated near-infrared II fluorescent probe for lung metastatic diagnosis and intraoperative imaging of tumor","volume":"426","author":"Wang","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.345120_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.109157","article-title":"Determination of glutathione and glutathione disulfide using liquid chromatography: a review on recent applications","volume":"193","author":"Tsiasioti","year":"2023","journal-title":"Microchem. J."},{"issue":"7","key":"10.1016\/j.aca.2026.345120_bib12","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1021\/ac504737x","article-title":"Detection of reactive metabolites using isotope-labeled glutathione trapping and simultaneous neutral loss and precursor ion scanning with ultra-high-pressure liquid chromatography triple quadruple mass spectrometry","volume":"87","author":"Huang","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345120_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aca.2015.05.036","article-title":"Facile and controllable one-step fabrication of molecularly imprinted polymer membrane by magnetic field directed self-assembly for electrochemical sensing of glutathione","volume":"886","author":"Zhu","year":"2015","journal-title":"Anal. Chim. Acta"},{"issue":"12","key":"10.1016\/j.aca.2026.345120_bib14","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1039\/D0AN00582G","article-title":"A novel strategy for rhodamine B-based fluorescent probes with a selective glutathione response for bioimaging in living cells","volume":"145","author":"Li","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2026.345120_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.125395","article-title":"Dual-locked NIR fluorescent probe for detection of GSH and lipid droplets and its bioimaging application in cancer model","volume":"327","author":"Qin","year":"2025","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.aca.2026.345120_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128447","article-title":"A novel \"off-on\" ratiometric fluorescent probe based on nitrogen-doped carbon dots for silver ion and glutathione assays","volume":"296","author":"Ma","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.345120_bib17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bios.2017.07.065","article-title":"Carbon dots based photoelectrochemical sensors for ultrasensitive detection of glutathione and its applications in probing of myocardial infarction","volume":"99","author":"Li","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"50","key":"10.1016\/j.aca.2026.345120_bib18","doi-asserted-by":"crossref","first-page":"20168","DOI":"10.1021\/ja2100774","article-title":"Intracellular glutathione detection using MnO2-nanosheet-modified upconversion nanoparticles","volume":"133","author":"Deng","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2026.345120_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2021.120362","article-title":"A sensitive fluorescence \"turn on\" nanosensor for glutathione detection based on Ce-MOF and gold nanoparticles","volume":"265","author":"Gong","year":"2022","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"Pt 2","key":"10.1016\/j.aca.2026.345120_bib20","article-title":"Metal-organic framework as a mimetic enzyme with excellent adaptability for sensitive chemiluminescence detection of glutathione in cell lysate","volume":"238","author":"Yang","year":"2022","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.aca.2026.345120_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1021\/ar9001069","article-title":"Semiconductor nanocrystals: structure, properties, and band gap engineering","volume":"43","author":"Smith","year":"2010","journal-title":"Acc. Chem. Res."},{"issue":"15","key":"10.1016\/j.aca.2026.345120_bib22","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1039\/C8TB03043J","article-title":"In situ aqueous synthesis of genetically engineered polypeptide-capped Ag2S quantum dots for second near-infrared fluorescence\/photoacoustic imaging and photothermal therapy","volume":"7","author":"Zhao","year":"2019","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.aca.2026.345120_bib23","article-title":"Boron-doped carbon quantum dots: a 'turn-off' fluorescent probe for dopamine detection","volume":"32","author":"Rais","year":"2020","journal-title":"Nanotechnology"},{"issue":"Part 2","key":"10.1016\/j.aca.2026.345120_bib24","article-title":"Activatable near-infrared fluorogenic probe for monitoring GSH variations in synergistic PTX and RSL3 treatment of hypopharyngeal carcinoma","volume":"444","author":"Qi","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"issue":"16","key":"10.1016\/j.aca.2026.345120_bib25","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1039\/C8CS00268A","article-title":"Two-dimensional metal-organic framework nanosheets: synthesis and applications","volume":"47","author":"Zhao","year":"2018","journal-title":"Chem. Soc. Rev."},{"issue":"8","key":"10.1016\/j.aca.2026.345120_bib26","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1021\/ja0762588","article-title":"Metal-peptide frameworks (MPFs): \"bioinspired\" metal organic frameworks","volume":"130","author":"Mantion","year":"2008","journal-title":"J. Am. Chem. Soc."},{"issue":"46","key":"10.1016\/j.aca.2026.345120_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202211409","article-title":"Engineering of reversible NIR-II redox-responsive fluorescent probes for imaging of inflammation in vivo","volume":"61","author":"He","year":"2022","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.aca.2026.345120_bib28","article-title":"Microwave synthesis of silver sulfide near-infrared fluorescent quantum dots and their detection of dopamine","volume":"10","author":"Bao","year":"2022","journal-title":"Biosens. Bioelectron. X."},{"key":"10.1016\/j.aca.2026.345120_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.127274","article-title":"A highly sensitive fluorescence biosensor based on polylysine functionalized quantum dots for serum GDF-15 detection","volume":"285","author":"Chen","year":"2025","journal-title":"Talanta"},{"issue":"45","key":"10.1016\/j.aca.2026.345120_bib30","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1002\/adma.201503648","article-title":"Ultrathin 2D metal-organic framework nanosheets","volume":"27","author":"Zhao","year":"2015","journal-title":"Adv. Mater."},{"issue":"19","key":"10.1016\/j.aca.2026.345120_bib31","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1039\/D2TB00375A","article-title":"Supramolecular assemblies of histidine-containing peptides with switchable hydrolase and peroxidase activities through Cu(II) binding and co-assembling","volume":"10","author":"Zhang","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"29","key":"10.1016\/j.aca.2026.345120_bib32","doi-asserted-by":"crossref","first-page":"9846","DOI":"10.1002\/anie.201903981","article-title":"Specific generation of singlet oxygen through the Russell mechanism in hypoxic tumors and GSH depletion by Cu-TCPP nanosheets for cancer therapy","volume":"58","author":"Wang","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2026.345120_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.memsci.2020.118888","article-title":"Photothermal responsive ultrathin Cu-TCPP nanosheets\/sulfonated polystyrene nanocomposite photo-switch proton conducting membranes","volume":"620","author":"Hussain","year":"2021","journal-title":"J. Membr. Sci."},{"issue":"3","key":"10.1016\/j.aca.2026.345120_bib34","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1021\/acsanm.2c04853","article-title":"Detection and bioimaging of glutathione in cells via a turn-on near-infrared fluorescent nanoprobe composed of Ag2S quantum dots and CoOOH nanosheets","volume":"6","author":"Chen","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"issue":"51","key":"10.1016\/j.aca.2026.345120_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202313612","article-title":"Fast antioxidation kinetics of glutathione intracellularly monitored by a dual-wire nanosensor","volume":"62","author":"Jiao","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.aca.2026.345120_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.119316","article-title":"Cytidine-gold nanoclusters as peroxidase mimetic for colorimetric detection of glutathione (GSH), glutathione disulfide (GSSG) and glutathione reductase (GR)","volume":"250","author":"Jiang","year":"2021","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.aca.2026.345120_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112325","article-title":"A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to evaluate drug-resistance level","volume":"165","author":"Pang","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"9","key":"10.1016\/j.aca.2026.345120_bib38","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1021\/acs.analchem.8b05961","article-title":"Glutathione regulated inner filter effect of MnO2 nanosheets on boron nitride quantum dots for sensitive assay","volume":"91","author":"Peng","year":"2019","journal-title":"Anal. Chem."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702600070X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702600070X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:29:38Z","timestamp":1770485378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000326702600070X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":38,"alternative-id":["S000326702600070X"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.345120","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A peptide-functionalized quantum Dots\/MOF nanosheets fluorescence biosensor for glutathione sensing and cellular imaging","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.345120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"345120"}}