{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:24:44Z","timestamp":1786983884018,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100024348","name":"Policy Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.aca.2026.345410","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:31:40Z","timestamp":1774078300000},"page":"345410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Topology-engineered dopamine-mediated flower-like gold nanoparticle adjuvants: Boosting immune responses and enabling sensitive immunoassays for albendazole residue detection"],"prefix":"10.1016","volume":"1403","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-8993","authenticated-orcid":false,"given":"Jiaqi","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-1522","authenticated-orcid":false,"given":"Weihua","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.345410_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116106","article-title":"Environmental risk assessment of the anthelmintic albendazole in Eastern Africa, based on a systematic review","volume":"269","author":"Belew","year":"2021","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.aca.2026.345410_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02489-18","article-title":"Pharmacokinetics of albendazole, albendazole sulfoxide, and albendazole sulfone determined from plasma, blood, dried-blood spots, and mitra samples of hookworm-infected adolescents","volume":"63","author":"Schulz","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.aca.2026.345410_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137168","article-title":"Hapten prediction, monoclonal antibody preparation, and development of an immunochromatographic assay for the detection of fenamiphos","volume":"487","author":"Lu","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"2","key":"10.1016\/j.aca.2026.345410_bib4","article-title":"Dual-assist heterologous antigens screening: an effective strategy to improve the sensitivity of lateral flow immunoassay","volume":"463","author":"Chen","year":"2025","journal-title":"Food Chem."},{"issue":"15","key":"10.1016\/j.aca.2026.345410_bib5","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.2174\/1389557517666170228115801","article-title":"Endogenous and exogenous natural adjuvants for vaccine development","volume":"17","author":"Bolhassani","year":"2017","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.aca.2026.345410_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105349","article-title":"A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies","volume":"203","author":"Prashar","year":"2022","journal-title":"Antivir. Res."},{"issue":"4","key":"10.1016\/j.aca.2026.345410_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s40259-024-00667-0","article-title":"Monoclonal antibody generation using single B cell screening for treating infectious diseases","volume":"38","author":"Schardt","year":"2024","journal-title":"BioDrugs"},{"key":"10.1016\/j.aca.2026.345410_bib8","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1182\/blood-2019-129680","article-title":"Elotuzumab enhances the Th2-Mediated immune response of dendritic cell induced by immunomodulatory drugs (IMiDs)","volume":"134","author":"Azuma","year":"2019","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.aca.2026.345410_bib9","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1111\/all.16182","article-title":"The stimulation of TH2 cells results in increased IL-5 and IL-13 production via the H4 receptor","volume":"79","author":"Nikolouli","year":"2024","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.aca.2026.345410_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/vaccines8010128","article-title":"Better adjuvants for better vaccines: progress in adjuvant delivery systems, modifications, and adjuvant-antigen codelivery","volume":"8","author":"Wang","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.aca.2026.345410_bib11","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.2147\/JIR.S499403","article-title":"The benefits and safety of monoclonal antibodies: implications for cancer immunotherapy","volume":"18","author":"Zhang","year":"2025","journal-title":"J. Inflamm. Res."},{"issue":"3","key":"10.1016\/j.aca.2026.345410_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100935","article-title":"Multifunctional protein conjugates with Built-in adjuvant (Adjuvant-Protein-Antigen) as cancer vaccines boost potent immune responses","volume":"23","author":"Du","year":"2020","journal-title":"iScience"},{"issue":"13","key":"10.1016\/j.aca.2026.345410_bib13","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1039\/C8CS00028J","article-title":"Tailoring inorganic nanoadjuvants towards next-generation vaccines","volume":"47","author":"Li","year":"2018","journal-title":"Chem. Soc. Rev."},{"issue":"44","key":"10.1016\/j.aca.2026.345410_bib14","doi-asserted-by":"crossref","first-page":"8072","DOI":"10.1002\/adfm.201603651","article-title":"Immune complexes mimicking synthetic vaccine nanoparticles for enhanced migration and cross-presentation of dendritic cells","volume":"26","author":"Kim","year":"2016","journal-title":"Adv. Funct. Mater."},{"issue":"16","key":"10.1016\/j.aca.2026.345410_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202111670","article-title":"Understanding structure-function relationships of nanoadjuvants for enhanced cancer vaccine efficacy","volume":"32","author":"Tan","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"11","key":"10.1016\/j.aca.2026.345410_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk2444","article-title":"Lymph-targeted high-density lipoprotein-mimetic nanovaccine for multi-antigenic personalized cancer immunotherapy","volume":"10","author":"Liu","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.aca.2026.345410_bib17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s11671-017-1828-z","article-title":"The effect of superparamagnetic iron oxide nanoparticle surface charge on Antigen cross-presentation","volume":"12","author":"Mou","year":"2017","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.aca.2026.345410_bib18","article-title":"IgM-functionalized biomimetic nanovaccine for immunological activation and bacterial toxin neutralization","volume":"383","author":"Yu","year":"2025","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.aca.2026.345410_bib19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/vaccines12010028","article-title":"Uptake quantification of antigen carried by nanoparticles and its impact on carrier adjuvanticity evaluation","volume":"12","author":"Zhu","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.aca.2026.345410_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/BTER:100:1:001","article-title":"Mammalian sensitivity to elemental gold (Auo)","volume":"100","author":"Eisler","year":"2004","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.aca.2026.345410_bib21","first-page":"7625","article-title":"Immunomodulation of nanoparticles in nanomedicine applications","volume":"110","author":"Jiao","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"19","key":"10.1016\/j.aca.2026.345410_bib22","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1073\/pnas.1305804110","article-title":"Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates","volume":"110","author":"Choi","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.aca.2026.345410_bib23","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/adhm.201300597","article-title":"Gold nanoparticles displaying tumor\u2010associated self\u2010antigens as a potential vaccine for cancer immunotherapy","volume":"3","author":"Ahn","year":"2014","journal-title":"Adv. Healthcare Mater."},{"issue":"17","key":"10.1016\/j.aca.2026.345410_bib24","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1039\/D5NR01030F","article-title":"Immunomodulatory effects of metal nanoparticles: current trends and future prospects","volume":"17","author":"Barik","year":"2025","journal-title":"Nanoscale"},{"issue":"3","key":"10.1016\/j.aca.2026.345410_bib25","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1039\/C6SC03631G","article-title":"Immunological properties of gold nanoparticles","volume":"8","author":"Dykman","year":"2017","journal-title":"Chem. Sci."},{"issue":"15","key":"10.1016\/j.aca.2026.345410_bib26","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1039\/D2CS00848C","article-title":"Adjuvant physiochemistry and advanced nanotechnology for vaccine development","volume":"52","author":"Ren","year":"2023","journal-title":"Chem. Soc. Rev."},{"issue":"17","key":"10.1016\/j.aca.2026.345410_bib27","doi-asserted-by":"crossref","first-page":"7236","DOI":"10.1021\/acs.nanolett.1c02274","article-title":"Precision wormlike nanoadjuvant governs potency of vaccination","volume":"21","author":"Sun","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.aca.2026.345410_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138396","article-title":"Poria cocos polysaccharide-honeycomb manganese oxide nanoparticles as a vaccine adjuvant to induce potent immune responses","volume":"286","author":"Xu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.aca.2026.345410_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.140586","article-title":"Interface coordination achieving excellent optical properties of three-dimensional dendritic gold nanoparticles for immunochromatographic performance","volume":"455","author":"Shao","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"8","key":"10.1016\/j.aca.2026.345410_bib30","doi-asserted-by":"crossref","first-page":"13871","DOI":"10.1021\/acsnano.1c06081","article-title":"Dopamine receptor-mediated binding and cellular uptake of polydopamine-coated nanoparticles","volume":"15","author":"Liu","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.aca.2026.345410_bib31","article-title":"Chiral seeded growth of gold nanorods into fourfold twisted nanoparticles with plasmonic optical activity","volume":"35","author":"Ni","year":"2022","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.aca.2026.345410_bib32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12951-023-01782-w","article-title":"Aluminum-based metal-organic framework nanoparticles as pulmonary vaccine adjuvants","volume":"21","author":"Stillman","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"10","key":"10.1016\/j.aca.2026.345410_bib33","doi-asserted-by":"crossref","first-page":"9155","DOI":"10.1021\/acsnano.2c12660","article-title":"Nanoparticle spikes enhance cellular uptake via regulating myosin IIA recruitment","volume":"17","author":"Huang","year":"2023","journal-title":"ACS Nano"},{"issue":"42","key":"10.1016\/j.aca.2026.345410_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202401776","article-title":"A Metal-phenolic network-enabled nanoadjuvant to modulate immune responses","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.aca.2026.345410_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139380","article-title":"Novel litchi-like Au-Ag nanospheres driven dual-readout lateral flow immunoassay for sensitive detection of pyrimethanil","volume":"450","author":"Shu","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.aca.2026.345410_bib36","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ijbiomac.2018.08.108","article-title":"Immunopotentiation of Polysaccharides of Atractylodes macrocephala Koidz-loaded nanostructured lipid carriers as an adjuvant","volume":"120","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.aca.2026.345410_bib37","article-title":"Preparation of hapten and monoclonal antibody of hesperetin and establishment of enzyme-linked immunosorbent assay","volume":"281","author":"Liu","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.345410_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s12951-023-02116-6","article-title":"Potentiating humoral and cellular immunity using a novel hybrid polymer-lipid nanoparticle adjuvant for HBsAg-VLP vaccine","volume":"21","author":"Liu","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"8","key":"10.1016\/j.aca.2026.345410_bib39","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.7150\/thno.42364","article-title":"Self-assembled colloidal gold superparticles to enhance the sensitivity of lateral flow immunoassays with sandwich format","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.aca.2026.345410_bib40","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1038\/s41467-025-58663-z","article-title":"Lateral flow immunoassay using plasmonic scattering","volume":"16","author":"Lee","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.aca.2026.345410_bib41","author":"Wang"},{"issue":"15","key":"10.1016\/j.aca.2026.345410_bib42","article-title":"Engineered collaborative grown model regulation and LSPR-tunable of Pd@Au core-shell nanoparticles for highly sensitive fluorescence quenching lateral flow immunoassay","volume":"280","author":"Yin","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.aca.2026.345410_bib43","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jconrel.2012.02.007","article-title":"Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells","volume":"160","author":"Unger","year":"2012","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.aca.2026.345410_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biomaterials.2019.03.012","article-title":"Co-delivery of antigen and dual agonists by programmed mannose-targeted cationic lipid-hybrid polymersomes for enhanced vaccination","volume":"206","author":"Zhu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.aca.2026.345410_bib45","first-page":"15","article-title":"Mature dendritic cell-derived dendrosomes swallow oxaliplatin-loaded nanoparticles to boost immunogenic chemotherapy and tumor antigen-specific immunotherapy","volume":"15","author":"Chen","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.aca.2026.345410_bib46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2147\/IJN.S15457","article-title":"Improved antigen cross-presentation by polyethyleneimine-based nanoparticles","volume":"6","author":"Chen","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.aca.2026.345410_bib47","article-title":"\u201cFour-in-One\u201d multifunctional nanohybrids integrated magnetic colorimetric catalytic SERS-driven lateral flow immunoassay for ultrasensitive detection of MPXV","volume":"449","author":"Liu","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"12","key":"10.1016\/j.aca.2026.345410_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202570078","article-title":"Electropositive magnetic fluorescent Nanoprobe-Mediated immunochromatographic assay for the ultrasensitive and simultaneous detection of bacteria","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026003600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026003600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:38:31Z","timestamp":1776173911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026003600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":48,"alternative-id":["S0003267026003600"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.345410","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topology-engineered dopamine-mediated flower-like gold nanoparticle adjuvants: Boosting immune responses and enabling sensitive immunoassays for albendazole residue detection","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.345410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"345410"}}