{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:37:00Z","timestamp":1792417020736,"version":"4.4.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2025A0505010003"],"award-info":[{"award-number":["2025A0505010003"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Provincial Medical Research Foundation","doi-asserted-by":"publisher","award":["A2023131"],"award-info":[{"award-number":["A2023131"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011478","name":"Foshan Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372775"],"award-info":[{"award-number":["82372775"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573475"],"award-info":[{"award-number":["82573475"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF0721500"],"award-info":[{"award-number":["2023YFF0721500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3406900"],"award-info":[{"award-number":["2024YFC3406900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Department of Science and Technology of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.aca.2026.345421","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:32:05Z","timestamp":1773991925000},"page":"345421","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A digital microfluidics-based single-cell ddPCR platform for high-throughput gene copy number analysis applied to single cultured cells"],"prefix":"10.1016","volume":"1403","author":[{"given":"Yicheng","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yechen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-5182","authenticated-orcid":false,"given":"Siyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5297-2592","authenticated-orcid":false,"given":"Khadija","family":"Urooj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-2287","authenticated-orcid":false,"given":"Hanbin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mude","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enguang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.aca.2026.345421_bib1","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1039\/C8LC00990B","article-title":"Digital polymerase chain reaction technology\u2013recent advances and future perspectives","volume":"18","author":"Sreejith","year":"2018","journal-title":"Lab Chip"},{"issue":"4","key":"10.1016\/j.aca.2026.345421_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/s18041271","article-title":"dPCR: a technology review","volume":"18","author":"Quan","year":"2018","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.aca.2026.345421_bib3","article-title":"Medical diagnostic value of digital PCR (dPCR): a systematic review","volume":"6","author":"Sophia","year":"2023","journal-title":"Biomed. Eng. Advan."},{"key":"10.1016\/j.aca.2026.345421_bib4","article-title":"Digital PCR for the characterization of reference materials","volume":"96","author":"Megan","year":"2024","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.aca.2026.345421_bib5","article-title":"Multiplexed digital polymerase chain reaction as a powerful diagnostic tool","volume":"181","author":"Martina","year":"2021","journal-title":"Biosens. Bioelectron."},{"issue":"6","key":"10.1016\/j.aca.2026.345421_bib6","first-page":"1766","article-title":"Multi-gene measurable residual disease assessed by digital polymerase chain reaction has clinical and biological utility in acute myeloid leukemia patients receiving venetoclax\/azacitidine","volume":"109","author":"Winters","year":"2024","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.aca.2026.345421_bib7","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2022.33.e15","article-title":"Clinical evaluation of a droplet digital PCR assay for detecting POLE mutations and molecular classification of endometrial cancer","volume":"33","author":"Kim","year":"2022","journal-title":"J. Gynecol. Oncol."},{"issue":"9","key":"10.1016\/j.aca.2026.345421_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093141","article-title":"Digital PCR: a reliable tool for analyzing and monitoring hematologic malignancies","volume":"21","author":"Coccaro","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.aca.2026.345421_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/jalm\/jfad103","article-title":"Applications of digital polymerase chain reaction (dPCR) in molecular and clinical testing","volume":"9","author":"Wainman","year":"2024","journal-title":"J. Appl. Lab. Med."},{"issue":"5","key":"10.1016\/j.aca.2026.345421_bib10","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1039\/D2LC00756H","article-title":"Digital microfluidics for biological analysis and applications","volume":"23","author":"Xu","year":"2023","journal-title":"Lab Chip"},{"issue":"19","key":"10.1016\/j.aca.2026.345421_bib11","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1039\/D4LC00495G","article-title":"Democratizing digital microfluidics by a cloud-based design and manufacturing platform","volume":"24","author":"Wang","year":"2024","journal-title":"Lab Chip"},{"issue":"17","key":"10.1016\/j.aca.2026.345421_bib12","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1021\/acs.analchem.3c00150","article-title":"Large-area electronics-enabled high-resolution digital microfluidics for parallel single-cell manipulation","volume":"95","author":"Hu","year":"2023","journal-title":"Anal. Chem."},{"issue":"15","key":"10.1016\/j.aca.2026.345421_bib13","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1039\/D1LC00421B","article-title":"\"One-to-three\" droplet generation in digital microfluidics for parallel chemiluminescence immunoassays","volume":"21","author":"Jin","year":"2021","journal-title":"Lab Chip"},{"key":"10.1016\/j.aca.2026.345421_bib14","series-title":"2020 IEEE International Electron Devices Meeting (IEDM)","first-page":"35.5. 1","article-title":"Large-area manufacturable active matrix digital microfluidics platform for high-throughput biosample handling","author":"Ma","year":"2020"},{"issue":"5","key":"10.1016\/j.aca.2026.345421_bib15","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1021\/jacsau.4c00027","article-title":"AM-DMF-SCP: integrated single-cell proteomics analysis on an active matrix digital microfluidic chip","volume":"4","author":"Yang","year":"2024","journal-title":"JACS Au"},{"issue":"1","key":"10.1016\/j.aca.2026.345421_bib16","article-title":"Deep learning-assisted label-free parallel cell sorting with digital microfluidics","volume":"12","author":"Guo","year":"2025","journal-title":"Adv. Sci."},{"issue":"8","key":"10.1016\/j.aca.2026.345421_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41581-018-0021-7","article-title":"Single-cell RNA sequencing for the study of development, physiology and disease","volume":"14","author":"Potter","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"issue":"14","key":"10.1016\/j.aca.2026.345421_bib18","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1007\/s00253-018-9021-6","article-title":"Rapid development of stable transgene CHO cell lines by CRISPR\/Cas9-mediated site-specific integration into C12orf35","volume":"102","author":"Zhao","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"26","key":"10.1016\/j.aca.2026.345421_bib19","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1182\/blood-2016-02-629063","article-title":"CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date","volume":"127","author":"Park","year":"2016","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.aca.2026.345421_bib20","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/s41417-021-00418-1","article-title":"Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study","volume":"29","author":"Sheykhhasan","year":"2022","journal-title":"Cancer Gene Ther."},{"issue":"5","key":"10.1016\/j.aca.2026.345421_bib21","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.3390\/curroncol29050293","article-title":"CAR T cell therapy for chronic lymphocytic leukemia: successes and shortcomings","volume":"29","author":"Todorovic","year":"2022","journal-title":"Curr. Oncol."},{"issue":"1","key":"10.1016\/j.aca.2026.345421_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tmrv.2019.08.003","article-title":"Anti-CD19 CAR T-Cell therapy for B-Cell non-hodgkin lymphoma","volume":"34","author":"Abramson","year":"2020","journal-title":"Transfus. Med. Rev."},{"key":"10.1016\/j.aca.2026.345421_bib23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.omtm.2023.07.003","article-title":"Detection and quantification of integrated vector copy number by multiplex droplet digital PCR in dual-transduced CAR T\u00a0cells","volume":"30","author":"Wang","year":"2023","journal-title":"Mol. Ther., Methods Clin. Dev."},{"key":"10.1016\/j.aca.2026.345421_bib24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.omtm.2020.02.003","article-title":"Optimized assessment of qPCR-Based vector copy numbers as a safety parameter for GMP-grade CAR T cells and monitoring of frequency in patients","volume":"17","author":"Kunz","year":"2020","journal-title":"Mol. Ther., Methods Clin. Dev."},{"issue":"4","key":"10.1016\/j.aca.2026.345421_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13040598","article-title":"T-Cell dysfunction as a limitation of adoptive immunotherapy: current concepts and mitigation strategies","volume":"13","author":"Janelle","year":"2021","journal-title":"Cancers (Basel)"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026003715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026003715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:15:20Z","timestamp":1776172520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026003715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":25,"alternative-id":["S0003267026003715"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.345421","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A digital microfluidics-based single-cell ddPCR platform for high-throughput gene copy number analysis applied to single cultured cells","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.345421","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"345421"}}