{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:08:00Z","timestamp":1778936880452,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004322","name":"Agilent Technologies Inc","doi-asserted-by":"publisher","award":["5010"],"award-info":[{"award-number":["5010"]}],"id":[{"id":"10.13039\/100004322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006380","name":"Universit\u00e4t f\u00fcr Bodenkultur Wien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.aca.2026.345429","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:50:20Z","timestamp":1774108220000},"page":"345429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rapid quantitative bioanalysis using LC-HRIM-QTOFMS with flexible sample delivery and variable traveling wave profiles"],"prefix":"10.1016","volume":"1404","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0585-8730","authenticated-orcid":false,"given":"Sabrina M.","family":"Cramer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Kowarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diethard","family":"Mattanovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5045-7293","authenticated-orcid":false,"given":"Stephan","family":"Hann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1373-7493","authenticated-orcid":false,"given":"Tim","family":"Causon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.345429_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1387-3806(01)00511-5","article-title":"Multidimensional separations of complex peptide mixtures: a combined high-performance liquid chromatography\/ion mobility\/time-of-flight mass spectrometry approach","volume":"212","author":"Valentine","year":"2001","journal-title":"Int. J. Mass Spectrom."},{"issue":"10","key":"10.1016\/j.aca.2026.345429_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-anchem-061516-045212","article-title":"Coupling front-end separations, ion mobility spectrometry, and mass spectrometry for enhanced multidimensional biological and environmental analyses","volume":"10","author":"Zheng","year":"2017","journal-title":"Annu. Rev. Anal. Chem."},{"key":"10.1016\/j.aca.2026.345429_bib3","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1007\/s13361-019-02288-2","article-title":"Ion mobility spectrometry: fundamental concepts, instrumentation, applications, and the road ahead","volume":"30","author":"Dodds","year":"2019","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.aca.2026.345429_bib4","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1021\/acs.analchem.6b01915","article-title":"Ultra-high resolution ion mobility separations utilizing traveling waves in a 13 m serpentine path length structures for lossless ion manipulations module","volume":"88","author":"Deng","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345429_bib5","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1039\/C7AN00031F","article-title":"New frontiers for mass spectrometry based upon structures for lossless ion manipulations","volume":"142","author":"Ibrahim","year":"2017","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2026.345429_bib6","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1002\/slct.201600460","article-title":"Ion mobility separations of isomers based upon long path length structures for lossless ion manipulations combined with mass spectrometry","volume":"1","author":"Deng","year":"2016","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.aca.2026.345429_bib7","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1021\/acs.analchem.7b00185","article-title":"Serpentine ultralong path with extended routing (SUPER) high resolution traveling wave ion Mobility-MS using structures for lossless ion manipulations","volume":"89","author":"Deng","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345429_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.aca.2020.12.022","article-title":"High-defined quantitative snapshots of the ganglioside lipidome using high resolution ion mobility SLIM assisted shotgun lipidomics","volume":"1146","author":"Wormwood Moser","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.345429_bib9","doi-asserted-by":"crossref","first-page":"13809","DOI":"10.1021\/acs.analchem.5c00417","article-title":"Rapid multi-omics for bacterial identification using flow injection-ion mobility-mass spectrometry","volume":"97","author":"Hynds","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345429_bib10","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1021\/jasms.0c00434","article-title":"High-resolution ion-mobility-enabled peptide mapping for high-throughput critical quality attribute monitoring","volume":"32","author":"Arndt","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.aca.2026.345429_bib11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/chem.202004004","article-title":"A unified approach to phytosiderophore natural products","volume":"27","author":"Kratena","year":"2021","journal-title":"Chemistry"},{"key":"10.1016\/j.aca.2026.345429_bib12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/jlcr.3242","article-title":"Synthesis of [13C4]-labeled 2'-deoxymugineic acid","volume":"57","author":"Walter","year":"2014","journal-title":"J. Label. Compd. Radiopharm."},{"key":"10.1016\/j.aca.2026.345429_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1475-2859-7-23","article-title":"Overexpression of the riboflavin biosynthetic pathway in Pichia pastoris","volume":"7","author":"Marx","year":"2008","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.aca.2026.345429_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341718","article-title":"Surveying the mugineic acid family: ion mobility - quadrupole time-of-flight mass spectrometry (IM-QTOFMS) characterization and tandem mass spectrometry (LC-ESI-MS\/MS) quantification of all eight naturally occurring phytosiderophores","volume":"1278","author":"Spiridon","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.345429_bib15","doi-asserted-by":"crossref","first-page":"16854","DOI":"10.1021\/acs.analchem.4c03624","article-title":"Overcoming the strong sample solvent effect for sustainability measurement challenges in liquid chromatography. Example for Bisphenol-A","volume":"96","author":"Graf","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345429_bib16","first-page":"6","article-title":"The gradient delay volume, part I: theory","volume":"1","author":"Stoll","year":"2024","journal-title":"LC GC Int."},{"key":"10.1016\/j.aca.2026.345429_bib17","doi-asserted-by":"crossref","first-page":"14930","DOI":"10.1021\/acs.analchem.0c02100","article-title":"Ion mobility spectrometry with high ion utilization efficiency using traveling wave-based structures for lossless ion manipulations","volume":"92","author":"Li","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345429_bib18","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1021\/acs.analchem.7b00112","article-title":"Variable-velocity traveling-wave ion mobility separation enhancing peak capacity for data-independent acquisition proteomics","volume":"89","author":"Haynes","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345429_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464207","article-title":"Evaluating dynamic traveling wave profiles for the enhancement of separation and sensitivity in traveling wave structures for lossless ion manipulations","volume":"1706","author":"Kinlein","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.aca.2026.345429_bib20","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1021\/jasms.5c00140","article-title":"Assessment of variable traveling wave profiles for small-molecule applications in ion mobility spectrometry-mass spectrometry (IMS-MS)","volume":"36","author":"Dodds","year":"2025","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.aca.2026.345429_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aca.2015.11.043","article-title":"Sampling frequency, response times and embedded signal filtration in fast, high efficiency liquid chromatography: a tutorial","volume":"907","author":"Wahab","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.345429_bib22","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1021\/jasms.1c00217","article-title":"Effect of sampling rate and data pretreatment for targeted and nontargeted analysis by means of liquid chromatography coupled to drift time ion mobility quadruple time-of-flight mass spectrometry","volume":"32","author":"T\u00f6tsch","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.aca.2026.345429_bib23","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1021\/acscentsci.7b00250","article-title":"Are we approaching a speed limit for the chromatographic separation of enantiomers?","volume":"3","author":"Welch","year":"2017","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.aca.2026.345429_bib24","series-title":"Eurachem Guide: the Fitness for Purpose of Analytical Methods \u2013 a Laboratory Guide to Method Validation and Related Topics","year":"2025"},{"key":"10.1016\/j.aca.2026.345429_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.338508","article-title":"Novel acquisition strategies for metabolomics using drift tube ion mobility-quadrupole resolved all ions time-of-flight mass spectrometry (IM-QRAI-TOFMS)","volume":"1163","author":"Feuerstein","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.345429_bib26","doi-asserted-by":"crossref","first-page":"20179","DOI":"10.1021\/acs.analchem.4c03808","article-title":"Rounded turn SLIM design for high-resolution ion mobility mass spectrometry analysis of small molecules","volume":"96","author":"Deng","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345429_bib27","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1021\/acs.analchem.0c04799","article-title":"Masked multiplexed separations to enhance duty cycle for structures for lossless ion manipulations","volume":"93","author":"Clowers","year":"2021","journal-title":"Anal. Chem."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702600379X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000326702600379X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:21:16Z","timestamp":1778934076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000326702600379X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":27,"alternative-id":["S000326702600379X"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.345429","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid quantitative bioanalysis using LC-HRIM-QTOFMS with flexible sample delivery and variable traveling wave profiles","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.345429","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"345429"}}