{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:20:05Z","timestamp":1783164005211,"version":"3.54.6"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001851","name":"Ministry of Earth Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020589","name":"National Centre for Polar and Ocean Research","doi-asserted-by":"publisher","award":["NCPOR \/2019\/PACER-POP\/BS-01"],"award-info":[{"award-number":["NCPOR \/2019\/PACER-POP\/BS-01"]}],"id":[{"id":"10.13039\/501100020589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.aca.2026.345648","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:00:30Z","timestamp":1778860830000},"page":"345648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of extraction solvents for untargeted metabolomics in characterizing Antarctic cryoconite hole dissolved organic matter"],"prefix":"10.1016","volume":"1413","author":[{"given":"Swapnil","family":"Mundhe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saborni","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aritri","family":"Sanyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0758-4530","authenticated-orcid":false,"given":"Anirban","family":"Majumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-1226","authenticated-orcid":false,"given":"Narendra Y.","family":"Kadoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-7396","authenticated-orcid":false,"given":"Dhiraj","family":"Dhotre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4009-5924","authenticated-orcid":false,"given":"Vitthal T.","family":"Barvkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamim A.","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runa","family":"Antony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.345648_bib1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10533-022-00900-4","article-title":"Microbial biogeochemistry and phosphorus limitation in cryoconite holes on glaciers across the taylor valley, McMurdo dry valleys, Antarctica","volume":"158","author":"Schmidt","year":"2022","journal-title":"Biogeochemistry"},{"key":"10.1016\/j.aca.2026.345648_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-42118-9","article-title":"Evaluation of an untargeted nano-liquid chromatography-mass spectrometry approach to expand coverage of low molecular weight dissolved organic matter in Arctic soil","volume":"9","author":"Ladd","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aca.2026.345648_bib3","article-title":"Characterization of small micro-and nanoparticles in antarctic snow by electron microscopy and raman micro-spectroscopy","volume":"14","author":"Riboni","year":"2024","journal-title":"Appl. Sci. (Switzerland)"},{"key":"10.1016\/j.aca.2026.345648_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.01783","article-title":"Physiological capabilities of cryoconite hole microorganisms","volume":"11","author":"Poniecka","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.aca.2026.345648_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150874","article-title":"Cryoconite \u2013 from minerals and organic matter to bioengineered sediments on glacier's surfaces","volume":"807","author":"Rozwalak","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aca.2026.345648_bib6","doi-asserted-by":"crossref","DOI":"10.1890\/07-0187.1","article-title":"Glacial ecosystems","volume":"78","author":"Hodson","year":"2008","journal-title":"Ecol. Monogr."},{"key":"10.1016\/j.aca.2026.345648_bib7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1657\/1938-4246-45.4.440","article-title":"Do cryoconite holes have the potential to be significant sources of C, N, and P to downstream depauperate ecosystems of taylor valley, Antarctica?","volume":"45","author":"Bagshaw","year":"2013","journal-title":"Arctic Antarct. Alpine Res."},{"key":"10.1016\/j.aca.2026.345648_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10201-017-0528-9","article-title":"Snapshot of micro-animals and associated biotic and abiotic environmental variables on the edge of the south-west Greenland ice sheet","volume":"19","author":"Zawierucha","year":"2018","journal-title":"Limnology"},{"key":"10.1016\/j.aca.2026.345648_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3189\/S0022143000014167","article-title":"Cryoconite holes on sermikavsak, west Greenland","volume":"22","author":"Gribbon","year":"1979","journal-title":"J. Glaciol."},{"key":"10.1016\/j.aca.2026.345648_bib10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/0309133315616574","article-title":"Cryoconite: the dark biological secret of the cryosphere","volume":"40","author":"Cook","year":"2016","journal-title":"Prog. Phys. Geogr."},{"key":"10.1016\/j.aca.2026.345648_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3161\/00034541ANZ2018.68.1.007","article-title":"High mitochondrial diversity in a new water bear species (Tardigrada: Eutardigrada) from Mountain glaciers in central Asia, with the erection of a new genus cryoconicus","volume":"68","author":"Zawierucha","year":"2018","journal-title":"Annal. Zool."},{"key":"10.1016\/j.aca.2026.345648_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262039","article-title":"Trophic and symbiotic links between obligate-glacier water bears (Tardigrada) and cryoconite microorganisms","volume":"17","author":"Zawierucha","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.aca.2026.345648_bib13","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1365-2486.2008.01758.x","article-title":"High microbial activity on glaciers: importance to the global carbon cycle","volume":"15","author":"Anesio","year":"2009","journal-title":"Glob. Change Biol."},{"key":"10.1016\/j.aca.2026.345648_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41522-017-0019-0","article-title":"The microbiome of glaciers and ice sheets","volume":"3","author":"Anesio","year":"2017","journal-title":"npj Biofilms Microbiomes"},{"key":"10.1016\/j.aca.2026.345648_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.micres.2018.01.004","article-title":"Microbial communities and their potential for degradation of dissolved organic carbon in cryoconite hole environments of Himalaya and Antarctica","volume":"208","author":"Sanyal","year":"2018","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.aca.2026.345648_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.00065","article-title":"Comparison of microbial communities in the sediments and water columns of frozen cryoconite holes in the McMurdo Dry Valleys, Antarctica","volume":"10","author":"Sommers","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.aca.2026.345648_bib17","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1111\/1462-2920.16485","article-title":"Icescape-scale metabolomics reveals cyanobacterial and topographic control of the core metabolism of the cryoconite ecosystem of an Arctic ice cap","volume":"25","author":"Gokul","year":"2023","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.aca.2026.345648_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/1462-2920.16574","article-title":"The exometabolome of microbial communities inhabiting bare ice surfaces on the southern Greenland Ice Sheet","volume":"26","author":"Doting","year":"2024","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.aca.2026.345648_bib19","article-title":"Integrated \u201cOmics,\u201d","volume":"6","author":"Lutz","year":"2015","journal-title":"targeted metabolite and single-cell analyses of arctic snow algae functionality and adaptability, Front. Microbiol."},{"key":"10.1016\/j.aca.2026.345648_bib20","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.numecd.2021.01.008","article-title":"The evolving landscape of untargeted metabolomics","volume":"31","author":"Di Minno","year":"2021","journal-title":"Nutr. Metab. Cardiovasc"},{"key":"10.1016\/j.aca.2026.345648_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-44035-y","article-title":"Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics","volume":"14","author":"Bittremieux","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.aca.2026.345648_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-40333-7","article-title":"Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics","volume":"14","author":"Bowen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.aca.2026.345648_bib23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.soilbio.2014.10.007","article-title":"Untargeted soil metabolomics methods for analysis of extractable organic matter","volume":"80","author":"Swenson","year":"2015","journal-title":"Soil Biol. Biochem."},{"key":"10.1016\/j.aca.2026.345648_bib24","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4939-8757-3_4","article-title":"Untargeted soil metabolomics using liquid chromatography\u2013mass spectrometry and gas chromatography\u2013mass spectrometry","author":"Swenson","year":"2019"},{"key":"10.1016\/j.aca.2026.345648_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/soilsystems5010010","article-title":"Untargeted exometabolomics provides a powerful approach to investigate biogeochemical hotspots with vegetation and polygon type in arctic tundra soils","volume":"5","author":"Ladd","year":"2021","journal-title":"Soil Syst."},{"key":"10.1016\/j.aca.2026.345648_bib26","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.1007\/s00253-021-11489-3","article-title":"Marine dissolved organic matter: a vast and unexplored molecular space","volume":"105","author":"Catal\u00e1","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.aca.2026.345648_bib27","doi-asserted-by":"crossref","DOI":"10.1007\/s42832-023-0179-1","article-title":"Characterization of dissolved organic matter distribution in forestland and farmland of mollisol based on untargeted metabolomics","volume":"5","author":"Yao","year":"2023","journal-title":"Soil Ecol. Lett."},{"key":"10.1016\/j.aca.2026.345648_bib28","doi-asserted-by":"crossref","DOI":"10.1029\/2006JG000358","article-title":"Metabolic activity and diversity of cryoconites in the Taylor Valley, Antarctica","volume":"112","author":"Foreman","year":"2007","journal-title":"J. Geophys. Res. Biogeosci."},{"key":"10.1016\/j.aca.2026.345648_bib29","doi-asserted-by":"crossref","first-page":"13215","DOI":"10.1021\/acs.est.6b03971","article-title":"Chemical composition of microbe-derived dissolved organic matter in cryoconite in tibetan plateau glaciers: insights from fourier transform ion cyclotron resonance mass spectrometry analysis","volume":"50","author":"Feng","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aca.2026.345648_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.01165","article-title":"Cryoconite hole location in east-antarctic untersee oasis shapes physical and biological diversity","volume":"11","author":"Weisleitner","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.aca.2026.345648_bib31","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s12275-024-00140-1","article-title":"Autotrophy to heterotrophy: shift in bacterial functions during the melt season in antarctic cryoconite holes","volume":"62","author":"Sanyal","year":"2024","journal-title":"J. Microbiol."},{"key":"10.1016\/j.aca.2026.345648_bib32","doi-asserted-by":"crossref","DOI":"10.1029\/2011JG001798","article-title":"Controls on the composition and lability of dissolved organic matter in Siberia's Kolyma River basin","volume":"117","author":"Mann","year":"2012","journal-title":"J. Geophys. Res. Biogeosci."},{"key":"10.1016\/j.aca.2026.345648_bib33","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/ngeo1581","article-title":"Biogeochemically diverse organic matter in Alpine glaciers and its downstream fate","volume":"5","author":"Singer","year":"2012","journal-title":"Nat. Geosci."},{"key":"10.1016\/j.aca.2026.345648_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00216-012-6363-2","article-title":"Molecular characterization of dissolved organic matter (DOM): a critical review","volume":"405","author":"Nebbioso","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aca.2026.345648_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gca.2012.11.029","article-title":"Comparison of cryoconite organic matter composition from Arctic and Antarctic glaciers at the molecular-level","volume":"104","author":"Pautler","year":"2013","journal-title":"Geochem. Cosmochim. Acta"},{"key":"10.1016\/j.aca.2026.345648_bib36","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1021\/es405246a","article-title":"Origin and sources of dissolved organic matter in snow on the east antarctic ice sheet","volume":"48","author":"Antony","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aca.2026.345648_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130557","article-title":"Indexing permafrost soil organic matter degradation using high-resolution mass spectrometry","volume":"10","author":"Mann","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.aca.2026.345648_bib38","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10533-016-0215-7","article-title":"Redistribution of soil organic matter by permafrost disturbance in the Canadian High Arctic","volume":"128","author":"Grewer","year":"2016","journal-title":"Biogeochemistry"},{"key":"10.1016\/j.aca.2026.345648_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/jms.4613","article-title":"Investigation of space charge effects and ion trapping capacity on direct introduction ultra-high-resolution mass spectrometry workflows for metabolomics","volume":"55","author":"Hohenester","year":"2020","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.aca.2026.345648_bib40","doi-asserted-by":"crossref","DOI":"10.1039\/D3NP00050H","article-title":"Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products","author":"Vitale","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.aca.2026.345648_bib41","doi-asserted-by":"crossref","first-page":"26325","DOI":"10.1039\/C4RA02731K","article-title":"Evaluating solvent extraction systems using metabolomics approaches","volume":"4","author":"Martin","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.aca.2026.345648_bib42","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1002\/jssc.201100532","article-title":"Separation strategies for untargeted metabolomics","volume":"34","author":"Patti","year":"2011","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.aca.2026.345648_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11306-012-0434-4","article-title":"Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics","volume":"9","author":"Dunn","year":"2013","journal-title":"Metabolomics"},{"key":"10.1016\/j.aca.2026.345648_bib44","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.talanta.2018.01.084","article-title":"A review of nanoscale LC-ESI for metabolomics and its potential to enhance the metabolome coverage","volume":"182","author":"Chetwynd","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.345648_bib45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpba.2013.06.032","article-title":"Current practice of liquid chromatography-mass spectrometry in metabolomics and metabonomics","volume":"87","author":"Gika","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.aca.2026.345648_bib46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jchromb.2014.04.025","article-title":"Annotation of the human serum metabolome by coupling three liquid chromatography methods to high-resolution mass spectrometry","volume":"966","author":"Boudah","year":"2014","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.aca.2026.345648_bib47","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1074\/mcp.M114.046508","article-title":"Optimized analytical procedures for the untargeted metabolomic profiling of human urine and plasma by combining hydrophilic interaction (HILIC) and reverse-phase liquid chromatography (RPLC)-mass spectrometry","volume":"14","author":"Contrepois","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.aca.2026.345648_bib48","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/mas.21445","article-title":"HILIC-MS for metabolomics: an attractive and complementary approach to RPLC-MS","volume":"35","author":"Tang","year":"2016","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.aca.2026.345648_bib49","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1021\/ac7023409","article-title":"Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites","volume":"80","author":"Winder","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345648_bib50","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/molecules14062167","article-title":"Effect of extraction solvent\/technique on the antioxidant activity of selected medicinal plant extracts","volume":"14","author":"Sultana","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.aca.2026.345648_bib51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jchromb.2016.06.047","article-title":"Sample preparation optimization in fecal metabolic profiling","volume":"1047","author":"Deda","year":"2017","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.aca.2026.345648_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-34593-y","article-title":"Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models","volume":"13","author":"Schippers","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aca.2026.345648_bib53","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/bioinformatics\/btac040","article-title":"RawHummus: an R Shiny app for automated raw data quality control in metabolomics","volume":"38","author":"Dong","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.aca.2026.345648_bib54","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.aca.2026.345648_bib55","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/bioinformatics\/btu019","article-title":"ProbMetab: an R package for Bayesian probabilistic annotation of LC-MS-based metabolomics","volume":"30","author":"Silva","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.aca.2026.345648_bib56","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/ac051437y","article-title":"XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification","volume":"78","author":"Smith","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345648_bib57","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/ac202450g","article-title":"CAMERA: an integrated strategy for compound spectra extraction and annotation of liquid chromatography\/mass spectrometry data sets","volume":"84","author":"Kuhl","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345648_bib58","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1021\/ac2000994","article-title":"PeakML\/mzMatch: a file format, Java library, R library, and tool-chain for mass spectrometry data analysis","volume":"83","author":"Scheltema","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345648_bib59","author":"Tiffany"},{"key":"10.1016\/j.aca.2026.345648_bib60","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.aca.2026.345648_bib61","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11306-007-0068-0","article-title":"Minimum reporting standards for plant biology context information in metabolomic studies","volume":"3","author":"Fiehn","year":"2007","journal-title":"Metabolomics"},{"key":"10.1016\/j.aca.2026.345648_bib62","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis: Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"10.1016\/j.aca.2026.345648_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.greeac.2024.100199","article-title":"Condensed phase membrane introduction mass spectrometry: a new frontier for the real-time monitoring of hazardous chemical migration from food contact materials","volume":"12","author":"Piergiovanni","year":"2025","journal-title":"Green Analytical Chemistry"},{"key":"10.1016\/j.aca.2026.345648_bib64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cca.2017.10.029","article-title":"Metabolomic analysis\u2014Addressing NMR and LC-MS related problems in human feces sample preparation","volume":"489","author":"Moosmang","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.aca.2026.345648_bib65","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/chromsci\/16.6.223","article-title":"Classification off the solvent properties of common liquids","volume":"16","author":"Snyder","year":"1978","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.aca.2026.345648_bib66","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-020-01669-z","article-title":"An LC-QToF MS based method for untargeted metabolomics of human fecal samples","volume":"16","author":"Cheng","year":"2020","journal-title":"Metabolomics"},{"key":"10.1016\/j.aca.2026.345648_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/metabo7040053","article-title":"Analysis of intracellular metabolites from microorganisms: quenching and extraction protocols","volume":"7","author":"Pinu","year":"2017","journal-title":"Metabolites"},{"key":"10.1016\/j.aca.2026.345648_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2018.05.031","article-title":"A review on human fecal metabolomics: methods, applications and the human fecal metabolome database","volume":"1030","author":"Karu","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.345648_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005440","article-title":"How large is the metabolome? A critical analysis of data exchange practices in chemistry","volume":"4","author":"Kind","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.aca.2026.345648_bib70","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1021\/cr300484s","article-title":"New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era","volume":"113","author":"Kuehnbaum","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aca.2026.345648_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.464930","article-title":"Impact of four different extraction methods and three different reconstitution solvents on the untargeted metabolomics analysis of human and rat urine samples","volume":"1725","author":"Hemmer","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.aca.2026.345648_bib72","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1021\/acs.analchem.7b00859","article-title":"RPLC-HILIC and SFC with mass spectrometry: Polarity-extended organic molecule screening in environmental (Water) samples","volume":"89","author":"Bieber","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.345648_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.soilbio.2004.06.010","article-title":"The carbon we do not see - the impact of low molecular weight compounds on carbon dynamics and respiration in forest soils: a review","volume":"37","author":"Van Hees","year":"2005","journal-title":"Soil Biol. Biochem."},{"key":"10.1016\/j.aca.2026.345648_bib74","doi-asserted-by":"crossref","first-page":"13946","DOI":"10.1073\/pnas.1511705112","article-title":"Ancient low-molecular-weight organic acids in permafrost fuel rapid carbon dioxide production upon thaw","volume":"112","author":"Drake","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.aca.2026.345648_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/frsen.2022.953733","article-title":"Spatiotemporal change analysis for snowmelt over the Antarctic ice shelves using scatterometers","volume":"3","author":"Luis","year":"2022","journal-title":"Frontiers in Remote Sensing"},{"key":"10.1016\/j.aca.2026.345648_bib76","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-019-1631-1","article-title":"Impact of the used solvent on the reconstitution efficiency of evaporated biosamples for untargeted metabolomics studies","volume":"16","author":"Manier","year":"2020","journal-title":"Metabolomics"},{"key":"10.1016\/j.aca.2026.345648_bib77","article-title":"Extraction of pigments from microalgae and cyanobacteria-a review on current methodologies","volume":"11","author":"Pagels","year":"2021","journal-title":"Appl. Sci. (Switzerland)"},{"key":"10.1016\/j.aca.2026.345648_bib78","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2672.2006.03052.x","article-title":"Comparative analysis of environmental DNA extraction and purification methods from different humic acid-rich soils","volume":"102","author":"Lakay","year":"2007","journal-title":"J. Appl. Microbiol."},{"issue":"7","key":"10.1016\/j.aca.2026.345648_bib79","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1021\/acs.jproteome.7b00103","article-title":"Optimized extraction method to remove humic acid interferences from soil samples prior to microbial proteome measurements","volume":"16","author":"Qian","year":"2017","journal-title":"J. Proteome Res."},{"issue":"2","key":"10.1016\/j.aca.2026.345648_bib80","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1890\/08-2338.1","article-title":"Plant diversity effects on soil microorganisms support the singular hypothesis","volume":"91","author":"Eisenhauer","year":"2010","journal-title":"Ecology"},{"key":"10.1016\/j.aca.2026.345648_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2021.102424","article-title":"The immediate effect of riboflavin and lumichrome on the mitigation of saline stress in the microalga Chlorella sorokiniana by the plant-growth-promoting bacterium Azospirillum brasilense","volume":"58","author":"Palacios","year":"2021","journal-title":"Algal Res."},{"key":"10.1016\/j.aca.2026.345648_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/life8010008","article-title":"Reporting key features in cold-adapted bacteria","volume":"8","author":"Tribelli","year":"2018","journal-title":"Life"},{"key":"10.1016\/j.aca.2026.345648_bib83","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00792-017-0939-x","article-title":"Adaptations of archaeal and bacterial membranes to variations in temperature, pH and pressure","volume":"21","author":"Siliakus","year":"2017","journal-title":"Extremophiles"},{"key":"10.1016\/j.aca.2026.345648_bib84","first-page":"1","article-title":"Microbial genomics amidst the arctic crisis","volume":"6","author":"Edwards","year":"2020","journal-title":"Microb. Genom."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026005982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026005982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:49:01Z","timestamp":1783162141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026005982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":84,"alternative-id":["S0003267026005982"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.345648","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of extraction solvents for untargeted metabolomics in characterizing Antarctic cryoconite hole dissolved organic matter","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.345648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"345648"}}